3.4.24.86: ADAM 17 endopeptidase

This is an abbreviated version!
For detailed information about ADAM 17 endopeptidase, go to the full flat file.

Reaction

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains =

Synonyms

(TACE/ADAM17/CD156q), (TACE:ADAM17), a disintegrin and metallo protease domain 17, a disintegrin and metalloprotease 17, a disintegrin and metalloprotease-17, a disintegrin and metalloproteinase 17, a disintegrin and metalloproteinase-17, ADAM-17, ADAM17, ADAM17 proteinase, ADAM17/tumor necrosis factor-alpha (TNF-A)converting enzyme, ADAMTS-2, CD156, H-TACE, human TACE B, metalloprotease TACE, metalloprotease-disintegrin tumour necrosis factor alpha convertase, metalloproteinase ADAM17, pro tumor necrosis factor cleavage enzyme, pro-tumor necrosis factor-alpha-processing enzyme, proteinase, pro-tumor necrosis factor (9CI), sheddase, TACE, TACE proteinase, TACE/ADAM17, TNF converting enzyme, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha processing protease, TNFalpha converting enzyme, tumor necrosis factor alpha convertase, tumor necrosis factor alpha converting enzyme, tumor necrosis factor alpha-converting enzyme, tumor necrosis factor-alpha converting enzyme, tumor necrosis factor-alpha-converting enzyme, tumour necrosis factor alpha-converting enzyme, tumour necrosis factor-alpha converting enzyme

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.86 ADAM 17 endopeptidase

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Results	in table
47	Activating Compound
45	AA Sequence
48	Application
1	CAS Registry Number
33	Cloned(Commentary)
10	Crystallization (Commentary)
3494	Disease/ Diagnostics
22	Expression
47	General Information
4	General Stability
384	IC50 Value
690	Inhibitors
12	kcat/KM [mM/s]
157	Ki Value [mM]
15	KM Value [mM]
90	Localization
18	Metals/Ions
17	Molecular Weight [Da]
102	Natural Substrates/ Products (Substrates)
228	Organism
44	PDB ID
5	pH Optimum
3	Posttranslational Modification
17	Protein Variants
16	Purification (Commentary)
1	Reaction
209	Reference
286	Source Tissue
1	Storage Stability
500	Substrates and Products (Substrate)
5	Subunits
184	Synonyms
4	Temperature Optimum [°C]
14	Turnover Number [1/s]

Reaction

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Reaction on EC 3.4.24.86 - ADAM 17 endopeptidase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains

proTNF-alpha + H2O = soluble TNF-alpha. Cleavage of the precursor of tumor necrosis factor proTNFalpha to the mature tumor necrosis factor TNF-alpha, Swiss-Prot Acesssion Numbers: P78536(human), Q77636(pig), Q9Z1K9(rat), Q9Z0F8(mouse), Q923X3(chinese hamster). In peptidase family M12. In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNFa, which induces inflammation.

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