Literature summary for 2.5.1.47 extracted from

Mori, M.; Tsuge, S.; Fukasawa, W.; Jeelani, G.; Nakada-Tsukui, K.; Nonaka, K.; Matsumoto, A.; Omura, S.; Nozaki, T.; Shiomi, K.
Discovery of antiamebic compounds that inhibit cysteine synthase from the enteric parasitic protist Entamoeba histolytica by screening of microbial secondary metabolites (2018), Front. Cell. Infect. Microbiol., 8, 409 .

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Application

Application	Comment	Organism
analysis	development of a primary cell-based phenotypic screening in both the presence and absence of L-cysteine and selection hits that show differential amebicidal effects between the two conditions	Entamoeba histolytica

Inhibitors

Inhibitors	Comment	Organism	Structure
deoxyfrenolicin	-	Entamoeba histolytica
pencolide	shows cysteine deprivation-dependent antiamebic activity,with 7.6 times lower IC50 in the absence of cysteine than that in the presence of cysteine; shows cysteine deprivation-dependent antiamebic activity,with 7.6 times lower IC50 in the absence of cysteine than that in the presence of cysteine	Entamoeba histolytica

Organism

Organism	UniProt	Comment	Textmining
Entamoeba histolytica	-	-	-
Entamoeba histolytica	Q401L7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
trophozoite	-	Entamoeba histolytica	-

Synonyms

Synonyms	Comment	Organism
CS1	-	Entamoeba histolytica
CS3	-	Entamoeba histolytica

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	IC50 value 24 microg/ml, pH not specified in the publication, temperature not specified in the publication	Entamoeba histolytica	deoxyfrenolicin
additional information	-	IC50 value 25 microg/ml, pH not specified in the publication, temperature not specified in the publication	Entamoeba histolytica	deoxyfrenolicin
0.217	-	pH not specified in the publication, temperature not specified in the publication	Entamoeba histolytica	pencolide
0.233	-	pH not specified in the publication, temperature not specified in the publication	Entamoeba histolytica	pencolide

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Release 2023.1 (January 2023)