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Literature summary for 3.4.24.86 extracted from

  • Wang, Y.; Zhang, A.C.; Ni, Z.; Herrera, A.; Walcheck, B.
    ADAM17 activity and other mechanisms of soluble L-selectin production during death receptor-induced leukocyte apoptosis (2010), J. Immunol., 184, 4447-4454.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-selectin + H2O
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 Homo sapiens ?
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L-selectin + H2O during early events of death receptor-mediated neutrophil apoptosis, L-selectin downregulation occurs primarily by ADAM17-mediated shedding. During later stages of induced leukocyte apoptosis, soluble L-selectin production occurs independent of ADAM17 Mus musculus ?
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General Information

General Information Comment Organism
physiological function during early events of death receptor-mediated neutrophil apoptosis, L-selectin downregulation occurs primarily by ADAM17-mediated shedding. ADAM17 activity occurs during programmed cell death. The cleavage of particular ADAM17 substrates may be an additional component of the anti-inflammatory program initiated by apoptotic neutrophils. During later stages of induced leukocyte apoptosis, soluble L-selectin production occurs independent of ADAM17, as well as membrane events, such as blebbing and microparticle production Mus musculus
physiological function shRNA-approach to knock down ADAM17 expression in Jurkat cells show that during early events of death receptor-mediated neutrophil apoptosis, L-selectin downregulation occurs primarily by ADAM17-mediated shedding. The downregulation of L-selectin occurs by ectodomain shedding Homo sapiens