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Literature summary for 3.4.24.86 extracted from

  • Canault, M.; Tellier, E.; Bonardo, B.; Mas, E.; Aumailley, M.; Juhan-Vague, I.; Nalbone, G.; Peiretti, F.
    FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity (2006), J. Cell. Physiol., 208, 363-372.
    View publication on PubMed
Search for more literature for 3.4.24.86

Activating Compound

Activating Compound Comment Organism Structure
four and half LIM domain 2 protein four and half LIM domain 2 protein binds both ADAM-17 and the actin-based cytoskeletonand is involved in the regulation of ADAM-17 cellular localization and activity Rattus norvegicus
furin activates ADAM-17 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoskeleton only the mature form of ADAM-17 associates with the cytoskeleton Rattus norvegicus 5856
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Sephacryl HR300 column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
H9c2 cell
-
 Rattus norvegicus
-
macrophage
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proTNF-alpha + H2O
-
 Rattus norvegicus soluble TNF-alpha
-
 ?

Synonyms

Synonyms Comment Organism
ADAM-17
-
 Rattus norvegicus
tumor necrosis factor-alpha converting enzyme
-
 Rattus norvegicus