3.4.22.27: cathepsin S

This is an abbreviated version!
For detailed information about cathepsin S, go to the full flat file.

Word Map on EC 3.4.22.27

3.4.22.27

cathepsins

lysosomal

point-of-care

cystatins

dendritic

atherosclerosis

proteinases

elastin

papain

antigen-presenting

histocompatibility

autoimmune

drug development

lacrimal

papain-like

diagnostics

ii-associated

elastolytic

resource-limited

s-deficient

procathepsins

l-like

pharmacology

endostatin

microglial

fractalkine

medicine

par2

collagenolytic

syphilis

ii-restricted

Reaction

similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and additional information activity on the Z-Val-Val-Arg-/- compound =

Synonyms

C01.034, Cat S, Cat-S, cath S, cathepsin S, cathepsin S-like cysteine proteinase, cathepsin Sa, CatS, CatSPP, CTSS, Hacp-s, PfCTSSa, PoCtS, rs1136774, rs16827671, rs34495036, rs35989725, rs3754212, rs7534124, SoCatS

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.27 cathepsin S

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Results	in table
19	Activating Compound
22	AA Sequence
24	Application
1	CAS Registry Number
38	Cloned(Commentary)
6	Crystallization (Commentary)
1711	Disease/ Diagnostics
7	Expression
19	General Information
1	General Stability
721	IC50 Value
1063	Inhibitors
16	kcat/KM [mM/s]
188	Ki Value [mM]
78	KM Value [mM]
46	Localization
4	Metals/Ions
21	Molecular Weight [Da]
79	Natural Substrates/ Products (Substrates)
584	Organism
143	PDB ID
24	pH Optimum
12	pH Range
9	pH Stability
8	pI Value
16	Posttranslational Modification
20	Protein Variants
19	Purification (Commentary)
2	Reaction
21	Reaction Type
167	Reference
5	Renatured (Commentary)
235	Source Tissue
24	Specific Activity [micromol/min/mg]
1	Storage Stability
273	Substrates and Products (Substrate)
19	Subunits
123	Synonyms
11	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
38	Turnover Number [1/s]

KM Value

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of the Enzyme Summary Page.

KM Value on EC 3.4.22.27 - cathepsin S

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0.017

(4-methyl-7-[[(2S)-2-(4-[(1S)-1-(4-methylcyclohexyl)-1-[(thiophen-3-ylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-2-oxo-2H-chromen-3-yl)acetic acid

-

-

0.00556

(7-methoxycoumarin-4-yl)-acetyl-GRWPPMGLPWEK(2,4-dinitrophenyl)-D-Arg-NH2

-

-

0.41

(7-[[(2S)-2-(4-[(1S)-1,2-dimethyl-1-[(phenylcarbonyl)amino]propyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid

-

-

0.3

(7-[[(2S)-2-(4-[(1S)-1,2-dimethyl-1-[(thiophen-3-ylcarbonyl)amino]propyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid

-

-

0.057

(7-[[(2S)-2-(4-[(1S)-1-cyclohexyl-1-[(phenylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid

-

-

0.13

(7-[[(2S)-2-(4-[(1S)-1-cyclohexyl-1-[(thiophen-3-ylcarbonyl)amino]ethyl]-1H-1,2,3-triazol-1-yl)hexanoyl]amino]-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid

-

-

0.0081

benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin

-

pH 6.5, 25°C

0.0034

benzyloxycarbonyl-Leu-Leu-Arg-7-amido-4-methylcoumarin

-

pH 6.5, 25°C

0.0147 - 0.042

benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin

show

0.0121 - 0.0125

benzyloxycarbonyl-Phe-Val-Arg-7-amido-4-methylcoumarin

show

0.006 - 0.288

benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin

show

0.0016

GRWH-norleucine-VGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00188

GRWHDVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00142

GRWHFVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00514

GRWHGVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00048

GRWHIVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.17

GRWHKFSVRWE

in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C

0.04

GRWHKISVRWE

in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C

0.09

GRWHKLSVRWE

in 0.1 M citrate buffer, pH 5.5 containing 4 mM dithiothreitol, at 37°C

0.00194

GRWHKVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00324

GRWHPVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00418

GRWHT-norleucine-GLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.01237

GRWHTDGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.0021

GRWHTFGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.01286

GRWHTGGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00395

GRWHTIGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00782

GRWHTKGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00779

GRWHTMGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00591

GRWHTPGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.0093

GRWHTTGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.01047

GRWHTV-norleucine-LRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.0028

GRWHTVDLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00258

GRWHTVFLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00171

GRWHTVG-citrulline-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00073

GRWHTVG-norleucine-RWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.0048

GRWHTVGFRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00198

GRWHTVGIRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00525

GRWHTVGKRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00314

GRWHTVGLDWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00527

GRWHTVGLFWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00312

GRWHTVGLHWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.0015

GRWHTVGLIWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00105

GRWHTVGLKWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00131

GRWHTVGLPWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00259

GRWHTVGLQWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.01668

GRWHTVGLRDE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.0082

GRWHTVGLRFE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.01648

GRWHTVGLRGE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.01493

GRWHTVGLRHE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.0082

GRWHTVGLRIE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.03787

GRWHTVGLRKE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.01154

GRWHTVGLRRE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00237

GRWHTVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00244

GRWHTVGRRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00237

GRWHTVGVRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00512

GRWHTVILRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.02747

GRWHTVKLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.01998

GRWHTVPLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.0249

GRWHTVQLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00506

GRWHTVTLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.00276

GRWHVVGLRWE-Lys(2,4-dinitrophenyl)-D-Arg-NH2

-

0.02 mM substrate, 1.3 nM CatS, 50 mM sodium acetate, 4 mM dithiothreitol, pH 5.5, 37°C

0.0015

o-aminobenzoic acid-Leu-Glu-Gln-(N-[2,4-dinitrophenyl]ethylenediamine)

-

-

0.0073

tert-butyloxycarbonyl-Phe-Leu-Arg-7-amido-4-methylcoumarin

-

pH 6.5, 25°C

0.0375

tert-butyloxycarbonyl-Phe-Phe-Arg-7-amido-4-methylcoumarin

-

pH 6.5, 25°C

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Release 2023.1 (January 2023)