EC Number   |
Application |
Reference |
|---|
    2.5.1.47 | agriculture |
dehydration stress enhances the activity of enzyme OASTL, as well as Cys content by 20.0% and 25.6%, respectively. The treatment of NaHS plus dehydration stress enhances OASTL activity and Cys content by 20.7% and 22.9%, respectively, compared with the stressed plants. The inclusion of H2S scavenger hypotaurine slows down the activity of OASTL by 27.9. A similar inhibitory effect of hypotaurine is also noticed on Cys content, which exhibits a 31.9% lower value than the stressed seedlings |
759362 |
| 2.5.1.47 | analysis |
development of a primary cell-based phenotypic screening in both the presence and absence of L-cysteine and selection hits that show differential amebicidal effects between the two conditions |
759226 |
| 2.5.1.47 | biotechnology |
transgenic plants expressing serine acetyltransferase and cysteine synthase can mitigate detrimental effects of cadmium toxicity, perhaps by efficiently producing and accumulating sulfuric compounds |
689449 |
| 2.5.1.47 | drug development |
cysteine biosynthetic pathway is absent in humans but essential in microbial pathogens, suggesting that it provides potential targets for the development of novel antibacterial compounds |
738828 |
| 2.5.1.47 | drug development |
cysteine synthase is a potential drug target for trichomoniasis |
737803 |
| 2.5.1.47 | drug development |
O-acetyl-L-serine sulfhydrylase is a promising target for inhibiting the growth of Entamoeba histolytica |
738892 |
| 2.5.1.47 | drug development |
since mammals lack OASS, the enzyme is a potential target for antimicrobial agents |
738249 |
| 2.5.1.47 | drug development |
the enzyme is a rational drug target against amebiasis |
738292 |
| 2.5.1.47 | environmental protection |
H2S is a major environmental pollutant, highly toxic to living organisms at high concentrations. Even at low concentrations, it causes an unpleasant odor from wetlands, especially from wastewater. Plants can utilize hydrogen sulfide as a sulfur source to synthesize cysteine. It is thus feasible to use aquatic plants, which possess high potential for sulfur assimilation, to remove hydrogen sulfide from the wetland. Transgenic rice plants over-expressing cysteine synthase exhibit 3fold elevated cysteine synthase activity, and incorporate more H2S into cysteine and glutathione than their wild type counterparts upon exposure to a high level of H2S. Overexpression of cysteine synthase in aquatic plants is a viable approach to remove H2S from polluted environments |
676400 |
| 2.5.1.47 | medicine |
humans lack cysteine synthase. Therefore, this parasite enzyme could be an exploitable drug target |
674625 |
