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2'-dATP + D-galactose
2'-dADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
2-amino-2-deoxy-D-galactose + ATP
2-amino-2-deoxy-D-galactose 1-phosphate + ADP
-
Substrates: -
Products: -
?
2-deoxy-D-galactose + ATP
2-deoxy-D-galactose 1-phosphate + ADP
-
Substrates: -
Products: -
?
3'-dATP + D-galactose
3'-dADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
3-deoxy-D-galactose + ATP
?
-
Substrates: -
Products: -
?
ADP + alpha-D-galactose 1-phosphate
ATP + alpha-D-galactose
-
Substrates: -
Products: -
r
alpha-D-galactose + ATP
alpha-D-galactose 1-phosphate + ADP
-
Substrates: -
Products: -
?
ATP + 2-amino-2-deoxy-D-galactose
ADP + 2-amino-2-deoxy-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-alpha-D-galactose 1-phosphate
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-D-galactose 1-phosphate
ATP + 3-deoxy-3-fluorogalactose
ADP + 3-deoxy-3-fluorogalactose 1-phosphate
ATP + 3-deoxy-3-methyl-D-galactose
ADP + 3-deoxy-3-methyl-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 3-deoxy-D-galactose
ADP + 3-deoxy-D-galactose 1-phosphate
ATP + 4-deoxy-4-fluorogalactose
ADP + 4-deoxy-4-fluorogalactose 1-phosphate
Substrates: 21% conversion
Products: -
?
ATP + 4-deoxy-D-galactose
ADP + 4-deoxy-alpha-D-galactose 1-phosphate
-
Substrates: substrate only for mutants Y223F, Y223W
Products: -
?
ATP + 6-deoxy-6-fluorogalactose
ADP + 6-deoxy-6-fluorogalactose 1-phosphate
Substrates: 28% conversion
Products: -
?
ATP + 6-deoxy-D-galactose
ADP + 6-deoxy-alpha-D-galactose 1-phosphate
ATP + 6-deoxy-D-galactose
ADP + 6-deoxy-D-galactose 1-phosphate
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
ATP + D-galactosamine
ADP + alpha-D-galactosamine 1-phosphate
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
ATP + D-galactose
ADP + D-galactose 1-phosphate
Substrates: -
Products: -
?
ATP + D-galacturonic acid
ADP + alpha-D-galacturonic acid 1-phosphate
-
Substrates: substrate: galacturonic acid, specific activity: 0.09 micromol/min/mg
Products: -
?
ATP + D-galacturonic acid
ADP + D-galacturonic acid 1-phosphate
ATP + D-glucose
ADP + alpha-D-glucose 1-phosphate
ATP + D-talose
ADP + alpha-D-talose 1-phosphate
ATP + galactose
ADP + alpha-D-galactose 1-phosphate
ATP + L-altrose
ADP + L-altrose 1-phosphate
-
Substrates: -
Products: -
?
ATP + L-arabinose
ADP + L-arabinose 1-phosphate
Substrates: 10% conversion after 2 h under optimised conditions
Products: -
?
ATP + L-glucose
ADP + alpha-L-glucose 1-phosphate
-
Substrates: substrate only for mutants Y223F, Y223W
Products: -
?
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
CTP + D-galactose
CDP + alpha-D-galactose 1-phosphate
-
Substrates: substrate: CTP, specific activity: 0.551 micromol/min/mg
Products: -
?
D-fucose + ATP
?
-
Substrates: -
Products: -
?
D-galactosamine + ATP
?
-
Substrates: -
Products: -
?
D-talose + ATP
alpha-D-talose 1-phosphate + ADP
-
Substrates: -
Products: -
?
dATP + D-galactose
dADP + alpha-D-galactose 1-phosphate
-
Substrates: substrate: dATP, specific activity: 138 micromol/min/mg
Products: -
?
dCTP + D-galactose
dCDP + alpha-D-galactose 1-phosphate
-
Substrates: substrate: dCTP, specific activity: 0.931 micromol/min/mg
Products: -
?
deoxy-ATP + D-galactose
deoxyADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
dGTP + D-galactose
dGDP + alpha-D-galactose 1-phosphate
-
Substrates: substrate: dGTP, specific activity: 31.9 micromol/min/mg
Products: -
?
dTTP + D-galactose
?
-
Substrates: substrate: dTTP, specific activity: 2.5 micromol/min/mg
Products: -
?
dUTP + D-galactose
dUDP + alpha-D-galactose 1-phosphate
-
Substrates: substrate: dUTP, specific activity: 1.5 micromol/min/mg
Products: -
?
GTP + D-galactose
GDP + alpha-D-galactose 1-phosphate
-
Substrates: substrate: GTP, specific activity: 28.5 micromol/min/mg
Products: -
?
ITP + D-galactose
IDP + alpha-D-galactose 1-phosphate
-
Substrates: substrate: ITP, specific activity: 15.7 micromol/min/mg
Products: -
?
UTP + D-galactose
UDP + alpha-D-galactose 1-phosphate
-
Substrates: substrate: UTP, specific activity: 0.52 micromol/min/mg
Products: -
?
additional information
?
-
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-alpha-D-galactose 1-phosphate
-
Substrates: substrate: 2-deoxygalactose, specific activity: 99.7 micromol/min/mg
Products: -
?
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-alpha-D-galactose 1-phosphate
Substrates: -
Products: -
?
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-D-galactose 1-phosphate
Substrates: -
Products: -
?
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 2-deoxy-D-galactose
ADP + 2-deoxy-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 3-deoxy-3-fluorogalactose
ADP + 3-deoxy-3-fluorogalactose 1-phosphate
Substrates: 27% conversion
Products: -
?
ATP + 3-deoxy-3-fluorogalactose
ADP + 3-deoxy-3-fluorogalactose 1-phosphate
Substrates: 27% conversion
Products: -
?
ATP + 3-deoxy-D-galactose
ADP + 3-deoxy-D-galactose 1-phosphate
Substrates: 19% conversion
Products: -
?
ATP + 3-deoxy-D-galactose
ADP + 3-deoxy-D-galactose 1-phosphate
Substrates: 85% conversion after 2 h under optimised conditions
Products: -
?
ATP + 3-deoxy-D-galactose
ADP + 3-deoxy-D-galactose 1-phosphate
Substrates: 85% conversion after 2 h under optimised conditions
Products: -
?
ATP + 6-deoxy-D-galactose
ADP + 6-deoxy-alpha-D-galactose 1-phosphate
-
Substrates: substrate: 6-deoxygalactose, specific activity: 0.0781 micromol/min/mg
Products: -
?
ATP + 6-deoxy-D-galactose
ADP + 6-deoxy-alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 6-deoxy-D-galactose
ADP + 6-deoxy-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + 6-deoxy-D-galactose
ADP + 6-deoxy-D-galactose 1-phosphate
Substrates: 57% conversion
Products: -
?
ATP + 6-deoxy-D-galactose
ADP + 6-deoxy-D-galactose 1-phosphate
Substrates: 57% conversion
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: -
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: -
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: -
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: -
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: the enzyme catalyses the first committed step in the Leloir pathway
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: negative charge at residue 174 is essential for catalysis
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
r
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: 72% conversion
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: 72% conversion
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: involved in Leloir pathway
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: 91% conversion after 2 h under optimised conditions
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: involved in Leloir pathway
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: 91% conversion after 2 h under optimised conditions
Products: -
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactosamine
ADP + alpha-D-galactosamine 1-phosphate
-
Substrates: substrate: D-galactosamine, specific activity: 12.5 micromol/min/mg
Products: -
?
ATP + D-galactosamine
ADP + alpha-D-galactosamine 1-phosphate
Substrates: -
Products: -
?
ATP + D-galactosamine
ADP + alpha-D-galactosamine 1-phosphate
Substrates: 68% conversion
Products: -
?
ATP + D-galactosamine
ADP + alpha-D-galactosamine 1-phosphate
Substrates: 68% conversion
Products: -
?
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
Substrates: 100% of the activity with alpha-D-galactose
Products: -
?
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
Substrates: 100% of the activity with alpha-D-galactose
Products: -
?
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
Substrates: -
Products: -
?
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
Substrates: 87% conversion after 2 h under optimised conditions
Products: -
?
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
Substrates: 87% conversion after 2 h under optimised conditions
Products: -
?
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: very strict substrate specificity for galactose and ATP
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: substrate: ATP, specific activity: 137 micromol/min/mg
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: substrate: D-galactose, specific activity: 158 micromol/min/mg
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: unidirectional towards galactose phosphorylation
Products: -
ir
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
ir
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
ir
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-galacturonic acid
ADP + D-galacturonic acid 1-phosphate
Substrates: 20.2% of the activity with alpha-D-galactose
Products: -
?
ATP + D-galacturonic acid
ADP + D-galacturonic acid 1-phosphate
Substrates: 20.2% of the activity with alpha-D-galactose
Products: -
?
ATP + D-glucose
ADP + alpha-D-glucose 1-phosphate
Substrates: 52.5% of the activity with alpha-D-galactose
Products: -
?
ATP + D-glucose
ADP + alpha-D-glucose 1-phosphate
Substrates: 52.5% of the activity with alpha-D-galactose
Products: -
?
ATP + D-glucose
ADP + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-glucose
ADP + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-glucose
ADP + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-glucose
ADP + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-talose
ADP + alpha-D-talose 1-phosphate
-
Substrates: substrate only for mutants Y223F, Y223W
Products: -
?
ATP + D-talose
ADP + alpha-D-talose 1-phosphate
Substrates: -
Products: -
?
ATP + D-talose
ADP + alpha-D-talose 1-phosphate
-
Substrates: -
Products: -
?
ATP + D-talose
ADP + alpha-D-talose 1-phosphate
Substrates: 41% conversion
Products: -
?
ATP + D-talose
ADP + alpha-D-talose 1-phosphate
Substrates: 41% conversion
Products: -
?
ATP + galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: the enzyme catalyzes the first step in the conversion of galactose to glucose. Galactokinase deficiency is characterized by galactosemia, galactosuria and cataract formation in early childhood
Products: -
?
ATP + galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: galactokinase deficiency is an autosomal recessive disorder, which causes cataract formation in children not maintained on a lactose-free diet
Products: -
?
ATP + galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: galaktokinase deficiency is an autosomal recessive disorder characterized by hypergalactosemia and cataract formation
Products: -
?
ATP + galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: lack of fully functional galactokinase is one cause of the inherited disease galactosemia, the main clinical manifestation of which is the early onset of cataracts
Products: -
?
ATP + galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: -
Products: -
?
ATP + galactose
ADP + alpha-D-galactose 1-phosphate
-
Substrates: first step in the Leloir pathway for galactose metabolism
Products: -
?
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
Substrates: 15.5% of the activity with alpha-D-galactose
Products: -
?
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
Substrates: 15.5% of the activity with alpha-D-galactose
Products: -
?
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
Substrates: -
Products: -
?
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
Substrates: 40% conversion after 2 h under optimised conditions
Products: -
?
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
Substrates: 40% conversion after 2 h under optimised conditions
Products: -
?
additional information
?
-
-
Substrates: no tolerance for C-4 changes in the substrate
Products: -
?
additional information
?
-
-
Substrates: no substrate: N-acetyl-D-galactosamine, L-arabinose, D-fucose, D-glucose
Products: -
?
additional information
?
-
-
Substrates: amino acid side chains responsible for anchoring the sugar ligand to the protein include Arg36, Glu42, Asp45, ASp183, and Tyr233
Products: -
?
additional information
?
-
-
Substrates: mechanism of the reaction is sequential in both directions. Residue Asp183 acts as a catalytic base that deprotonates the C1 hydroxyl group of galactose. The pH-kcat profile of the synthesis of galactose 1-phosphate has a pKa of 6.9 likely due to Asp183. The pH-kcat/KGal profile of the reverse reaction lacks a key pKa required for a direct proton transfer mechanism. Arg36 may lower the pKa of the C1 hydroxyl to facilitate deprotonation
Products: -
?
additional information
?
-
-
Substrates: galactokinase Gal1p is a regulator of transcription. Gal1p activates Gal4p, the activator of GAL genes. Gal1p activates Gal4p by direct interaction with the Gal4p inhibitor Gal80p. Interaction requires galactose, adenosine triphosphate and the regulatory function of Gal1p. The gal1p-gal80p complex formation results in the inactivation of Gal80p, thereby transmitting the galactose signal to Gal4p
Products: -
?
additional information
?
-
-
Substrates: L-arabinose, D-fucose, L-glucose, and D-talose are no substrates
Products: -
?
additional information
?
-
-
Substrates: L-arabinose, D-fucose, L-glucose, and D-talose are no substrates
Products: -
?
additional information
?
-
-
Substrates: key enzyme for cellulase induction during growth on lactose
Products: -
?
additional information
?
-
-
Substrates: induction of the gal pathway and cellulase genes involves no transcriptional inducer function of the galactokinase in Hypocrea jecorina
Products: -
?
additional information
?
-
-
Substrates: induction of the gal pathway and cellulase genes involves no transcriptional inducer function of the galactokinase in Hypocrea jecorina
Products: -
?
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