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Literature summary for 3.4.24.86 extracted from

  • Nelson, K.K.; Schlondorff, J.; Blobel, C.P.
    Evidence for an interaction of the metalloprotease-disintegrin tumor necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2.beta (1999), Biochem. J., 343, 673-680.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharide
-
Homo sapiens
phorbol ester stimulates the TACE-mediated release of TNF-alpha from cells Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cDNA clones coding for various segments of the TACE cytotail Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm cytoplasmic tail Homo sapiens 5737
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein + H2O shedding Homo sapiens ?
-
?
L-selectin + H2O shedding Homo sapiens ?
-
?
p75 tumour necrosis factor receptor + H2O shedding Homo sapiens ?
-
?
proTNF-alpha + H2O
-
Homo sapiens soluble TNF-alpha
-
?
transforming growth factor alpha + H2O TGF alpha shedding Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
metalloprotease-disintegrin tumour necrosis factor alpha convertase
-
Homo sapiens