Literature summary for 3.4.24.86 extracted from

Li, X.; Fan, H.
Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha cnverting enzyme (TACE) (2004), J. Biol. Chem., 279, 27365-27375.

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Protein Variants

Protein Variants	Comment	Organism
C225Y	overexpression of C225 and C600Y TACE by transient transfection largely compensates for maturation defects in the variants but fails to restore TNF-alpha and TGF-alpha release in the shedding-defective CHO cell lines and fibroblasts derived from TACE-null mouse embryos	Cricetulus griseus
C600Y	overexpression of C225 and C600Y TACE by transient transfection largely compensates for maturation defects in the variants but fails to restore TNF-alpha and TGF-alpha release in the shedding-defective CHO cell lines and fibroblasts derived from TACE-null mouse embryos	Cricetulus griseus

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	Q6W3F6	tumor necrosis factor-alpha-converting enzyme mutant variant M2a	-
Cricetulus griseus	Q6W3F6	tumor necrosis factor-alpha-converting enzyme mutant variant M2b	-
Cricetulus griseus	Q6W3F7	tumor necrosis factor-alpha-converting enzyme mutant variant M1	-
Cricetulus griseus	Q6W3F8	tumor necrosis factor-alpha-converting enzyme	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CHO cell	mutated sublines M1 and M2. M1 contains only one expressible TACE allele encoding an M435I point mutation in the catalytic center of the protease, and M2 cells produce two TACE variants with distinct point mutations in the catalytic domain (C22Y) and the cysteine-rich/disintegrin domain (C600Y)	Cricetulus griseus	-

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Release 2023.1 (January 2023)