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3.4.22.27: cathepsin S

This is an abbreviated version!
For detailed information about cathepsin S, go to the full flat file.

Word Map on EC 3.4.22.27

Reaction

similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and additional information activity on the Z-Val-Val-Arg-/- compound =

Synonyms

C01.034, Cat S, Cat-S, cath S, cathepsin S, cathepsin S-like cysteine proteinase, cathepsin Sa, CatS, CatSPP, CTSS, Hacp-s, PfCTSSa, PoCtS, rs1136774, rs16827671, rs34495036, rs35989725, rs3754212, rs7534124, SoCatS

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.27 cathepsin S

Turnover Number

Turnover Number on EC 3.4.22.27 - cathepsin S

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.46
(4-methyl-7-[[(2S)-2-(4-[(1S)-1-(4-methylcyclohexyl)-1-[(thiophen-3-ylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-2-oxo-2H-chromen-3-yl)acetic acid
-
-
5.666
(7-methoxycoumarin-4-yl)-acetyl-GRWPPMGLPWEK(2,4-dinitrophenyl)-D-Arg-NH2
-
-
0.45
(7-[[(2S)-2-(4-[(1S)-1,2-dimethyl-1-[(phenylcarbonyl)amino]propyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid
-
-
0.77
(7-[[(2S)-2-(4-[(1S)-1,2-dimethyl-1-[(thiophen-3-ylcarbonyl)amino]propyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid
-
-
0.2
(7-[[(2S)-2-(4-[(1S)-1-cyclohexyl-1-[(phenylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid
-
-
0.22
(7-[[(2S)-2-(4-[(1S)-1-cyclohexyl-1-[(thiophen-3-ylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid
-
-
0.000000011
azocasein
-
in presence of urea
-
0.02 - 13
benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin
15.1 - 40.5
benzyloxycarbonyl-L-Val-L-Val-L-Arg-7-amido-4-methylcoumarin
1.1
benzyloxycarbonyl-Leu-Leu-Arg-7-amido-4-methylcoumarin
-
pH 6.5, 25°C
0.0283 - 7
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
2.9
benzyloxycarbonyl-Phe-Val-Arg-7-amido-4-methylcoumarin
-
pH 6.5, 25°C
12.4 - 33.1
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin
3.3
butyloxycarbonyl-L-Phe-L-Phe-L-Arg-7-amido-4-methylcoumarin
-
pH 6.5, 25°C
-
30 - 65
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin
0.000000548
Collagen
-
alpha-chain
0.000000000583
gelatin
-
alpha-chain
-
11
GRWHKFSVRWE
in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C
3
GRWHKISVRWE
in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C
44
GRWHKLSVRWE
in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C
2.5
o-aminobenzoic acid-Leu-Glu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)
-
-
6.1
tert-butyloxycarbonyl-Phe-Leu-Arg-7-amido-4-methylcoumarin
-
pH 6.5, 25°C
8.6
tert-butyloxycarbonyl-Phe-Phe-Arg-7-amido-4-methylcoumarin
-
pH 6.5, 25°C
additional information
additional information
-