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IUBMB CommentsA pyridoxal-phosphate protein. Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors. Not identical with EC 2.5.1.51 (beta-pyrazolylalanine synthase), EC 2.5.1.52 (L-mimosine synthase) and EC 2.5.1.53 (uracilylalanine synthase).
Synonyms
gyy4137, cysteine synthase, cysteine synthetase, o-acetylserine sulfhydrylase, oastl, oas-tl, o-acetylserine(thiol)lyase, csase, o-acetylserine (thiol) lyase, oass-a,
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acetylserine sulfhydrylase
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beta-cyano-alanine synthase
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beta-cyano-L-alanine synthase
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Cys synthase complex
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serine acetyltransferase (EC 2.3.1.30) and O-acetylserine thiol lyase reversibly form the heterooligomeric Cys synthase complex
cysteine synthase 1
UniProt
cysteine synthase, chloroplastic/chromoplastic
UniProt
cysteine synthase, mitochondrial
UniProt
cysteine synthetase
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EC 4.2.99.8
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formerly
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O -acetylserine (thiol)-lyase
O-acetyl-L-serine (thiol) lyase
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O-acetyl-L-serine acetate-lyase (adding hydrogen sulfide)
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O-acetyl-L-serine sulfhydrylase
O-acetyl-L-serine sulfhydrylase B
O-acetyl-L-serine sulfohydrolase
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O-acetyl-L-serine(thiol)lyase
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O-acetyl-serine (thiol) lyase
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O-acetylserine (thiol) lyase
O-acetylserine (Thiol)-lyase
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O-acetylserine (thiol)-lyase A
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O-acetylserine (thiol)-lyase B
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O-acetylserine (thiol)lyase
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O-acetylserine sulfhydrylase
O-acetylserine sulfhydrylase A
O-acetylserine sulfhydrylase B
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O-acetylserine sulfhydrylase isoenzyme B
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O-acetylserine sulfhydrylase-A
O-acetylserine sulfhydrylase-B
O-acetylserine thiol lyase
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O-acetylserine(thiol)lyase
O-acetylserine-(thiol)lyase
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O-acetylserine-O-acetylhomoserine sulfhydro-lyase
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O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
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protein ONSET OF LEAF DEATH 3
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S-sulfocysteine synthase
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sulfhydrylase/cysteine synthase
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synthase, cysteine
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BAbS19_I09950
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CS1
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CS26
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CSase
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CSase A
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CSase B
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cysK
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CysK1
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CysK2
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CysM
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Cysteine synthase
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cysteine synthase A
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cysteine synthase A
UniProt
cysteine synthase B
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cysteine synthase B
UniProt
DcsD
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Fn1220
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lanthionine synthase
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lanthionine synthase
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LbrCS
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O -acetylserine (thiol)-lyase
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O -acetylserine (thiol)-lyase
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O-acetyl-L-serine sulfhydrylase
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O-acetyl-L-serine sulfhydrylase
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O-acetyl-L-serine sulfhydrylase B
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O-acetyl-L-serine sulfhydrylase B
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O-acetylserine (thiol) lyase
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O-acetylserine (thiol) lyase
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O-acetylserine (thiol) lyase
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O-acetylserine (thiol) lyase
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O-acetylserine (thiol) lyase
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O-acetylserine (thiol) lyase
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O-acetylserine (thiol) lyase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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cysteine synthase is a multiprotein assembly formed by the pyridoxal 5'-phosphate-dependent enzyme O-acetylserine sulfhydrylase and serine acetyltransferase
O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase
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O-acetylserine sulfhydrylase A
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O-acetylserine sulfhydrylase A
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O-acetylserine sulfhydrylase A
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O-acetylserine sulfhydrylase A
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O-acetylserine sulfhydrylase A
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O-acetylserine sulfhydrylase A
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O-acetylserine sulfhydrylase A
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O-acetylserine sulfhydrylase A
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O-acetylserine sulfhydrylase A
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O-acetylserine sulfhydrylase A
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O-acetylserine sulfhydrylase A
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O-acetylserine sulfhydrylase-A
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O-acetylserine sulfhydrylase-A
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O-acetylserine sulfhydrylase-A
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O-acetylserine sulfhydrylase-B
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O-acetylserine sulfhydrylase-B
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O-acetylserine sulfhydrylase-B
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O-acetylserine(thiol)lyase
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O-acetylserine(thiol)lyase
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O-acetylserine(thiol)lyase
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O-acetylserine(thiol)lyase
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O-acetylserine(thiol)lyase
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OAS-TL
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OAS-TL A
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OAS-TL B
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OASS
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OASS-A
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OASS-B
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OASS-B
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produced under unaerobic grwoth conditions in contrast to OASS-A
OASTL
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OASTL-A
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OASTL-A1
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SSC synthase
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
mechanism
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
mechanism
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
ping-pong bi-bi mechanism
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
mechanism interpreted in structural context, conformational changes during catalysis
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
mechanism similar to those of other pyridoxal enzymes
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
identification and spectral characterization of the external aldimine of the reaction, mechanism
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
mechanism of reverse reaction
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
model of reaction mechanism
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
geometric model of reaction, comparison isoenzyme CysK
O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
ping-pong bi-bi mechanism
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
model of reaction mechanism
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
A pyridoxal-phosphate protein. Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors. Not identical with EC 2.5.1.51 (beta-pyrazolylalanine synthase), EC 2.5.1.52 (L-mimosine synthase) and EC 2.5.1.53 (uracilylalanine synthase).
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 L-cysteine
(2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) + H2S
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?
3-chloro-L-alanine + NaHS
L-cysteine + ?
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beta-replacement reaction, enzyme can be induced by 3-chloro-L-alanine
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?
5-thio-2-nitrobenzoate + O-acetyl-L-serine
acetate + ?
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beta-chloro-L-alanine + 2-nitro-5-thiobenzoate
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chloroalanine + sulfide
cysteine + chloride
cyanide + cysteine
beta-cyanoalanine + sulfide
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cysteine + CN-
cyanoalanine + H2S
L-Cys + acetate
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involved in mobilization of sulfide from cysteine for Fe-S cluster formation, significance in vivo unclear
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L-Cys + acetate
O-acetyl-L-Ser + H2S
L-Cys + dithiothreitol
beta-cyanoalanine + H2S
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?
L-cysteine + cyanide
cyanoalanine + H2S
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?
L-cysteine + dithiothreitol
S-(2,3-hydroxy-4-thiobutyl)-L-cysteine + H2S
L-cysteine + H2O
L-serine + H2S
A0A1J9VES8
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?
L-cysteine + L-cysteine
L-lanthionine + H2S
L-cysteine + L-homocysteine
L-cystathionine + H2S
L-homocysteine + L-serine
L-cystathionine + H2O
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?
L-homoserine + sulfide
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1.6% of the activity with O-acetyl-L-serine
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monofluoralanine + H2S
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NaN3 + O-acetyl-Ser
beta-azidoalanine + sodium acetate
O-acetyl-L-Ser + 1,2,3,4-tetrazole
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O-acetyl-L-Ser + 1,2,3-benzotriazole
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weak activity
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?
O-acetyl-L-Ser + 1,2,4-triazole
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O-acetyl-L-Ser + 1-propanethiol
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O-acetyl-L-Ser + 2-propene-1-thiol
S-allyl-L-cysteine + ?
O-acetyl-L-Ser + 3-mercapto-1,2,4-triazole
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O-acetyl-L-Ser + 5-mercapto-2-nitrobenzoate
S-(3-carboxy-4-nitrophenyl)-L-cysteine + ?
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?
O-acetyl-L-Ser + benzenethiol
L-cys + benzylacetate
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O-acetyl-L-Ser + cysteamine
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weak activity
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O-acetyl-L-Ser + H2S
L-Cys + acetate
O-acetyl-L-Ser + hydrogen sulfide
L-Cys + acetate
O-acetyl-L-Ser + isoxazolin-5-one
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O-acetyl-L-Ser + mercaptoacetic acid
S-carboxymethyl-L-cysteine
O-acetyl-L-Ser + methyl mercaptan
S-methylcysteine + acetate
O-acetyl-L-Ser + NaCN
beta-cyanoalanine + sodium acetate
O-acetyl-L-Ser + pyrazole
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weak activity
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O-acetyl-L-Ser + S2O32-
S-sulfocysteine + ?
O-acetyl-L-Ser + sodium azide
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weak activity
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O-acetyl-L-Ser + sodium thiosulfate
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O-acetyl-L-Ser + sulfide
L-Cys + acetate
O-acetyl-L-Ser + thiosulfate
S-sulfocysteine + sodium acetate
O-acetyl-L-serine
L-cysteine + acetate
O-acetyl-L-serine + 5-thio-2-nitrobenzoate
? + acetate
O-acetyl-L-serine + H2O
pyruvate + acetate + NH3
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?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
2.5.1.47 cysteine synthase
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