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Disease on EC 3.4.22.27 - cathepsin S

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DISEASE
TITLE OF PUBLICATION
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Acute Coronary Syndrome
Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound.
Adenocarcinoma
Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis.
Albuminuria
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Alzheimer Disease
Cathepsin S increases tau oligomer formation through limited cleavage, but only IL-6, not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy.
Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates.
Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S.
The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study.
Anemia
Digital Hemoglobinometers as Point-of-Care Testing Devices for Hemoglobin Estimation: A Validation Study from India.
Integrated point-of-care testing (POCT) for HIV, syphilis, malaria and anaemia at antenatal facilities in western Kenya: a qualitative study exploring end-users' perspectives of appropriateness, acceptability and feasibility.
Aneurysm
Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases.
Insights from molecular modeling into the selective inhibition of cathepsin S by its inhibitor.
Angina, Stable
Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease.
Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients.
Angina, Unstable
Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease.
Increased serum cathepsin S in patients with atherosclerosis and diabetes.
Aortic Aneurysm
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm.
Aortic Aneurysm, Abdominal
Cathepsin S is associated with degradation of collagen I in abdominal aortic aneurysm.
Combined Cathepsin S and hs-CRP predicting inflammation of abdominal aortic aneurysm.
Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
Determination of cathepsin S abundance and activity in human plasma and implications for clinical investigation.
Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.
Pharmacological Inhibition of Cathepsin S Suppresses Abdominal Aortic Aneurysm in Mice.
Plasma cathepsin s and cystatin C levels and risk of abdominal aortic aneurysm: a randomized population-based study.
Plasma Cathepsin S is Associated with High-density Lipoprotein Cholesterol and Bilirubin in Patients with Abdominal Aortic Aneurysms.
Aortic Diseases
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice.
Aortic Valve Disease
Apolipoprotein A-I proteolysis in aortic valve stenosis: role of cathepsin S.
Aortic Valve Stenosis
Apolipoprotein A-I proteolysis in aortic valve stenosis: role of cathepsin S.
Arteriosclerosis
Effects of intermittent exercise on biomarkers of cardiovascular risk in night shift workers.
Arteritis
Cathepsin S and Protease-Activated Receptor-2 Drive Alloimmunity and Immune Regulation in Kidney Allograft Rejection.
Arthritis
Cathepsin S inhibitors as novel immunomodulators.
Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis.
Cathepsin S: therapeutic, diagnostic, and prognostic potential.
Collagenolytic protease expression in cranial cruciate ligament and stifle synovial fluid in dogs with cranial cruciate ligament rupture.
Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S.
Molecular modeling assisted identification and biological evaluation of potent cathepsin S inhibitors.
Spinal cathepsin S and fractalkine contribute to chronic pain in collagen induced arthritis.
The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints.
Arthritis, Experimental
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice.
Arthritis, Rheumatoid
Advances in cathepsin S inhibitor design.
An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity.
Cathepsin S and cathepsin L in serum and synovial fluid in rheumatoid arthritis with and without autoantibodies.
Cathepsin S inhibitors: WO2010070615.
Circulating plasma levels of cathepsin S and L are not associated with disease severity in patients with rheumatoid arthritis.
Serum cathepsin S and cystatin C: relationship to subclinical carotid atherosclerosis in rheumatoid arthritis.
The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.
Asthma
Association between SNPs in the promoter region in cathepsin S and risk of asthma in Chinese Han population.
Binding of chondroitin 4-sulfate to cathepsin s regulates its enzymatic activity.
Circadian and concentration profile of cathepsin S in sera from healthy subjects and asthmatic patients.
Genetic and Pharmacological Evaluation of Cathepsin S in a Mouse Model of Asthma.
Overexpression of cathepsin s induces chronic atopic dermatitis in mice.
Single nucleotide polymorphisms of cathepsin S and the risks of asthma attack induced by acaroid mites.
Astrocytoma
Cathepsin S expression: An independent prognostic factor in glioblastoma tumours--A pilot study.
Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vivo.
The clinical significance of cathepsin S expression in human astrocytomas.
Atherosclerosis
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
Binding of chondroitin 4-sulfate to cathepsin s regulates its enzymatic activity.
Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway.
Cathepsin S contributes to macrophage migration via degradation of elastic fibre integrity to facilitate vein graft neointimal hyperplasia.
Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells.
Cathepsin S inhibitors as novel immunomodulators.
Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis.
Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis.
Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease.
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Correlation of cathepsin S with coronary stenosis degree, carotid thickness, blood pressure, glucose and lipid metabolism and vascular endothelial function in atherosclerosis.
CTSS promoter -25G/A: not a risk factor for CHD in Chinese.
Cystathionine ? Lyase Sulfhydrates the RNA Binding Protein HuR to Preserve Endothelial Cell Function and Delay Atherogenesis.
Cysteine protease cathepsin S as a key step in antigen presentation.
Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice.
Determination of cathepsin S abundance and activity in human plasma and implications for clinical investigation.
Discovery of novel cathepsin S inhibitors by pharmacophore-based virtual high-throughput screening.
Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression.
Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates.
Increased serum cathepsin S in patients with atherosclerosis and diabetes.
Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis.
Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels.
Lysosomal cysteine proteases in atherosclerosis.
Multiple Statistical Methods for Assessing Differential Gene Expression in Microarray Data of Diabetic Model Rats to Predict the Molecular Mechanism of Atorvastatin on Anti-Atherogenesis.
Overexpression of cathepsin s induces chronic atopic dermatitis in mice.
Pharmacological Inhibition of Cathepsin S Decreases Atherosclerotic Lesions in Apoe-/- Mice.
Plasma Cathepsin S is Associated with High-density Lipoprotein Cholesterol and Bilirubin in Patients with Abdominal Aortic Aneurysms.
Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound.
REPLY: Treatment with oxLDL antibody reduces cathepsin S expression in atherosclerosis via down-regulating ADAR1-mediated RNA editing.
Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice with Chronic Renal Disease.
Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men.
Toll-like receptor 7 deficiency protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.
Transfer of exosomal microRNA-203-3p from dendritic cells to bone marrow-derived macrophages reduces development of atherosclerosis by downregulating Ctss in mice.
Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions.
Treatment with oxLDL antibody reduces cathepsin S expression in atherosclerosis via down-regulating ADAR1-mediated RNA editing.
Weight loss reduces adipose tissue cathepsin S and its circulating levels in morbidly obese women.
[Impact of olmesartan medoxomil on atherosclerosis lesions in apolipoprotein E knockout mice].
Autoimmune Diseases
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.
An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity.
Aod1 controlling day 3 thymectomy-induced autoimmune ovarian dysgenesis in mice encompasses two linked quantitative trait loci with opposing allelic effects on disease susceptibility.
Binding of chondroitin 4-sulfate to cathepsin s regulates its enzymatic activity.
Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity.
Cathepsin S inhibitors: WO2010070615.
Cloning, expression analysis and enzymatic characterization of cathepsin S from olive flounder (Paralichthys olivaceus).
Cysteine protease cathepsin S as a key step in antigen presentation.
Inhibition of Cathepsin S Reduces Allogeneic T Cell Priming but Not Graft-versus-Host Disease Against Minor Histocompatibility Antigens.
Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors.
Synthesis of proline analogues as potent and selective cathepsin S inhibitors.
Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity.
[Virtual screening study of cathepsin S natural inhibitor].
Bacterial Infections
Cathepsin S of Sciaenops ocellatus: Identification, transcriptional expression and enzymatic activity.
Expression profile analysis of two cathepsin S in channel catfish (Ictalurus punctatus) mucosal tissues following bacterial challenge.
Brain Injuries, Traumatic
Inhibition of cathepsin S produces neuroprotective effects after traumatic brain injury in mice.
Brain Neoplasms
Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vivo.
Breast Neoplasms
A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer.
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.
Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells.
Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells.
Is There Any Role for Serum Cathepsin S and CRP Levels on Prognostic Information in Breast Cancer? The Swedish Mammography Cohort.
Long-term endurance training increases serum cathepsin S levels in healthy female subjects.
Recent advances in the field of anti-cancer immunotherapy.
Up-regulation of cathepsin S expression by HSP90 and 5-HT7 receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer.
Carcinogenesis
Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors.
Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma.
Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.
Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways.
Carcinoma, Hepatocellular
Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma.
Cathepsin S silencing induces apoptosis of human hepatocellular carcinoma cells.
Melittin suppresses cathepsin S-induced invasion and angiogenesis via blocking of the VEGF-A/VEGFR-2/MEK1/ERK1/2 pathway in human hepatocellular carcinoma.
Silencing cathepsin S gene expression inhibits growth, invasion and angiogenesis of human hepatocellular carcinoma in vitro.
[Effects of up-regulation of cathepsin S by HBx gene on HepG2 cell].
Carcinoma, Non-Small-Cell Lung
Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non-Small Cell Lung Cancer.
Cardiomegaly
Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR ? and ? expression and reducing TC, MMP-9, and Cat S levels.
Cardiovascular Diseases
Acute phase serum cathepsin S level and cathepsin S/cystatin C ratio are the associated factors with cerebral infarction and their diagnostic value for cerebral infarction.
Association between serum cathepsin S and mortality in older adults.
Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations.
Cathepsin S: therapeutic, diagnostic, and prognostic potential.
Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S.
Point-of-care testing in primary care: A systematic review on implementation aspects addressed in test evaluations.
Serum cathepsin S and cystatin C: relationship to subclinical carotid atherosclerosis in rheumatoid arthritis.
Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men.
The genetic polymorphisms of cathepsin S were associated with metabolic disorders in a Chinese Han population.
Carotid Artery Diseases
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Serum cathepsin S and cystatin C: relationship to subclinical carotid atherosclerosis in rheumatoid arthritis.
cathepsin s deficiency
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.
Cathepsin S controls adipocytic and osteoblastic differentiation, bone turnover, and bone microarchitecture.
Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors.
Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury.
Cathepsin S Deficiency Mitigated Chronic Stress-Related Neointimal Hyperplasia in Mice.
Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation.
Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
Effective suppression of donor specific antibody production by Cathepsin S inhibitors in a mouse transplantation model.
Cerebral Infarction
Acute phase serum cathepsin S level and cathepsin S/cystatin C ratio are the associated factors with cerebral infarction and their diagnostic value for cerebral infarction.
Association between CTSS gene polymorphism and the risk of acute atherosclerotic cerebral infarction in Chinese population: a case-control study.
Cholestasis
[The effect of Cathepsin S in primary biliary cholangitis].
Coinfection
Repurposing Saquinavir for Host-Directed Therapy to Control Mycobacterium Tuberculosis Infection.
Colitis
Cathepsin S is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR2-dependent Mechanism in Mice.
Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Colorectal Neoplasms
Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity.
Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis.
Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization.
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.
The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study.
[Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer].
Communicable Diseases
Application of nanodiagnostics in point-of-care tests for infectious diseases.
Connective Tissue Diseases
Connective tissue diseases. Inhibiting cathepsin S to treat SLE and lupus nephritis.
Coronary Artery Disease
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease.
Correlation of cathepsin S with coronary stenosis degree, carotid thickness, blood pressure, glucose and lipid metabolism and vascular endothelial function in atherosclerosis.
Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases.
Increased plasma levels of CATS mRNA but not CATB mRNA in patients with coronary atherosclerosis.
Optimisation of methods for quantifying plasma mRNA levels from genes responsible for coronary artery plaque development and destabilization.
Coronary Disease
Cathepsin B and S as markers for cardiovascular risk and all-cause mortality in patients with stable coronary heart disease during 10 years: a CLARICOR trial sub-study.
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Coronary Stenosis
Correlation of cathepsin S with coronary stenosis degree, carotid thickness, blood pressure, glucose and lipid metabolism and vascular endothelial function in atherosclerosis.
Cough
Introducing new point-of-care tests for common infections in publicly funded clinics in South Africa: a qualitative study with primary care clinicians.
COVID-19
COVID-19 Point-of-Care Diagnostics That Satisfy Global Target Product Profiles.
Performance of two rapid point of care SARS-COV-2 antibody assays against laboratory-based automated chemiluminescent immunoassays for SARS-COV-2 IG-G, IG-M and total antibodies.
Rapid community point-of-care testing for COVID-19 (RAPTOR-C19): protocol for a platform diagnostic study.
Rapid lateral flow tests for the detection of SARS-CoV-2 neutralizing antibodies.
The diagnostic accuracy of isothermal nucleic acid point-of-care tests for human coronaviruses: A systematic review and meta-analysis.
Cystic Fibrosis
A new player in the game: epithelial cathepsin S in early cystic fibrosis lung disease.
Cathepsin S: therapeutic, diagnostic, and prognostic potential.
miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production.
Molecular modeling assisted identification and biological evaluation of potent cathepsin S inhibitors.
Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease.
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult ?ENaC-Tg Mice.
Dacryocystitis
Phenylephrine increases tear cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway.
Dengue
Controlled peptide solvation in portion-mixing libraries of FRET peptides: improved specificity determination for Dengue 2 virus NS2B-NS3 protease and human cathepsin S.
Dermatitis
Cathepsin S, a new pruritus biomarker in clinical dandruff/seborrhoeic dermatitis evaluation.
Dermatitis, Atopic
Overexpression of cathepsin s induces chronic atopic dermatitis in mice.
Overexpression of Cathepsin S Induces Chronic Atopic Dermatitis in Mice.
Diabetes Complications
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
Diabetes Mellitus
Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels.
Diabetes Mellitus, Type 2
Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
Circulating cathepsin S improves glycaemic control in mice.
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Determination of cathepsin S abundance and activity in human plasma and implications for clinical investigation.
Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes.
Diabetic Nephropathies
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
Diabetic Retinopathy
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
Diphtheria
Common Reference-Based Tandem Mass Tag Multiplexing for the Relative Quantification of Peptides: Design and Application to Degradome Analysis of Diphtheria Toxoid.
Down Syndrome
The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study.
Dry Eye Syndromes
Phenylephrine increases tear cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway.
Dyslipidemias
Cholesterol Point-of-Care Testing for Community Pharmacies: A Review of the Current Literature.
Esophageal Neoplasms
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Fatty Liver
Serum lipocalin-2, cathepsin S and chemerin levels and nonalcoholic fatty liver disease.
Fibromyalgia
High levels of cathepsin S and cystatin C in patients with fibromyalgia syndrome.
Gastrointestinal Neoplasms
Cathepsin S as a target in gastric cancer.
Gaucher Disease
Aberrant progranulin, YKL-40, cathepsin D and cathepsin S in Gaucher disease.
Glioblastoma
Cathepsin S expression: An independent prognostic factor in glioblastoma tumours--A pilot study.
Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways.
Inhibition of Cathepsin S Induces Mitochondrial Apoptosis in Glioblastoma Cell Lines Through Mitochondrial Stress and Autophagosome Accumulation.
Inhibition of Cathepsin S Restores TGF-?-induced Epithelial-to-mesenchymal Transition and Tight Junction Turnover in Glioblastoma Cells.
[Cathepsin S (CTSS) is highly expressed in temozolomide-resistant glioblastoma T98G cells and associated with poor prognosis].
Glomerulonephritis
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Glomerulonephritis, IGA
The Clinical Significance and Potential Role of Cathepsin S in IgA Nephropathy.
Graft vs Host Disease
Inhibition of Cathepsin S Reduces Allogeneic T Cell Priming but Not Graft-versus-Host Disease Against Minor Histocompatibility Antigens.
Graves Disease
Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease.
Heart Diseases
Correlation of cathepsin S with coronary stenosis degree, carotid thickness, blood pressure, glucose and lipid metabolism and vascular endothelial function in atherosclerosis.
Heart Failure
Soluble Glycoprotein 130 and Heat Shock Protein 27 as Novel Candidate Biomarkers of Chronic Heart Failure with Preserved Ejection Fraction.
[Association between lososomal cysteine protease cathepsin's activation and left ventricular function and remodeling in hypertensive heart failure rats]
Heart Valve Diseases
Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels.
Hepatitis
Point-of-care testing and the control of infectious diseases.
Hepatitis B
Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma.
Performance of point of care assays for hepatitis B and C viruses in chronic kidney disease patients.
[Effects of up-regulation of cathepsin S by HBx gene on HepG2 cell].
Hepatitis C
Hepatitis C virus-mediated inhibition of cathepsin s increases invariant-chain expression on hepatocyte surface.
Performance of point of care assays for hepatitis B and C viruses in chronic kidney disease patients.
HIV Infections
Challenges of HIV diagnosis and management in the context of pre-exposure prophylaxis (PrEP), post-exposure prophylaxis (PEP), test and start and acute HIV infection: a scoping review.
Hydronephrosis
Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis.
Hyperalgesia
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
Cathepsin S in the spinal microglia contributes to remifentanil-induced hyperalgesia in rats.
Cathepsin S is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR2-dependent Mechanism in Mice.
Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Role of the cysteine protease cathepsin S in neuropathic hyperalgesia.
Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.
Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.
Hypercholesterolemia
The genetic polymorphisms of cathepsin S were associated with metabolic disorders in a Chinese Han population.
Hypergammaglobulinemia
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Hyperglycemia
Impact of an inpatient multidisciplinary glucose control management program.
Hypersensitivity
An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity.
Changes in vascular permeability in the spinal cord contribute to chemotherapy-induced neuropathic pain.
Hypertension
Cathepsin S promotes the development of pulmonary arterial hypertension.
Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men.
[Association between lososomal cysteine protease cathepsin's activation and left ventricular function and remodeling in hypertensive heart failure rats]
Hypertension, Pulmonary
Cathepsin S promotes the development of pulmonary arterial hypertension.
Infections
"It's not a time spent issue, it's a 'what have you spent your time doing?' issue…" A qualitative study of UK patient opinions and expectations for implementation of Point of Care Tests for sexually transmitted infections and antimicrobial resistance.
A novel electronic algorithm using host biomarker point-of-care tests for the management of febrile illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trial.
An ideal test? A multi-country qualitative study of clinicians' and patients' views of point of care tests for lower respiratory tract infection in primary care.
Cathepsin L maturation and activity is impaired in macrophages harboring M. avium and M. tuberculosis.
Cathepsin S supports acid-independent infection by some reoviruses.
COVID-19 Point-of-Care Diagnostics That Satisfy Global Target Product Profiles.
COVID-19 point-of-care testing in care homes: what are the lessons for policy and practice?
Expression profile analysis of two cathepsin S in channel catfish (Ictalurus punctatus) mucosal tissues following bacterial challenge.
Genome-wide identification, expression signature and immune functional analysis of two cathepsin S (CTSS) genes in turbot (Scophthalmus maximus L.).
In-vitro diagnostic point-of-care tests in paediatric ambulatory care: A systematic review and meta-analysis.
Introducing new point-of-care tests for common infections in publicly funded clinics in South Africa: a qualitative study with primary care clinicians.
Molecular cloning, sequencing and characterization of channel catfish (Ictalurus punctatus, Rafinesque 1818) cathepsin S gene.
Mycobacterium bovis bacillus Calmette-Guérin secreting active cathepsin S stimulates expression of mature MHC class II molecules and antigen presentation in human macrophages.
Mycobacterium bovis BCG attenuates surface expression of mature class II molecules through IL-10-dependent inhibition of cathepsin S.
Performance of point-of-care tests for the detection of chlamydia trachomatis infections: A systematic review and meta-analysis.
Point of care tests for invasive fungal infections: a blueprint for increasing availability in Africa.
Point-of-care diagnostics: needs of African health care workers and their role combating global antimicrobial resistance.
Point-of-care testing for HCV infection: recent advances and implications for alternative screening.
Rapid community point-of-care testing for COVID-19 (RAPTOR-C19): protocol for a platform diagnostic study.
Role of Cathepsin S in Periodontal Inflammation and Infection.
Simultaneous Quantitative Detection of Helicobacter Pylori Based on a Rapid and Sensitive Testing Platform using Quantum Dots-Labeled Immunochromatiographic Test Strips.
Influenza, Human
Do point-of-care tests (POCTs) offer a new paradigm for the management of patients with influenza?
Emerging point of care tests for influenza: innovation or status quo.
Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo.
Integrating molecular point-of-care testing for influenza into primary care: a mixed-methods feasibility study.
Point of care testing: diagnosis outside the virology laboratory.
The clinical utility of point-of-care tests for influenza in ambulatory care: A systematic review and meta-analysis.
Insulin Resistance
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
Influence of a prudent diet on circulating cathepsin S in humans.
Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels.
Serum Cathepsin S Is Associated With Decreased Insulin Sensitivity and the Development of Diabetes Type 2 in a Community-Based Cohort of Elderly Men.
Serum lipocalin-2, cathepsin S and chemerin levels and nonalcoholic fatty liver disease.
Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity.
Joint Diseases
The proinflammatory cytokines interleukin-1? and tumor necrosis factor ? promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes.
Kidney Neoplasms
Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP.
Liver Diseases
Plasma signature of neurological disease in the monogenetic disorder niemann-pick type C.
Point-of-Care Testing in Liver Disease and Liver Surgery.
Serum lipocalin-2, cathepsin S and chemerin levels and nonalcoholic fatty liver disease.
Liver Neoplasms
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Lung Diseases
A new player in the game: epithelial cathepsin S in early cystic fibrosis lung disease.
Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics.
Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease.
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult ?ENaC-Tg Mice.
Lung Diseases, Interstitial
Cathepsin S, a new serum biomarker of sarcoidosis discovered by transcriptome analysis of alveolar macrophages.
Decreased serum cathepsin S levels in patients with systemic sclerosis-associated interstitial lung disease.
Lung Injury
Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury.
Lung Neoplasms
Cathepsin S in tumours, regional lymph nodes and sera of patients with lung cancer: relation to prognosis.
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non-Small Cell Lung Cancer.
The effect of catalase on migration and invasion of lung cancer cells by regulating the activities of cathepsin S, L, and K.
Lupus Erythematosus, Systemic
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.
Global Proteomics Deciphered Novel-Function of Osthole Against Pulmonary Arterial Hypertension.
Lupus Nephritis
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.
Connective tissue diseases. Inhibiting cathepsin S to treat SLE and lupus nephritis.
Lymphoma, B-Cell
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections.
Novel urine biomarkers to distinguish UTI from culture-negative pyuria.
Lymphoma, Follicular
Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma.
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma.
Lymphoma, Non-Hodgkin
Cathepsin S Protease Mediates T-Cell Response in Non-Hodgkin Lymphoma.
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma.
Malaria
In-vitro diagnostic point-of-care tests in paediatric ambulatory care: A systematic review and meta-analysis.
Integrated point-of-care testing (POCT) for HIV, syphilis, malaria and anaemia at antenatal facilities in western Kenya: a qualitative study exploring end-users' perspectives of appropriateness, acceptability and feasibility.
Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences.
Measles
Investigation of a measles outbreak in Zimbabwe, 2010: potential of a point of care test to replace laboratory confirmation of suspected cases.
Melanoma
Cathepsin S and its inhibitor cystatin C: imbalance in uveal melanoma.
Metabolic Syndrome
Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
Proportional correlates of adipolin and cathepsin S in metabolic syndrome patients with and without prediabetes.
The genetic polymorphisms of cathepsin S were associated with metabolic disorders in a Chinese Han population.
Mouth Neoplasms
Inhibition of cathepsin S confers sensitivity to methyl protodioscin in oral cancer cells via activation of p38 MAPK/JNK signaling pathways.
Sulforaphane suppresses oral cancer cell migration by regulating cathepsin S expression.
Multiple Sclerosis
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.
Advances in cathepsin S inhibitor design.
An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity.
Cathepsins and their endogenous inhibitors Cystatins: Expression and Modulation in Multiple Sclerosis.
Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2.
Muscular Dystrophies
Cathepsin S contributes to the pathogenesis of muscular dystrophy in mice.
Myasthenia Gravis
Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis.
Myasthenia Gravis, Autoimmune, Experimental
Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease.
Myocardial Infarction
Cathepsin S degrades arresten and canstatin in infarcted area after myocardial infarction in rats.
Increased plasma cathepsin S and trombospondin-1 in patients with acute ST segment elevation myocardial infarction.
Increased serum cathepsin S in patients with atherosclerosis and diabetes.
Myositis
Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies.
Nasopharyngeal Neoplasms
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Neoplasm Metastasis
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.
Cathepsin S as a target in gastric cancer.
Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma.
Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis.
Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells.
Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis.
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells.
Increased levels of macrophage-secreted cathepsin S during prostate cancer progression in TRAMP mice and patients.
Leading the invasion: The role of Cathepsin S in the tumour microenvironment.
Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry.
Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation.
Silencing cathepsin S gene expression inhibits growth, invasion and angiogenesis of human hepatocellular carcinoma in vitro.
Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway.
Neoplasms
A bioavailable cathepsin S nitrile inhibitor abrogates tumor development.
A Chitosan-PLGA based catechin hydrate nanoparticles used in targeting of lungs and cancer treatment.
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.
A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer.
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.
Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity.
Antibody targeting of cathepsin S inhibits angiogenesis and synergistically enhances anti-VEGF.
Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis.
Association between serum cathepsin S and mortality in older adults.
Autophagy-Regulated ROS from Xanthine Oxidase Acts as an Early Effector for Triggering Late Mitochondria-Dependent Apoptosis in Cathepsin S-Targeted Tumor Cells.
Binding of chondroitin 4-sulfate to cathepsin s regulates its enzymatic activity.
Cathepsin S and its inhibitor cystatin C: imbalance in uveal melanoma.
Cathepsin S as a target in gastric cancer.
Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors.
Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors.
Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization.
Cathepsin S in tumours, regional lymph nodes and sera of patients with lung cancer: relation to prognosis.
Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma.
Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis.
Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis.
Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer.
Cathepsin S: therapeutic, diagnostic, and prognostic potential.
Chlorella powder inhibits the activities of peptidase cathepsin S, PLA2, cyclooxygenase-2, thromboxane synthase, tyrosine phosphatases, tumor necrosis factor-alpha converting enzyme, calpain and kinases.
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis.
Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vivo.
Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation.
DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells.
Dynamic Model of Protease State and Inhibitor Trafficking to Predict Protease Activity in Breast Cancer Cells.
Effects of novel human cathepsin S inhibitors on cell migration in human cancer cells.
Endothelial Dysfunction in Tristetraprolin-deficient Mice is not caused by Enhanced TNF-? Expression.
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S.
Fat cell-derived modulators of vascular cell pathophysiology: the list keeps growing.
Fsn0503h antibody-mediated blockade of cathepsin S as a potential therapeutic strategy for the treatment of solid tumors.
Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9.
Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells.
IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung.
In vivo imaging of mouse tumors by a lipidated cathepsin S substrate.
Increased levels of macrophage-secreted cathepsin S during prostate cancer progression in TRAMP mice and patients.
Influence of a prudent diet on circulating cathepsin S in humans.
Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.
Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways.
Inhibition of Cathepsin S Induces Mitochondrial Apoptosis in Glioblastoma Cell Lines Through Mitochondrial Stress and Autophagosome Accumulation.
Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP.
Is There Any Role for Serum Cathepsin S and CRP Levels on Prognostic Information in Breast Cancer? The Swedish Mammography Cohort.
Leading the invasion: The role of Cathepsin S in the tumour microenvironment.
Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels.
Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry.
Molecular modeling assisted identification and biological evaluation of potent cathepsin S inhibitors.
Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery.
Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor.
Pro-inflammatory cytokines induce expression of matrix-metabolizing enzymes in human cervical smooth muscle cells.
Radiation-induced cathepsin S is involved in radioresistance.
Recent advances in the field of anti-cancer immunotherapy.
Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L-like proteases in tumor microenvironment.
Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation.
Silencing cathepsin S gene expression inhibits growth, invasion and angiogenesis of human hepatocellular carcinoma in vitro.
Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway.
The clinical significance of cathepsin S expression in human astrocytomas.
The proinflammatory cytokines interleukin-1? and tumor necrosis factor ? promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes.
The Role of Affordable, Point-of-Care Technologies for Cancer Care in Low- and Middle-Income Countries: A Review and Commentary.
Up-regulation of cathepsin S expression by HSP90 and 5-HT7 receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer.
Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress.
[Effects of up-regulation of cathepsin S by HBx gene on HepG2 cell].
Nephritis
Connective tissue diseases. Inhibiting cathepsin S to treat SLE and lupus nephritis.
Neuralgia
Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor.
Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model.
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain.
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain.
Microglial signalling mechanisms: Cathepsin S and Fractalkine.
Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2.
Recent advances in the design of cathepsin S inhibitors.
Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.
Neuroinflammatory Diseases
Hydrogen sulfide inhibits ATP-induced neuroinflammation and A?1-42 synthesis by suppressing the activation of STAT3 and cathepsin S.
Niemann-Pick Diseases
Cathepsin S contributes to microglia-mediated olfactory dysfunction through the regulation of Cx3cl1-Cx3cr1 axis in a Niemann-Pick disease type C1 model.
Non-alcoholic Fatty Liver Disease
Serum lipocalin-2, cathepsin S and chemerin levels and nonalcoholic fatty liver disease.
Obesity
Cathepsin S controls adipocytic and osteoblastic differentiation, bone turnover, and bone microarchitecture.
Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradation.
Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis.
Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation.
Circulating cathepsin S improves glycaemic control in mice.
Determination of cathepsin S abundance and activity in human plasma and implications for clinical investigation.
Discovery of novel cathepsin S inhibitors by pharmacophore-based virtual high-throughput screening.
Emerging role of cathepsin S in obesity and its associated diseases.
Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates.
Molecular modeling assisted identification and biological evaluation of potent cathepsin S inhibitors.
Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men.
Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity.
Obesity, Abdominal
Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
Obstetric Labor, Premature
Omega-3 Polyunsaturated Fatty Acids Reduce Preterm Labor by Inhibiting Trophoblast Cathepsin S and Inflammasome Activation.
Osteoporosis
Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides.
The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.
Ovarian Neoplasms
CTD-2020K17.1, a Novel Long Non-Coding RNA, Promotes Migration, Invasion, and Proliferation of Serous Ovarian Cancer Cells In Vitro.
Long Noncoding RNA CTD-2589M5.4 Inhibits Ovarian Cancer Cell Proliferation, Migration, and Invasion Via Downregulation of the Extracellular Matrix-Receptor Interaction Pathway.
Two SPRi biosensors for the determination of cathepsin S in blood plasma.
Overweight
Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
Pancreatic Neoplasms
The influence of linker length on the properties of cathepsin S cleavable (177)Lu-labeled HPMA copolymers for pancreatic cancer imaging.
Pancreatitis
Active Cathepsins B, L and S in Murine and Human Pancreatitis.
Papilloma, Inverted
Expression of cathepsin S and its inhibitor stefin A in sinonasal inverted papilloma.
Paralysis
Cathepsin S increases tau oligomer formation through limited cleavage, but only IL-6, not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy.
Pediatric Obesity
Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity.
Periodontal Diseases
Role of Cathepsin S in Periodontal Inflammation and Infection.
Periodontitis
Role of Cathepsin S in Periodontal Inflammation and Infection.
Peripheral Arterial Disease
Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases.
Peripheral Nerve Injuries
Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state.
Role of the cysteine protease cathepsin S in neuropathic hyperalgesia.
Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.
Peripheral Nervous System Diseases
Targeting lysosomal cysteine protease cathepsin S reveals immunomodulatory therapeutic strategy for oxaliplatin-induced peripheral neuropathy.
Pneumoconiosis
Cathepsin S, a new serum biomarker of sarcoidosis discovered by transcriptome analysis of alveolar macrophages.
Pneumonia
Genetic and Pharmacological Evaluation of Cathepsin S in a Mouse Model of Asthma.
Point-of-care testing for community-acquired pneumonia: do we have all the answers?
Prediabetic State
Proportional correlates of adipolin and cathepsin S in metabolic syndrome patients with and without prediabetes.
Prostatic Neoplasms
Increased levels of macrophage-secreted cathepsin S during prostate cancer progression in TRAMP mice and patients.
Proteinuria
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Pruritus
Cathepsin S, a new pruritus biomarker in clinical dandruff/seborrhoeic dermatitis evaluation.
Skullcapflavone II Suppresses TNF-?/IFN-?-Induced TARC, MDC, and CTSS Production in HaCaT Cells.
Psoriasis
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.
Advances in cathepsin S inhibitor design.
Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36?.
Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome.
Pulmonary Arterial Hypertension
Cathepsin S promotes the development of pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
A highly significant association between Cathepsin S gene polymorphisms rs12068264 and chronic obstructive pulmonary disease susceptibility in Han Chinese population.
Cathepsin S inhibitors as novel immunomodulators.
Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD.
Common functional polymorphisms in the cathepsin S promoter in Japanese subjects: possible contribution to pulmonary emphysema.
Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD.
Protein Phosphatase 2A Reduces Cigarette Smoke-Induced Cathepsin S and Loss of Lung Function.
Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult ?ENaC-Tg Mice.
[The association between Cathepsin S and pulmonary function and CT phenotypes in patients with chronic obstructive pulmonary disease].
Pulmonary Emphysema
Common functional polymorphisms in the cathepsin S promoter in Japanese subjects: possible contribution to pulmonary emphysema.
Pulmonary Eosinophilia
Genetic and Pharmacological Evaluation of Cathepsin S in a Mouse Model of Asthma.
Renal Insufficiency, Chronic
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.
Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease.
Performance of point of care assays for hepatitis B and C viruses in chronic kidney disease patients.
Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice with Chronic Renal Disease.
Respiratory Tract Infections
An ideal test? A multi-country qualitative study of clinicians' and patients' views of point of care tests for lower respiratory tract infection in primary care.
Assessing the potential of upper respiratory tract point-of-care testing: a systematic review of the prognostic significance of upper respiratory tract microbes.
COVID-19 point-of-care testing in care homes: what are the lessons for policy and practice?
In-vitro diagnostic point-of-care tests in paediatric ambulatory care: A systematic review and meta-analysis.
Sarcoidosis
Cathepsin S, a new serum biomarker of sarcoidosis discovered by transcriptome analysis of alveolar macrophages.
Scleroderma, Systemic
Decreased serum cathepsin S levels in patients with systemic sclerosis-associated interstitial lung disease.
Scrub Typhus
Scrub typhus point-of-care testing: A systematic review and meta-analysis.
Seizures
Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures.
Sepsis
Systemic inflammation and protease profile of Afro-Caribbean patients with sepsis.
Sexually Transmitted Diseases
"It's not a time spent issue, it's a 'what have you spent your time doing?' issue…" A qualitative study of UK patient opinions and expectations for implementation of Point of Care Tests for sexually transmitted infections and antimicrobial resistance.
Advancing point of care diagnostics for the control and prevention of STIs: the way forward.
Patterns of point-of-care test use among obstetricians and gynaecologists in the US.
Perceptions of an ideal point-of-care test for sexually transmitted infections--a qualitative study of focus group discussions with medical providers.
Point-of-care diagnostics: needs of African health care workers and their role combating global antimicrobial resistance.
Point-of-care testing for HCV infection: recent advances and implications for alternative screening.
signal peptidase ii deficiency
B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.
Sjogren's Syndrome
Insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors.
Sleep Apnea, Obstructive
Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes.
Speech Disorders
The Communication Attitude Test (CAT-S): normative values for 220 Swedish children.
ST Elevation Myocardial Infarction
Increased plasma cathepsin S and trombospondin-1 in patients with acute ST segment elevation myocardial infarction.
Stomach Diseases
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Stomach Neoplasms
Cathepsin S as a target in gastric cancer.
Cathepsin S mediates gastric cancer cell migration and invasion via a putative network of metastasis-associated proteins.
Cathepsin S Mediates Gastric Cancer Cell Migration and Invasion via a Putative Network of Metastasis-Associated Proteins.
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Stroke
Point-of-Care-Testing in Acute Stroke Management: An Unmet Need Ripe for Technological Harvest.
Supranuclear Palsy, Progressive
Cathepsin S increases tau oligomer formation through limited cleavage, but only IL-6, not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy.
Synovitis
Detecting cathepsin activity in human osteoarthritis via activity-based probes.
Syphilis
Estimating the uptake of maternal syphilis screening and other antenatal interventions before and after national rollout of syphilis point-of-care testing in Ghana.
Factors associated with failure to screen for syphilis during antenatal care in Ghana: a case control study.
Field evaluation of two point-of-care tests for syphilis among men who have sex with men, Verona, Italy.
Integrated point-of-care testing (POCT) for HIV, syphilis, malaria and anaemia at antenatal facilities in western Kenya: a qualitative study exploring end-users' perspectives of appropriateness, acceptability and feasibility.
Patterns of point-of-care test use among obstetricians and gynaecologists in the US.
Point-of-care diagnostics: needs of African health care workers and their role combating global antimicrobial resistance.
Rollout of rapid point of care tests for antenatal syphilis screening in Ghana: healthcare provider perspectives and experiences.
Standardised protocol for a prospective cross-sectional multicentre clinic-based evaluation of two dual point-of-care tests for the screening of HIV and syphilis in men who have sex with men, sex workers and pregnant women.
The impact of antenatal syphilis point of care testing on pregnancy outcomes: A systematic review.
Tauopathies
Cathepsin S increases tau oligomer formation through limited cleavage, but only IL-6, not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy.
Thrombophilia
Point-of-Care Testing in Liver Disease and Liver Surgery.
Thrombosis
Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma.
Insights from molecular modeling into the selective inhibition of cathepsin S by its inhibitor.
Point-of-Care Testing in Liver Disease and Liver Surgery.
Triple Negative Breast Neoplasms
A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer.
Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis.
Tuberculosis
Cathepsin L maturation and activity is impaired in macrophages harboring M. avium and M. tuberculosis.
Urinary Bladder Neoplasms
Cathepsin S inhibition changes regulatory T-cell activity in regulating bladder cancer and immune cell proliferation and apoptosis.
Uterine Cervical Neoplasms
Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells.
Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells.
Vascular Diseases
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Fat cell-derived modulators of vascular cell pathophysiology: the list keeps growing.
Vascular System Injuries
Fat cell-derived modulators of vascular cell pathophysiology: the list keeps growing.
Venous Thromboembolism
Point-of-care testing in primary care: A systematic review on implementation aspects addressed in test evaluations.
Virus Diseases
Point of care testing: diagnosis outside the virology laboratory.
Vitreoretinopathy, Proliferative
Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.