Any feedback?
Literature summary for 4.2.1.22 extracted from
- Biosynthesis and proteolytic activation of cystathionine beta-synthase in rat liver (1984), J. Biol. Chem., 25, 588-593.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.8 | - |
homocysteine | enzyme composed of MW 48000 subunits | Rattus norvegicus |  |
| 4 | - |
L-Ser | - |
Rattus norvegicus | |
| 25 | - |
homocysteine | enzyme composed of MW 68000 subunits | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 48000 | - |
2 * 48000, proteolytically activated enzyme, derived from 4 * 68000 enzyme, SDS-PAGE | Rattus norvegicus |
| 68000 | - |
2 * 48000, proteolytically activated enzyme, derived from 4 * 68000 enzyme, SDS-PAGE | Rattus norvegicus |
| 68000 | - |
4 * 68000, enzyme from fresh liver extract, SDS-PAGE | Rattus norvegicus |
| 100000 | - |
aged enzyme extract, gel filtration | Rattus norvegicus |
| 250000 | - |
fresh enzyme extract, gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Serine + homocysteine | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | the tetrameric enzyme, MW 4 * 68000, is processed to a dimeric (2 * 48000) enzyme by proteolysis, 60fold increase of activity | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Serine + homocysteine | - |
Rattus norvegicus | Cystathionine + H2O | - |
? | |
| L-Serine + homocysteine | - |
Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 48000, proteolytically activated enzyme, derived from 4 * 68000 enzyme, SDS-PAGE | Rattus norvegicus |
| tetramer | 4 * 68000, enzyme from fresh liver extract, SDS-PAGE | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | requirement | Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
