Ligand O-acetyl-L-serine

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Basic Ligand Information

Molecular Structure
Picture of O-acetyl-L-serine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H9NO4
O-acetyl-L-serine
VZXPDPZARILFQX-BYPYZUCNSA-N
Synonyms:
O-acetyl-(S)-Ser, O-acetyl-L-Ser, O-acetyl-Ser, O-acetyl-serine, O-acetyl serine, O-acetylserine, O3-acetyl-L-serine


Show all pahtways known for Show all BRENDA pathways known for O-acetyl-L-serine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (55 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O-acetyl-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + acetate
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O3-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate
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O3-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate
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O-acetyl-L-serine + thiosulfate = S-sulfo-L-cysteine + acetate
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O-acetyl-L-serine + S2- = L-cysteine + acetic acid
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O3-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate
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O3-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate
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2 O3-acetyl-L-serine + 2 uracil = 3-(uracil-1-yl)-L-alanine + 3-(uracil-3-yl)-L-alanine + 2 acetate
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O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
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O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate
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O-Acetyl-L-serine + pyrazole = ?
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In Vivo Product in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-cystathionine + acetate = O-acetyl-L-serine + L-homocysteine
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Substrate in Enzyme-catalyzed Reactions (343 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O-Acetyl-(S)-Ser + pyruvate + NADH = N-[1-(R)-(Carboxy)ethyl]-(S)-O-acetyl-Ser + NAD+
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O3-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate
show the reaction diagram
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O3-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate
show the reaction diagram
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2 O3-acetyl-L-serine + 2 uracil = 3-(uracil-1-yl)-L-alanine + 3-(uracil-3-yl)-L-alanine + 2 acetate
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O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate
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O-acetylserine + H2O = serine + acetate
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O-acetyl-L-serine = ?
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O-acetyl-L-serine + H2O = acetate + pyruvate + NH3
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O-acetyl-L-serine + H2O = 2-oxopropanoate + NH3 + acetate
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O-acetyl-L-serine + H2O = acetate + pyruvate + NH3
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Product in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-cystathionine + acetate = O-acetyl-L-serine + L-homocysteine
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Inhibitor in Enzyme-catalyzed Reactions (46 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak
-
1 mM, more than 80% reemaining activity
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10 mM, 50% inhibition
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strong
-
-
-
-
-

3D Structure of Enzyme-Ligand-Complex (PDB) (23 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (63 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
2
-
30C, pH 8.0

KM Value (148 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
5.94
-
pyruvate and NADH as cosubstrates
0.047
-
-
2.5
-
-
6.25
-
-
2.5
-
-
20
-
enzyme A

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
21.8
-
-

References & Links

Links to other databases for O-acetyl-L-serine

ChEBI
PubChem
ChEBI
PubChem