3.4.22.27: cathepsin S
This is an abbreviated version!
For detailed information about cathepsin S, go to the full flat file.
Word Map on EC 3.4.22.27
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3.4.22.27
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cathepsins
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lysosomal
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point-of-care
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cystatins
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dendritic
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atherosclerosis
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proteinases
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elastin
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papain
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antigen-presenting
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histocompatibility
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autoimmune
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drug development
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lacrimal
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papain-like
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diagnostics
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ii-associated
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elastolytic
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resource-limited
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s-deficient
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procathepsins
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l-like
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pharmacology
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endostatin
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microglial
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fractalkine
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medicine
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par2
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collagenolytic
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syphilis
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ii-restricted
- 3.4.22.27
- cathepsins
- lysosomal
-
point-of-care
- cystatins
- dendritic
- atherosclerosis
- proteinases
- elastin
- papain
-
antigen-presenting
-
histocompatibility
- autoimmune
- drug development
-
lacrimal
-
papain-like
- diagnostics
-
ii-associated
-
elastolytic
-
resource-limited
-
s-deficient
-
procathepsins
-
l-like
- pharmacology
- endostatin
- microglial
- fractalkine
- medicine
- par2
-
collagenolytic
- syphilis
-
ii-restricted
Reaction
similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and additional information activity on the Z-Val-Val-Arg-/- compound =
Synonyms
C01.034, Cat S, Cat-S, cath S, cathepsin S, cathepsin S-like cysteine proteinase, cathepsin Sa, CatS, CatSPP, CTSS, Hacp-s, PfCTSSa, PoCtS, rs1136774, rs16827671, rs34495036, rs35989725, rs3754212, rs7534124, SoCatS
ECTree
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Turnover Number
Turnover Number on EC 3.4.22.27 - cathepsin S
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0.46
(4-methyl-7-[[(2S)-2-(4-[(1S)-1-(4-methylcyclohexyl)-1-[(thiophen-3-ylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-2-oxo-2H-chromen-3-yl)acetic acid
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5.666
(7-methoxycoumarin-4-yl)-acetyl-GRWPPMGLPWEK(2,4-dinitrophenyl)-D-Arg-NH2
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-
0.45
(7-[[(2S)-2-(4-[(1S)-1,2-dimethyl-1-[(phenylcarbonyl)amino]propyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid
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-
0.77
(7-[[(2S)-2-(4-[(1S)-1,2-dimethyl-1-[(thiophen-3-ylcarbonyl)amino]propyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid
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-
0.2
(7-[[(2S)-2-(4-[(1S)-1-cyclohexyl-1-[(phenylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid
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-
0.22
(7-[[(2S)-2-(4-[(1S)-1-cyclohexyl-1-[(thiophen-3-ylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid
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3.3
butyloxycarbonyl-L-Phe-L-Phe-L-Arg-7-amido-4-methylcoumarin
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pH 6.5, 25°C
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11
GRWHKFSVRWE
in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C
3
GRWHKISVRWE
in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C
44
GRWHKLSVRWE
in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C
15.1
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pH 5.0, room temperature
12.4
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pH 5.0, room temperature
20.3
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin
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pH 5.0, room temperature
20.3
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin
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pH 5.0, room temperature
33.1
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin
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pH 5.0, room temperature