Ligand acetic acid

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Basic Ligand Information

Molecular Structure

C₂H₄O₂

acetic acid

QTBSBXVTEAMEQO-UHFFFAOYSA-N

Synonyms:

acetate, acetic acid', carboxymethyl-dethia-CoA, CH3CO2-, CH3COO-, CH3COOH

MetaCyc

(S)-lactate fermentation to propanoate, acetate and hydrogen, 1,2-propanediol biosynthesis from lactate (engineered), 11-oxyandrogens biosynthesis, 2,6-dinitrotoluene degradation, 2-nitrotoluene degradation

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Show all BRENDA pathways known for acetic acid

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (37 results)

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1.2.7.5

acetate + H+ + reduced ferredoxin = acetaldehyde + H2O + oxidized ferredoxin

737164, 740209, 740953

1.20.99.1

arsenate + acetate = arsenite + ?

287859

2.5.1.134

L-cystathionine + acetate = O-acetyl-L-serine + L-homocysteine

ATP + acetate = ADP + acetyl phosphate

642182, 761931, 642167, 642177, 642172, 642198, 642183, 642185, 761854, 642166, 760774, 642170, 642171, 642173, 642174, 642175, 642178, 642176, 642181, 642189, 642186, 642197, 642191, 642194, 642196, 487537, 642190, 642179, 690888, 762441, 691204, 693619, 739218, 727558, 738528, 737465, 738717, 738854, 738863, 739591, 761006, 760947, 642180, 642195, 642184, 727342, 727804

acetate + propanoyl-CoA = acetyl-CoA + propanoate

724088

2.8.3.14

5-hydroxypentanoyl-CoA + acetate = acetyl-CoA + 5-hydroxypentanoate

acetate + oxalyl-CoA = acetyl-CoA + oxalate

acetate = 2-oxoethanal + H2O

ATP + acetate + CoA = ADP + phosphate + acetyl-CoA

716267, 727557, 746438, 693061, 745215, 744414, 744911, 662774, 744820

6.2.1.22

ATP + acetate + citrate (pro-3S)-lyase = ?

693, 695

In Vivo Product in Enzyme-catalyzed Reactions (476 results)

(S)-lactate + O2 = acetate + CO2 + H2O

(S)-lactate + O2 = acetate + CO2 + H2O

390102, 440397, 440399, 440401, 440402, 440404, 440408, 440412, 440420, 440403, 440413, 0

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

1.2.1.4

3 entries

1.2.1.48

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

Gly + H2O + O2 = acetate + NH3 + H2O2

6kbp, 3D-view

2.1.1.152

S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate

0, 3209, 644278

2.3.1.16

acetyl-CoA + H2O = acetate + CoA

6pca, 3D-view

2.3.1.187

malonate + acetyl-[acyl-carrier protein] = acetate + malonyl-[acyl-carrier protein]

2.3.1.84

acetyl-CoA + alcohol = CoA + acetate

2.3.3.21

(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate

2.5.1.113

O-acetyl-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + acetate

5i7r, 3D-view

2.5.1.118

O3-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate

2.5.1.119

O3-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate

O3-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate

2.5.1.52

O3-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate

2.5.1.53

2 O3-acetyl-L-serine + 2 uracil = 3-(uracil-1-yl)-L-alanine + 3-(uracil-3-yl)-L-alanine + 2 acetate

2.5.1.65

O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate

2.6.99.3

O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate

2.7.1.61

D-glucose + acetyl phosphate = D-glucose 6-phosphate + acetate

2.7.2.1

ADP + acetyl phosphate = ATP + acetate

acetyl-CoA + citrate = acetate + (3S)-citryl-CoA

643831

2.8.3.11

acetyl-[acyl-carrier protein] + citramalate = citramalyl-[acyl-carrier protein] + acetate

acetyl-CoA + malonate = acetate + malonyl-CoA

3.1.1.1

8 entries

3.1.1.105

3-O-acetylpapaveroxine + H2O = narcotine hemiacetal + acetate

3.1.1.106

4 entries

3.1.1.113

ethyl acetate + H2O = acetate + ethanol

3.1.1.114

methyl acetate + H2O = methanol + acetate

3.1.1.2

4 entries

3.1.1.35

peracetic acid = acetic acid + H2O

5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate

4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate

0, 646028

3,4-diacetoxybutynylbithiophene + H2O = 3-hydroxy-4-acetoxybutynylbithiophene + acetate

acetylated rhamnogalacturonan I + H2O = acetate + deacetylated rhamnogalacturonan I

3.1.2.1

acetyl-CoA + H2O = CoA + acetate

0, 652385, 650340

3.1.2.16

[citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate

643850, 643852, 643851

Phosphonoacetate + H2O = acetate + phosphate

N4-acetylcytidine + H2O = cytidine + acetate

3.5.1.136

N,N'-diacetylchitobiose + H2O = beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + acetate

3.5.1.137

4-nitrophenyl acetate + H2O = 4-nitrophenol + acetate

N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate

N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate

3.5.1.48

2 entries

3.5.1.49

acetamide + H2O = acetate + NH3

3.5.1.51

4-acetamidobutanoyl-CoA + H2O = acetate + 4-aminobutanoyl-CoA

N-acetyl-D-glutamate + H2O = acetate + D-glutamate

N2-acetyl-L-citrulline + H2O = L-citrulline + acetate

3.5.5.1

acetonitrile + 2 H2O = acetic acid + NH3

3.6.1.7

acetylphosphate + H2O = acetate + phosphate

3.7.1.1

oxaloacetate + H2O = oxalate + acetate

210609, 210612, 0, 210614, 210610, 210608

3.7.1.24

2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate

3.7.1.25

(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate

3.7.1.6

acetylpyruvate + H2O = acetate + pyruvate

289294, 289295

3.8.1.2

iodoacetic acid + H2O = acetic acid + iodide + H+

1zrn, 3D-view

4.1.1.88

malonate + H+ = acetate + CO2

4.1.3.6

citrate = acetate + oxaloacetate

0, 441599, 492186, 653146, 649579

3r4i, 3D-view

4.2.1.130

glyoxal + H2O = acetate

4lru, 3D-view

4.2.99.24

salutaridinol 7-O-acetate = thebaine + acetate

4.4.1.9

2 entries

6.2.1.13

ADP + phosphate + acetyl-CoA = ATP + acetate + CoA

0, 649507, 651402, 651644

Substrate in Enzyme-catalyzed Reactions (148 results)

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1.1.1.270

24-methylenepollinastanone + NADPH + acetate = 24-methylenepollinastanol + NADP+

286474

1.1.1.34

(R,S)-mevaldehyde + acetate = ?

286578

1.1.99.36

acetate + N,N-dimethyl-4-nitrosoaniline = ? + 4-(hydroxylamino)-N,N-dimethylaniline

708364

1.11.1.13

NADH + acetate = NAD+ + ?

658297

1.2.1.3

acetate + NADH + H+ = acetaldehyde + NAD+ + H2O

arsenate + acetate = arsenite + ?

287859

1.97.1.9

selenate + acetate = selenite + H2O + CO2

644812

2.1.2.2

acetate + ATP = acetyl phosphate + ADP

485732, 485739

2.1.3.10

malonyl-CoA + acetate = acetyl-CoA + malonate

684745

2.3.3.21

acetate + pyruvate = citramalate

748351, 748589

2.4.1.7

sucrose + acetate = D-fructose + 1-O-acetyl-alpha-D-glucopyranose

685688

2.5.1.134

L-cystathionine + acetate = O-acetyl-L-serine + L-homocysteine

L-cystathionine + acetate = O-acetyl-L-homoserine + L-cysteine

ATP + acetate = ADP + acetyl phosphate

760452

2.7.2.2

ATP + NH3 + acetate = ADP + ?

642219, 642228

2we5, 3D-view

2.7.2.6

ATP + acetate = ADP + acetyl phosphate

642342

2.7.2.7

ATP + acetate = ADP + acetyl phosphate

756087, 642343, 642344, 761102

2.8.3.1

2 entries

2.8.3.12

glutaryl-CoA + acetate = glutarate + acetyl-CoA

94485, 645952, 645954, 645957

acetate + oxalyl-CoA = acetyl-CoA + oxalate

726342

2.8.3.27

acetate + succinyl-CoA = acetyl-CoA + succinate

2-chloro-5,5-dimethyl-1,3-cyclohexanedimedon + Br- + acetic acid + H2O2 = 2-chloro-2-bromo-5,5-dimethyl-1,3-cyclohexanedimedon + acetic acid + H2O

D-glucosamine 6-phosphate + acetate = N-acetyl-D-glucosamine 6-phosphate + H2O

acetate + oxaloacetate = citrate

33352, 33363

3r4i, 3D-view

4.2.1.130

acetate = 2-oxoethanal + H2O

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

648

6.2.1.17

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

657, 656, 655578, 692841, 745242, 660, 654636, 659, 655, 656716

6.2.1.22

10 entries

6.2.1.25

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

651721

6.2.1.3

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

728248

6.2.1.30

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

648914

6.2.1.35

acyl-carrier protein + acetate + ATP = acetyl-acyl carrier protein + AMP + diphosphate

685053

6.2.1.36

acetate + ATP + coenzyme A = acetyl-CoA + AMP + diphosphate

692841

6.2.1.40

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

727751

6.2.1.44

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

ATP + acetate + N1-(5-phospho-beta-D-ribosyl)glycinamide = ?

760556

Product in Enzyme-catalyzed Reactions (3999 results)

(S)-lactate + O2 = acetate + CO2 + H2O

1tb3, 3D-view

1.1.99.20

acetaldehyde + acceptor + H2O = acetic acid + reduced acceptor

(2R)-hydroxypropylphosphonate + O2 = 2-oxopropylphosphonate + hydroxymethylphosphonate + acetate

4yar, 3D-view

1.13.11.89

(R)-1-hydroxyethylphosphonic acid + O2 = acetate + phosphate

1.13.12.4

2 entries

1.14.13.54

17alpha-Hydroxyprogesterone + NADPH + O2 = androstenedione + acetate + NADP+ + H2O

0, 7389

acetaldehyde + H2O + O2 = acetic acid + H2O2

393008, 644655

2ckj, 3D-view

1.2.1.10

acetaldehyde + NAD+ = acetate + NADH + H+

1.2.1.12

p-nitrophenyl acetate + H2O = p-nitrophenol + acetate

4wnc, 3D-view

1.2.1.18

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

1.2.1.19

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

288081, 288082

1.2.1.21

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

acetaldehyde + NAD(P)+ + H2O = acetate + NAD(P)H + H+

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

1.2.1.32

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

1.2.1.36

2 entries

1.2.1.39

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

1.2.1.4

4 entries

1.2.1.41

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

1.2.1.46

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

1.2.1.47

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

0, 288255, 288254

1.2.1.48

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

390324, 0

1.2.1.5

44 entries

1.2.1.65

acetaldehyde + NAD+ + H2O = acetate + NADH + 2 H+

1.2.1.69

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

1.2.1.88

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

1.2.1.99

acetaldehyde + NAD+ + H2O = acetate + NADH + H+

acetaldehyde + H2O + O2 = acetate + H2O2

1.2.3.3

2 entries

1.2.3.7

acetaldehyde + O2 + H2O = acetate + H2O2

acetaldehyde + H2O = acetate + ethanol

acetaldehyde + 2,6-dichlorophenolindophenol + H2O = acetate + reduced 2,6-dichlorophenolindophenol

1.3.98.5

harderoheme IV + peracetic acid = ? + CO2 + 2 acetate

1.4.3.3

Gly + H2O + O2 = acetate + NH3 + H2O2

6kbp, 3D-view

1.97.1.9

selenate + lactate = selenite + H2O + acetate + HCO3-

644812, 0

2.1.1.152

2 entries

2.1.3.10

acetyl-CoA + malonate = malonyl-CoA + acetate

2.3.1.16

acetyl-CoA + H2O = acetate + CoA

6pca, 3D-view

2.3.1.187

malonate + acetyl-[acyl-carrier protein] = acetate + malonyl-[acyl-carrier protein]

2.3.1.35

3 entries

2.3.1.43

1-O-alkyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O = 1-O-alkyl-2-lyso-sn-glycerol-3-phosphocholine + acetate

487010, 487009

2.3.1.84

acetyl-CoA + alcohol = CoA + acetate

2.3.3.10

acetyl-CoA + H2O = acetate + CoA

488098, 0

2.3.3.13

acetyl-CoA + H2O = acetate + CoA

2.3.3.21

(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate

2.5.1.113

O-acetyl-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + acetate

5i7r, 3D-view

2.5.1.118

O3-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate

2.5.1.119

O3-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate

2 O3-acetyl-L-serine + 2 uracil = 3-(uracil-1-yl)-L-alanine + 3-(uracil-3-yl)-L-alanine + 2 acetate

638056, 638057, 0

2.5.1.65

2 entries

2.6.99.3

O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate

2.7.1.136

2 entries

2.7.1.146

acetyl-phosphate + D-fructose 6-phosphate = acetate + D-fructose 1,6-bisphosphate

2.7.1.157

acetyl-phosphate + N-acetyl-alpha-D-galactosamine = acetate + N-acetyl-alpha-D-galactosamine 1-phosphate

2.7.1.61

3 entries

2.7.1.77

acetylphosphate + inosine = acetate + IMP

2.7.2.1

ADP + acetyl phosphate = ATP + acetate

1tuy, 3D-view