Literature summary for 3.4.24.86 extracted from

Liu, Y.; Wang, Z.; Ji, Y.; Li, F.
siRNA of ADAM17 gene induces apoptosis, proliferation inhibition and enhances the effects of genistein on HepG2 cells (2009), J. Nanjing Med. Univ., 23, 127-131.

No PubMed abstract available

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	silencing of ADAM17 by siRNA leads to significant inhibition of cell proliferation compared to the control groups at 24, 48 and 72 hours, and apoptosis is significantly increased at 48 hours. Cells that received a combination of siRNA transfection and genistein treatment, show a further significant decrease of proliferation and increase in apoptosis compared with either treatment alone	Homo sapiens

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Release 2023.1 (January 2023)