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Literature summary for 4.2.1.22 extracted from

  • Chen, X.; Jhee, K.H.; Kruger, W.D.
    Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine (2004), J. Biol. Chem., 279, 52082-52086.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in yeast or in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.74
-
L-serine pH 8.6 Homo sapiens
6.11
-
L-cysteine pH 8.6 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Cysteine + DL-homocysteine full-length enzyme and truncated enzyme form lacking the C-terminal regulatory domain Homo sapiens Cystathionine + H2S
-
?
L-Serine + homocysteine
-
Homo sapiens Cystathionine + H2O
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.13
-
L-cysteine pH 8.6 Homo sapiens
4.39
-
L-cysteine pH 8.6 Homo sapiens
10.2
-
L-serine pH 8.6 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine stimulates Homo sapiens