3.4.22.27: cathepsin S
This is an abbreviated version!
For detailed information about cathepsin S, go to the full flat file.
Word Map on EC 3.4.22.27
-
3.4.22.27
-
cathepsins
-
lysosomal
-
point-of-care
-
cystatins
-
dendritic
-
atherosclerosis
-
proteinases
-
elastin
-
papain
-
antigen-presenting
-
histocompatibility
-
autoimmune
-
drug development
-
lacrimal
-
papain-like
-
diagnostics
-
ii-associated
-
elastolytic
-
resource-limited
-
s-deficient
-
procathepsins
-
l-like
-
pharmacology
-
endostatin
-
microglial
-
fractalkine
-
medicine
-
par2
-
collagenolytic
-
syphilis
-
ii-restricted
- 3.4.22.27
- cathepsins
- lysosomal
-
point-of-care
- cystatins
- dendritic
- atherosclerosis
- proteinases
- elastin
- papain
-
antigen-presenting
-
histocompatibility
- autoimmune
- drug development
-
lacrimal
-
papain-like
- diagnostics
-
ii-associated
-
elastolytic
-
resource-limited
-
s-deficient
-
procathepsins
-
l-like
- pharmacology
- endostatin
- microglial
- fractalkine
- medicine
- par2
-
collagenolytic
- syphilis
-
ii-restricted
Reaction
similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and additional information activity on the Z-Val-Val-Arg-/- compound =
Synonyms
C01.034, Cat S, Cat-S, cath S, cathepsin S, cathepsin S-like cysteine proteinase, cathepsin Sa, CatS, CatSPP, CTSS, Hacp-s, PfCTSSa, PoCtS, rs1136774, rs16827671, rs34495036, rs35989725, rs3754212, rs7534124, SoCatS
ECTree
3.4.22.27 cathepsin SAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.27 - cathepsin S
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CX3CL1 + H2O
?
cathepsin S is able to cleave membrane-anchored CX3CL1, releasing a 55-kDa fragment to the medium
-
-
?
Ii-p10 + H2O
?
-
i.e. MHC classe-associated invariant chain, cathepsin S is the only human cysteine protease able to efficiently degrade the Ii-p10 fragment in epithelial cells
-
-
?
invariant chain + H2O
?
-
invariant chain li is degraded by CatS to the class II-associated invariant chain peptide which dissociates from the MHC-II molecule by forming a complex with the human leucocyte antigen-DM
-
-
?
laminin alpha5-chain + H2O
?
the laminin-alpha5-chain is cleaved by CatS specifically at the Ser-Val bond
-
-
?
MHC class II-associated invariant chain Ii + H2O
?
-
degradation, cathepsin S and MHC class II-associated invariant chain Ii are responsible for in vivo control of endosomal size and multivesicular morphology
-
-
?
prion protein 94-233 + H2O
prion protein 135-233 + prion protein 117-233 + prion protein 114-233
-
in vitro, enzyme causes specific and limited N-terminal truncation of prion protein 94-233
major soluble fragments, the region of prion protein between S135 and N146 is a major target for selective cleavage cathepsins S
-
?
Elastin + H2O
?
-
elastolytic enzyme activity of cathepsin S in artherosclerotic lesions, degradation of aortic elastin contributing to atherosclerosis and diabetes
-
-
?
Ii protein + H2O
Ii fragments
-
inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments
-
-
?
Ii protein + H2O
Ii fragments
-
inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments
-
-
?
additional information
?
-
-
cathepsin S catalyzes a key step in antigen presentation, detailed overview
-
-
?
additional information
?
-
-
key protease responsible for the removal of the invariant chain from MHC class II molecules, the enzyme plays a major role in antigen presentation
-
-
?
additional information
?
-
-
cathepsin S is considered crucial for normal presentation of major histocompatibility complex class II-restricted antigens by antigen presenting cells to CD4+ T cells. It is a key enzyme for the degradation of the class II-associated invariant chain, a process that is required for effective antigen loading of class II molecules
-
-
?
additional information
?
-
-
the enzyme may contribute to the contact-dependent elastase activity of live human alveolar macrophages
-
-
?
additional information
?
-
-
Cat S is involved in degradtion of extracellular matrix and smooth muscle cell invasion, but not in adhesion and migration, overview, the enzyme shows elastolytic and collagenolytic activities on smooth muscle cell plasma membranes, overview
-
-
?
additional information
?
-
-
cathepsin S catalyzes a key step in antigen presentation, detailed overview, Cat S might be involved in psoriasis induction due to an increased interferon gamma level in the epidermis, Cat S is increased in neurons of Alzheimer's disease and Down's syndrome patients, where Cat S facilitates the formation of amyloidbeta from its precursor protein, Cat S might also be involved in asthma, Sjörgren's syndrome, allergen-specific T-cell proliferation in autoimmune processes, and atherosclerosis, overview
-
-
?
additional information
?
-
-
cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors, the enzyme is required for neoplastic progression, overview
-
-
?
additional information
?
-
-
serum cathepsin S is increased in patients with atherosclerosis and diabetes, the cystatin C level might play a role in disease development, overview
-
-
?
additional information
?
-
-
the enzyme is involved in obesity and development of adiposity, enzyme regulation in subcutaneous adipose tissue, cathepsin S is upregulated in obesity, overview
-
-
?
additional information
?
-
cathepsin S is putatively involved in the pathogenesis of COPD
-
-
?
additional information
?
-
-
cathepsin S is putatively involved in the pathogenesis of COPD
-
-
?
additional information
?
-
-
CatS is capable of degrading a range of extracellular matrix macromolecules
-
-
?
additional information
?
-
-
CatS is identified as a compound involved in MHC class II maturation and trafficking within antigen presentation pathways, as well as in the control of processing antigens and the formation of peptide-receptive class II dimers
-
-
?
additional information
?
-
-
CatS is one of the major proteases involved in antigen processing
-
-
?
additional information
?
-
CTSS is a cysteine protease that has a central role in remodeling the extracellular matrix and it is implicated in the etiology of cardiovascular disease
-
-
?
additional information
?
-
-
CTSS is a cysteine protease that has a central role in remodeling the extracellular matrix and it is implicated in the etiology of cardiovascular disease
-
-
?
additional information
?
-
-
enzyme mediates degradation of the MHC class II invariant chain and participates in antigen processing
-
-
?
additional information
?
-
in antigen presenting cells Cat S plays an essential role in the proteolytic events that lead to antigen presentation at the cells surface for recognition by T cells
-
-
?
additional information
?
-
-
in the case of atherosclerotic lesions, the local extracellular matrix is degraded either by CatS secreted by smooth muscle cells and macrophages or by circulating CatS produced by adipose tissue, this elastolytic activity of CatS causes the migration of blood monocytes and smooth muscle cells into the vascular wall which leads to the progression of atherosclerotic lesions
-
-
?
additional information
?
-
major role of Cat S in these cells is the processing of the major histocompatibility complex class II associated invariant chain, which is essential for the normal functioning of the immune system, Cat S is largely responsible for the last proteolytic cleavage step of the invariant chain that produces class II-associated leupeptin induced peptide
-
-
?
additional information
?
-
-
protease is implicated in the development of atherosclerotic lesions in both animal
-
-
?
additional information
?
-
-
the cysteine protease cathepsin S is involved in the pathogenesis of autoimmune disorders, atherosclerosis and obesity
-
-
?
additional information
?
-
-
the function of cathepsin S within antigen presenting cells relates to its pivotal role in major histocompatibility class II restricted antigen presentation to CD4+ T-lymphocytes, cathepsin S mediates the final proteolytic cleavage of the invariant chain chaperone molecule 2 thereby facilitating the subsequent presentation of MHC-II associated peptides to CD4+ T-cells
-
-
?
additional information
?
-
-
the major role of CAT S is the processing of the major histocompatibility complex (MHC) class II associated invariant chain, which is essential for the normal functioning of the immune system
-
-
?
additional information
?
-
this enzyme serves a crucial role in MHC class II mediated immune systems, resulting in CD4+ T cell activation
-
-
?
additional information
?
-
-
this enzyme serves a crucial role in MHC class II mediated immune systems, resulting in CD4+ T cell activation
-
-
?
additional information
?
-
cathepsin S-dependent activation of PAR-2 activation
-
-
?
additional information
?
-
-
cathepsin S-dependent activation of PAR-2 activation
-
-
?
additional information
?
-
-
cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules
-
-
?
additional information
?
-
-
cathepsin S catalyzes a key step in antigen presentation, detailed overview
-
-
?
additional information
?
-
-
cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors, the enzyme is required for neoplastic progression, overview
-
-
?
additional information
?
-
-
cathepsin S in professional antigen-presenting cells, APC, controls MHC class II-mediated antigen presentation by epithelial cells in vivo, and plays a critical role in invariant chain degradation
-
-
?
additional information
?
-
-
cathepsin S is responsible for murine autoimmune myasthenia gravis pathogenesis, overview
-
-
?
additional information
?
-
-
cathepsin S, a cysteine protease, plays an important role in generating peptides for the vacuolar, TAP-independent MHC class I cross-presentation in vivo
-
-
?
additional information
?
-
-
cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis
-
-
?
additional information
?
-
-
cathepsins are primarily involved in general protein turnover, CATS belongs to the cathepsins with a distinct substrate specificity
-
-
?
additional information
?
-
-
catS is a potent elastolytic protease and accelerates calcification in atherosclerotic mice with chronic renal disease induced by 5/6 nephrectemy
-
-
?
additional information
?
-
-
CatS is implicated in the regulation of intracellular cholesterol metabolism
-
-
?
additional information
?
-
-
CATS participates in inflammatory processes accompanying aging and pathologies of the central nervous system
-
-
?
additional information
?
-
-
it degrades the invariant chain Ii, which is crucial to the immune response since it acts as an essential step in MHC class II antigen presentation
-
-
?
additional information
?
-
-
cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors, the enzyme is required for neoplastic progression, overview
-
-
?
additional information
?
-
-
cathepsin S in professional antigen-presenting cells, APC, controls MHC class II-mediated antigen presentation by epithelial cells in vivo, and plays a critical role in invariant chain degradation
-
-
?
additional information
?
-
-
cathepsin S is responsible for murine autoimmune myasthenia gravis pathogenesis, overview
-
-
?
additional information
?
-
-
proteolysis of prion protein by cathepsin S generates a soluble-structured intermediate oligomeric form, with potential implications for neurotoxic mechanisms
-
-
?
additional information
?
-
-
cathepsin S is implicated as a key enzyme in the processing of major histocompatability complex class II molecules
-
-
?
additional information
?
-
-
primary role of the enzyme in heterophagocytosis of proteins from the ultrafiltrate
-
-
?
additional information
?
-
-
cathepsin S is possibly involved in thyroid hormone biosynthesis
-
-
?
additional information
?
-
-
cathepsin S catalyzes a key step in antigen presentation, detailed overview
-
-
?
additional information
?
-
-
CATS is an important player in the spinal mechanisms involved in chronic pain induction and maintenance
-
-
?
additional information
?
-
-
CATS is widely expressed in the brain and is implicated in several neurological conditions such as Alzheimer's disease, amyotrophic lateral sclerosis and age-related inflammation, CATS is also implicated in neuropathic hyperalgesia and allodynia
-
-
?
additional information
?
-
-
key protease responsible for the removal of the invariant chain from MHC class II molecules, the enzyme plays a major role in antigen presentation
-
-
?
