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Literature summary for 3.4.24.86 extracted from

  • Xue, C.B.; He, X.; Corbett, R.L.; Roderick, J.; Wasserman, Z.R.; Liu, R.Q.; Jaffee, B.D.; Covington, M.B.; Qian, M.; Trzaskos, J.M.; Newton, R.C.; Magolda, R.L.; Wexler, R.R.; Decicco, C.P.
    Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release (2001), J. Med. Chem., 44, 3351-3354.
    View publication on PubMed
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Application

Application Comment Organism
medicine therapeutic potential of TACE inhibitors benefit in treating autoimmune diseases like Crohn's disease or rheumatoid arthritis Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Homo sapiens
-
 Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
macrocyclic hydroxamic acid
-
 Homo sapiens
macrocyclic hydroxamic acid
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular disintegrin and protease regions Sus scrofa
-
-
membrane membrane-bound Homo sapiens 16020
-
membrane membrane-bound Sus scrofa 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
 pig
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
75kDaTNFR2 + H2O
-
 Homo sapiens ?
-
 ?
75kDaTNFR2 + H2O
-
 Sus scrofa ?
-
 ?
p55 TNFR1 + H2O
-
 Homo sapiens ?
-
 ?
p55 TNFR1 + H2O
-
 Sus scrofa ?
-
 ?
p75 tumour necrosis factor receptor + H2O
-
 Homo sapiens ?
-
 ?
p75 tumour necrosis factor receptor + H2O
-
 Sus scrofa ?
-
 ?
proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?
transforming growth factor alpha + H2O
-
 Sus scrofa ?
-
 ?