Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lipopolysaccharide | lipopolysaccharide-vehicle or lipopolysaccharide-ranitidine treatments of rats causes a significant increase in hepatic TACE activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BMS-561392 | TACE inhibitor also named DPC-333 is administered 15 min before ranitidine or its vehicle. Serum TNF-alpha concentration are measured 1 h afterwards. lipopolysaccharide/ranitidine treatment causes a significant increase in serum TNF-alpha concentration compared with lipopolysaccharide/vehicle treatment. Inhibitor does not affect serum TNF-alpha concentration after lipopolysaccharide/vehicle treatment. By contrast, it decreases serum TNF-alpha concentration after lipopolysaccharide/ranitidine treatment to the same level as lipopolysaccharide/vehicle treatment at both 1 h. In addition, TACE inhibitor decreases plasma active plasminogen activator inhibitor-1 concentration after lipopolysaccharide/ranitidine treatment to almost the same level as lipopolysaccharide/vehicle treatment | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
TNF-alpha + H2O | Rattus norvegicus | ranitidine enhances TNF-alpha production after lipopolysaccharide treatment through augmented p38 activation, and this seems to occur through TACE | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | TACE cleaves proTNF-alpha in its active form | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
TNF-alpha + H2O | ranitidine enhances TNF-alpha production after lipopolysaccharide treatment through augmented p38 activation, and this seems to occur through TACE | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TACE | - |
Rattus norvegicus |