Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Serine + homocysteine | Homo sapiens | irreversible step in transsulfuration pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | trypsinolyis occurs initially at Lys30, Lys36, Lys39, then at Arg413 and transforms the tetrameric enzyme to a dimer of MW 85000 which is twice as active as the tetramer | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Serine + homocysteine | - |
Homo sapiens | Cystathionine + H2O | - |
? | |
L-Serine + homocysteine | irreversible step in transsulfuration pathway | Homo sapiens | ? | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
dissociation of tetrameric enzyme to dimeric form, initiated by proteolysis decreases thermostability | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens |