3.4.22.27: cathepsin S
This is an abbreviated version!
For detailed information about cathepsin S, go to the full flat file.
Word Map on EC 3.4.22.27
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3.4.22.27
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cathepsins
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lysosomal
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point-of-care
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cystatins
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dendritic
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atherosclerosis
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proteinases
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elastin
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papain
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antigen-presenting
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histocompatibility
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autoimmune
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drug development
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lacrimal
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papain-like
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diagnostics
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ii-associated
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elastolytic
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resource-limited
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s-deficient
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procathepsins
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l-like
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pharmacology
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endostatin
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microglial
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fractalkine
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medicine
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par2
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collagenolytic
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syphilis
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ii-restricted
- 3.4.22.27
- cathepsins
- lysosomal
-
point-of-care
- cystatins
- dendritic
- atherosclerosis
- proteinases
- elastin
- papain
-
antigen-presenting
-
histocompatibility
- autoimmune
- drug development
-
lacrimal
-
papain-like
- diagnostics
-
ii-associated
-
elastolytic
-
resource-limited
-
s-deficient
-
procathepsins
-
l-like
- pharmacology
- endostatin
- microglial
- fractalkine
- medicine
- par2
-
collagenolytic
- syphilis
-
ii-restricted
Reaction
similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and additional information activity on the Z-Val-Val-Arg-/- compound =
Synonyms
C01.034, Cat S, Cat-S, cath S, cathepsin S, cathepsin S-like cysteine proteinase, cathepsin Sa, CatS, CatSPP, CTSS, Hacp-s, PfCTSSa, PoCtS, rs1136774, rs16827671, rs34495036, rs35989725, rs3754212, rs7534124, SoCatS
ECTree
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Crystallization
Crystallization on EC 3.4.22.27 - cathepsin S
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2.5 A structure of a complex between human cathepsin S and a potent irreversible inhibitor, vapor diffusion methods at 17°C, where the reservoir contains 1.25 M ammonium sulfate, 70 mM MES, pH 6.5, and 7 mM CoCl2
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cathepsin S mixed with morpholine-4-carboxylic acid [1S-(2-benzyloxy-1R-cyano-ethylcarbamoyl)-3-methylbutyl]amide, crystals are grown by vapor diffusion at room temperature in hanging drops
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cathepsin S-inhibitor complex with the mechanism-based inhibitor Mu(morpholine urea)-Phe-homoPhe-vinylsulfonyl-benzene, vapor diffusion with hanging drops, optimization of parameters results in diffraction-quality crystals produced in 0.2 M (NH4)3PO4, 0.1 M Na3-citrate, pH 5.6 at 17°C. The best crystals to date have been obtained by feeding the crystal drop with 0.0003 ml of protein solution every 5 days for approximately 2 months
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crystal complex of cathepson S with potent covalent inhibitors, microcrystals are grown at 22°C by hanging drop vapor diffusion method
crystallization of the enzyme in complex with an heterocyclic arylaminoethyl amide inhibitor, crystallization in presence of 0.2 M zinc acetate, X-ray diffraction structure determination and analysis at 1.8 A resolution
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determination of the crystal structure of the enzyme cocrystallized with the irreversible vinyl-sulfone inhibitor APC-2848 or with a reversible dipeptide-nitrile inhibitor, crystal structure determination of the C25S mutant cathepsin S
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