3.4.22.27: cathepsin S
This is an abbreviated version!
For detailed information about cathepsin S, go to the full flat file.
Word Map on EC 3.4.22.27
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3.4.22.27
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cathepsins
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lysosomal
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point-of-care
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cystatins
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dendritic
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atherosclerosis
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proteinases
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elastin
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papain
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antigen-presenting
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histocompatibility
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autoimmune
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drug development
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lacrimal
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papain-like
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diagnostics
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ii-associated
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elastolytic
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resource-limited
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s-deficient
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procathepsins
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l-like
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pharmacology
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endostatin
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microglial
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fractalkine
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medicine
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par2
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collagenolytic
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syphilis
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ii-restricted
- 3.4.22.27
- cathepsins
- lysosomal
-
point-of-care
- cystatins
- dendritic
- atherosclerosis
- proteinases
- elastin
- papain
-
antigen-presenting
-
histocompatibility
- autoimmune
- drug development
-
lacrimal
-
papain-like
- diagnostics
-
ii-associated
-
elastolytic
-
resource-limited
-
s-deficient
-
procathepsins
-
l-like
- pharmacology
- endostatin
- microglial
- fractalkine
- medicine
- par2
-
collagenolytic
- syphilis
-
ii-restricted
Reaction
similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and additional information activity on the Z-Val-Val-Arg-/- compound =
Synonyms
C01.034, Cat S, Cat-S, cath S, cathepsin S, cathepsin S-like cysteine proteinase, cathepsin Sa, CatS, CatSPP, CTSS, Hacp-s, PfCTSSa, PoCtS, rs1136774, rs16827671, rs34495036, rs35989725, rs3754212, rs7534124, SoCatS
ECTree
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Activating Compound
Activating Compound on EC 3.4.22.27 - cathepsin S
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kainate
kainate treatment (15 mg/kg) induces a 3.3fold increased cathepsin S expression
Ozone
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cathepsin S levels peak 3 h after ozone exposure in bronchoalveolar lavage cells
radiation
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radiation induced production of CatS at both the mRNA and protein level and increased its protease activity, that IFN regulatory factor-1 is the critical transcriptional mediator of interferon-gamma-dependent CatS production after radiation, treatment with as little as 0.5 Gy of radiation induces CatS mRNA, the highest levels are induced in response to treatment with 10 Gy of radiation
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TNF-alpha
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cathepsin S can be upregulated by TNF-alpha in endothelial cells and cathepsin S induces endothelial cell motility, invasion and migration
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the presence of 0.2 mM dithiothreitol is required to maintain cathepsin activity
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IFN-gamma and interleukin-1beta induce cathepsin S expression in smooth muscle plasma membranes
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additional information
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recombinant CatS is activated in 100 mM sodium acetate, pH 5.5 containing 1 mM EDTA and 2 mM dithiothreitol for 30 min at 37°C
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additional information
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treatment with taxol and cisplatin do not induces CatS expression
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additional information
cathepsin expression is not increased by nicotin treatment (10 mg/kg)
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