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Literature summary for 2.7.1.6 extracted from
- Galactokinase from human erythrocytes (1975), Methods Enzymol., 42C, 47-53.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.236 | - |
D-galactose | - |
Homo sapiens |  |
| 0.342 | - |
ATP | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 26000 | - |
2 * 26000, SDS-PAGE | Homo sapiens |
| 55000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + galactose | Homo sapiens | the enzyme catalyzes the first step in the conversion of galactose to glucose. Galactokinase deficiency is characterized by galactosemia, galactosuria and cataract formation in early childhood | ADP + alpha-D-galactose 1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | activity is high at birth and decrases so that by the age of approximately 4 years it reaches the adult value | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0812 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 3.0 M ammonium sulfate, 10% loss of activity after 6 d | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-galactose | unidirectional towards galactose phosphorylation | Homo sapiens | ADP + alpha-D-galactose 1-phosphate | - |
ir | |
| ATP + galactose | the enzyme catalyzes the first step in the conversion of galactose to glucose. Galactokinase deficiency is characterized by galactosemia, galactosuria and cataract formation in early childhood | Homo sapiens | ADP + alpha-D-galactose 1-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 26000, SDS-PAGE | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
- |
Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | isoelectric focusing in a pH 5-8 stabilized sucrose gradient | - |
5.7 |
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Release 2023.1 (January 2023)
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