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3.4.24.86: ADAM 17 endopeptidase

This is an abbreviated version!
For detailed information about ADAM 17 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.86

Reaction

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains =

Synonyms

(TACE/ADAM17/CD156q), (TACE:ADAM17), a disintegrin and metallo protease domain 17, a disintegrin and metalloprotease 17, a disintegrin and metalloprotease-17, a disintegrin and metalloproteinase 17, a disintegrin and metalloproteinase-17, ADAM-17, ADAM17, ADAM17 proteinase, ADAM17/tumor necrosis factor-alpha (TNF-A)converting enzyme, ADAMTS-2, CD156, H-TACE, human TACE B, metalloprotease TACE, metalloprotease-disintegrin tumour necrosis factor alpha convertase, metalloproteinase ADAM17, pro tumor necrosis factor cleavage enzyme, pro-tumor necrosis factor-alpha-processing enzyme, proteinase, pro-tumor necrosis factor (9CI), sheddase, TACE, TACE proteinase, TACE/ADAM17, TNF converting enzyme, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha processing protease, TNFalpha converting enzyme, tumor necrosis factor alpha convertase, tumor necrosis factor alpha converting enzyme, tumor necrosis factor alpha-converting enzyme, tumor necrosis factor-alpha converting enzyme, tumor necrosis factor-alpha-converting enzyme, tumour necrosis factor alpha-converting enzyme, tumour necrosis factor-alpha converting enzyme

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.86 ADAM 17 endopeptidase

Activating Compound

Activating Compound on EC 3.4.24.86 - ADAM 17 endopeptidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
12-HPETE
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i.e. 12-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid, a peroxide synthesized in the platelet lipoxygenase pathway, induces TACE-mediated receptor cleavage
angiotensin II
treatment with angiotensin II results in angiotensin II type 1 receptor AT1R-mediated increase in myocardial TACE expression and activity, and membrane translocation of TACE
anti-Ro/SSA autoantibody
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i.e. antinuclear autoantibodies in the blood directed against Ro/Sjögren's syndrome ribonucleoprotein A antigen. Adalimumab appears to be significantly more efficacious than Etanercept in preventing TACE activation caused by anti-Ro/SSA autoantibodies
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bortezomib
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stimulates ADAM17-catalyzed shedding of CD30, blocks bortezomib-stimulated sCD30 release from L540 cells with an IC50 of approximately 230 nM
cytochalasin D
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four and half LIM domain 2 protein
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four and half LIM domain 2 protein binds both ADAM-17 and the actin-based cytoskeletonand is involved in the regulation of ADAM-17 cellular localization and activity
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furin
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activates ADAM-17
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glucose oxidase
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oxidative damage via glucose oxidase or hydrogen peroxide activates TACE and induces shedding of its targets, glycoprotein Ibalpha and glycoprotein V, in murine and human platelets. The TACE activation is independent of platelet activation. TACE activation induced by hydrogen peroxide is dependent on p38 mitogen-activated protein kinase signalling, whereas protein kinase C, phosphoinositide 3-kinase, and caspases are not involved. Inhibition of p38 cytoplasmic targets, phospholipase A2 and heat shock protein 27, does not prevent shedding, whereas blocking 12-lipoxygenase or Src kinase slightly inhibits TACE activation
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glutamate
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the shedding activity of the enzyme is increased during glutamate stimulation
granulocyte-macrophage colony-stimulating factor
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granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin-4 in combination potently up-regulate tumor necrosis factor-alpha coverting enzyme TACE and activity in monocytes, causing ectodomain shedding of M-CSF receptor
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heparan sulfate
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removal of cell surface heparan sulfate increases TACE activity and TACE-dependent formation of ErbB4 80 kDa intracellular domain
hydrogen peroxide
-
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interleukin-4
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granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin-4 in combination potently up-regulate tumor necrosis factor-alpha coverting enzyme TACE and activity in monocytes, causing ectodomain shedding of M-CSF receptor
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lipopolysaccharide
N-formyl-L-methionyl-phenylalanine
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ADAM17 substrates undergo efficient turnover during extended neutrophil activation by N-formyl-L-methionyl-phenylalanine
oxygen
-
low oxygen concentrations enhance TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 to the 5' promoter region
p38 mitogen-activated protein kinase
-
increased and sustained cell surface levels of TACE, and phosphorylation of its cytoplasmic tail, a hallmark of TACE activation, occur in lymphocytes and monocytes following p38 MAPK activation
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phorbol 12-myristate 13-acetate
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potent activator of ADAM17
phorbol 12-myristate-13-acetate
phorbol ester
phorbol-12-myristate 13-acetate
-
-
Quinacrine
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thrombin receptor agonistic peptide-6
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SFLLRN
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Tumor necrosis factor alpha
-
20 ng/ml tumor necrosis factor alpha enhances TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 to the 5' promoter region
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additional information
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