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3.4.22.27: cathepsin S

This is an abbreviated version!
For detailed information about cathepsin S, go to the full flat file.

Word Map on EC 3.4.22.27

Reaction

similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and additional information activity on the Z-Val-Val-Arg-/- compound =

Synonyms

C01.034, Cat S, Cat-S, cath S, cathepsin S, cathepsin S-like cysteine proteinase, cathepsin Sa, CatS, CatSPP, CTSS, Hacp-s, PfCTSSa, PoCtS, rs1136774, rs16827671, rs34495036, rs35989725, rs3754212, rs7534124, SoCatS

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.27 cathepsin S

Expression

Expression on EC 3.4.22.27 - cathepsin S

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
CTSS gene expression is increased after cells have been treated with recombinant CTSS for 24 h. CTSS protein expression in cell lysates measured using the human CTSS ELISA kit also reveal that the protein increases after 8 h CTSS treatment
high expression in pre parasitic J2s and female stages
hormonal regulation in maternal tissue
-
hypoxia increases the levels of CatS gene and protein in cultured HUVECs
induced in psoriatic keratinocytes
-
PoCtS expression increased significantly in muscle 6 h post-injection of bacterial lipopolysaccharide
-
SoCatS expression is enhanced by bacterial infection with fish pathogenic Edwardsiella tarda, a fish pathogen. In kidney, significant induction of SoCatS occurs at 4 h (2.31fold) and 8 h (2.55fold) post-infection. In liver, significant induction of SoCatS (3.0fold) is only observed at 24 h post-infection. In spleen, SoCatS expression is significantly upregulated at 12 h post-infection (5.46fold) and at 24 h post-infection (4.23fold)