3.4.22.27: cathepsin S
This is an abbreviated version!
For detailed information about cathepsin S, go to the full flat file.
Word Map on EC 3.4.22.27
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3.4.22.27
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cathepsins
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lysosomal
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point-of-care
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cystatins
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dendritic
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atherosclerosis
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proteinases
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elastin
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papain
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antigen-presenting
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histocompatibility
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autoimmune
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drug development
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lacrimal
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papain-like
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diagnostics
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ii-associated
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elastolytic
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resource-limited
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s-deficient
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procathepsins
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l-like
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pharmacology
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endostatin
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microglial
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fractalkine
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medicine
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par2
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collagenolytic
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syphilis
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ii-restricted
- 3.4.22.27
- cathepsins
- lysosomal
-
point-of-care
- cystatins
- dendritic
- atherosclerosis
- proteinases
- elastin
- papain
-
antigen-presenting
-
histocompatibility
- autoimmune
- drug development
-
lacrimal
-
papain-like
- diagnostics
-
ii-associated
-
elastolytic
-
resource-limited
-
s-deficient
-
procathepsins
-
l-like
- pharmacology
- endostatin
- microglial
- fractalkine
- medicine
- par2
-
collagenolytic
- syphilis
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ii-restricted
Reaction
similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and additional information activity on the Z-Val-Val-Arg-/- compound =
Synonyms
C01.034, Cat S, Cat-S, cath S, cathepsin S, cathepsin S-like cysteine proteinase, cathepsin Sa, CatS, CatSPP, CTSS, Hacp-s, PfCTSSa, PoCtS, rs1136774, rs16827671, rs34495036, rs35989725, rs3754212, rs7534124, SoCatS
ECTree
3.4.22.27 cathepsin SAdvanced search results
results (
results (Specific Activity
Specific Activity on EC 3.4.22.27 - cathepsin S
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SPECIFIC ACTIVITY [µmol/min/mg] 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
additional information
additional information
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Cat S activity quantification in serum of healthy persons and atherosclerosis and/or diabetes patients, non-atheroma, and atheroma patients with myocardial infarction, overview
additional information
an independent obese adult population, associations between 3 CTSS variants (rs10888390, rs10888394 and rs1136774) and plasma Apo-A1 levels in women are found
additional information
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an independent obese adult population, associations between 3 CTSS variants (rs10888390, rs10888394 and rs1136774) and plasma Apo-A1 levels in women are found
additional information
cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations
additional information
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cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations
additional information
CTSS circulating levels are increased in obese individuals and decreased following weight loss induced by gastric surgery
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CTSS circulating levels are increased in obese individuals and decreased following weight loss induced by gastric surgery
additional information
CTSS contributes independently to plasma Apo-A1 and HDL-Clevels in both healthy and obese populations, with the most prominent CTSS polymorphism (rs10888390) explaining 3.8% of the variance in plasma Apo-A1 phenotype levels in obese women
additional information
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CTSS contributes independently to plasma Apo-A1 and HDL-Clevels in both healthy and obese populations, with the most prominent CTSS polymorphism (rs10888390) explaining 3.8% of the variance in plasma Apo-A1 phenotype levels in obese women
additional information
CTSS sequence variations are associated with two human metabolic risk factors for cardiovascular diseases, plasma Apo-A1 and HDL-C concentrations
additional information
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CTSS sequence variations are associated with two human metabolic risk factors for cardiovascular diseases, plasma Apo-A1 and HDL-C concentrations
additional information
CTSS sequence variations are associated with two human metabolic risk factors for cardiovascular diseases: plasma Apo-A1 and HDL-C concentrations
additional information
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CTSS sequence variations are associated with two human metabolic risk factors for cardiovascular diseases: plasma Apo-A1 and HDL-C concentrations
additional information
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dendritic and B-cells show significantly lower endosomal CatS activity compared with macrophages, the CatS activity in endosomal extracts from macrophages is 10times higher than in the corresponding extracts from B-cell line and even 30times higher than in endosomal fractions from dendritic cells, CatS activity differs not only between the different types of antigen presenting sells but also between endosomal and lysosomal compartments of one cell type
additional information
in a lean cohort, which corresponds to a general French population, significant associations between the rs11576175 variant and the plasma Apo-A1 and HDL-C in women and men are identified
additional information
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in a lean cohort, which corresponds to a general French population, significant associations between the rs11576175 variant and the plasma Apo-A1 and HDL-C in women and men are identified
additional information
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macrophage endosomal extracts even show a 600fold higher CatS activity compared with lysosomal extracts
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the median tear CTSS activity in patients with Sjögren's syndrome is 4.1fold higher than that in patients with other autoimmune diseases, 2.1fold higher than that in patients with nonspecific dry eye disease, and 41.1fold higher than that in healthy control subjects
additional information
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the median tear CTSS activity in patients with Sjögren's syndrome is 4.1fold higher than that in patients with other autoimmune diseases, 2.1fold higher than that in patients with nonspecific dry eye disease, and 41.1fold higher than that in healthy control subjects
additional information
up-regulation of cathepsin S transcript during the early stage of Edwardsiella ictaluri infection, leading to speculate that CTSS may play a role in infection
additional information
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up-regulation of cathepsin S transcript during the early stage of Edwardsiella ictaluri infection, leading to speculate that CTSS may play a role in infection
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CATS protein expression increases in the cerebral cortex, the cerebellum and the hippocampus, the proform is the predominant enzymatic form in all analyzed age groups
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CATS transcript and protein are strongly increased between 3 and 5 months of age in the central nervous system of SOD1-G93A transgenic mice with amyotrophic lateral sclerosis
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in a transgenic mouse model of amyotrophic lateral sclerosis expressing mutant superoxide dismutase 1, CATS transcript and protein levels are significantly upregulated in spinal cord and lower brain regions displaying neuronal degeneration
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leucocyte CatS deficiency leads to a markedly altered plaque morphology and composition, which can in part be attributed to fewer elastic lamina ruptures and a higher resistance of macrophages to apoptosis and necrosis
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osteogenic activity decreases in apolipoprotein-/-/catS-/- mouse aortas with chronic renal disease
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the number of CATS immunopositive cells with glial morphology clearlyincreases in 4-week- and 26-30-month old mice
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cathepsin S, a cellular enzyme shows enhanced expression in pathogenic conditions
additional information
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expression and activity of CATS is upregulated in the spinal cord during the development and progression of neuropathic pain in the CNS of the rat 5th lumbar spinal nerve transection model after the lesion, the strongest increase in protein content is found in the thoracic segment (63.6%)
