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3.4.22.27: cathepsin S

This is an abbreviated version!
For detailed information about cathepsin S, go to the full flat file.

Word Map on EC 3.4.22.27

Reaction

similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and additional information activity on the Z-Val-Val-Arg-/- compound =

Synonyms

C01.034, Cat S, Cat-S, cath S, cathepsin S, cathepsin S-like cysteine proteinase, cathepsin Sa, CatS, CatSPP, CTSS, Hacp-s, PfCTSSa, PoCtS, rs1136774, rs16827671, rs34495036, rs35989725, rs3754212, rs7534124, SoCatS

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.27 cathepsin S

Activating Compound

Activating Compound on EC 3.4.22.27 - cathepsin S

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
As2O3
-
produces reactive oxygen species, also induces CatS expression
bleomycin
-
produces reactive oxygen species, also induces CatS expression
Brij 35
-
0.011% slight increases (over 10%)
dithiothreitol
H2O2
-
produces reactive oxygen species, also induces CatS expression
IFN-gamma
-
-
-
interferon-gamma
-
-
-
kainate
kainate treatment (15 mg/kg) induces a 3.3fold increased cathepsin S expression
Ozone
-
cathepsin S levels peak 3 h after ozone exposure in bronchoalveolar lavage cells
radiation
-
radiation induced production of CatS at both the mRNA and protein level and increased its protease activity, that IFN regulatory factor-1 is the critical transcriptional mediator of interferon-gamma-dependent CatS production after radiation, treatment with as little as 0.5 Gy of radiation induces CatS mRNA, the highest levels are induced in response to treatment with 10 Gy of radiation
-
TNF-alpha
-
cathepsin S can be upregulated by TNF-alpha in endothelial cells and cathepsin S induces endothelial cell motility, invasion and migration
-
Triton X-100
-
slight increases (over 10%)
Tween 20
-
0.01%, slight increases (over 10%)
additional information
-