Crystallization (Comment) | Organism |
---|---|
to 2.4 A resolution | Lactiplantibacillus plantarum |
Protein Variants | Comment | Organism |
---|---|---|
A70S | residue at the substrate binding pocket, important for the H2S-generating activity | Lactiplantibacillus plantarum |
E223G | residue at the substrate binding pocket, important for the H2S-generating activity | Lactiplantibacillus plantarum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.4 | - |
L-homocysteine | formation of L-cystathionine, mutant E223G, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
0.54 | - |
L-homocysteine | formation of L-cystathionine, wild-type, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
3 | - |
L-cysteine | formation of L-cystathionine, mutant A70S, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
5.9 | - |
L-cysteine | formation of L-cystathionine, wild-type, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
8.9 | - |
L-cysteine | formation of (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid), wild-type, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
20 | - |
L-homocysteine | formation of L-cystathionine, mutant A70S, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
37 | - |
L-cysteine | formation of (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid), mutant E223G, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
37 | - |
L-cysteine | formation of L-cystathionine, mutant E223G, pH 7.5, 37°C | Lactiplantibacillus plantarum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Lactiplantibacillus plantarum | F9UT54 | bifunctional cystathionine beta-synthase EC 4.2.1.22 and O-acetyl-L-serine sulfhydrylase, EC 2.5.1.47 | - |
Lactiplantibacillus plantarum ATCC BAA-793 | F9UT54 | bifunctional cystathionine beta-synthase EC 4.2.1.22 and O-acetyl-L-serine sulfhydrylase, EC 2.5.1.47 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-cysteine | - |
Lactiplantibacillus plantarum | (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) + H2S | - |
? | |
2 L-cysteine | - |
Lactiplantibacillus plantarum ATCC BAA-793 | (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) + H2S | - |
? | |
L-cysteine + L-homocysteine | - |
Lactiplantibacillus plantarum | L-cystathionine + H2S | - |
? | |
L-cysteine + L-homocysteine | - |
Lactiplantibacillus plantarum ATCC BAA-793 | L-cystathionine + H2S | - |
? | |
O-acetyl-L-serine | - |
Lactiplantibacillus plantarum | L-cysteine + acetate | - |
? | |
O-acetyl-L-serine | - |
Lactiplantibacillus plantarum ATCC BAA-793 | L-cysteine + acetate | - |
? | |
O-acetyl-L-serine + H2O | - |
Lactiplantibacillus plantarum | pyruvate + acetate + NH3 | - |
? | |
O-acetyl-L-serine + H2O | - |
Lactiplantibacillus plantarum ATCC BAA-793 | pyruvate + acetate + NH3 | - |
? | |
O-acetyl-L-serine + L-homocysteine | - |
Lactiplantibacillus plantarum | cystathionine + acetate | - |
? | |
O-acetyl-L-serine + L-homocysteine | - |
Lactiplantibacillus plantarum ATCC BAA-793 | cystathionine + acetate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.022 | - |
L-cysteine | formation of (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid), mutant E223G, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
0.6 | - |
L-cysteine | formation of L-cystathionine, mutant E223G, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
1.1 | - |
L-cysteine | formation of (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid), wild-type, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
2 | - |
L-cysteine | formation of L-cystathionine, mutant A70S, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
7.6 | - |
L-cysteine | formation of L-cystathionine, wild-type, pH 7.5, 37°C | Lactiplantibacillus plantarum |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0006 | - |
L-cysteine | formation of (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid), mutant E223G, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
0.12 | - |
L-cysteine | formation of (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid), wild-type, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
0.15 | - |
L-homocysteine | formation of L-cystathionine, mutant A70S, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
0.83 | - |
L-homocysteine | formation of L-cystathionine, mutant E223G, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
1.3 | - |
L-cysteine | formation of L-cystathionine, wild-type, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
1.5 | - |
L-cysteine | formation of L-cystathionine, mutant A70S, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
8.9 | - |
L-cysteine | formation of L-cystathionine, mutant E223G, pH 7.5, 37°C | Lactiplantibacillus plantarum | |
14 | - |
L-homocysteine | formation of L-cystathionine, wild-type, pH 7.5, 37°C | Lactiplantibacillus plantarum |