Literature summary for 4.2.1.22 extracted from

Sen, S.; Kawahara, B.; Gupta, D.; Tsai, R.; Khachatryan, M.; Roy-Chowdhuri, S.; Bose, S.; Yoon, A.; Faull, K.; Farias-Eisner, R.; Chaudhuri, G.
Role of cystathionine beta-synthase in human breast cancer (2015), Free Radic. Biol. Med., 86, 228-238 .

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Application

Application	Comment	Organism
medicine	breast cancer patient-derived tissues and breast cancer cells exhibit significantly increased levels of CBS when compared with their normal counterparts, associated with increased levels of H2S and cystathionine. Silencing of CBS in breast cancer cells causes a significant decrease in the levels of H2S and cystathionine but does not affect the growth of these cells per se, in in vitro cultures. CBS-silenced cells exhibit significantly reduced growth in the presence of activated macrophages and in xenograft models, associated with an increase in the steady state levels of reactive aldehyde-derived protein adducts	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hs-578T cell	-	Homo sapiens	-
MCF-10A cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-468 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)