Disease on EC 3.4.22.27 - cathepsin S
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Acute Coronary Syndrome
Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
Acute Coronary Syndrome
Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound.
Adenocarcinoma
Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis.
Albuminuria
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
Albuminuria
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Alzheimer Disease
Cathepsin S increases tau oligomer formation through limited cleavage, but only IL-6, not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy.
Alzheimer Disease
Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates.
Alzheimer Disease
Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S.
Alzheimer Disease
The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study.
Anemia
Digital Hemoglobinometers as Point-of-Care Testing Devices for Hemoglobin Estimation: A Validation Study from India.
Anemia
Integrated point-of-care testing (POCT) for HIV, syphilis, malaria and anaemia at antenatal facilities in western Kenya: a qualitative study exploring end-users' perspectives of appropriateness, acceptability and feasibility.
Aneurysm
Insights from molecular modeling into the selective inhibition of cathepsin S by its inhibitor.
Angina, Stable
Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
Angina, Stable
Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease.
Angina, Stable
Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients.
Angina, Unstable
Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease.
Angina, Unstable
Increased serum cathepsin S in patients with atherosclerosis and diabetes.
Aortic Aneurysm
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Aortic Aneurysm
Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm.
Aortic Aneurysm, Abdominal
Cathepsin S is associated with degradation of collagen I in abdominal aortic aneurysm.
Aortic Aneurysm, Abdominal
Combined Cathepsin S and hs-CRP predicting inflammation of abdominal aortic aneurysm.
Aortic Aneurysm, Abdominal
Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
Aortic Aneurysm, Abdominal
Determination of cathepsin S abundance and activity in human plasma and implications for clinical investigation.
Aortic Aneurysm, Abdominal
Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.
Aortic Aneurysm, Abdominal
Pharmacological Inhibition of Cathepsin S Suppresses Abdominal Aortic Aneurysm in Mice.
Aortic Aneurysm, Abdominal
Plasma cathepsin s and cystatin C levels and risk of abdominal aortic aneurysm: a randomized population-based study.
Aortic Aneurysm, Abdominal
Plasma Cathepsin S is Associated with High-density Lipoprotein Cholesterol and Bilirubin in Patients with Abdominal Aortic Aneurysms.
Aortic Diseases
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice.
Aortic Valve Disease
Apolipoprotein A-I proteolysis in aortic valve stenosis: role of cathepsin S.
Aortic Valve Stenosis
Apolipoprotein A-I proteolysis in aortic valve stenosis: role of cathepsin S.
Arteriosclerosis
Effects of intermittent exercise on biomarkers of cardiovascular risk in night shift workers.
Arteritis
Cathepsin S and Protease-Activated Receptor-2 Drive Alloimmunity and Immune Regulation in Kidney Allograft Rejection.
Arthritis
Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis.
Arthritis
Collagenolytic protease expression in cranial cruciate ligament and stifle synovial fluid in dogs with cranial cruciate ligament rupture.
Arthritis
Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S.
Arthritis
Molecular modeling assisted identification and biological evaluation of potent cathepsin S inhibitors.
Arthritis
Spinal cathepsin S and fractalkine contribute to chronic pain in collagen induced arthritis.
Arthritis
The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints.
Arthritis, Experimental
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice.
Arthritis, Rheumatoid
An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity.
Arthritis, Rheumatoid
Cathepsin S and cathepsin L in serum and synovial fluid in rheumatoid arthritis with and without autoantibodies.
Arthritis, Rheumatoid
Circulating plasma levels of cathepsin S and L are not associated with disease severity in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Serum cathepsin S and cystatin C: relationship to subclinical carotid atherosclerosis in rheumatoid arthritis.
Arthritis, Rheumatoid
The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.
Asthma
Association between SNPs in the promoter region in cathepsin S and risk of asthma in Chinese Han population.
Asthma
Circadian and concentration profile of cathepsin S in sera from healthy subjects and asthmatic patients.
Asthma
Single nucleotide polymorphisms of cathepsin S and the risks of asthma attack induced by acaroid mites.
Astrocytoma
Cathepsin S expression: An independent prognostic factor in glioblastoma tumours--A pilot study.
Astrocytoma
Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vivo.
Atherosclerosis
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.
Atherosclerosis
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Atherosclerosis
Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
Atherosclerosis
Binding of chondroitin 4-sulfate to cathepsin s regulates its enzymatic activity.
Atherosclerosis
Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway.
Atherosclerosis
Cathepsin S contributes to macrophage migration via degradation of elastic fibre integrity to facilitate vein graft neointimal hyperplasia.
Atherosclerosis
Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells.
Atherosclerosis
Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis.
Atherosclerosis
Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease.
Atherosclerosis
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Atherosclerosis
Correlation of cathepsin S with coronary stenosis degree, carotid thickness, blood pressure, glucose and lipid metabolism and vascular endothelial function in atherosclerosis.
Atherosclerosis
Cystathionine ? Lyase Sulfhydrates the RNA Binding Protein HuR to Preserve Endothelial Cell Function and Delay Atherogenesis.
Atherosclerosis
Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice.
Atherosclerosis
Determination of cathepsin S abundance and activity in human plasma and implications for clinical investigation.
Atherosclerosis
Discovery of novel cathepsin S inhibitors by pharmacophore-based virtual high-throughput screening.
Atherosclerosis
Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
Atherosclerosis
IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression.
Atherosclerosis
Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates.
Atherosclerosis
Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis.
Atherosclerosis
Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels.
Atherosclerosis
Multiple Statistical Methods for Assessing Differential Gene Expression in Microarray Data of Diabetic Model Rats to Predict the Molecular Mechanism of Atorvastatin on Anti-Atherogenesis.
Atherosclerosis
Pharmacological Inhibition of Cathepsin S Decreases Atherosclerotic Lesions in Apoe-/- Mice.
Atherosclerosis
Plasma Cathepsin S is Associated with High-density Lipoprotein Cholesterol and Bilirubin in Patients with Abdominal Aortic Aneurysms.
Atherosclerosis
Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound.
Atherosclerosis
REPLY: Treatment with oxLDL antibody reduces cathepsin S expression in atherosclerosis via down-regulating ADAR1-mediated RNA editing.
Atherosclerosis
Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice with Chronic Renal Disease.
Atherosclerosis
Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men.
Atherosclerosis
Toll-like receptor 7 deficiency protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.
Atherosclerosis
Transfer of exosomal microRNA-203-3p from dendritic cells to bone marrow-derived macrophages reduces development of atherosclerosis by downregulating Ctss in mice.
Atherosclerosis
Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions.
Atherosclerosis
Treatment with oxLDL antibody reduces cathepsin S expression in atherosclerosis via down-regulating ADAR1-mediated RNA editing.
Atherosclerosis
Weight loss reduces adipose tissue cathepsin S and its circulating levels in morbidly obese women.
Atherosclerosis
[Impact of olmesartan medoxomil on atherosclerosis lesions in apolipoprotein E knockout mice].
Autoimmune Diseases
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.
Autoimmune Diseases
An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity.
Autoimmune Diseases
Aod1 controlling day 3 thymectomy-induced autoimmune ovarian dysgenesis in mice encompasses two linked quantitative trait loci with opposing allelic effects on disease susceptibility.
Autoimmune Diseases
Binding of chondroitin 4-sulfate to cathepsin s regulates its enzymatic activity.
Autoimmune Diseases
Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity.
Autoimmune Diseases
Cloning, expression analysis and enzymatic characterization of cathepsin S from olive flounder (Paralichthys olivaceus).
Autoimmune Diseases
Inhibition of Cathepsin S Reduces Allogeneic T Cell Priming but Not Graft-versus-Host Disease Against Minor Histocompatibility Antigens.
Autoimmune Diseases
Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors.
Autoimmune Diseases
Synthesis of proline analogues as potent and selective cathepsin S inhibitors.
Autoimmune Diseases
Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity.
Bacterial Infections
Cathepsin S of Sciaenops ocellatus: Identification, transcriptional expression and enzymatic activity.
Bacterial Infections
Expression profile analysis of two cathepsin S in channel catfish (Ictalurus punctatus) mucosal tissues following bacterial challenge.
Brain Injuries, Traumatic
Inhibition of cathepsin S produces neuroprotective effects after traumatic brain injury in mice.
Brain Neoplasms
Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vivo.
Breast Neoplasms
A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer.
Breast Neoplasms
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.
Breast Neoplasms
Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells.
Breast Neoplasms
Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells.
Breast Neoplasms
Is There Any Role for Serum Cathepsin S and CRP Levels on Prognostic Information in Breast Cancer? The Swedish Mammography Cohort.
Breast Neoplasms
Long-term endurance training increases serum cathepsin S levels in healthy female subjects.
Breast Neoplasms
Up-regulation of cathepsin S expression by HSP90 and 5-HT7 receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer.
Carcinogenesis
Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors.
Carcinogenesis
Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.
Carcinogenesis
Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways.
Carcinoma, Hepatocellular
Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Cathepsin S silencing induces apoptosis of human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Melittin suppresses cathepsin S-induced invasion and angiogenesis via blocking of the VEGF-A/VEGFR-2/MEK1/ERK1/2 pathway in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Silencing cathepsin S gene expression inhibits growth, invasion and angiogenesis of human hepatocellular carcinoma in vitro.
Carcinoma, Hepatocellular
[Effects of up-regulation of cathepsin S by HBx gene on HepG2 cell].
Carcinoma, Non-Small-Cell Lung
Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non-Small Cell Lung Cancer.
Cardiomegaly
Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR ? and ? expression and reducing TC, MMP-9, and Cat S levels.
Cardiovascular Diseases
Acute phase serum cathepsin S level and cathepsin S/cystatin C ratio are the associated factors with cerebral infarction and their diagnostic value for cerebral infarction.
Cardiovascular Diseases
Association between serum cathepsin S and mortality in older adults.
Cardiovascular Diseases
Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
Cardiovascular Diseases
Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations.
Cardiovascular Diseases
Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S.
Cardiovascular Diseases
Point-of-care testing in primary care: A systematic review on implementation aspects addressed in test evaluations.
Cardiovascular Diseases
Serum cathepsin S and cystatin C: relationship to subclinical carotid atherosclerosis in rheumatoid arthritis.
Cardiovascular Diseases
Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men.
Cardiovascular Diseases
The genetic polymorphisms of cathepsin S were associated with metabolic disorders in a Chinese Han population.
Carotid Artery Diseases
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Carotid Artery Diseases
Serum cathepsin S and cystatin C: relationship to subclinical carotid atherosclerosis in rheumatoid arthritis.
cathepsin s deficiency
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.
cathepsin s deficiency
Cathepsin S controls adipocytic and osteoblastic differentiation, bone turnover, and bone microarchitecture.
cathepsin s deficiency
Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors.
cathepsin s deficiency
Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury.
cathepsin s deficiency
Cathepsin S Deficiency Mitigated Chronic Stress-Related Neointimal Hyperplasia in Mice.
cathepsin s deficiency
Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation.
cathepsin s deficiency
Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
cathepsin s deficiency
Effective suppression of donor specific antibody production by Cathepsin S inhibitors in a mouse transplantation model.
Cerebral Infarction
Acute phase serum cathepsin S level and cathepsin S/cystatin C ratio are the associated factors with cerebral infarction and their diagnostic value for cerebral infarction.
Cerebral Infarction
Association between CTSS gene polymorphism and the risk of acute atherosclerotic cerebral infarction in Chinese population: a case-control study.
Coinfection
Repurposing Saquinavir for Host-Directed Therapy to Control Mycobacterium Tuberculosis Infection.
Colitis
Cathepsin S is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR2-dependent Mechanism in Mice.
Colitis
Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe.
Colitis
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Colorectal Neoplasms
Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity.
Colorectal Neoplasms
Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis.
Colorectal Neoplasms
Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization.
Colorectal Neoplasms
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Colorectal Neoplasms
Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.
Colorectal Neoplasms
The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study.
Colorectal Neoplasms
[Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer].
Communicable Diseases
Application of nanodiagnostics in point-of-care tests for infectious diseases.
Connective Tissue Diseases
Connective tissue diseases. Inhibiting cathepsin S to treat SLE and lupus nephritis.
Coronary Artery Disease
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Coronary Artery Disease
Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease.
Coronary Artery Disease
Correlation of cathepsin S with coronary stenosis degree, carotid thickness, blood pressure, glucose and lipid metabolism and vascular endothelial function in atherosclerosis.
Coronary Artery Disease
Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases.
Coronary Artery Disease
Increased plasma levels of CATS mRNA but not CATB mRNA in patients with coronary atherosclerosis.
Coronary Artery Disease
Optimisation of methods for quantifying plasma mRNA levels from genes responsible for coronary artery plaque development and destabilization.
Coronary Disease
Cathepsin B and S as markers for cardiovascular risk and all-cause mortality in patients with stable coronary heart disease during 10 years: a CLARICOR trial sub-study.
Coronary Disease
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Coronary Stenosis
Correlation of cathepsin S with coronary stenosis degree, carotid thickness, blood pressure, glucose and lipid metabolism and vascular endothelial function in atherosclerosis.
Cough
Introducing new point-of-care tests for common infections in publicly funded clinics in South Africa: a qualitative study with primary care clinicians.
COVID-19
Performance of two rapid point of care SARS-COV-2 antibody assays against laboratory-based automated chemiluminescent immunoassays for SARS-COV-2 IG-G, IG-M and total antibodies.
COVID-19
Rapid community point-of-care testing for COVID-19 (RAPTOR-C19): protocol for a platform diagnostic study.
COVID-19
The diagnostic accuracy of isothermal nucleic acid point-of-care tests for human coronaviruses: A systematic review and meta-analysis.
Cystic Fibrosis
A new player in the game: epithelial cathepsin S in early cystic fibrosis lung disease.
Cystic Fibrosis
miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production.
Cystic Fibrosis
Molecular modeling assisted identification and biological evaluation of potent cathepsin S inhibitors.
Cystic Fibrosis
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult ?ENaC-Tg Mice.
Dacryocystitis
Phenylephrine increases tear cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway.
Dengue
Controlled peptide solvation in portion-mixing libraries of FRET peptides: improved specificity determination for Dengue 2 virus NS2B-NS3 protease and human cathepsin S.
Dermatitis
Cathepsin S, a new pruritus biomarker in clinical dandruff/seborrhoeic dermatitis evaluation.
Dermatitis, Atopic
Overexpression of cathepsin s induces chronic atopic dermatitis in mice.
Dermatitis, Atopic
Overexpression of Cathepsin S Induces Chronic Atopic Dermatitis in Mice.
Diabetes Complications
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
Diabetes Mellitus
Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels.
Diabetes Mellitus, Type 2
Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
Diabetes Mellitus, Type 2
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Diabetes Mellitus, Type 2
Determination of cathepsin S abundance and activity in human plasma and implications for clinical investigation.
Diabetes Mellitus, Type 2
Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes.
Diabetic Nephropathies
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
Diabetic Retinopathy
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
Diphtheria
Common Reference-Based Tandem Mass Tag Multiplexing for the Relative Quantification of Peptides: Design and Application to Degradome Analysis of Diphtheria Toxoid.
Down Syndrome
The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study.
Dry Eye Syndromes
Phenylephrine increases tear cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway.
Dyslipidemias
Cholesterol Point-of-Care Testing for Community Pharmacies: A Review of the Current Literature.
Esophageal Neoplasms
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Fatty Liver
Serum lipocalin-2, cathepsin S and chemerin levels and nonalcoholic fatty liver disease.
Fibromyalgia
High levels of cathepsin S and cystatin C in patients with fibromyalgia syndrome.
Gaucher Disease
Aberrant progranulin, YKL-40, cathepsin D and cathepsin S in Gaucher disease.
Glioblastoma
Cathepsin S expression: An independent prognostic factor in glioblastoma tumours--A pilot study.
Glioblastoma
Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways.
Glioblastoma
Inhibition of Cathepsin S Induces Mitochondrial Apoptosis in Glioblastoma Cell Lines Through Mitochondrial Stress and Autophagosome Accumulation.
Glioblastoma
Inhibition of Cathepsin S Restores TGF-?-induced Epithelial-to-mesenchymal Transition and Tight Junction Turnover in Glioblastoma Cells.
Glioblastoma
[Cathepsin S (CTSS) is highly expressed in temozolomide-resistant glioblastoma T98G cells and associated with poor prognosis].
Glomerulonephritis
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Glomerulonephritis, IGA
The Clinical Significance and Potential Role of Cathepsin S in IgA Nephropathy.
Graft vs Host Disease
Inhibition of Cathepsin S Reduces Allogeneic T Cell Priming but Not Graft-versus-Host Disease Against Minor Histocompatibility Antigens.
Graves Disease
Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease.
Heart Diseases
Correlation of cathepsin S with coronary stenosis degree, carotid thickness, blood pressure, glucose and lipid metabolism and vascular endothelial function in atherosclerosis.
Heart Failure
Soluble Glycoprotein 130 and Heat Shock Protein 27 as Novel Candidate Biomarkers of Chronic Heart Failure with Preserved Ejection Fraction.
Heart Failure
[Association between lososomal cysteine protease cathepsin's activation and left ventricular function and remodeling in hypertensive heart failure rats]
Heart Valve Diseases
Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels.
Hepatitis B
Performance of point of care assays for hepatitis B and C viruses in chronic kidney disease patients.
Hepatitis C
Hepatitis C virus-mediated inhibition of cathepsin s increases invariant-chain expression on hepatocyte surface.
Hepatitis C
Performance of point of care assays for hepatitis B and C viruses in chronic kidney disease patients.
HIV Infections
Challenges of HIV diagnosis and management in the context of pre-exposure prophylaxis (PrEP), post-exposure prophylaxis (PEP), test and start and acute HIV infection: a scoping review.
Hydronephrosis
Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis.
Hyperalgesia
Cathepsin S in the spinal microglia contributes to remifentanil-induced hyperalgesia in rats.
Hyperalgesia
Cathepsin S is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR2-dependent Mechanism in Mice.
Hyperalgesia
Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state.
Hyperalgesia
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Hyperalgesia
Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.
Hyperalgesia
Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.
Hypercholesterolemia
The genetic polymorphisms of cathepsin S were associated with metabolic disorders in a Chinese Han population.
Hypergammaglobulinemia
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Hypersensitivity
An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity.
Hypersensitivity
Changes in vascular permeability in the spinal cord contribute to chemotherapy-induced neuropathic pain.
Hypertension
Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men.
Hypertension
[Association between lososomal cysteine protease cathepsin's activation and left ventricular function and remodeling in hypertensive heart failure rats]
Hypertension, Pulmonary
Cathepsin S promotes the development of pulmonary arterial hypertension.
Infections
"It's not a time spent issue, it's a 'what have you spent your time doing?' issue
" A qualitative study of UK patient opinions and expectations for implementation of Point of Care Tests for sexually transmitted infections and antimicrobial resistance.
Infections
A novel electronic algorithm using host biomarker point-of-care tests for the management of febrile illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trial.
Infections
An ideal test? A multi-country qualitative study of clinicians' and patients' views of point of care tests for lower respiratory tract infection in primary care.
Infections
Cathepsin L maturation and activity is impaired in macrophages harboring M. avium and M. tuberculosis.
Infections
COVID-19 point-of-care testing in care homes: what are the lessons for policy and practice?
Infections
Expression profile analysis of two cathepsin S in channel catfish (Ictalurus punctatus) mucosal tissues following bacterial challenge.
Infections
Genome-wide identification, expression signature and immune functional analysis of two cathepsin S (CTSS) genes in turbot (Scophthalmus maximus L.).
Infections
In-vitro diagnostic point-of-care tests in paediatric ambulatory care: A systematic review and meta-analysis.
Infections
Introducing new point-of-care tests for common infections in publicly funded clinics in South Africa: a qualitative study with primary care clinicians.
Infections
Molecular cloning, sequencing and characterization of channel catfish (Ictalurus punctatus, Rafinesque 1818) cathepsin S gene.
Infections
Mycobacterium bovis bacillus Calmette-Guérin secreting active cathepsin S stimulates expression of mature MHC class II molecules and antigen presentation in human macrophages.
Infections
Mycobacterium bovis BCG attenuates surface expression of mature class II molecules through IL-10-dependent inhibition of cathepsin S.
Infections
Performance of point-of-care tests for the detection of chlamydia trachomatis infections: A systematic review and meta-analysis.
Infections
Point of care tests for invasive fungal infections: a blueprint for increasing availability in Africa.
Infections
Point-of-care diagnostics: needs of African health care workers and their role combating global antimicrobial resistance.
Infections
Point-of-care testing for HCV infection: recent advances and implications for alternative screening.
Infections
Rapid community point-of-care testing for COVID-19 (RAPTOR-C19): protocol for a platform diagnostic study.
Infections
Simultaneous Quantitative Detection of Helicobacter Pylori Based on a Rapid and Sensitive Testing Platform using Quantum Dots-Labeled Immunochromatiographic Test Strips.
Influenza, Human
Do point-of-care tests (POCTs) offer a new paradigm for the management of patients with influenza?
Influenza, Human
Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo.
Influenza, Human
Integrating molecular point-of-care testing for influenza into primary care: a mixed-methods feasibility study.
Influenza, Human
The clinical utility of point-of-care tests for influenza in ambulatory care: A systematic review and meta-analysis.
Insulin Resistance
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Insulin Resistance
Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
Insulin Resistance
Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels.
Insulin Resistance
Serum Cathepsin S Is Associated With Decreased Insulin Sensitivity and the Development of Diabetes Type 2 in a Community-Based Cohort of Elderly Men.
Insulin Resistance
Serum lipocalin-2, cathepsin S and chemerin levels and nonalcoholic fatty liver disease.
Insulin Resistance
Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity.
Joint Diseases
The proinflammatory cytokines interleukin-1? and tumor necrosis factor ? promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes.
Kidney Neoplasms
Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP.
Liver Diseases
Plasma signature of neurological disease in the monogenetic disorder niemann-pick type C.
Liver Diseases
Serum lipocalin-2, cathepsin S and chemerin levels and nonalcoholic fatty liver disease.
Liver Neoplasms
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Lung Diseases
A new player in the game: epithelial cathepsin S in early cystic fibrosis lung disease.
Lung Diseases
Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics.
Lung Diseases
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult ?ENaC-Tg Mice.
Lung Diseases, Interstitial
Cathepsin S, a new serum biomarker of sarcoidosis discovered by transcriptome analysis of alveolar macrophages.
Lung Diseases, Interstitial
Decreased serum cathepsin S levels in patients with systemic sclerosis-associated interstitial lung disease.
Lung Injury
Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury.
Lung Neoplasms
Cathepsin S in tumours, regional lymph nodes and sera of patients with lung cancer: relation to prognosis.
Lung Neoplasms
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Lung Neoplasms
Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non-Small Cell Lung Cancer.
Lung Neoplasms
The effect of catalase on migration and invasion of lung cancer cells by regulating the activities of cathepsin S, L, and K.
Lupus Erythematosus, Systemic
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.
Lupus Erythematosus, Systemic
Global Proteomics Deciphered Novel-Function of Osthole Against Pulmonary Arterial Hypertension.
Lupus Nephritis
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Lupus Nephritis
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.
Lupus Nephritis
Connective tissue diseases. Inhibiting cathepsin S to treat SLE and lupus nephritis.
Lymphoma, B-Cell
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections.
Lymphoma, Follicular
Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma.
Lymphoma, Follicular
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma.
Lymphoma, Non-Hodgkin
Cathepsin S Protease Mediates T-Cell Response in Non-Hodgkin Lymphoma.
Lymphoma, Non-Hodgkin
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma.
Malaria
In-vitro diagnostic point-of-care tests in paediatric ambulatory care: A systematic review and meta-analysis.
Malaria
Integrated point-of-care testing (POCT) for HIV, syphilis, malaria and anaemia at antenatal facilities in western Kenya: a qualitative study exploring end-users' perspectives of appropriateness, acceptability and feasibility.
Malaria
Point-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences.
Measles
Investigation of a measles outbreak in Zimbabwe, 2010: potential of a point of care test to replace laboratory confirmation of suspected cases.
Metabolic Syndrome
Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
Metabolic Syndrome
Proportional correlates of adipolin and cathepsin S in metabolic syndrome patients with and without prediabetes.
Metabolic Syndrome
The genetic polymorphisms of cathepsin S were associated with metabolic disorders in a Chinese Han population.
Mouth Neoplasms
Inhibition of cathepsin S confers sensitivity to methyl protodioscin in oral cancer cells via activation of p38 MAPK/JNK signaling pathways.
Mouth Neoplasms
Sulforaphane suppresses oral cancer cell migration by regulating cathepsin S expression.
Multiple Sclerosis
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.
Multiple Sclerosis
An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity.
Multiple Sclerosis
Cathepsins and their endogenous inhibitors Cystatins: Expression and Modulation in Multiple Sclerosis.
Multiple Sclerosis
Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2.
Muscular Dystrophies
Cathepsin S contributes to the pathogenesis of muscular dystrophy in mice.
Myasthenia Gravis
Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis.
Myasthenia Gravis, Autoimmune, Experimental
Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease.
Myocardial Infarction
Cathepsin S degrades arresten and canstatin in infarcted area after myocardial infarction in rats.
Myocardial Infarction
Increased plasma cathepsin S and trombospondin-1 in patients with acute ST segment elevation myocardial infarction.
Myocardial Infarction
Increased serum cathepsin S in patients with atherosclerosis and diabetes.
Myositis
Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies.
Nasopharyngeal Neoplasms
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Neoplasm Metastasis
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.
Neoplasm Metastasis
Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma.
Neoplasm Metastasis
Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis.
Neoplasm Metastasis
Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells.
Neoplasm Metastasis
Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis.
Neoplasm Metastasis
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Neoplasm Metastasis
Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells.
Neoplasm Metastasis
Increased levels of macrophage-secreted cathepsin S during prostate cancer progression in TRAMP mice and patients.
Neoplasm Metastasis
Leading the invasion: The role of Cathepsin S in the tumour microenvironment.
Neoplasm Metastasis
Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry.
Neoplasm Metastasis
Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation.
Neoplasm Metastasis
Silencing cathepsin S gene expression inhibits growth, invasion and angiogenesis of human hepatocellular carcinoma in vitro.
Neoplasm Metastasis
Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway.
Neoplasms
A Chitosan-PLGA based catechin hydrate nanoparticles used in targeting of lungs and cancer treatment.
Neoplasms
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.
Neoplasms
A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer.
Neoplasms
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.
Neoplasms
Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity.
Neoplasms
Antibody targeting of cathepsin S inhibits angiogenesis and synergistically enhances anti-VEGF.
Neoplasms
Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis.
Neoplasms
Autophagy-Regulated ROS from Xanthine Oxidase Acts as an Early Effector for Triggering Late Mitochondria-Dependent Apoptosis in Cathepsin S-Targeted Tumor Cells.
Neoplasms
Binding of chondroitin 4-sulfate to cathepsin s regulates its enzymatic activity.
Neoplasms
Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors.
Neoplasms
Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors.
Neoplasms
Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization.
Neoplasms
Cathepsin S in tumours, regional lymph nodes and sera of patients with lung cancer: relation to prognosis.
Neoplasms
Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis.
Neoplasms
Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer.
Neoplasms
Chlorella powder inhibits the activities of peptidase cathepsin S, PLA2, cyclooxygenase-2, thromboxane synthase, tyrosine phosphatases, tumor necrosis factor-alpha converting enzyme, calpain and kinases.
Neoplasms
Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis.
Neoplasms
Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vivo.
Neoplasms
Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation.
Neoplasms
DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells.
Neoplasms
Dynamic Model of Protease State and Inhibitor Trafficking to Predict Protease Activity in Breast Cancer Cells.
Neoplasms
Effects of novel human cathepsin S inhibitors on cell migration in human cancer cells.
Neoplasms
Endothelial Dysfunction in Tristetraprolin-deficient Mice is not caused by Enhanced TNF-? Expression.
Neoplasms
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Neoplasms
Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S.
Neoplasms
Fat cell-derived modulators of vascular cell pathophysiology: the list keeps growing.
Neoplasms
Fsn0503h antibody-mediated blockade of cathepsin S as a potential therapeutic strategy for the treatment of solid tumors.
Neoplasms
Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9.
Neoplasms
Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells.
Neoplasms
Increased levels of macrophage-secreted cathepsin S during prostate cancer progression in TRAMP mice and patients.
Neoplasms
Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.
Neoplasms
Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways.
Neoplasms
Inhibition of Cathepsin S Induces Mitochondrial Apoptosis in Glioblastoma Cell Lines Through Mitochondrial Stress and Autophagosome Accumulation.
Neoplasms
Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP.
Neoplasms
Is There Any Role for Serum Cathepsin S and CRP Levels on Prognostic Information in Breast Cancer? The Swedish Mammography Cohort.
Neoplasms
Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels.
Neoplasms
Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry.
Neoplasms
Molecular modeling assisted identification and biological evaluation of potent cathepsin S inhibitors.
Neoplasms
Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery.
Neoplasms
Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor.
Neoplasms
Pro-inflammatory cytokines induce expression of matrix-metabolizing enzymes in human cervical smooth muscle cells.
Neoplasms
Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L-like proteases in tumor microenvironment.
Neoplasms
Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation.
Neoplasms
Silencing cathepsin S gene expression inhibits growth, invasion and angiogenesis of human hepatocellular carcinoma in vitro.
Neoplasms
Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway.
Neoplasms
The proinflammatory cytokines interleukin-1? and tumor necrosis factor ? promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes.
Neoplasms
The Role of Affordable, Point-of-Care Technologies for Cancer Care in Low- and Middle-Income Countries: A Review and Commentary.
Neoplasms
Up-regulation of cathepsin S expression by HSP90 and 5-HT7 receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer.
Neoplasms
Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress.
Nephritis
Connective tissue diseases. Inhibiting cathepsin S to treat SLE and lupus nephritis.
Neuralgia
Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor.
Neuralgia
Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model.
Neuralgia
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain.
Neuralgia
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain.
Neuralgia
Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2.
Neuralgia
Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.
Neuroinflammatory Diseases
Hydrogen sulfide inhibits ATP-induced neuroinflammation and A?1-42 synthesis by suppressing the activation of STAT3 and cathepsin S.
Niemann-Pick Diseases
Cathepsin S contributes to microglia-mediated olfactory dysfunction through the regulation of Cx3cl1-Cx3cr1 axis in a Niemann-Pick disease type C1 model.
Non-alcoholic Fatty Liver Disease
Serum lipocalin-2, cathepsin S and chemerin levels and nonalcoholic fatty liver disease.
Obesity
Cathepsin S controls adipocytic and osteoblastic differentiation, bone turnover, and bone microarchitecture.
Obesity
Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradation.
Obesity
Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation.
Obesity
Determination of cathepsin S abundance and activity in human plasma and implications for clinical investigation.
Obesity
Discovery of novel cathepsin S inhibitors by pharmacophore-based virtual high-throughput screening.
Obesity
Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates.
Obesity
Molecular modeling assisted identification and biological evaluation of potent cathepsin S inhibitors.
Obesity
Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men.
Obesity
Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity.
Obesity, Abdominal
Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
Obstetric Labor, Premature
Omega-3 Polyunsaturated Fatty Acids Reduce Preterm Labor by Inhibiting Trophoblast Cathepsin S and Inflammasome Activation.
Osteoporosis
Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides.
Osteoporosis
The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.
Ovarian Neoplasms
CTD-2020K17.1, a Novel Long Non-Coding RNA, Promotes Migration, Invasion, and Proliferation of Serous Ovarian Cancer Cells In Vitro.
Ovarian Neoplasms
Long Noncoding RNA CTD-2589M5.4 Inhibits Ovarian Cancer Cell Proliferation, Migration, and Invasion Via Downregulation of the Extracellular Matrix-Receptor Interaction Pathway.
Ovarian Neoplasms
Two SPRi biosensors for the determination of cathepsin S in blood plasma.
Overweight
Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
Pancreatic Neoplasms
The influence of linker length on the properties of cathepsin S cleavable (177)Lu-labeled HPMA copolymers for pancreatic cancer imaging.
Papilloma, Inverted
Expression of cathepsin S and its inhibitor stefin A in sinonasal inverted papilloma.
Paralysis
Cathepsin S increases tau oligomer formation through limited cleavage, but only IL-6, not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy.
Pediatric Obesity
Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity.
Peripheral Arterial Disease
Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases.
Peripheral Nerve Injuries
Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state.
Peripheral Nerve Injuries
Role of the cysteine protease cathepsin S in neuropathic hyperalgesia.
Peripheral Nerve Injuries
Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.
Peripheral Nervous System Diseases
Targeting lysosomal cysteine protease cathepsin S reveals immunomodulatory therapeutic strategy for oxaliplatin-induced peripheral neuropathy.
Pneumoconiosis
Cathepsin S, a new serum biomarker of sarcoidosis discovered by transcriptome analysis of alveolar macrophages.
Pneumonia
Genetic and Pharmacological Evaluation of Cathepsin S in a Mouse Model of Asthma.
Pneumonia
Point-of-care testing for community-acquired pneumonia: do we have all the answers?
Prediabetic State
Proportional correlates of adipolin and cathepsin S in metabolic syndrome patients with and without prediabetes.
Prostatic Neoplasms
Increased levels of macrophage-secreted cathepsin S during prostate cancer progression in TRAMP mice and patients.
Proteinuria
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Pruritus
Cathepsin S, a new pruritus biomarker in clinical dandruff/seborrhoeic dermatitis evaluation.
Pruritus
Skullcapflavone II Suppresses TNF-?/IFN-?-Induced TARC, MDC, and CTSS Production in HaCaT Cells.
Psoriasis
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.
Psoriasis
Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36?.
Psoriasis
Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome.
Pulmonary Arterial Hypertension
Cathepsin S promotes the development of pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
A highly significant association between Cathepsin S gene polymorphisms rs12068264 and chronic obstructive pulmonary disease susceptibility in Han Chinese population.
Pulmonary Disease, Chronic Obstructive
Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD.
Pulmonary Disease, Chronic Obstructive
Common functional polymorphisms in the cathepsin S promoter in Japanese subjects: possible contribution to pulmonary emphysema.
Pulmonary Disease, Chronic Obstructive
Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD.
Pulmonary Disease, Chronic Obstructive
Protein Phosphatase 2A Reduces Cigarette Smoke-Induced Cathepsin S and Loss of Lung Function.
Pulmonary Disease, Chronic Obstructive
Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.
Pulmonary Disease, Chronic Obstructive
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult ?ENaC-Tg Mice.
Pulmonary Disease, Chronic Obstructive
[The association between Cathepsin S and pulmonary function and CT phenotypes in patients with chronic obstructive pulmonary disease].
Pulmonary Emphysema
Common functional polymorphisms in the cathepsin S promoter in Japanese subjects: possible contribution to pulmonary emphysema.
Pulmonary Eosinophilia
Genetic and Pharmacological Evaluation of Cathepsin S in a Mouse Model of Asthma.
Renal Insufficiency, Chronic
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.
Renal Insufficiency, Chronic
Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease.
Renal Insufficiency, Chronic
Performance of point of care assays for hepatitis B and C viruses in chronic kidney disease patients.
Renal Insufficiency, Chronic
Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice with Chronic Renal Disease.
Respiratory Tract Infections
An ideal test? A multi-country qualitative study of clinicians' and patients' views of point of care tests for lower respiratory tract infection in primary care.
Respiratory Tract Infections
Assessing the potential of upper respiratory tract point-of-care testing: a systematic review of the prognostic significance of upper respiratory tract microbes.
Respiratory Tract Infections
COVID-19 point-of-care testing in care homes: what are the lessons for policy and practice?
Respiratory Tract Infections
In-vitro diagnostic point-of-care tests in paediatric ambulatory care: A systematic review and meta-analysis.
Sarcoidosis
Cathepsin S, a new serum biomarker of sarcoidosis discovered by transcriptome analysis of alveolar macrophages.
Scleroderma, Systemic
Decreased serum cathepsin S levels in patients with systemic sclerosis-associated interstitial lung disease.
Seizures
Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures.
Sexually Transmitted Diseases
"It's not a time spent issue, it's a 'what have you spent your time doing?' issue
" A qualitative study of UK patient opinions and expectations for implementation of Point of Care Tests for sexually transmitted infections and antimicrobial resistance.
Sexually Transmitted Diseases
Advancing point of care diagnostics for the control and prevention of STIs: the way forward.
Sexually Transmitted Diseases
Patterns of point-of-care test use among obstetricians and gynaecologists in the US.
Sexually Transmitted Diseases
Perceptions of an ideal point-of-care test for sexually transmitted infections--a qualitative study of focus group discussions with medical providers.
Sexually Transmitted Diseases
Point-of-care diagnostics: needs of African health care workers and their role combating global antimicrobial resistance.
Sexually Transmitted Diseases
Point-of-care testing for HCV infection: recent advances and implications for alternative screening.
signal peptidase ii deficiency
B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.
Sjogren's Syndrome
Insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors.
Sleep Apnea, Obstructive
Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes.
Speech Disorders
The Communication Attitude Test (CAT-S): normative values for 220 Swedish children.
ST Elevation Myocardial Infarction
Increased plasma cathepsin S and trombospondin-1 in patients with acute ST segment elevation myocardial infarction.
Stomach Diseases
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Stomach Neoplasms
Cathepsin S mediates gastric cancer cell migration and invasion via a putative network of metastasis-associated proteins.
Stomach Neoplasms
Cathepsin S Mediates Gastric Cancer Cell Migration and Invasion via a Putative Network of Metastasis-Associated Proteins.
Stomach Neoplasms
Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer.
Stroke
Point-of-Care-Testing in Acute Stroke Management: An Unmet Need Ripe for Technological Harvest.
Supranuclear Palsy, Progressive
Cathepsin S increases tau oligomer formation through limited cleavage, but only IL-6, not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy.
Syphilis
Estimating the uptake of maternal syphilis screening and other antenatal interventions before and after national rollout of syphilis point-of-care testing in Ghana.
Syphilis
Factors associated with failure to screen for syphilis during antenatal care in Ghana: a case control study.
Syphilis
Field evaluation of two point-of-care tests for syphilis among men who have sex with men, Verona, Italy.
Syphilis
Integrated point-of-care testing (POCT) for HIV, syphilis, malaria and anaemia at antenatal facilities in western Kenya: a qualitative study exploring end-users' perspectives of appropriateness, acceptability and feasibility.
Syphilis
Patterns of point-of-care test use among obstetricians and gynaecologists in the US.
Syphilis
Point-of-care diagnostics: needs of African health care workers and their role combating global antimicrobial resistance.
Syphilis
Rollout of rapid point of care tests for antenatal syphilis screening in Ghana: healthcare provider perspectives and experiences.
Syphilis
Standardised protocol for a prospective cross-sectional multicentre clinic-based evaluation of two dual point-of-care tests for the screening of HIV and syphilis in men who have sex with men, sex workers and pregnant women.
Syphilis
The impact of antenatal syphilis point of care testing on pregnancy outcomes: A systematic review.
Tauopathies
Cathepsin S increases tau oligomer formation through limited cleavage, but only IL-6, not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy.
Thrombosis
Insights from molecular modeling into the selective inhibition of cathepsin S by its inhibitor.
Triple Negative Breast Neoplasms
A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer.
Triple Negative Breast Neoplasms
Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis.
Tuberculosis
Cathepsin L maturation and activity is impaired in macrophages harboring M. avium and M. tuberculosis.
Urinary Bladder Neoplasms
Cathepsin S inhibition changes regulatory T-cell activity in regulating bladder cancer and immune cell proliferation and apoptosis.
Uterine Cervical Neoplasms
Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells.
Uterine Cervical Neoplasms
Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells.
Vascular Diseases
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Vascular Diseases
Fat cell-derived modulators of vascular cell pathophysiology: the list keeps growing.
Vascular System Injuries
Fat cell-derived modulators of vascular cell pathophysiology: the list keeps growing.
Venous Thromboembolism
Point-of-care testing in primary care: A systematic review on implementation aspects addressed in test evaluations.
Vitreoretinopathy, Proliferative
Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.
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