Ligand L-cystathionine

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Basic Ligand Information

Molecular Structure
Picture of L-cystathionine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H14N2O4S
L-cystathionine
ILRYLPWNYFXEMH-WHFBIAKZSA-N
Synonyms:
(-)cystathionine, cystathionine, L-allo-cystathionine, L-allocystathionine, S-[(2R)-2-amino-2-carboxyethyl]-L-homocysteine


Show all pahtways known for Show all BRENDA pathways known for L-cystathionine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-cystathionine + acetate = O-acetyl-L-serine + L-homocysteine
show the reaction diagram
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cystathionine + H2O = homocysteine + pyruvate + NH3
show the reaction diagram
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L-cystathionine + H2O = L-homocysteine + pyruvate + NH3
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (36 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-cystathionine + acetate = O-acetyl-L-serine + L-homocysteine
show the reaction diagram
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L-cystathionine + phenylpyruvate = S-(2-oxo-2-carboxyethyl)homocysteine + L-phenylalanine
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cystathionine + H2O = homocysteine + pyruvate + NH3
show the reaction diagram
-
L-cystathionine + H2O = ?
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(-)cystathionine = ?
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L-cystathionine + H2O = L-homocysteine + pyruvate + NH3
show the reaction diagram
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L-2-aminoadipate + L-cystathionine + L-valine + ATP = N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
20% activation at 5 mM
-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive, gamma-elimination
-
substrate inhibition at concentrations above 6 mM
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (76 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
310
-
pH 8.5, 37C, recombinant enzyme
11
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pH 8.3, 30C

KM Value (101 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3
-
pH 7.5, 30C
1.9
-
pH 9.0, 37C
0.05
-
pH 8.5, 37C, recombinant enzyme
0.27
-
-
4
-
pH 8.3, 30C
3.9
-
-

References & Links

Links to other databases for L-cystathionine

ChEBI
PubChem
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PubChem