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Synonyms
cbs, cystathionine beta-synthase, cystathionine-beta-synthase, cnnm2, cystathionine beta synthase, serine sulfhydrylase, ytcbs, serine sulfhydrase, cdcp2, cbs424,
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L-serine + L-homocysteine = L-cystathionine + H2O
L-serine + L-homocysteine = L-cystathionine + H2O
mechanism
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L-serine + L-homocysteine = L-cystathionine + H2O
mechanism
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L-serine + L-homocysteine = L-cystathionine + H2O
ping-pong mechanism
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L-serine + L-homocysteine = L-cystathionine + H2O
ping-pong mechanism
L-serine + L-homocysteine = L-cystathionine + H2O
sequential bisubstrate mechanism in which no product release occurs until both substrates are bound to the enzyme to form a ternary complex
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L-serine + L-homocysteine = L-cystathionine + H2O
sequential bisubstrate mechanism in which no product release occurs until both substrates are bound to the enzyme to form a ternary complex
Steinernema bibionis
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L-serine + L-homocysteine = L-cystathionine + H2O
carbanion and aminacrylate intermediates in the CBS-catalyzed reaction, arrangement of the protein residues and pyridoxal 5'-phosphate cofactor in the active site pocket, and reaction mechanism, overview
L-serine + L-homocysteine = L-cystathionine + H2O
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2 L-cysteine
(2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) + H2S
beta-Chloro-DL-alanine + DL-homocysteine
?
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-
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?
beta-Cyano-DL-alanine + DL-homocysteine
?
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-
-
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?
DL-Serine-O-sulfate + DL-homocysteine
?
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-
-
-
?
L-allothreonine + homocysteine
? + H2O
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-
-
?
L-cysteine
H2S + L-serine
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-
-
?
L-Cysteine + 1-butanethiol
?
L-Cysteine + 1-mercapto-2-propanol
HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + H2S
L-Cysteine + 1-pentanethiol
?
L-Cysteine + 2-mercaptoethanol
HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
L-cysteine + 2-mercaptoethanol
S-hydroxyethyl-L-cysteine + H2S
L-Cysteine + cysteamine
?
L-Cysteine + dithioerythritol
?
L-Cysteine + dithiothreitol
?
L-Cysteine + DL-homocysteine
Cystathionine + H2S
L-cysteine + H2O
L-serine + H2S
A0A1J9VES8
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-
-
?
L-cysteine + L-homocysteine
L-cystathionine + H2S
L-cysteine + L-serine
lanthionine + H2O
-
-
-
?
L-Cysteine + monothioglycerol
?
L-serine + cysteamine
L-thialysine
-
-
-
-
?
L-serine + H2O
NH3 + pyruvate
-
wild-type enzyme shows no beta-elimination reaction, beta elimination is only detectable in the following mutants: T81A, S82A, T85A, Q157A, Q157E, Q157H, Y158F
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?
L-serine + H2S
L-cysteine
-
-
-
?
L-Serine + homocysteine
?
L-Serine + homocysteine
Cystathionine + H2O
L-Serine + HS-
Cysteine + OH-
L-serine + L-cysteine
?
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-
-
-
?
L-serine + L-homocysteine
?
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-
-
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r
L-serine + L-homocysteine
cystathionine + H2O
L-serine + L-homocysteine
L-cystathionine + H2O
O-acetyl-L-serine
L-cysteine + acetate
O-acetyl-L-serine + H2O
pyruvate + acetate + NH3
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
A0A1J9VES8
-
-
-
?
O-acetyl-L-serine + L-homocysteine
?
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poor substrate for both the wild type and the N- and C-terminally truncated enzyme 71â400 CBS
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?
O-acetyl-L-serine + L-homocysteine
cystathionine + acetate
S-Methyl-L-cysteine + DL-homocysteine
?
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?
additional information
?
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2 L-cysteine
(2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) + H2S
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-
?
2 L-cysteine
(2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) + H2S
-
-
-
?
cysteine + ?
H2S + ?
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?
cysteine + ?
H2S + ?
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-
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?
L-Cysteine + 1-butanethiol
?
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-
-
-
?
L-Cysteine + 1-butanethiol
?
-
-
-
-
?
L-Cysteine + 1-mercapto-2-propanol
HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + H2S
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-
-
-
?
L-Cysteine + 1-mercapto-2-propanol
HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + H2S
-
-
-
-
?
L-Cysteine + 1-mercapto-2-propanol
HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + H2S
-
-
-
-
?
L-Cysteine + 1-mercapto-2-propanol
HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + H2S
-
activated L-serine sulfhydrase
-
?
L-Cysteine + 1-pentanethiol
?
-
-
-
-
?
L-Cysteine + 1-pentanethiol
?
-
-
-
-
?
L-Cysteine + 2-mercaptoethanol
HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
-
-
-
-
?
L-Cysteine + 2-mercaptoethanol
HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
-
-
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?
L-Cysteine + 2-mercaptoethanol
HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
-
-
-
-
?
L-Cysteine + 2-mercaptoethanol
HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
-
-
-
?
L-Cysteine + 2-mercaptoethanol
HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
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-
-
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?
L-Cysteine + 2-mercaptoethanol
HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
Steinernema bibionis
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?
L-Cysteine + 2-mercaptoethanol
HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
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?
L-cysteine + 2-mercaptoethanol
S-hydroxyethyl-L-cysteine + H2S
-
-
-
-
?
L-cysteine + 2-mercaptoethanol
S-hydroxyethyl-L-cysteine + H2S
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-
?
L-Cysteine + cysteamine
?
-
-
-
-
?
L-Cysteine + cysteamine
?
-
-
-
-
?
L-Cysteine + dithioerythritol
?
-
-
-
-
?
L-Cysteine + dithioerythritol
?
-
-
-
-
?
L-Cysteine + dithiothreitol
?
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-
-
-
?
L-Cysteine + dithiothreitol
?
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-
-
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?
L-Cysteine + DL-homocysteine
Cystathionine + H2S
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-
-
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?
L-Cysteine + DL-homocysteine
Cystathionine + H2S
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full-length enzyme and truncated enzyme form lacking the C-terminal regulatory domain
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?
L-Cysteine + DL-homocysteine
Cystathionine + H2S
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-
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?
L-Cysteine + DL-homocysteine
Cystathionine + H2S
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-
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?
L-Cysteine + DL-homocysteine
Cystathionine + H2S
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-
-
?
L-Cysteine + DL-homocysteine
Cystathionine + H2S
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-
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?
L-Cysteine + DL-homocysteine
Cystathionine + H2S
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-
-
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?
L-cysteine + L-homocysteine
L-cystathionine + H2S
A0A1J9VES8
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-
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?
L-cysteine + L-homocysteine
L-cystathionine + H2S
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-
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r
L-cysteine + L-homocysteine
L-cystathionine + H2S
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-
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?
L-cysteine + L-homocysteine
L-cystathionine + H2S
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-
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?
L-cysteine + L-homocysteine
L-cystathionine + H2S
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-
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?
L-cysteine + L-homocysteine
L-cystathionine + H2S
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-
-
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r
L-Cysteine + monothioglycerol
?
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-
-
-
?
L-Cysteine + monothioglycerol
?
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-
-
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?
L-Cysteine + monothioglycerol
?
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-
-
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?
L-Serine + homocysteine
?
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-
-
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?
L-Serine + homocysteine
?
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-
-
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?
L-Serine + homocysteine
?
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synthesis of cystathionine
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?
L-Serine + homocysteine
?
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?
L-Serine + homocysteine
?
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?
L-Serine + homocysteine
?
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irreversible step in transsulfuration pathway
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?
L-Serine + homocysteine
?
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reduced activity of EC 4.2.1.22 in patients with homocystinuria due to mutations in the CBS gene
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?
L-Serine + homocysteine
?
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?
L-Serine + homocysteine
?
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?
L-Serine + homocysteine
?
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?
L-Serine + homocysteine
?
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initial step in transsulfuration forming cysteine. Homocysteine is a relatively toxic amino acid, which levels have to be kept low
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?
L-Serine + homocysteine
?
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synthesis of cystathionine
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?
L-Serine + homocysteine
?
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?
L-Serine + homocysteine
?
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reverse trans-sulfuration pathway
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?
L-Serine + homocysteine
?
Steinernema bibionis
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-
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?
L-Serine + homocysteine
?
-
-
-
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?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
ir
-
?
L-Serine + homocysteine
Cystathionine + H2O
beta-replacement reaction
-
?
L-Serine + homocysteine
Cystathionine + H2O
catalyzes a beta-replacement reaction in which an electronegative substituent in the beta-position of the amino acid substrate is replaced by a nucleophile, binding of L-serine as the external aldimine is faster than formation of the aminoacrylate intermediate, the rate-limiting step is the reaction of aminoacrylate with L-homocysteine to form L-cystathione, rate of the forward reaction is 38fold greater than the reverse reaction
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
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?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
-
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r
L-Serine + homocysteine
Cystathionine + H2O
-
hydroxylgroup of serine is replaced by the thiol of homocysteine
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r
L-Serine + homocysteine
Cystathionine + H2O
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in the forward direction an external aldimine of serine and an aminoacrylate intermediate are formed, the aminoacrylate binds to homocysteine and converts to cystathione, in the reverse reaction cystathione binds to the enzyme and is rapidly converted to the aminoacrylate without accumulation of the external aldimine
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r
L-Serine + homocysteine
Cystathionine + H2O
Steinernema bibionis
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-
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?
L-Serine + homocysteine
Cystathionine + H2O
Steinernema bibionis
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?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
?
L-Serine + homocysteine
Cystathionine + H2O
-
-
-
r
L-Serine + HS-
Cysteine + OH-
4.2.1.22 cystathionine beta-synthase
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