Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.22 extracted from

  • Puranik, M.; Weeks, C.L.; Lahaye, D.; Kabil, O.; Taoka, S.; Nielsen, S.B.; Groves, J.T.; Banerjee, R.; Spiro, T.G.
    Dynamics of carbon monoxide binding to cystathionine beta-synthase (2006), J. Biol. Chem., 281, 13433-13438.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.22

Inhibitors

Inhibitors Comment Organism Structure
CO can bind to the cofactor heme, resulting in enzyme inhibition. CBS exhibits strong anticooperativity in CO binding Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P35520
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + L-homocysteine
-
 Homo sapiens cystathionine + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
heme carbon monoxide or nitric oxide can bind to the cofactor, resulting in enzyme inhibition Homo sapiens