3.4.22.27: cathepsin S

This is an abbreviated version!
For detailed information about cathepsin S, go to the full flat file.

Word Map on EC 3.4.22.27

3.4.22.27

cathepsins

lysosomal

point-of-care

cystatins

dendritic

atherosclerosis

proteinases

elastin

papain

antigen-presenting

histocompatibility

autoimmune

drug development

lacrimal

papain-like

diagnostics

ii-associated

elastolytic

resource-limited

s-deficient

procathepsins

l-like

pharmacology

endostatin

microglial

fractalkine

medicine

par2

collagenolytic

syphilis

ii-restricted

Reaction

similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and additional information activity on the Z-Val-Val-Arg-/- compound =

Synonyms

C01.034, Cat S, Cat-S, cath S, cathepsin S, cathepsin S-like cysteine proteinase, cathepsin Sa, CatS, CatSPP, CTSS, Hacp-s, PfCTSSa, PoCtS, rs1136774, rs16827671, rs34495036, rs35989725, rs3754212, rs7534124, SoCatS

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.27 cathepsin S

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Results	in table
19	Activating Compound
22	AA Sequence
24	Application
1	CAS Registry Number
38	Cloned(Commentary)
6	Crystallization (Commentary)
1711	Disease/ Diagnostics
7	Expression
19	General Information
1	General Stability
721	IC50 Value
1063	Inhibitors
16	kcat/KM [mM/s]
188	Ki Value [mM]
78	KM Value [mM]
46	Localization
4	Metals/Ions
21	Molecular Weight [Da]
79	Natural Substrates/ Products (Substrates)
584	Organism
143	PDB ID
24	pH Optimum
12	pH Range
9	pH Stability
8	pI Value
16	Posttranslational Modification
20	Protein Variants
19	Purification (Commentary)
2	Reaction
21	Reaction Type
167	Reference
5	Renatured (Commentary)
235	Source Tissue
24	Specific Activity [micromol/min/mg]
1	Storage Stability
273	Substrates and Products (Substrate)
19	Subunits
123	Synonyms
11	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
38	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 3.4.22.27 - cathepsin S

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Homo sapiens

P25774

at temperatures above 26°C activity rapidly declines after short initial increase

682669

2 entries

Bos taurus

pH 5.5-7.0, in presence for dithiothreitol and EDTA stable for 240 min. 10-12% of the enzyme activity is lost after 60 min at pH 7.5 or pH 4.0. In absence of dithiothreitol and EDTA the enzyme is inactivated at pH 4.0 by 70% after 60 min

647978

Homo sapiens

above, inactivated within min

647986