EC Number   |
Protein Variants |
Reference |
|---|
    2.5.1.47 | A70S |
residue at the substrate binding pocket, important for the H2S-generating activity |
-, 749243 |
| 2.5.1.47 | A72S |
mutant produces more H2S than wild-type |
747747 |
| 2.5.1.47 | DELTAE115-K118 |
mutation disables the interaction of O-acetylserine (thiol) lyase with serine acetyltransferase |
-, 672428 |
| 2.5.1.47 | E220R |
not able to release H2S |
747747 |
| 2.5.1.47 | E223G |
residue at the substrate binding pocket, important for the H2S-generating activity |
-, 749243 |
| 2.5.1.47 | F143A |
mutant retains one molecule of pyridoxal 5'-phosphate per subunit, mutant reacts with O-acetylserine but the rate is significantly smaller, kcat/KM (O-acetylserine): 950/Msec |
704338 |
| 2.5.1.47 | F143D |
mutant retains one molecule of pyridoxal 5'-phosphate per subunit, mutant reacts with O-acetylserine but the rate is significantly smaller, kcat/KM (O-acetylserine): 150/Msec |
704338 |
| 2.5.1.47 | F143S |
mutant retains one molecule of pyridoxal 5'-phosphate per subunit, mutant reacts with O-acetylserine but the rate is significantly smaller, kcat/KM (O-acetylserine): 380/Msec |
704338 |
| 2.5.1.47 | F143Y |
mutant retains one molecule of pyridoxal 5'-phosphate per subunit, reaction with O-acetylserine is inhibited |
704338 |
| 2.5.1.47 | G162E |
naturally occuring mutation, the EMS-induced single nucleotide substitution in the cytosolic OASTL-A1 gene in the Ler-0 accession of Arabidopsis thaliana causes early senescence and death in plants, and is referred to as onset of leaf death3 (old3-1) |
739303 |
