Literature summary for 4.2.1.22 extracted from

Romero, I.; Tellez, J.; Romanha, A.J.; Steindel, M.; Grisard, E.C.
Upregulation of cysteine synthase and cystathionine beta-synthase contributes to Leishmania braziliensis survival under oxidative stress (2015), Antimicrob. Agents Chemother., 59, 4770-4781 .

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Organism

Organism	UniProt	Comment	Textmining
Leishmania braziliensis	A4H8W8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
amastigote	intracellular amastigote	Leishmania braziliensis	-
promastigote	enzyme is 1.5- to 1.7-times more abundant in the extracts from promastigotes than in those from amastigotes	Leishmania braziliensis	-

Synonyms

Synonyms	Comment	Organism
CysB	-	Leishmania braziliensis
LbrM.17.0230	locus name	Leishmania braziliensis

Expression

Organism	Comment	Expression
Leishmania braziliensis	stage-specific increase in the levels of protein expression and activity under in vitro stress conditions induced by hydrogen peroxide, S-nitroso-N-acetylpenicillamine, or antimonial compounds	up

General Information

General Information	Comment	Organism
physiological function	Leishmania braziliensis promastigotes and amastigotes overexpressing cysteine synthase and cystathionine beta-synthase show enhanced ability to resist oxidative stress compared to that of nontransfected cells, resulting in a phenotype far more resistant to treatment with the pentavalent form of antimony in vitro	Leishmania braziliensis

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Release 2023.1 (January 2023)