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Literature summary for 2.5.1.47 extracted from

  • Lithgow, J.K.; Hayhurst, E.J.; Cohen, G.; Aharonowitz, Y.; Foster, S.J.
    Role of a cysteine synthase in Staphylococcus aureus (2004), J. Bacteriol., 186, 1579-1590.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.47

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockout mutant, grows poorly in cysteine-limiting conditions and produces significantly less cysteine than wild-type. Mutant shows increased sensitivity to tellurite, hydrogen peroxide, acid, and diamide. Mutant cells have a significantly reduced ability to recover from starvation in amino acid- or phosphate-limiting conditions Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O-acetyl-L-Ser + sodium thiosulfate Staphylococcus aureus
-
 ?
-
 ?
O-acetyl-L-Ser + sodium thiosulfate Staphylococcus aureus SH1000
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus SH1000
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-acetyl-L-Ser + sodium thiosulfate
-
 Staphylococcus aureus ?
-
 ?
O-acetyl-L-Ser + sodium thiosulfate
-
 Staphylococcus aureus SH1000 ?
-
 ?

Synonyms

Synonyms Comment Organism
CysM
-
 Staphylococcus aureus

General Information

General Information Comment Organism
malfunction mutation of cysM causes increased sensitivity of Staphylococcus (S.) aureus to tellurite (15fold), hydrogen peroxide (45fold), acid (30fold after 4h at pH 2.0), and diamide (but not methyl viologen) and also significantly reduces the ability to recover from starvation in amino acid- or phosphate-limiting conditions. A cysM knockout mutant grows poorly in cysteine-limiting conditions Staphylococcus aureus