Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P78536 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HVEC cell | ADAM17 proteolytic targets, amphiregulin, transforming growth factor (TGF-alpha), syndecan-1 (SDC1), and tumor necrosis factor receptor 1 (TNFR1), are shed from HVECs in response to staphylococcal superantigen toxic shock syndrome toxin TSST-1. ADAM17, but not related ADAM10, is required for amphiregulin, TGF-alpha, and TNFR1 shedding. Both ADAM10 and ADAM17 contribute to SDC1 shedding and IL-8 production by HVECs in response to TSST-1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amphiregulin + H2O | ADAM17, but not related ADAM10, is required for amphiregulin, TGF-alpha, and TNFR1 shedding | Homo sapiens | ? | - |
? | |
syndecan-1 + H2O | both ADAM10 and ADAM17 contribute to SDC1 shedding | Homo sapiens | ? | - |
? | |
TGF-alpha + H2O | ADAM17, but not related ADAM10, is required for amphiregulin, TGF-alpha, and TNFR1 shedding | Homo sapiens | ? | - |
? | |
tumor necrosis factor receptor 1 + H2O | ADAM17, but not related ADAM10, is required for amphiregulin, TGF-alpha, and TNFR1 shedding | Homo sapiens | ? | - |
? |