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Literature summary for 3.4.24.86 extracted from

  • Scheller, J.; Chalaris, A.; Garbers, C.; Rose-John, S.
    ADAM17: A molecular switch to control inflammation and tissue regeneration (2011), Trends Immunol., 32, 380-387.
    View publication on PubMed
Search for more literature for 3.4.24.86

Activating Compound

Activating Compound Comment Organism Structure
phorbol 12-myristate 13-acetate potent activator of ADAM17 Mus musculus

Protein Variants

Protein Variants Comment Organism
T735A the mutant has a basal TGF-alpha shedding activity lower than that of wild type cells and shedding is not induced by p38 MAPK Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
tissue inhibitor of metalloproteinase-3
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
AREG + H2O Mus musculus
-
 ?
-
 ?
CD26L + H2O Mus musculus
-
 ?
-
 ?
FLT-3L + H2O Mus musculus
-
 ?
-
 ?
GPIba + H2O Mus musculus
-
 ?
-
 ?
HB-EGF + H2O Mus musculus
-
 ?
-
 ?
ICAM-1 + H2O Mus musculus
-
 ?
-
 ?
interleukin-6 receptor + H2O Mus musculus
-
 soluble interleukin-6 receptor + ?
-
 ?
L-selectin + H2O Mus musculus ADAM17 is the main sheddase of the adhesion protein L-selectin ?
-
 ?
Notch1 + H2O Mus musculus
-
 ?
-
 ?
p55 TNF-alpha RI + H2O Mus musculus
-
 ?
-
 ?
p75 TNF-alpha RII + H2O Mus musculus
-
 ?
-
 ?
proTGF-alpha + H2O Mus musculus
-
 soluble TGF-alpha
-
 ?
proTNF-alpha + H2O Mus musculus
-
 soluble TNF-alpha + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ACE2 + H2O
-
 Mus musculus ?
-
 ?
ALCAM + H2O
-
 Mus musculus ?
-
 ?
AREG + H2O
-
 Mus musculus ?
-
 ?
CD163 + H2O
-
 Mus musculus ?
-
 ?
CD26L + H2O
-
 Mus musculus ?
-
 ?
CD30 + H2O
-
 Mus musculus ?
-
 ?
CD40 + H2O
-
 Mus musculus ?
-
 ?
CD44 + H2O
-
 Mus musculus ?
-
 ?
CD89 + H2O
-
 Mus musculus ?
-
 ?
CD91 + H2O
-
 Mus musculus ?
-
 ?
collagen type XVII + H2O
-
 Mus musculus ?
-
 ?
CSF-1 + H2O
-
 Mus musculus ?
-
 ?
CSF1R + H2O
-
 Mus musculus ?
-
 ?
DLL1 + H2O
-
 Mus musculus ?
-
 ?
DSG2 + H2O
-
 Mus musculus ?
-
 ?
EpCAM + H2O
-
 Mus musculus ?
-
 ?
EPCR + H2O
-
 Mus musculus ?
-
 ?
epigen + H2O
-
 Mus musculus ?
-
 ?
ErbB4 + H2O
-
 Mus musculus ?
-
 ?
EREG + H2O
-
 Mus musculus ?
-
 ?
FLT-3L + H2O
-
 Mus musculus ?
-
 ?
fractalkine + H2O
-
 Mus musculus ?
-
 ?
GPIba + H2O
-
 Mus musculus ?
-
 ?
HB-EGF + H2O
-
 Mus musculus ?
-
 ?
heregulin + H2O
-
 Mus musculus ?
-
 ?
ICAM-1 + H2O
-
 Mus musculus ?
-
 ?
IGF-2 receptor + H2O
-
 Mus musculus ?
-
 ?
interleukin-1 receptor 2 + H2O
-
 Mus musculus ?
-
 ?
interleukin-6 receptor + H2O
-
 Mus musculus soluble interleukin-6 receptor + ?
-
 ?
Jagged protein + H2O
-
 Mus musculus ?
-
 ?
JAM-A + H2O
-
 Mus musculus ?
-
 ?
KL-1 + H2O
-
 Mus musculus ?
-
 ?
KL-2 + H2O
-
 Mus musculus ?
-
 ?
L-selectin + H2O ADAM17 is the main sheddase of the adhesion protein L-selectin Mus musculus ?
-
 ?
L1-CAM + H2O
-
 Mus musculus ?
-
 ?
LAG-3 + H2O
-
 Mus musculus ?
-
 ?
LOX-1 + H2O
-
 Mus musculus ?
-
 ?
lymphotoxin-alpha + H2O
-
 Mus musculus ?
-
 ?
LYPD3 + H2O
-
 Mus musculus ?
-
 ?
MICA + H2O
-
 Mus musculus ?
-
 ?
MICB + H2O
-
 Mus musculus ?
-
 ?
MUC-1 + H2O
-
 Mus musculus ?
-
 ?
NCAM + H2O
-
 Mus musculus ?
-
 ?
nectin-4 + H2O
-
 Mus musculus ?
-
 ?
Notch1 + H2O
-
 Mus musculus ?
-
 ?
NPR + H2O
-
 Mus musculus ?
-
 ?
p55 TNF-alpha RI + H2O
-
 Mus musculus ?
-
 ?
p75 TNF-alpha RII + H2O
-
 Mus musculus ?
-
 ?
p75NTR + H2O
-
 Mus musculus ?
-
 ?
PMEL17 + H2O
-
 Mus musculus ?
-
 ?
Pref1 + H2O
-
 Mus musculus ?
-
 ?
proTGF-alpha + H2O
-
 Mus musculus soluble TGF-alpha
-
 ?
proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha + ?
-
 ?
PrPc + H2O
-
 Mus musculus ?
-
 ?
PTP-LAR + H2O
-
 Mus musculus ?
-
 ?
Ptprz + H2O
-
 Mus musculus ?
-
 ?
SDC1 + H2O
-
 Mus musculus ?
-
 ?
SDC4 + H2O
-
 Mus musculus ?
-
 ?
SEMA4D + H2O
-
 Mus musculus ?
-
 ?
SORCS1 + H2O
-
 Mus musculus ?
-
 ?
sorCS3 + H2O
-
 Mus musculus ?
-
 ?
SORL1 + H2O
-
 Mus musculus ?
-
 ?
SORT1 + H2O
-
 Mus musculus ?
-
 ?
TMEFF2 + H2O
-
 Mus musculus ?
-
 ?
TRANCE/RANKL + H2O
-
 Mus musculus ?
-
 ?
TrkA + H2O
-
 Mus musculus ?
-
 ?
vasorin + H2O
-
 Mus musculus ?
-
 ?
VCAM-1 + H2O
-
 Mus musculus ?
-
 ?
VEGFR2 + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM17
-
 Mus musculus
TACE
-
 Mus musculus
tumor necrosis factor-alpha converting enzyme
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus ADAM17 is upregulated in most tumor cells up

General Information

General Information Comment Organism
malfunction ADAM17-deficient mice have defects in the mammary epithelium, vascular system, lung, eye, hair, heart and skin and as a result die between embryonic day 17.5 and the first few days after birth Mus musculus
physiological function ADAM17 plays an in vivo role in controlling inflammation and tissue regeneration. ADAM17 modulates inflammation by activation of TNFR- and IL-6R-mediated signal transduction. ADAM17 activity regulates both homeostatic and activation-induced changes in cell surface L-selectin density and, thus, might direct the migration patterns of activated lymphocytes and neutrophils in vivo. Apoptosis leads to activation of ADAM17. During ADAM17 maturation, the prodomain is removed by furin cleavage. ADAM17 protects hepatocytes from apoptosis Mus musculus