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Ligand L-homocysteine

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

cysteine metabolism, methionine metabolism

KEGG

Antifolate resistance, Biosynthesis of amino acids, Biosynthesis of secondary metabolites, Cysteine and methionine metabolism, NOD-like receptor signaling pathway, Sulfur metabolism more

MetaCyc

autoinducer AI-2 biosynthesis I, autoinducer AI-2 biosynthesis II (Vibrio), folate transformations I, folate transformations II, glycine betaine degradation I, glycine betaine degradation II (mammalian), homocysteine and cysteine interconversion, hydrogen sulfide biosynthesis II (mammalian), L-cysteine biosynthesis III (from L-homocysteine), L-cysteine biosynthesis VI (from L-methionine), L-homocysteine biosynthesis, L-methionine biosynthesis I, L-methionine biosynthesis II (plants), L-methionine biosynthesis III, L-methionine biosynthesis IV (archaea), L-methionine degradation I (to L-homocysteine), L-methionine salvage from L-homocysteine, lyngbyatoxin biosynthesis, N10-formyl-tetrahydrofolate biosynthesis, S-adenosyl-L-methionine cycle I, S-adenosyl-L-methionine cycle II, S-methyl-L-methionine cycle more

Show all BRENDA pathways known for L-homocysteine

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (23 results)

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Show Natural Substrate (23 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.10

S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine

441383, 441384, 441385, 441386, 441388, 441389, 485143, 441382, 441387

5dmm, 3D-view

2.1.1.10

S-methyl-L-methionine + L-homocysteine = 2 L-methionine

692948, 694665, 441387

5dmm, 3D-view

2.1.1.10

S-methyl-L-methionine + L-homocysteine = L-methionine

692820

5dmm, 3D-view

2.1.1.13

N5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

657836

1q8a, 3D-view

2.1.1.13

N5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

657836

1q8j, 3D-view

2.1.1.13

N5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

657836

3bof, 3D-view

2.1.1.13

N5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

657836

3bol, 3D-view

2.1.1.13

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

437712, 441173, 660282, 658413

1q8a, 3D-view

2.1.1.13

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

437712, 441173, 660282, 658413

1q8j, 3D-view

2.1.1.13

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

437712, 441173, 660282, 658413

3bof, 3D-view

2.1.1.13

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

437712, 441173, 660282, 658413

3bol, 3D-view

2.1.1.10

3 entries

2.1.1.13

8 entries

2.1.1.3

dimethylthetin + L-homocysteine = S-methylthioglycolate + L-methionine

485244

-

2.1.1.5

N,N,N-trimethylglycine + L-homocysteine = N,N-dimethylglycine + L-methionine

441244, 441233

4m3p, 3D-view

2.1.1.5

L-homocysteine + betaine = L-methionine + dimethylglycine

658186, 658928

4m3p, 3D-view

3.3.1.1

L-homocysteine + adenosine = S-adenosyl-L-homocysteine + H2O

731159

-

3.3.1.1

L-homocysteine + adenosine + H2O = S-adenosyl-L-homocysteine

732154

-

4.2.1.22

L-Serine + homocysteine = ?

5584, 5586, 5587, 5588, 5591, 5592, 5600, 5601, 5602, 5585, 5589, 5595, 5598, 5596, 5593, 5603, 5597, 5590, 5594, 5599, 5604, 5605

-

4.2.1.22

L-serine + L-homocysteine = cystathionine + H2O

682533, 682810

-

4.2.1.22

L-serine + L-homocysteine = L-cystathionine + H2O

714912, 730477, 714179, 715808, 715809, 728933, 728945, 730143, 730146, 730755, 714248, 716763, 714071, 715150, 729799

-

4.4.1.11

L-homocysteine = 2-oxobutanoate + NH3 + hydrogen sulfide

728952

3vk4, 3D-view

4.4.1.11

L-homocysteine = 2-oxobutanoate + NH3 + hydrogen sulfide

728952

5x30, 3D-view

2.1.1.5

2 entries

3.3.1.1

2 entries

4.2.1.22

3 entries

4.4.1.11

2 entries

4.4.1.2

L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate

722937

-

6.1.1.10

ATP + L-homocysteine + tRNAMet = ?

652862

-

In Vivo Product in Enzyme-catalyzed Reactions (19 results)

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Show Natural Product (19 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.8.4.1

GSH + homocystine = GSSG + homocysteine

395020

-

2.1.1.1

L-methionine + nicotinamide = L-homocysteine + 1-methylnicotinamide

-

-

2.5.1.134

L-cystathionine + acetate = O-acetyl-L-serine + L-homocysteine

-

-

2.5.1.49

O-acetyl-L-homoserine + H2S = L-homocysteine + acetic acid

-

-

2.5.1.49

O-acetyl-L-homoserine + S2- = L-homocysteine + acetic acid

-

-

2.5.1.49

o-acetyl-L-homoserine + H2S = L-homocysteine + acetate

-

-

3.3.1.1

S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine

137135, 137127, 137136, 137125, 137128, 137130, 137140, 137150, 137139, 137119, 137124, 137149, 137131, 137132, 137138, 137148, 137137, 137120, 137121, 137123, 137133, 137143, 137144, 137145, 137147, 137126, 137122, 137134, 137141, 137129, 137146

-

3.3.1.1

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

-

-

2.5.1.49

3 entries

3.3.1.1

2 entries

3.4.22.40

L-homocysteine-thiolactone + H2O = L-homocysteine

-

-

4.4.1.1

L-cystathionine + H2O = L-homocysteine + pyruvate + NH3

-

-

4.4.1.13

L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate

-

-

4.4.1.13

L-cystathionine + H2O = L-homocysteine + pyruvate + NH3

-

-

4.4.1.21

S-ribosylhomocysteine = homocysteine + 4,5-dihydroxy-2,3-pentanedione

-

1jqw, 3D-view

4.4.1.21

S-ribosylhomocysteine = homocysteine + 4,5-dihydroxy-2,3-pentanedione

-

1jvi, 3D-view

4.4.1.21

S-ribosylhomocysteine = L-homocysteine + 4,5-dihydroxy-2,3-pentanedione

-

1jqw, 3D-view

4.4.1.21

S-ribosylhomocysteine = L-homocysteine + 4,5-dihydroxy-2,3-pentanedione

-

1jvi, 3D-view

4.4.1.21

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione

-

1jqw, 3D-view

4.4.1.21

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione

-

1jvi, 3D-view

4.4.1.13

2 entries

4.4.1.21

6 entries

4.4.1.8

L-cystathionine + H2O = L-homocysteine + pyruvate + NH3

-

-

Substrate in Enzyme-catalyzed Reactions (171 results)

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Show Substrate (171 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.3.2

L-homocysteine + H2O + O2 = 4-thio-2-ketobutyric acid + NH3 + H2O2

391775, 391812

-

1.8.5.4

sulfide + homocysteine + coenzyme Q1 = homocysteine persulfide + reduced coenzyme Q1

738630

-

1.8.5.8

hydrogen sulfide + homocysteine + coenzyme Q1 = ?

745313

-

2.1.1.10

S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine

441383, 441382, 441384, 441385, 441386, 441388, 441389, 485143, 692948, 441387, 693336, 694665

5dmm, 3D-view

2.1.1.10

S-adenosyl-D-methionine + L-homocysteine = ?

441383, 441386

5dmm, 3D-view

2.1.1.10

S-methyl-L-methionine + L-homocysteine = ?

441383, 441384, 687808

5dmm, 3D-view

2.1.1.10

S-adenosyl-L-ethionine + L-homocysteine = S-adenosyl-L-homocysteine + L-ethionine

441385

5dmm, 3D-view

2.1.1.10

S-adenosyl-L-methionine + L-homocysteine = ?

687808

5dmm, 3D-view

2.1.1.10

S-methyl-L-methionine + L-homocysteine = 2 L-methionine

733302, 441387, 692948, 694665

5dmm, 3D-view

2.1.1.10

S-methyl-L-methionine + L-homocysteine = L-methionine

692820

5dmm, 3D-view

2.1.1.10

(R,S)-S-adenosyl-L-methionine + L-homocysteine = L-methionine + S-adenosyl-L-homocysteine

719868, 733302

5dmm, 3D-view

2.1.1.10

(S,S)-S-adenosyl-L-methionine + L-homocysteine = L-methionine + S-adenosyl-L-homocysteine

719868

5dmm, 3D-view

2.1.1.13

N5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

441178, 441179, 441188, 441192, 437717, 441177, 441194, 441189, 657836

1q8a, 3D-view

2.1.1.13

N5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

441178, 441179, 441188, 441192, 437717, 441177, 441194, 441189, 657836

1q8j, 3D-view

2.1.1.13

N5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

441178, 441179, 441188, 441192, 437717, 441177, 441194, 441189, 657836

3bof, 3D-view

2.1.1.13

N5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

441178, 441179, 441188, 441192, 437717, 441177, 441194, 441189, 657836

3bol, 3D-view

2.1.1.13

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441183, 441172, 441174, 704166, 706495, 706520, 672821, 673604, 676875, 684467, 703638, 437717, 673596, 437712, 441173, 441194, 702050, 706493, 700779

1q8a, 3D-view

2.1.1.13

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441183, 441172, 441174, 704166, 706495, 706520, 672821, 673604, 676875, 684467, 703638, 437717, 673596, 437712, 441173, 441194, 702050, 706493, 700779

1q8j, 3D-view

2.1.1.13

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441183, 441172, 441174, 704166, 706495, 706520, 672821, 673604, 676875, 684467, 703638, 437717, 673596, 437712, 441173, 441194, 702050, 706493, 700779

3bof, 3D-view

2.1.1.13

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441183, 441172, 441174, 704166, 706495, 706520, 672821, 673604, 676875, 684467, 703638, 437717, 673596, 437712, 441173, 441194, 702050, 706493, 700779

3bol, 3D-view

2.1.1.13

N5-methyltetrahydropteroyltriglutamate + L-homocysteine = tetrahydropteroyltriglutamate + L-methionine

441183, 441172, 437712, 441173, 441180, 441194

1q8a, 3D-view

2.1.1.13

N5-methyltetrahydropteroyltriglutamate + L-homocysteine = tetrahydropteroyltriglutamate + L-methionine

441183, 441172, 437712, 441173, 441180, 441194

1q8j, 3D-view

2.1.1.13

N5-methyltetrahydropteroyltriglutamate + L-homocysteine = tetrahydropteroyltriglutamate + L-methionine

441183, 441172, 437712, 441173, 441180, 441194

3bof, 3D-view

2.1.1.13

N5-methyltetrahydropteroyltriglutamate + L-homocysteine = tetrahydropteroyltriglutamate + L-methionine

441183, 441172, 437712, 441173, 441180, 441194

3bol, 3D-view

2.1.1.13

N5-methyltetrahydropteroylpentaglutamate + L-homocysteine = tetrahydropteroylpentaglutamate + L-methionine

437717, 441194

1q8a, 3D-view

2.1.1.13

N5-methyltetrahydropteroylpentaglutamate + L-homocysteine = tetrahydropteroylpentaglutamate + L-methionine

437717, 441194

1q8j, 3D-view

2.1.1.13

N5-methyltetrahydropteroylpentaglutamate + L-homocysteine = tetrahydropteroylpentaglutamate + L-methionine

437717, 441194

3bof, 3D-view

2.1.1.13

N5-methyltetrahydropteroylpentaglutamate + L-homocysteine = tetrahydropteroylpentaglutamate + L-methionine

437717, 441194

3bol, 3D-view

2.1.1.13

N5-methyltetrahydropteroylheptaglutamate + L-homocysteine = tetrahydropteroylheptaglutamate + L-methionine

441194

1q8a, 3D-view

2.1.1.13

N5-methyltetrahydropteroylheptaglutamate + L-homocysteine = tetrahydropteroylheptaglutamate + L-methionine

441194

1q8j, 3D-view

2.1.1.13

N5-methyltetrahydropteroylheptaglutamate + L-homocysteine = tetrahydropteroylheptaglutamate + L-methionine

441194

3bof, 3D-view

2.1.1.13

N5-methyltetrahydropteroylheptaglutamate + L-homocysteine = tetrahydropteroylheptaglutamate + L-methionine

441194

3bol, 3D-view

2.1.1.13

S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine

441183

1q8a, 3D-view

2.1.1.13

S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine

441183

1q8j, 3D-view

2.1.1.13

S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine

441183

3bof, 3D-view

2.1.1.13

S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine

441183

3bol, 3D-view

2.1.1.13

5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + L-homocysteine = ?

437717, 441194

1q8a, 3D-view

2.1.1.13

5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + L-homocysteine = ?

437717, 441194

1q8j, 3D-view

2.1.1.13

5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + L-homocysteine = ?

437717, 441194

3bof, 3D-view

2.1.1.13

5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + L-homocysteine = ?

437717, 441194

3bol, 3D-view

2.1.1.13

5-methyl-5,6,7,8-tetrahydropteroylheptaglutamate + homocysteine = ?

441194

1q8a, 3D-view

2.1.1.13

5-methyl-5,6,7,8-tetrahydropteroylheptaglutamate + homocysteine = ?

441194

1q8j, 3D-view

2.1.1.13

5-methyl-5,6,7,8-tetrahydropteroylheptaglutamate + homocysteine = ?

441194

3bof, 3D-view

2.1.1.13

5-methyl-5,6,7,8-tetrahydropteroylheptaglutamate + homocysteine = ?

441194

3bol, 3D-view

2.1.1.13

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

660282, 437712, 441173, 658413

1q8a, 3D-view

2.1.1.13

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

660282, 437712, 441173, 658413

1q8j, 3D-view

2.1.1.13

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

660282, 437712, 441173, 658413

3bof, 3D-view

2.1.1.13

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

660282, 437712, 441173, 658413

3bol, 3D-view

2.1.1.14

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441322, 671122

1u22, 3D-view

2.1.1.14

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441322, 671122

1xdj, 3D-view

2.1.1.14

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441322, 671122

3bq5, 3D-view

2.1.1.14

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441322, 671122

4l5z, 3D-view

2.1.1.14

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441322, 671122

4l6h, 3D-view

2.1.1.14

N5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441322, 671122

4qqu, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine

441334, 441172, 441323, 672156, 672157, 671587, 441322, 441331, 441337, 676741, 734490

1u22, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine

441334, 441172, 441323, 672156, 672157, 671587, 441322, 441331, 441337, 676741, 734490

1xdj, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine

441334, 441172, 441323, 672156, 672157, 671587, 441322, 441331, 441337, 676741, 734490

3bq5, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine

441334, 441172, 441323, 672156, 672157, 671587, 441322, 441331, 441337, 676741, 734490

4l5z, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine

441334, 441172, 441323, 672156, 672157, 671587, 441322, 441331, 441337, 676741, 734490

4l6h, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine

441334, 441172, 441323, 672156, 672157, 671587, 441322, 441331, 441337, 676741, 734490

4qqu, 3D-view

2.1.1.14

5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441334, 441337

1u22, 3D-view

2.1.1.14

5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441334, 441337

1xdj, 3D-view

2.1.1.14

5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441334, 441337

3bq5, 3D-view

2.1.1.14

5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441334, 441337

4l5z, 3D-view

2.1.1.14

5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441334, 441337

4l6h, 3D-view

2.1.1.14

5-methyltetrahydropteroylmonoglutamate + L-homocysteine = tetrahydropteroylmonoglutamate + L-methionine

441334, 441337

4qqu, 3D-view

2.1.1.14

S-adenosylmethionine + homocysteine = methionine + S-adenosylhomocysteine

441322

1u22, 3D-view

2.1.1.14

S-adenosylmethionine + homocysteine = methionine + S-adenosylhomocysteine

441322

1xdj, 3D-view

2.1.1.14

S-adenosylmethionine + homocysteine = methionine + S-adenosylhomocysteine

441322

3bq5, 3D-view

2.1.1.14

S-adenosylmethionine + homocysteine = methionine + S-adenosylhomocysteine

441322

4l5z, 3D-view

2.1.1.14

S-adenosylmethionine + homocysteine = methionine + S-adenosylhomocysteine

441322

4l6h, 3D-view

2.1.1.14

S-adenosylmethionine + homocysteine = methionine + S-adenosylhomocysteine

441322

4qqu, 3D-view

2.1.1.14

S-methylmethionine + homocysteine = methionine

441322

1u22, 3D-view

2.1.1.14

S-methylmethionine + homocysteine = methionine

441322

1xdj, 3D-view

2.1.1.14

S-methylmethionine + homocysteine = methionine

441322

3bq5, 3D-view

2.1.1.14

S-methylmethionine + homocysteine = methionine

441322

4l5z, 3D-view

2.1.1.14

S-methylmethionine + homocysteine = methionine

441322

4l6h, 3D-view

2.1.1.14

S-methylmethionine + homocysteine = methionine

441322

4qqu, 3D-view

2.1.1.14

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine

671587

1u22, 3D-view

2.1.1.14

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine

671587

1xdj, 3D-view

2.1.1.14

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine

671587

3bq5, 3D-view

2.1.1.14

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine

671587

4l5z, 3D-view

2.1.1.14

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine

671587

4l6h, 3D-view

2.1.1.14

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine

671587

4qqu, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamylglutamate + L-methionine

671587

1u22, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamylglutamate + L-methionine

671587

1xdj, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamylglutamate + L-methionine

671587

3bq5, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamylglutamate + L-methionine

671587

4l5z, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamylglutamate + L-methionine

671587

4l6h, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-gamma-glutamylglutamate + L-homocysteine = tetrahydropteroyl-gamma-glutamylglutamate + L-methionine

671587

4qqu, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-tri-L-glutamate + L-homocysteine = tetrahydropteroyl-tri-L-glutamate + L-methionine

704294

1u22, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-tri-L-glutamate + L-homocysteine = tetrahydropteroyl-tri-L-glutamate + L-methionine

704294

1xdj, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-tri-L-glutamate + L-homocysteine = tetrahydropteroyl-tri-L-glutamate + L-methionine

704294

3bq5, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-tri-L-glutamate + L-homocysteine = tetrahydropteroyl-tri-L-glutamate + L-methionine

704294

4l5z, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-tri-L-glutamate + L-homocysteine = tetrahydropteroyl-tri-L-glutamate + L-methionine

704294

4l6h, 3D-view

2.1.1.14

5-methyltetrahydropteroyl-tri-L-glutamate + L-homocysteine = tetrahydropteroyl-tri-L-glutamate + L-methionine

704294

4qqu, 3D-view

2.1.1.280

S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine

694691

-

2.1.1.280

S-adenosyl-L-methionine + L-homocysteine = ?

692948

-

2.1.1.10

9 entries

2.1.1.13

36 entries

2.1.1.14

48 entries

2.1.1.280

2 entries

2.1.1.3

dimethylthetin + L-homocysteine = S-methylthioglycolate + L-methionine

485244, 485245

-

2.1.1.5

N,N,N-trimethylglycine + L-homocysteine = N,N-dimethylglycine + L-methionine

441232, 441234, 441233, 441235, 441236, 441237, 441244

4m3p, 3D-view

2.1.1.5

dimethylacetothetin + L-homocysteine = ? + L-methionine

441243

4m3p, 3D-view

2.1.1.5

glycinebetaine + L-homocysteine = ? + L-methionine

441247, 441246

4m3p, 3D-view

2.1.1.5

L-homocysteine + betaine = L-methionine + dimethylglycine

676758, 684710, 687808, 703877, 658422, 673003, 675300, 689024, 701995, 705038, 657817, 671232, 702044, 705295, 441243, 658928, 735230, 671242, 658186, 671233

4m3p, 3D-view

2.1.1.5

L-homocysteine + S-methyl-L-methionine = ?

687808

4m3p, 3D-view

2.1.1.5

L-homocysteine + S-methylmethionine = ?

687808

4m3p, 3D-view

2.1.1.5

L-homocysteine + betaine = dimethylglycine + L-methionine

720080, 719035, 720040

4m3p, 3D-view

2.1.1.5

L-homocysteine + S-methylmethionine = 2 L-methionine

720202

4m3p, 3D-view

2.1.1.5

L-homocysteine + S-methyl-L-methionine = 2 L-methionine

735230

4m3p, 3D-view

2.5.1.47

L-homocysteine + L-serine = L-cystathionine + H2O

637385

-

2.5.1.47

L-cysteine + L-homocysteine = L-cystathionine + H2S

747747, 749243

-

2.5.1.47

O-acetyl-L-serine + L-homocysteine = cystathionine + acetate

749243, 721306

-

2.5.1.47

L-cysteine + L-homocysteine = L-cystathionine + acetate

747747

-

2.5.1.48

O-succinyl-L-serine + L-homocysteine = succinate + L-cystathionine

637427, 637431

-

2.5.1.48

O-acetyl-L-homoserine + L-homocysteine = L-homolanthionine + acetate

637439

-

2.1.1.5

9 entries

2.5.1.47

4 entries

2.5.1.48

2 entries

2.5.1.49

L-homocysteine + KCN = gamma-cyano-alpha-aminobutyric acid + H2S

662480

-

2.6.1.14

2-oxosuccinamic acid + L-homocysteine = L-asparagine + 4-mercapto-2-oxobutanoate

637254

-

2.6.1.64

L-homocysteine + phenylpyruvate = 4-mercapto-2-oxobutanoate + L-phenylalanine

640176

-

2.8.1.2

3-mercaptopyruvate + L-homocysteine = ?

725528

-

3.3.1.1

3-deazaadenosine + L-homocysteine = 3-deazaadenosylhomocysteine

137121, 137133, 137122, 137129

-

3.3.1.1

2-aza-3-deazaadenosine + homocysteine = ?

137121, 137122

-

3.3.1.1

nebularine + homocysteine = ?

137127, 137121, 137122, 137134

-

3.3.1.1

7-deaza-8-azaadenosine + homocysteine = ?

137127, 137121, 137122, 137134

-

3.3.1.1

N6-methyladenosine + homocysteine = ?

137127, 137121, 137122

-

3.3.1.1

adenosine N1-oxide + homocysteine = ?

137127, 137121, 137122, 137134

-

3.3.1.1

pyrazomycin + homocysteine = ?

137121, 137122

-

3.3.1.1

8-aminoadenosine + homocysteine = ?

137121, 137122

-

3.3.1.1

inosine + homocysteine = ?

137127, 137121, 137122

-

3.3.1.1

(+/-)-aristeromycin + homocysteine = ?

137122, 137121

-

3.3.1.1

3-deaza-(+/-)-aristeromycin + homocysteine = ?

137122, 137121

-

3.3.1.1

8-azaadenosine + homocysteine = ?

137121, 137122

-

3.3.1.1

2-aminoadenosine + homocysteine = ?

137122

-

3.3.1.1

N6-hydroxyadenosine + homocysteine = ?

137122

-

3.3.1.1

2-hydroxyadenosine + homocysteine = ?

137122

-

3.3.1.1

2-chloroadenosine + homocysteine = ?

137127, 137122

-

3.3.1.1

tubercidin + L-homocysteine = ?

137127

-

3.3.1.1

L-homocysteine + adenosine = S-adenosyl-L-homocysteine + H2O

724984, 678365, 731159

-

3.3.1.1

L-homocysteine + adenosine + H2O = S-adenosyl-L-homocysteine

732154

-

4.2.1.22

L-Serine + homocysteine = Cystathionine + H2O

5584, 5594, 650408, 5586, 5587, 5588, 5591, 5592, 5601, 5602, 5604, 649254, 649570, 649869, 649888, 649914, 650105, 650154, 650405, 650981, 652112, 652694, 652695, 665593, 678140, 650017, 652127, 652339, 652381, 5585, 5589, 5590, 5595, 5598, 652325, 5596, 5599, 649915, 650019, 650128, 650238, 652551, 5593, 5603, 5597, 5600, 650096, 650216, 652270

-

4.2.1.22

L-allothreonine + homocysteine = ? + H2O

650128

-

4.2.1.22

L-Serine + homocysteine = ?

5584, 5586, 5587, 5588, 5591, 5592, 5600, 5601, 5602, 5585, 5589, 5595, 5598, 5596, 5593, 5603, 5597, 5590, 5594, 5599, 5604, 5605

-

4.2.1.22

L-serine + L-homocysteine = cystathionine + H2O

675074, 682533, 663623, 677837, 678269, 680084, 680641, 681230, 682810

-

4.2.1.22

O-acetyl-L-serine + L-homocysteine = ?

677837

-

4.2.1.22

L-serine + L-homocysteine = L-cystathionine + H2O

698157, 714912, 730477, 696253, 696822, 697295, 698182, 698850, 701064, 704664, 714179, 715808, 715809, 728933, 728945, 730143, 730146, 730755, 686517, 695501, 702107, 714248, 697938, 716763, 714071, 715150, 729799, 747922

-

4.2.1.22

L-cysteine + L-homocysteine = L-cystathionine + H2S

704974, 702457, 746768, 747747, 749243

-

4.2.1.22

L-serine + L-homocysteine = ?

702457

-

4.2.1.22

O-acetyl-L-serine + L-homocysteine = cystathionine + acetate

749243

-

4.2.1.22

L-cysteine + L-homocysteine = L-cystathionine + acetate

747747

-

4.4.1.1

homocysteine = ?

5584

-

4.4.1.1

L-homoserine + L-homocysteine = L-homolanthionine

34489, 34505

-

4.4.1.1

L-homocysteine = ?

34506, 690967

-

4.4.1.1

L-homocysteine + H2O = H2S + ?

710075

-

4.4.1.1

L-homocysteine + H2O = NH3 + 2-oxobutanoate + H2S

709005

-

4.4.1.1

L-homocysteine + L-cysteine = L-cystathionine + H2S

709005

-

4.4.1.1

L-homocysteine + L-homocysteine = L-homolanthionine + H2S

709005, 709390

-

4.4.1.11

homocysteine + alkanethiol = S-alkylhomocysteine

34527

3vk4, 3D-view

4.4.1.11

homocysteine + alkanethiol = S-alkylhomocysteine

34527

5x30, 3D-view

4.4.1.11

L-homocysteine + H2O = ?

701880

3vk4, 3D-view

4.4.1.11

L-homocysteine + H2O = ?

701880

5x30, 3D-view

4.4.1.11

L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate

682347, 660904

3vk4, 3D-view

4.4.1.11

L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate

682347, 660904

5x30, 3D-view

4.4.1.11

L-homocysteine = 2-oxobutanoate + NH3 + hydrogen sulfide

728952

3vk4, 3D-view

4.4.1.11

L-homocysteine = 2-oxobutanoate + NH3 + hydrogen sulfide

728952

5x30, 3D-view

4.4.1.11

L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate

748253

3vk4, 3D-view

4.4.1.11

L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate

748253

5x30, 3D-view

3.3.1.1

19 entries

4.2.1.22

10 entries

4.4.1.1

7 entries

4.4.1.11

10 entries

4.4.1.13

L-homocysteine + H2O = ?

34689, 34691

-

4.4.1.2

L-homocysteine + H2O = H2S + NH3 + 2-oxobutanoate

34598, 34599, 34600

-

4.4.1.2

L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate

722937

-

4.4.1.2

2 entries

5.1.1.10

L-Homocysteine = D-Homocysteine

2045

-

6.1.1.10

ATP + L-homocysteine + tRNAMet = ?

652862

-

6.3.2.2

ATP + L-Glu + L-homocysteine = ADP + phosphate + gamma-L-Glu-L-homocysteine

1122, 1133, 649263, 1126

-

6.3.2.26

L-2-aminoadipate + L-homocysteine + L-valine + ATP = N-(5-amino-5-carboxypentanoyl)-L-homocysteinyl-D-valine + AMP + diphosphate

440081

-

Product in Enzyme-catalyzed Reactions (49 results)

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Show Product (49 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.8.4.1

GSH + homocystine = GSSG + homocysteine

395020

-

1.8.4.1

2 glutathione + homocystine = glutathione disulfide + 2 homocysteine

-

-

1.8.4.1

2 lysine + homocystine = glutathione disulfide + 2 homocysteine

-

-

1.8.4.1

cysteine + homocystine = cystine + 2 homocysteine

-

-

1.8.4.1

4 entries

2.1.1.1

L-methionine + nicotinamide = L-homocysteine + 1-methylnicotinamide

-

-

2.1.1.348

S-adenosyl-L-methionine + adenine in 5'-UACACUCGAUCU-GGACU-AAAGCUGCUC = homocysteine + 5'-UACACUCGAUCU-GG-(N6-methyl)ACU-AAAGCUGCUC

-

-

2.5.1.134

L-cystathionine + acetate = O-acetyl-L-serine + L-homocysteine

-

-

2.5.1.47

O-acetylhomoserine + H2S = homocysteine + ?

637329

-

2.5.1.48

L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate

637449, 637428

-

2.5.1.48

O-succinyl-L-homoserine + sodium sulfide = L-homocysteine + sodium succinate

-

-

2.5.1.48

O-succinyl-L-homoserine + H2S = L-homocysteine + succinate

637424, 637429

-

2.5.1.48

O-acetyl-L-homoserine + S2- = L-homocysteine + acetate

637439

-

2.5.1.48

O-phospho-L-homoserine + S2- = L-homocysteine + phosphate

637448

-

2.5.1.49

O-succinyl-L-homoserine + H2S = L-homocysteine + succinate

-

-

2.5.1.49

O-acetyl-L-homoserine + H2S = L-homocysteine + acetic acid

637329, 637331, 637835, 637836, 637824, 34702, 637834, 637832, 637830, 637841

-

2.5.1.49

L-homoserine + H2S = homocysteine + ?

-

-

2.5.1.49

O-succinyl-L-homoserine + H2S = homocysteine + ?

-

-

2.5.1.49

O-acetyl-L-homoserine + S2- = L-homocysteine + acetic acid

-

-

2.5.1.49

o-acetyl-L-homoserine + H2S = L-homocysteine + acetate

-

-

2.5.1.49

L-homoserine + H2S = L-homocysteine + H2O

-

-

2.5.1.49

2 O-acetyl-L-homoserine + H2S = 2 L-homocysteine + 2 acetate

-

-

2.5.1.48

5 entries

2.5.1.49

8 entries

3.1.1.25

homocysteinethiolactone + H2O = homocysteine

-

-

3.3.1.1

S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine

137135, 137127, 137136, 137125, 137128, 137130, 137140, 137150, 137139, 137119, 137124, 137149, 137131, 137132, 137138, 137148, 137137, 137120, 137121, 137123, 137133, 137143, 137144, 137145, 137147, 137126, 137122, 137134, 137141, 137129, 137146

-

3.3.1.1

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

-

-

3.3.1.1

2 entries

3.4.22.40

L-homocysteine-thiolactone + H2O = L-homocysteine

-

-

4.4.1.1

L-cystathionine = L-homocysteine + pyruvate + NH3

34506, 34507, 586904

-

4.4.1.1

L-cystathionine + H2O = L-homocysteine + pyruvate + NH3

-

-

4.4.1.1

L-cystathionine = homocysteine + pyruvate + NH3

-

-

4.4.1.13

L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate

34707, 34688, 34692, 34694, 34691, 34708, 34696, 34700, 34703, 34705, 34706, 34711, 34714, 34686, 34690, 34695, 34701, 34697, 34698, 34699, 34715, 34693, 34704, 34709, 34702, 34710, 34712, 34713, 34689, 34687

-

4.4.1.13

cystathionine + H2O = L-homocysteine + NH3 + pyruvate

649357, 651551

-

4.4.1.13

L-cystathionine + H2O = L-homocysteine + pyruvate + NH3

-

-

4.4.1.13

L-cystathionine = L-homocysteine + pyruvate + NH4+

-

-

4.4.1.21

S-ribosylhomocysteine = homocysteine + 4,5-dihydroxy-2,3-pentanedione

-

1jqw, 3D-view

4.4.1.21

S-ribosylhomocysteine = homocysteine + 4,5-dihydroxy-2,3-pentanedione

-

1jvi, 3D-view

4.4.1.21

S-ribosylhomocysteine = L-homocysteine + 4,5-dihydroxy-2,3-pentanedione

-

1jqw, 3D-view

4.4.1.21

S-ribosylhomocysteine = L-homocysteine + 4,5-dihydroxy-2,3-pentanedione

-

1jvi, 3D-view

4.4.1.21

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione

-

1jqw, 3D-view

4.4.1.21

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione

-

1jvi, 3D-view

4.4.1.21

S-ribosylhomocysteine = L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione

-

1jqw, 3D-view

4.4.1.21

S-ribosylhomocysteine = L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione

-

1jvi, 3D-view

4.4.1.21

(2R)-2-amino-4-[[(2S,4S)-2,4,5-trihydroxy-3-oxopentyl]sulfanyl]butanoic acid = L-homocysteine + ?

-

1jqw, 3D-view

4.4.1.21

(2R)-2-amino-4-[[(2S,4S)-2,4,5-trihydroxy-3-oxopentyl]sulfanyl]butanoic acid = L-homocysteine + ?

-

1jvi, 3D-view

4.4.1.21

S-ribosylhomocysteine = L-homocysteine + (S)-4,5-dihydroxy-2,3-pentanedione

-

1jqw, 3D-view

4.4.1.21

S-ribosylhomocysteine = L-homocysteine + (S)-4,5-dihydroxy-2,3-pentanedione

-

1jvi, 3D-view

4.4.1.21

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione

-

1jqw, 3D-view

4.4.1.21

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione

-

1jvi, 3D-view

4.4.1.28

cystathionine + H2O = NH3 + pyruvate + homocysteine

-

-

4.4.1.28

L-cystathionine + H2O = NH3 + pyruvate + homocysteine

-

-

4.4.1.1

3 entries

4.4.1.13

4 entries

4.4.1.21

14 entries

4.4.1.28

2 entries

4.4.1.8

L-cystathionine + H2O = L-homocysteine + pyruvate + NH3

-

-

Activator in Enzyme-catalyzed Reactions (10 results)

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Show Activating Compound (10 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.5.1.20

treatment of cells results in increase in enzyme mRNA and protein

687772

-

2.1.1.10

induces reaction

441382

5dmm, 3D-view

2.1.1.137

-

733740

-

2.1.1.19

can replace 2-mercaptoethanol

485198

-

3.2.2.13

10 fold activation

137034

-

3.3.1.1

protection against inactivation by arabinosyl adenine

137127

-

3.4.22.56

induces the enzyme activation 2.5fold and 4fold in endothelial progenitor cells at 0.1 mM and 0.2 mM, respectively. Vitamin B6, and B9 significantly impair homocysteine-mediated EPC caspase-3 activation in vitro, and inhibitor N-carbobenzyloxy-VAD-fluoromethyl ketone highly reduces the activating effect, overview

699135

-

3.4.22.61

induces the enzyme activation 3.5fold in endothelial progenitor cells at 0.2 mM

699135

-

3.4.24.35

homocysteine activates matrix metalloproteinase-9, muscimol ameliorates the homocysteine-mediated MMP-9 activation

709239

-

3.4.24.85

-

680187

-

Inhibitor in Enzyme-catalyzed Reactions (51 results)

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Show Inhibitors (51 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.11.1.9

GPx-1 is inhibited by 0.05-0.5 mM homocysteine, especially at low glutathione concentrations

688035

-

1.13.11.20

50% inhibition at 6.5 mM

659515

4piy, 3D-view

1.13.11.20

50% inhibition at 6.5 mM

659515

4piz, 3D-view

1.13.11.20

50% inhibition at 6.5 mM

659515

4xf4, 3D-view

1.13.11.20

50% inhibition at 6.5 mM

659515

4xf9, 3D-view

1.13.11.20

50% inhibition at 6.5 mM

659515

4xfa, 3D-view

1.13.11.20

50% inhibition at 6.5 mM

659515

4xfi, 3D-view

1.13.11.20

cysteine dioxygenase activity is reduced by 50% only when the molar ratio of homocysteine:cysteine dioxygenase reach about 30000:1

674873

4piy, 3D-view

1.13.11.20

cysteine dioxygenase activity is reduced by 50% only when the molar ratio of homocysteine:cysteine dioxygenase reach about 30000:1

674873

4piz, 3D-view

1.13.11.20

cysteine dioxygenase activity is reduced by 50% only when the molar ratio of homocysteine:cysteine dioxygenase reach about 30000:1

674873

4xf4, 3D-view

1.13.11.20

cysteine dioxygenase activity is reduced by 50% only when the molar ratio of homocysteine:cysteine dioxygenase reach about 30000:1

674873

4xf9, 3D-view

1.13.11.20

cysteine dioxygenase activity is reduced by 50% only when the molar ratio of homocysteine:cysteine dioxygenase reach about 30000:1

674873

4xfa, 3D-view

1.13.11.20

cysteine dioxygenase activity is reduced by 50% only when the molar ratio of homocysteine:cysteine dioxygenase reach about 30000:1

674873

4xfi, 3D-view

1.13.11.20

competitive inhibitor, binding structure, overview

743088

4piy, 3D-view

1.13.11.20

competitive inhibitor, binding structure, overview

743088

4piz, 3D-view

1.13.11.20

competitive inhibitor, binding structure, overview

743088

4xf4, 3D-view

1.13.11.20

competitive inhibitor, binding structure, overview

743088

4xf9, 3D-view

1.13.11.20

competitive inhibitor, binding structure, overview

743088

4xfa, 3D-view

1.13.11.20

competitive inhibitor, binding structure, overview

743088

4xfi, 3D-view

1.13.11.20

18 entries

1.2.1.11

in the reverse reaction

390187

-

1.4.3.13

-

685981

-

1.4.3.13

down-regulates LOX mRNA and transcriptional activity

686904

-

1.4.3.13

2 entries

1.5.3.7

at 0.005 mM 12% inactivation after 1 h incubation

392471

-

2.1.1.6

-

441551

-

2.1.1.67

-

485515

-

2.3.1.30

weak

34691, 486753, 486773

-

2.3.1.31

not

486781

-

2.3.1.31

-

486784

-

2.3.1.31

2 entries

2.5.1.47

competitive to sulfide

34691

-

2.5.1.48

partial inhibition of beta-elimination and gamma-elimination

637427

-

2.5.1.48

-

637429

-

2.5.1.48

2 entries

2.6.1.43

-

640045

-

2.7.1.39

-

641470

-

2.8.2.B1

-

289091

-

3.3.1.1

-

137135, 137137, 137148

-

3.4.24.24

-

683430

-

3.5.3.18

;

697831

2ci5, 3D-view

3.5.3.18

inhibition of the expression of DDAH-2 reduces the NO production induced by IL-1beta

718718

2ci5, 3D-view

3.5.3.18

-

670913, 690182

2ci5, 3D-view

3.5.3.18

3 entries

4.1.99.17

-

727960

-

4.2.1.22

substrate inhibition

701064

-

4.2.1.22

-

747922

-

4.2.1.22

2 entries

4.3.1.17

noncompetitive with respect to substrate, competitive with regard to pyridoxal 5'-phosphate

210787

-

4.3.1.3

irreversible in the presence of O2 and high pH

34285

-

4.4.1.13

strong

34691

-

4.4.1.14

slight

34572

-

4.4.1.9

uncompetitive vs. O-acetyl-L-serine, noncompetitive vs. chloroalanine and L-cysteine

652652

-

5.1.1.18

reacts with pyridoxal 5'-phosphate to yield thiazolidine derivative

747888

-

6.1.1.16

-

192, 58

-

6.3.4.4

poor

1538

-

7.2.2.13

inhibtory effect is reversed by alanine

655745

-

3D Structure of Enzyme-Ligand-Complex (PDB) (27 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (27 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.13.11.20

4piy, 3D-view

1.13.11.20

4piz, 3D-view

1.13.11.20

4xf4, 3D-view

1.13.11.20

4xf9, 3D-view

1.13.11.20

4xfa, 3D-view

1.13.11.20

4xfi, 3D-view

1.13.11.20

6 entries

1.7.6.1

4hpd, 3D-view

2.1.1.10

5dmm, 3D-view

2.1.1.13

1q8a, 3D-view

2.1.1.13

1q8j, 3D-view

2.1.1.13

3bof, 3D-view

2.1.1.13

3bol, 3D-view

2.1.1.14

1u22, 3D-view

2.1.1.14

1xdj, 3D-view

2.1.1.14

3bq5, 3D-view

2.1.1.14

4l5z, 3D-view

2.1.1.14

4l6h, 3D-view

2.1.1.14

4qqu, 3D-view

2.1.1.13

4 entries

2.1.1.14

6 entries

2.1.1.5

4m3p, 3D-view

2.8.1.7

5wt5, 3D-view

3.2.2.9

6po4, 3D-view

3.5.3.18

2ci5, 3D-view

4.4.1.11

3vk4, 3D-view

4.4.1.11

5x30, 3D-view

4.4.1.21

1jqw, 3D-view

4.4.1.21

1jvi, 3D-view

4.4.1.11

2 entries

4.4.1.21

2 entries

4.6.1.18

4ygw, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (57 results)

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Show Turnover Number (57 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.8.5.4

92

-

pH 7.4, 25°C

738630

2.1.1.10

0.38

-

pH 6, 30°C, cosubstrate: S-adenosyl-L-methionine

692948

2.1.1.14

0.33

-

in 50 mM potassium phosphate (pH 7.2), 50 mM Tris-Cl (pH 7.2) containing 0.1 mM MgSO4, 10 mM dithiothreitol and 2 mM L-homocysteine at 37°C

671587

2.1.1.14

0.417

-

in 50 mM potassium phosphate (pH 7.2), 50 mM Tris-Cl (pH 7.2) containing 0.1 mM MgSO4, 10 mM dithiothreitol and 2 mM L-homocysteine at 37°C

671587

2.1.1.14

0.45

-

37°C, pH not specified in the publication

734490

2.1.1.14

3 entries

2.1.1.280

0.38

-

with [methyl-14C]S-adenosyl-L-methionine, pH 6.5, 30°C

692948

2.1.1.5

0.000082

-

37°C, mutant enzyme E159K

657817

2.1.1.5

0.00023

-

37°C, mutant enzyme E159G

657817

2.1.1.5

0.0003

-

wild-type, cosubstrate S-methylmethionine, presence of 150 mM KCl, pH 7.5, 37°C

735230

2.1.1.5

0.001

-

37°C, mutant enzyme Y77A

657817

2.1.1.5

0.0021

-

37°C, mutant enzyme D26I

657817

2.1.1.5

0.0045

-

37°C, mutant enzyme T73G

657817

2.1.1.5

0.0051

-

37°C, mutant enzyme D26A

657817

2.1.1.5

0.0058

-

37°C, mutant enzyme T184G

657817

2.1.1.5

0.006

-

37°C, mutant enzyme C186S; 37°C, mutant enzyme E21A

657817

2.1.1.5

0.0072

-

37°C, mutant enzyme F74A

657817

2.1.1.5

0.0075

-

37°C, mutant enzyme A119G

657817

2.1.1.5

0.0076

-

37°C, mutant enzyme C186A

657817

2.1.1.5

0.009

-

37°C, mutant enzyme E21K

657817

2.1.1.5

0.014

-

37°C, wild-type enzyme

657817

2.1.1.5

0.0367

-

wild-type, pH 7.5, 37°C

735230

2.1.1.5

0.0378

-

wild-type, presence of 150 mM KCl, pH 7.5, 37°C

735230

2.1.1.5

16 entries

2.8.1.2

0.8

-

in 200 mM of HEPES, pH 7.4, at 37°C

725528

4.2.1.22

0.024

-

recombinant 6-His-tagged enzyme, in 50 mM Tris (pH 8.6), at 25°C

701064

4.2.1.22

0.031

0.51

37°C, pH 8.6, wild-type enzyme

680084

4.2.1.22

0.04

1.97

37°C, pH 8.6, mutant enzyme R266K

680084

4.2.1.22

0.09

-

37°C, pH 8.6, mutant enzyme I278T

680084

4.2.1.22

0.85

-

cosubstrate: L-serine, mutant S289A

702457

4.2.1.22

3.3

-

37°C, pH 8.0, wild-type enzyme, without S-adenosyl-L-methionine

677837

4.2.1.22

3.38

-

wild-type, production of H2S, pH 8.2, 37°C

747747

4.2.1.22

4.66

-

37°C, pH 8.0, wild-type enzyme, without S-adenosyl-L-methionine

677837

4.2.1.22

4.66

-

cosubstrate L-serine, pH 7.4, 37°C

746768

4.2.1.22

5.74

-

mutant E220R, pH 8.2, 37°C

747747

4.2.1.22

5.9

-

I435T mutant, 37°C, absence of S-adenosyl-L-methionine

650017

4.2.1.22

6.2

-

wild-type enzyme, 37°C, absence of S-adenosyl-L-methionine

650017

4.2.1.22

7.38

-

-

5599

4.2.1.22

7.93

-

37°C, pH 8.6, wild-type enzyme

680084

4.2.1.22

8.17

-

cosubstrate L-cysteine, pH 7.4, 37°C

746768

4.2.1.22

8.39

-

wild-type, pH 8.2, 37°C

747747

4.2.1.22

9.06

-

37°C, pH 8.6, mutant enzyme R266K

680084

4.2.1.22

10.91

-

mutant A72S, pH 8.2, 37°C

747747

4.2.1.22

12.7

-

37°C, pH 8.0, wild-type enzyme, with S-adenosyl-L-methionine

677837

4.2.1.22

12.7

-

cosubstrate L-serine, presence of S-adenosyl-L-methionine, pH 7.4, 37°C

746768

4.2.1.22

15.5

-

S466L mutant, 37°C, absence of S-adenosyl-L-methionine

650017

4.2.1.22

17

-

cosubstrate: L-serine, wild-type

702457

4.2.1.22

21.5

-

pH 8.6, 37°C

650216

4.2.1.22

26.78

-

cosubstrate L-cysteine, presence of S-adenosyl-L-methionine, pH 7.4, 37°C

746768

4.2.1.22

32.1

-

I435T mutant, 37°C, presence of S-adenosyl-L-methionine

650017

4.2.1.22

34

-

wild-type enzyme, 37°C, presence of S-adenosyl-L-methionine

650017

4.4.1.1

0.82

-

for mutante T67I

690967

4.4.1.1

3.5

-

for variante S403

690967

4.4.1.1

3.7

-

for variante I403

690967

4.2.1.22

26 entries

4.4.1.1

3 entries

4.4.1.11

1.7

-

pH 8.0, 37°C

748253

4.4.1.2

0.00139

-

pH 7.0, 35°C

722937

6.1.1.10

0.5

-

editing reaction, mitochondrial isozyme, pH 7.8, 25°C

652862

6.1.1.10

0.69

-

editing reaction, cytoplasmic isozyme, pH 7.8, 25°C

652862

6.1.1.10

6.08

-

editing reaction, cytoplasmic isozyme, pH 7.8, 25°C

652862

6.1.1.10

3 entries

K_M Value (138 results)

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Show KM Value (138 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.4.3.2

1.3

-

-

391775

1.8.5.4

22

-

pH 7.4, 25°C

738630

1.8.5.8

22

-

at pH 7.4 and 37°C

745313

2.1.1.10

0.018

-

pH 7.5, 30°C, cosubstrate: S-adenosyl-L-methionine

441387

2.1.1.10

0.027

-

pH 7.5, 25°C, cosubstrate: S-adenosyl-L-methionine

694665

2.1.1.10

0.03

-

pH 7.5, 25°C, cosubstrate: S-methyl-L-methionine

694665

2.1.1.10

0.035

-

pH 7.5, 30°C, cosubstrate: S-methyl-L-methionine

441387

2.1.1.10

0.045

-

pH 6, 30°C, cosubstrate: S-adenosyl-L-methionine

692948

2.1.1.10

0.067

-

pH 7.5, 30°C, cosubstrate: S-adenosyl-L-methionine

441387

2.1.1.10

0.077

-

pH 7.5, 30°C, cosubstrate: S-methyl-L-methionine

441387

2.1.1.13

0.0026

-

-

441210

2.1.1.13

0.006

-

in 50 mM phosphate buffer, pH 7.4, at 37°C

673596

2.1.1.13

0.016

-

-

441183

2.1.1.13

0.016

-

-

441188

2.1.1.13

0.029

-

in 50 mM potassium phosphate (pH 7.2), 50 mM Tris-HCl (pH 7.2), 0.1 mM MgSO4, and 10 mM dithiothreitol, at 37°C

702050

2.1.1.13

0.069

-

-

441217

2.1.1.13

0.43

-

-

441185

2.1.1.14

0.01

-

or less

441331

2.1.1.14

0.013

-

in 50 mM potassium phosphate (pH 7.2), 50 mM Tris-Cl (pH 7.2) containing 0.1 mM MgSO4, 10 mM dithiothreitol and 2 mM L-homocysteine at 37°C

671587

2.1.1.14

0.014

-

in 50 mM potassium phosphate (pH 7.2), 50 mM Tris-Cl (pH 7.2) containing 0.1 mM MgSO4, 10 mM dithiothreitol and 2 mM L-homocysteine at 37°C

671587

2.1.1.14

0.022

-

-

441328

2.1.1.14

0.025

-

37°C, pH not specified in the publication

734490

2.1.1.14

0.041

-

cosubstrate S-methyl-L-methionine

441322

2.1.1.14

0.069

-

-

441217

2.1.1.14

0.6

-

cosubstrate 5-methyltetrahydropteroylglutamate

441322

2.1.1.280

0.045

-

app. Km-value with [methyl-14C]S-adenosyl-L-methionine, pH 6.5, 30°C

692948

2.1.1.280

0.74

-

mutant enzyme A184T, wild-type enzyme is not active with L-homocysteine

694691

2.1.1.5

0.004

-

recombinant enzyme

441241

2.1.1.5

0.0076

-

mutant Arg16Cys

689024

2.1.1.5

0.012

0.021

-

441233

2.1.1.5

0.015

-

wild-type, presence of 150 mM KCl, pH 7.5, 37°C

735230

2.1.1.5

0.0158

-

mutant Arg239Gln

689024

2.1.1.5

0.017

-

37°C, mutant enzyme E21A

657817

2.1.1.5

0.0206

-

mutant Gly199Ser

689024

2.1.1.5

0.0216

-

mutant Pro197Ser

689024

2.1.1.5

0.025

-

37°C, mutant enzyme C186A

657817

2.1.1.5

0.029

-

wild-type

689024

2.1.1.5

0.032

-

-

441243

2.1.1.5

0.034

-

37°C, mutant enzyme T184G

657817

2.1.1.5

0.049

-

37°C, mutant enzyme T73G

657817

2.1.1.5

0.057

-

37°C, mutant enzyme F74A

657817

2.1.1.5

0.063

-

37°C, mutant enzyme D26A

657817

2.1.1.5

0.068

-

37°C, mutant enzyme A119G

657817

2.1.1.5

0.073

-

37°C, mutant enzyme E21K

657817

2.1.1.5

0.074

-

37°C, mutant enzyme C186S

657817

2.1.1.5

0.106

-

37°C, wild-type enzyme

657817

2.1.1.5

0.12

-

-

441234

2.1.1.5

0.12

-

betaine

441235

2.1.1.5

0.12

-

-

673003

2.1.1.5

0.338

-

wild-type, pH 7.5, 37°C

735230

2.1.1.5

1.3

-

-

441247

2.1.1.5

2.3

-

wild-type, cosubstrate S-methylmethionine, presence of 150 mM KCl, pH 7.5, 37°C

735230

2.1.1.10

7 entries

2.1.1.13

7 entries

2.1.1.14

8 entries

2.1.1.280

2 entries

2.1.1.5

25 entries

2.5.1.49

4.17

-

at 45°C, pH 7.5

662480

2.6.1.14

24.7

-

cosubstrate 2-oxosuccinamate

637254

2.8.1.2

12.5

-

in 200 mM of HEPES, pH 7.4, at 37°C

725528

3.3.1.1

0.06

-

-

137131

3.3.1.1

0.08

-

liver enzyme

137148

3.3.1.1

0.085

-

-

696860

3.3.1.1

0.13

-

-

137122

3.3.1.1

0.135

-

at pH 6.5 and 75°C

731159

3.3.1.1

0.135

-

pH 6.5, 75°C

746772

3.3.1.1

0.148

-

truncated recombinant enzyme

137146

3.3.1.1

0.15

-

-

137121

3.3.1.1

0.152

-

complete recombinant enzyme

137146

3.3.1.1

0.156

-

mutant Sahn 12

137150

3.3.1.1

0.163

-

wild-type R 1.1

137150

3.3.1.1

0.2

-

-

137124

3.3.1.1

0.25

-

-

137127

3.3.1.1

1.2

-

-

137136

3.3.1.1

4.5

-

-

137135

3.3.1.1

150

-

-

678365

4.2.1.22

0.05

-

S466L mutant, 37°C, absence of S-adenosyl-L-methionine

650017

4.2.1.22

0.08

-

wild-type enzyme, 37°C, presence of S-adenosyl-L-methionine

650017

4.2.1.22

0.1

-

I435T mutant, 37°C, absence of S-adenosyl-L-methionine

650017

4.2.1.22

0.16

-

mutant S289A

702457

4.2.1.22

0.17

-

wild-type enzyme, 37°C, absence of S-adenosyl-L-methionine

650017

4.2.1.22

0.2

-

I435T mutant, 37°C, presence of S-adenosyl-L-methionine

650017

4.2.1.22

0.21

-

wild-type

702457

4.2.1.22

0.29

-

wild-type, 37°C, pH not specified in the publication

747922

4.2.1.22

0.3

-

pH 8.6, 37°C

650216

4.2.1.22

0.31

-

mutant K523Sfs?18, 37°C, pH not specified in the publication

747922

4.2.1.22

0.32

-

wild-type, production of H2S, pH 8.2, 37°C

747747

4.2.1.22

0.32

-

mutant S500L, 37°C, pH not specified in the publication

747922

4.2.1.22

0.35

-

mutant V449G, 37°C, pH not specified in the publication

747922

4.2.1.22

0.4

-

mutant D444N, 37°C, pH not specified in the publication

747922

4.2.1.22

0.4

-

formation of L-cystathionine, mutant E223G, pH 7.5, 37°C

749243

4.2.1.22

0.43

-

recombinant 6-His-tagged enzyme, in 50 mM Tris (pH 8.6), at 25°C

701064

4.2.1.22

0.47

-

mutant L540Q, 37°C, pH not specified in the publication

747922

4.2.1.22

0.54

-

formation of L-cystathionine, wild-type, pH 7.5, 37°C

749243

4.2.1.22

0.59

-

-

5584

4.2.1.22

0.59

-

-

5586

4.2.1.22

0.59

-

-

5587

4.2.1.22

0.69

-

mutant P427L, 37°C, pH not specified in the publication

747922

4.2.1.22

0.8

-

enzyme composed of MW 48000 subunits

5585

4.2.1.22

1

-

37°C, pH 8.0, wild-type enzyme, with S-adenosyl-L-methionine

677837

4.2.1.22

1

-

synthesis of L-cystathionine, presence of S-adenosyl-L-methionine, pH 7.4, 37°C

746768

4.2.1.22

1.04

-

37°C, pH 8.0, wild-type enzyme, without S-adenosyl-L-methionine

677837

4.2.1.22

1.04

-

synthesis of L-cystathionine, pH 7.4, 37°C

746768

4.2.1.22

1.1

-

absence of S-adenosyl-L-methionine

5600

4.2.1.22

1.1

-

mutant enzyme S466L, in the presence of 0.25 mM S-adenosyl-L-methionine

698182

4.2.1.22

1.2

-

37°C, L-serine pre-treatment

652270

4.2.1.22

1.3

-

mutant R266K

704974

4.2.1.22

1.51

-

mutant E220R, pH 8.2, 37°C

747747

4.2.1.22

1.6

-

mutant R266K

704974

4.2.1.22

2

-

37°C, pH 8.6, mutant enzyme I278T

680084

4.2.1.22

2.2

-

37°C

649915

4.2.1.22

2.25

-

-

5599

4.2.1.22

2.3

-

37°C, homocysteine pre-treatment

652270

4.2.1.22

2.5

-

wild type enzyme, in the presence of 0.25 mM S-adenosyl-L-methionine

698182

4.2.1.22

2.73

-

wild-type, pH 8.2, 37°C

747747

4.2.1.22

3.4

-

mutant H67A

704974

4.2.1.22

3.41

-

enzyme form beta

5591

4.2.1.22

3.59

-

mutant A72S, pH 8.2, 37°C

747747

4.2.1.22

3.7

-

pH 8.0, 37°C

663623

4.2.1.22

3.98

-

enzyme form alpha

5591

4.2.1.22

4.31

-

cosubstrate L-cysteine, pH 7.4, 37°C

746768

4.2.1.22

4.48

-

cosubstrate L-cysteine, presence of S-adenosyl-L-methionine, pH 7.4, 37°C

746768

4.2.1.22

4.8

-

absence of S-adenosyl-L-methionine, recombinant enzyme

5601

4.2.1.22

5

-

presence of S-adenosyl-L-methionine, recombinant enzyme

5601

4.2.1.22

5

-

pH 6.8, 37°C, full length enzyme after L-serine pre-treatment

649869

4.2.1.22

5

-

wild-type

704974

4.2.1.22

7.17

-

37°C, pH 8.6, mutant enzyme R266K; 37°C, pH 8.6, wild-type enzyme

680084

4.2.1.22

9.7

-

pH 6.8, 37°C, deltaC143 mutant after L-serine pre-treatment

649869

4.2.1.22

15

-

pH 6.8, 37°C, full length enzyme after homocysteine pre-treatment

649869

4.2.1.22

18

-

-

5584

4.2.1.22

18

-

cosubstrate L-Ser

5594

4.2.1.22

20

-

formation of L-cystathionine, mutant A70S, pH 7.5, 37°C

749243

4.2.1.22

25

-

enzyme composed of MW 68000 subunits

5585

4.2.1.22

67

-

pH 6.8, 37°C, deltaC143 mutant after homocysteine pre-treatment

649869

4.4.1.1

5.4

-

for variante S403

690967

4.4.1.1

7

-

for variante I403

690967

4.4.1.1

8

-

for mutante T67I

690967

4.4.1.11

1.78

-

pH 8.0, 37°C

748253

4.4.1.11

6.43

-

-

701880

4.4.1.2

0.549

-

-

34598

4.4.1.2

2.46

-

pH 7.0, 35°C

722937

6.1.1.10

1.8

-

editing reaction, mitochondrial isozyme, pH 7.8, 25°C

652862

6.1.1.10

3.1

-

editing reaction, cytoplasmic isozyme, pH 7.8, 25°C

652862

3.3.1.1

16 entries

4.2.1.22

58 entries

4.4.1.1

3 entries

4.4.1.11

2 entries

4.4.1.2

2 entries

6.1.1.10

2 entries