3.4.22.27: cathepsin S
This is an abbreviated version!
For detailed information about cathepsin S, go to the full flat file.
Word Map on EC 3.4.22.27
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3.4.22.27
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cathepsins
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lysosomal
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point-of-care
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cystatins
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dendritic
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atherosclerosis
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proteinases
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elastin
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papain
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antigen-presenting
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histocompatibility
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autoimmune
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drug development
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lacrimal
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papain-like
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diagnostics
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ii-associated
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elastolytic
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resource-limited
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s-deficient
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procathepsins
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l-like
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pharmacology
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endostatin
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microglial
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fractalkine
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medicine
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par2
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collagenolytic
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syphilis
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ii-restricted
- 3.4.22.27
- cathepsins
- lysosomal
-
point-of-care
- cystatins
- dendritic
- atherosclerosis
- proteinases
- elastin
- papain
-
antigen-presenting
-
histocompatibility
- autoimmune
- drug development
-
lacrimal
-
papain-like
- diagnostics
-
ii-associated
-
elastolytic
-
resource-limited
-
s-deficient
-
procathepsins
-
l-like
- pharmacology
- endostatin
- microglial
- fractalkine
- medicine
- par2
-
collagenolytic
- syphilis
-
ii-restricted
Reaction
similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and additional information activity on the Z-Val-Val-Arg-/- compound =
Synonyms
C01.034, Cat S, Cat-S, cath S, cathepsin S, cathepsin S-like cysteine proteinase, cathepsin Sa, CatS, CatSPP, CTSS, Hacp-s, PfCTSSa, PoCtS, rs1136774, rs16827671, rs34495036, rs35989725, rs3754212, rs7534124, SoCatS
ECTree
3.4.22.27 cathepsin SAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.22.27 - cathepsin S
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
hypoxia increases the levels of CatS gene and protein in cultured HUVECs
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increased serum cathepsin S in patients with atherosclerosis and diabetes
additional information
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subcutaneous, of obese and lean individuals, adipocytes and stromal vascular fraction, the enzyme level in obese tissue is increased, genetic profiling and expression analysis, overview
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specific localization of cathepsin S activity in dendritic cells
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in nephron segments microdissected from lyophilized renal sections, highest cathepsin S activity is found in the proximal convoluted tubules followed by proximal straight tubules of the superficial cortex. In the remaining segments cathepsin S activity is hardly detectable
bone marrow-derived immune cells, cathepsin S expression is mainly restricted to antigen-presenting cells (APCs)
cathepsin S is expressed by macrophages infiltrating the human kidney
additional information
in human type 2 diabetic nephropathy, only CD68+ intrarenal monocytes express Cat-S mRNA, whereasCat-S protein is present along endothelial cells and inside proximal tubular epithelial cells also
additional information
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in human type 2 diabetic nephropathy, only CD68+ intrarenal monocytes express Cat-S mRNA, whereasCat-S protein is present along endothelial cells and inside proximal tubular epithelial cells also
additional information
in mouse type 2 diabetic nephropathy, only CD68+ intrarenal monocytes express Cat-S mRNA, whereasCat-S protein is present along endothelial cells and inside proximal tubular epithelial cells also. Transcriptome analysis
additional information
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in mouse type 2 diabetic nephropathy, only CD68+ intrarenal monocytes express Cat-S mRNA, whereasCat-S protein is present along endothelial cells and inside proximal tubular epithelial cells also. Transcriptome analysis
additional information
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the enzyme is expressed in antigen presenting cells
additional information
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cathepsin S is not expressed in HeLa-CIITA and MeIJuSo cells
additional information
SoCatS expression is detected in various tissues
additional information
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SoCatS expression is detected in various tissues
additional information
highest enzyme expression levels are seen in head kidney, fin, skin, spleen, and gill and the lowest levels are seen in the muscle, blood, liver, heart, intestine, and back kidney. Quantitative expression analysis in tissues, overview
