EC Number |
Inhibitors |
Structure |
---|
2.7.1.6 | 2-(1,3-benzoxazol-2-ylamino)-4-(4-chloro-1H-pyrazol-3-yl)-4,6,7,8-tetrahydroquinazolin-5(1H)-one |
inhibitory to isoform Galk1, no inhibition of isoform Galk2 up to 40 microM. Uncompetitive with respect to galactose, compound directly competes with ATP at the binding site, and galactose may be required to bind first. Compound is able to lower galactose 1-phosphate levels in primary fibroblasts of patients suffering Classic Galactosemia without significant effect on viability of cells |
|
2.7.1.6 | 3-mercaptoethanol |
- |
|
2.7.1.6 | adenosine-5'-[gamma-thio]triphosphate |
- |
|
2.7.1.6 | ADP |
competitive inhibitor of MgATP2- |
|
2.7.1.6 | ADP |
- |
|
2.7.1.6 | ADP |
competitive with respect to ATP, uncompetitive with respect to galactose |
|
2.7.1.6 | alpha-D-galactose 1-phosphate |
noncompetitive inhibitor of galactose |
|
2.7.1.6 | alpha-D-galactose 1-phosphate |
- |
|
2.7.1.6 | alpha-D-galactose 1-phosphate |
noncompetitive with respect to galactose |
|
2.7.1.6 | alpha-D-galactose 1-phosphate |
uncompetitive inhibitor with respect to galactose, mixed inhibitor with respect to ATP |
|