Literature summary for 4.2.1.22 extracted from

Majtan, T.; Pey, A.L.; Kraus, J.P.
Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine Potential approach to pharmacological chaperone therapy for homocystinuria (2016), Biochimie, 126, 6-13 .

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P35520	-	-

General Information	Comment	Organism
metabolism	binding of S-adenosylhomocysteine and sinefungin lead to stabilization of the regulatory domains without activation of CBS. Binding of these two ligands also affects the enzyme proteolysis	Homo sapiens

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Release 2023.1 (January 2023)