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Sulphur metabolism in Paracoccus denitrificans. Purification, properties and regulation of cysteinyl- and methionyl-tRNA synthetase
1977
Burnell, J.N.; Whatley, F.R.
Biochim. Biophys. Acta
481
266-278
-
Specificity and kinetic properties of the cysteinyl-tRNA synthetase from rat liver
1976
Pan, F.; Yu, T.C.; Duh, G.M.; Lee, H.H.
J. Chin. Biochem. Soc.
5
45-56
Glutathione biosynthesis: gamma-Glutamylcysteine synthetase from rat kidney
1985
Seelig, G.F.; Meister, A.
Methods Enzymol.
113
379-390
-
gamma-Glutamylcysteine synthetase from Proteus mirabilis
1982
Kumagai, H.; Nakayama, R.; Tochikura, T.
Agric. Biol. Chem.
46
1301-1309
-
gamma-Glutamylcysteine synthetase (rat kidney)
1971
Orlowski, M.; Meister, A.
Methods Enzymol.
17B
495-500
Nitro analogs of substrates for adenylosuccinate synthetase and adenylosuccinate lyase
1983
Porter, D.J.T.; Rudie, N.G.; Bright, H.J.
Arch. Biochem. Biophys.
225
157-163
-
Purification and characterization of amino acid racemase with very broad substrate specificity from Aeromonas caviae
1987
Inagaki, K.; Tanizawa, K.; Tanaka, H.; Soda, K.
Agric. Biol. Chem.
51
173-180
The beta-replacement-specific pyridoxal-P-dependent lyases
1984
Braunstein, A.E.; Goryachenkova, E.V.
Adv. Enzymol. Relat. Areas Mol. Biol.
56
1-89
Biosynthesis and proteolytic activation of cystathionine beta-synthase in rat liver
1984
Skovby, F.; Kraus, J.P.; Rosenberg, L.E.
J. Biol. Chem.
25
588-593
Cystathionine beta-synthase from human liver: improved purification scheme and additional characterization of the enzyme in crude and pure form
1983
Kraus, J.P.; Rosenberg, L.E.
Arch. Biochem. Biophys.
222
44-52
Purification and properties of cystathionine beta-synthase from human liver
1978
Kraus, J.; Packman, S.; Fowler, B.; Rosenberg, L.E.
J. Biol. Chem.
253
6523-6528
The existence of human liver cystathionine beta-synthase in multiple molecular forms
1977
Ansell, P.R.J.; Tudball, N.
Biochim. Biophys. Acta
483
443-451
-
Cystathionine synthase (rat liver)
1971
Suda, M.; Nakagawa, H.; Kimura, H.
Methods Enzymol.
17B
454-458
Rat cystathionine beta-synthase: expression of four alternatively spliced isoforms in transfected cultured cells
1992
Roper, M.D.; Kraus, J.P.
Arch. Biochem. Biophys.
298
514-521
Purification and properties of cystathionine synthase from human liver
1975
Tudball, N.; Reed, M.A.
Biochem. Biophys. Res. Commun.
67
550-555
Characterization of human cystathionine beta-synthase. Evidence for the identity of human L-serine dehydratase and cystathionine beta-synthase
1974
Porter, P.N.; Grishaver, M.S.; Jones, O.W.
Biochim. Biophys. Acta
364
128-139
An Aspergillus nidulans mutant lacking cystathionine beta-synthase: identity of L-serine sulfhydrolase with cystathionine beta-synthase and its distinctness from O-acetyl-L-serine sulfhydrolase
1973
Pieniazek, N.J.; Stepien, P.P.; Paszewski, A.
Biochim. Biophys. Acta
297
37-47
Specificity and some other properties of liver serine sulphhydrolase: evidence for its identity with cystathionine beta-synthase
1971
Braunstein, A.E.; Goryachenkova, E.V.; Tolosa, E.A.; Willhardt, I.H.; Yefremova, L.L.
Biochim. Biophys. Acta
242
247-260
-
Purification and properties of cystathionine synthetase from rat liver: separation of cystathionine synthetase from serine dehydratase
1968
Nakagawa, H.; Kimura, H.
Biochem. Biophys. Res. Commun.
32
208-214
-
Biosynthese des Cysteins. I. Nachweis und Isolierung der Serinsulfhydrase aus Bäckerhefe
1962
Schlossmann, K.; Brueggemann, J.; Lynen, F.
Biochem. Z.
336
258-273
Biochemical characterization of the enzyme responsible for activated L-serine sulphydrase" activity in nematodes
1992
Walker, J.; Barrett, J.
Exp. Parasitol.
74
205-215
The identification of a variant form of cystathionine beta-synthase
1992
Walker, J.; Barrett, J.; Thong, K.W.
Exp. Parasitol.
75
415-424
Purification and properties of Saccharomyces cerevisiae cystathionine beta-synthase
1994
Ono, B.I.; Kijima, K.; Inoue, T.; Miyoshi, A.I.; Matsuda, A.; Shinoda, S.
Yeast
10
333-339
Expression of human cystathionine beta-synthase in Escherichia coli: purification and characterization
1994
Bukovska, G.; Kery, V.; Kraus, J.P.
Protein Expr. Purif.
5
442-448
Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity
1998
Taoka, S.; Ohja, S.; Shan, X.; Kruger, W.D.; Banerjee, R.
J. Biol. Chem.
273
25179-25184
Binding of pyridoxal 5'-phosphate to the heme protein human cystathionine beta-synthase
1999
Kery, V.; Poneleit, L.; Meyer, J.D.; Manning, M.C.; Kraus, J.P.
Biochemistry
38
2716-2724
A novel cystathionine beta-synthase from Panagrellus redivivus (Nematoda)
1996
Papadopoulos, A.I.; Walker, J.; Barrett, J.
Int. J. Biochem. Cell Biol.
28
543-549
Trypsin cleavage of human cystathionine beta-synthase into an evolutionary conserved active core: structural and functional consequences
1998
Kery, V.; Poneleit, L.; Kraus, J.P.
Arch. Biochem. Biophys.
355
222-232
Characterization of mutations in the cystathionine beta-synthase gene in irish patients with homocystinuria
1998
Gallagher, P.M.; Naughten, E.; Hanson, N.Q.; Schwichtenberg, K.; Bignell, M.; Yuan, M.; Ward, P.; Yap, S.; Whitehead, A.S.; Tsai, M.Y.
Mol. Genet. Metab.
65
298-302
Stereospecific irreversible inhibition of histidine ammonia-lyase by L-cysteine
1974
Klee, C.B.
Biochemistry
13
4501-4507
Insight into the active site of Streptomyces cystathionine gamma-lyase based on the results of studies on its substrate specificity
1987
Kanzaki, H.; Nagasawa, T.; Yamada, H.
Biochim. Biophys. Acta
913
45-50
-
Synthesis of S-substituted L-homocysteine derivatives by cystathionine gamma-lyase of Streptomyces phaeochromogenes
1986
Kanzaki, H.; Kobayashi, M.; Nagasawa, T.; Yamada, H.
Agric. Biol. Chem.
50
391-397
Purification and characterization of cystathionine gamma-lyase from Lactobacillus fermentum DT41
1998
Smacchi, E.; Gobbetti, M.
FEMS Microbiol. Lett.
166
197-202
Cystalysin, a 46-kDa L-cysteine desulfhydrase from Treponema denticola: biochemical and biophysical characterization
1999
Chu, L.; Ebersole, J.L.; Kurzban, G.P.; Holt, S.C.
Clin. Infect. Dis.
28
442-450
Exchange reactions catalyzed by methioninase from Pseudomonas putida
1975
Ito, S.; Nakamura, T.; Eguchi, Y.
J. Biochem.
78
1105-1107
-
Purification and properties of 1-aminocyclopropane-1-carboxylate synthase of mesocarp of Cucurbita maxima Duch. fruits
1986
Nakajima, N.; Imaseki, H.
Plant Cell Physiol.
27
969-980
Trichomonas species: homocysteine desulphurase and serine sulphydrase activities
1987
Thong, K.W.; Coombs, G.H.
Exp. Parasitol.
63
143-151
-
Homocysteine desulphurase activity in trichomonads
1985
Thong, K.W.; Coombs, G.H.
IRCS Med. Sci. Libr. Compend.
13
493-494
Function of pyridoxal phosphate in desulfhydrase system of Proteus morganii
1951
Kallio, R.E.
J. Biol. Chem.
192
371-377
Cystathionine beta-lyase from Escherichia coli
1987
Uren, J.R.
Methods Enzymol.
143
483-486
-
Cystathionine beta-lyase from spinach
1987
Giovanelli, J.
Methods Enzymol.
143
443-449
-
beta-Cystathionase (Salmonella)
1971
Guggenheim, S.
Methods Enzymol.
17B
439-442
Purification and characterization of cystathionine beta-lyase from Lactococcus lactis subsp. cremonis B78 and its possible role in flavor development in cheese
1995
Alting, A.C.; Engels, W.J.M.; van Schalkwijk, S.; Exterkate, F.A.
Appl. Environ. Microbiol.
61
4037-4042
Cloning, purification, and characterization of beta-cystathionase from Escherichia coli
1982
Dwivedi, C.M.; Ragin, R.C.; Uren, J.R.
Biochemistry
21
3064-3069
Sulphur metabolism in Paracoccus denitrificans. Purification, properties and regulation of serine transacetylase, O-acetylserine sulphydrylase and beta-cystathionase
1977
Burnell, J.N.; Whatley, F.R.
Biochim. Biophys. Acta
481
246-265
beta-Cystathionase. In vivo inactivation by rhizobitoxine and role of the enzyme in methionine biosynthesis in corn seedlings
1972
Giovanelli, J.; Owens, L.D.; Mudd, S.H.
Plant Physiol.
51
492-503
Transsulfuration in higher plants. Partial purification and properties of beta-cystathionase of spinach
1971
Giovanelli, J.; Mudd, S.H.
Biochim. Biophys. Acta
227
654-670
Rhizobium-synthesized phytototoxin: an inhibitor of beta-cystathionase in Salmonella typhimurium
1968
Owens, L.D.; Guggenheim, S.; Hilton, J.L.
Biochim. Biophys. Acta
158
219-225
Cystathionine cleavage enzymes of Neurospora
1964
Flavin, M.; Slaughter, C.
J. Biol. Chem.
239
2212-2219
Cloning, purification, and crystallization of Escherichia coli cystathionine beta-lyase
1996
Laber, B.; Clausen, T.; Huber, R.; Messerschmidt, A.; Egner, U.; Muller-Fahrnow, A.; Pohlenz, H.D.
FEBS Lett.
379
94-96
Mechanism of inhibition of spinach beta-cystathionase by rhizobitoxine
1971
Giovanelli, J.; Owens, L.D.; Mudd, H.
Biochim. Biophys. Acta
227
671-684
-
Enzyme catalysed alpha,beta-elimination of selenocystathionine and selenocystine and their sulphur isologues by plant extracts
1986
McCluskey, T.J.; Scarf, A.R.; Anderson, J.W.
Phytochemistry
25
2063-2068
Methionine biosynthesis in higher plants. II. Purification and characterization of cystathionine beta-lyase from spinach chloroplasts
1995
Droux, M.; Ravanel, S.; Douce, R.
Arch. Biochem. Biophys.
316
585-595
Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and x-ray study
1997
Clausen, T.; Huber, R.; Messerschmidt, A.; Pohlenz, H.D.; Laber, B.
Biochemistry
36
12633-12643
Intracellular localization of aspartate kinase and the enzymes of threonine and methionine biosynthesis in green leaves
1983
Wallsgrove, R.M.; Lea, P.J.; Miflin, B.J.
Plant Physiol.
71
780-784
-
Biosynthesis of homocysteine in a facultative methylotroph, Pseudomonas FM518
1983
Morinaga, Y.; Tani, Y.; Yamada, H.
Agric. Biol. Chem.
47
2855-2860
-
The metC gene in Escherichia coli K-12: isolation and studies of relatedness in Enterobacteriaceae
1984
Michaeli, S.; Ron, E.Z.
FEMS Microbiol. Lett.
22
31-35
Sulfate assimilation in C4 plants. Intercellular and intracellular location of ATP sulfurylase, cysteine synthase, and cystathionine beta-lyase in maize leaves
1984
Burnell, J.N.
Plant Physiol.
75
873-875
Evolution in biosynthetic pathways: two enzymes catalyzing consecutive steps in methionine biosynthesis originate from a common ancestor and possess a similar regulatory region
1986
Belfaiza, J.; Parsot, C.; Martel, A.; Bouthier de la Tour, C.; Margarita, D.; Cohen, G.N.; Saint-Girons, I.
Proc. Natl. Acad. Sci. USA
83
867-871
Pyridoxal 5 phosphate binding site of Escherichia coli beta cystathionase and cystathionine gamma synthase comparison of their sequences
1987
Martel, A.; Bouthier de la Tour, C.; le Goffic, F.
Biochem. Biophys. Res. Commun.
147
565-571
Cloning and characterization of the metC gene from Salmonella typhimurium LT2
1987
Park, Y.M.; Stauffer, G.V.
Gene
60
291-297
-
Occurrence of two types of cystathionine beta-cleavage enzyme in Bacillus subtilis
1972
Sakata, T.; Hiroishi, S.; Kadota, H.
Agric. Biol. Chem.
36
333-335
Purification and properties of cystathionine beta-lyase from Arabidopsis thaliana overexpressed in Escherichia coli
1996
Ravanel, S.; Job, D.; Douce, R.
Biochem. J.
320
383-392
-
Cystathionine beta-lyase from Echinochloa colonum tissue culture
1998
Turner, W.L.; Pallett, K.E.; Lea, P.J.
Phytochemistry
47
189-196
Crystal structure of the pyridoxal-5 -phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A
1996
Clausen, T.; Huber, R.; Laber, B.; Pohlenz, H.D.; Messerschmidt, A.
J. Mol. Biol.
262
202-224
Toxicity of Bordetella avium beta-cystathionase toward MC3T3-E1 osteogenic cells
1993
Gentry-Weeks, C.R.; Keith, J.M.; Thompson, J.
J. Biol. Chem.
268
7298-7314
beta-Cystathionase from Bordetella avium. Role(s) of lysine 214 and cysteine residues in activity and cytotoxicity
1995
Gentry-Weeks, C.R.; Spokes, J.; Thompson, J.
J. Biol. Chem.
270
7695-7702
Mode of action of cystathionine beta-lyase
1997
Clausen, T.; Laber, B.; Messerschmidt, A.
Biol. Chem.
378
321-326
The C-S lyases of higher plants: homogeneous beta-cystathionase of spinach leaves
1991
Staton, A.L.; Mazelis, M.
Arch. Biochem. Biophys.
290
46-50
-
Effect of disulfide-reducing agents on activity of 1-methlyadenosine ribohydrolase in starfish follicle cells
1986
Mita, M.
Dev. Growth Differ.
28
67-74
-
Biochemical studies on structure and function of human placenta adenosyl homocysteinase
1988
Refaie, M.O.I.
J. Egypt. Med. Assoc.
71
235-246
Purification of bovine liver S-adenosylhomocysteine hydrolase by affinity chromatography on blue dextran-agarose
1988
Narayanan, S.R.; Borchardt, R.T.
Biochim. Biophys. Acta
965
22-28
Adenosylhomocysteinase (bovine)
1987
Chiang, P.K.
Methods Enzymol.
143
377-383
Adenosylhomocysteinase from Yellow lupine
1987
Guranowski, A.; Jakubowski, H.
Methods Enzymol.
143
430-434
-
Mechanism of action of S-adenosyl-L-homocysteine hydrolase. Measurement of kinetic isotope effects using adenosine-3'-d and S-adenosyl-L-homocysteine-3'-d as substrates
1985
Sinhababu, A.K.; Bartel, R.L.; Pochopin, N.; Borchardt, R.T.
J. Am. Chem. Soc.
107
7628-7632
S-Adenosylhomocysteine hydrolase from human placenta. Affinity purification and characterization
1985
Hershfield, M.S.; Aiyar, V.N.; Premakumar, R.; Small, W.C.
Biochem. J.
230
43-52
Purification and characterization of S-adenosylhomocysteine hydrolase from mouse mastocytoma P-815 cells. Evidence for cell cycle-specific fluctuation of the enzyme activity
1985
Ichikawa, A.; Sato, S.; Tomita, K.
J. Biochem.
97
189-197
Purification of S-adenosyl-L-homocysteine hydrolase from Dictyostelium discoideum: Reversible inactivation by cAMP and 2 -deoxyadenosine
1984
Hohman, R.J.; Guitton, M.C.; Veron, M.
Arch. Biochem. Biophys.
233
785-795
Occurrence of S-adenosylhomocysteine hydrolase in prokaryote cells. Characterization of the enzyme from Alcaligenes faecalis and role of the enzyme in the activated methyl cycle
1984
Shimizu, S.; Shiozaki, S.; Ohshiro, T.; Yamada, H.
Eur. J. Biochem.
141
385-392
-
S-Adenosyl-L-homocysteine hydrolase from mouse leukemic cells: Isolation and properties
1983
Merta, A.; Votruba, I.; Vesel², J.; Hol², A.
Collect. Czech. Chem. Commun.
48
2701-2708
S-Adenosylhomocysteine hydrolase from hamster liver: purification and kinetic properties
1983
Kim, I.K.; Zhang, C.Y.; Chiang, P.K.; Cantoni, G.L.
Arch. Biochem. Biophys.
226
65-72
Comparison of some physicochemical and kinetic properties of S-adenosylhomocysteine hydrolase from bovine liver, bovine adrenal cortex and mouse liver
1982
Doskeland, S.O.; Ueland, P.M.
Biochim. Biophys. Acta
708
185-193
Affinity-chromatographic purification of S-adenosyl-L-homocysteine hydrolase. Some properties of the enzyme from rat liver
1981
Kajander, E.O.; Raina, A.M.
Biochem. J.
193
503-512
S-Adenosylhomocysteine hydrolase from rat liver. Purification and some properties
1981
Fujioka, M.; Takata, Y.
J. Biol. Chem.
256
1631-1635
Adenosylhomocysteine hydrolase. Crystallization of the purified enzyme and its properties
1978
Richards, H.H.; Chiang, P.K.; Cantoni, G.L.
J. Biol. Chem.
253
4476-4480
Adenosylhomocysteinase from yellow lupin seeds. Purification and properties
1977
Guranowski, A.; Pawelkiewicz, J.
Eur. J. Biochem.
80
517-523
S-Adenosylhomocysteine metabolism in various species
1975
Walker, R.D.; Duerre, J.A.
Can. J. Biochem.
53
312-319
Purification and properties of S-adenosyl-L-homocysteine hydrolase from leaves of spinach beet
1976
Poulton, J.E.; Butt, V.S.
Arch. Biochem. Biophys.
172
135-142
Partial purification and characterization of S-adenosylhomocysteine hydrolase isolated from Saccharomyces cerevisiae
1972
Knudsen, R.C.; Yall, I.
J. Bacteriol.
112
569-575
Site-directed mutagenesis of rat liver S-adenosylhomocysteinease. Effect of conversion of aspartic acid 244 to glutamic acid on coenzyme binding
1990
Gomi, T.; Takata, Y.; Date, T.; Fujioka, M.; Aksamit, R.R.; Backlund Jr., P.S.; Cantoni, G.L.
J. Biol. Chem.
265
16102-16107
Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxyaldehydes and oximes synthesized from adenosine and sugar-modified analogues
1997
Wnuk, S.F.; Yuan, C.S.; Borchardt, R.T.; Balzarini, J.; De Clercq, E.; Robins, M.J.
J. Med. Chem.
40
1608-1628
4',5'-Unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase
1991
Jarvi, E.T.; McCarthy, J.R.; Mehdi, S.; Matthews, D.P.; Edwards, M.L.; Prakash, N.J.; Bowlin, T.L.; Sunkara, P.S.; Bey, P.
J. Med. Chem.
34
647-656
Trichomonas vaginalis: Expression and characterization of recombinant S-adenosylhomocysteinase
1998
Minotto, L.; Ko, G.A.; Edwards, M.R.; Bagnara, A.S.
Exp. Parasitol.
90
175-180
Effects of ions on adenosine binding and enzyme activity of purified S-adenosylhydrolase from bovine kidney
1998
Kloor, D.; Fuchs, S.; Petroktistis, F.; Delabar, U.; Muhlbauer, B.; Quast, U.; Osswald, H.
Biochem. Pharmacol.
56
1493-1496
Inhibition studies of S-adenosylhomocysteine hydrolase purified from Acinetobacter calcoaceticus ULA-501
1996
Impagnatiello, A.; Franceschini, N.; Oratore, A.; Bozzi, A.
Biochimie
78
267-272
-
Adenosine analogues as inhibitors or inactivators of S-adenosylhomocysteine hydrolase from bovine pancreas
1993
Bozzi, A.; Parisi, M.; Martini, F.
J. Enzyme Inhib.
7
159-167
Expression, purification, and characterization of recombinant S-adenosylhomocysteine hydrolase from the thermophilic archaeon Sulfolobus solfactorius
2000
Porcelli, M.; Fusco, S.; Inizio, T.; Zappia, V.; Cacciapuoti, G.
Protein Expr. Purif.
18
27-35
S-adenosylhomocysteine-hydrolase from bovine kidney: Enzymatic and binding properties
1996
Kloor, D.; Kurz, J.; Fuchs, S.; Faust, B.; Osswald, H.
Kidney Blood Press. Res.
19
100-108
A sensitive isotopic assay method for S-adenosylhomocysteine hydrolase. Some properties of the enzyme from rat liver
1976
Kajander, O.; Eloranta, T.; Raina, A.
Biochim. Biophys. Acta
438
522-531
S-Adenosylhomocysteine hydrolases as the primary target enzymes in androgen regulation of methylation complexes
1981
Liau, M.C.; Chang, C.F.; Saunders, G.F.; Tsai, Y.H.
Arch. Biochem. Biophys.
208
261-272
Selection and characterization of a murine lymphoid cell line partially deficient in S-adenosylhomocysteine hydrolase
1983
Kamatani, N.; Willis, E.H.; Carson, D.A.
Biochim. Biophys. Acta
762
205-214
Inhibition by homocysteine of serine dehydratase and other pyridoxal 5'-phosphate enzymes of the rat through cofactor blockage
1971
Pestana, A.; Sandoval, I.V.; Sols, A.
Arch. Biochem. Biophys.
146
373-379
Purification and characterization of S-adenosylhomocysteine deaminase from streptonigrin-producing Streptomyces flocculus
1989
Zulty, J.J.; Speedie, M.K.
J. Bacteriol.
171
6840-6844
Purification and properties of adenosine 5'-phosphosulphate sulphotransferase from Euglena
1991
Li, J.; Schiff, J.A.
Biochem. J.
274
355-360
Semi-aldehyde aspartic dehydrogenase of Saccharomyces cerevisiae: properties and regulation
1967
Surdin, Y.
Eur. J. Biochem.
2
341-348
-
Oxidative deamination of sulfur amino acids by bacterial and snake venom L-amino acid oxidase
1971
Chen, S.S.; Walgate, J.H.; Duerre, J.A.
Arch. Biochem. Biophys.
146
51-63
Enzymatic oxidation of L-homocysteine
1985
Cooper, A.J.L.; Meister, A.
Arch. Biochem. Biophys.
239
556-566
-
Mechanism-based inactivity of L-pipecolate oxidase by a sulfur-containing substrate analog, 5-thia-L-pipecolic acid
1997
Zabriskie, T.M.; Liang, X.
Bioorg. Med. Chem. Lett.
7
457-462
Glutathione-homocystine transhydrogenase
1955
Racker, E.
J. Biol. Chem.
217
867-874
-
Methionine biosynthesis (hog liver)
1971
Buchanan, J.M.
Methods Enzymol.
17B
371-378
-
Pentaglutamate derivatives of folate as substrates for rat liver tetrahydropteroylglutamate methyltransferase and 5,10-methylenetetrahydrofolate reductase
1975
Cheng, F.W.; Shane, B.; Stokstad, E.L.R.
Can. J. Biochem.
53
1020-1027
Biochemical studies on the activity of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus
1992
Zhang, J.; Wolfe, S.; Demain, A.L.
Biochem. J.
283
691-698
Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli
1964
Guest, J.R.; Friedman, S.; Foster, M.A.; Tejerina, G.; Woods, D.D.
Biochem. J.
92
497-504
Enzymatic synthesis of the methyl group of methionine
1964
Loughlin, R.E.; Elford, H.L.; Buchanan, J.M.
J. Biol. Chem.
239
2888-2895
Cobalamin and the synthesis of methionine by Escherichia coli
1964
Foster, M.A.; Dilworth, M.J.; Woods, D.D.
Nature
201
39-42
The isolation of N5-methyltetrahydrofolate-homocysteine transmethylase from bovine brain
1972
Magnum, J.H.; Steuart, B.W.; North, J.A.
Arch. Biochem. Biophys.
148
63-69
Escherichia coli B N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: binding of the folate substrate to the enzyme
1972
Taylor, R.T.; Hanna, M.L.
Arch. Biochem. Biophys.
151
401-413
On the cation sensibility of the vitamin B12-dependent methionine synthetase (5-methyltetrahydrofolate-homocysteine-methyltransferase from Escherichia coli)
1973
Rudiger, H.
FEBS Lett.
35
295-298
Isolation of a cobalamin containing 5-methyltetrahydrofolate-homocysteine transmethylase from mammalian kidney
1971
Mangum, J.H.; North, J.A.
Biochemistry
10
3765-3769
-
N5-Methyltetrahydrofolate-homocysteine methyltransferases
1973
Taylor, R.T.; Weissbach, H.
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
12
121-165
Purification and properties of the tetrahydropteroylglutamate methyltransferase from green beans (Phaseolus vulgaris)
1977
Grabau, W.; Rudiger, H.
Hoppe-Seyler's Z. Physiol. Chem.
358
695-698
-
N5-Methytetrahydrofolate-homocysteine (vitamin B12) methyltransferase (Escherichia coli B)
1971
Taylor, R.T.; Weissbach, H.
Methods Enzymol.
17B
379-388
-
B12-dependent methyl-H4-Folate homocysteine methyltransferase in Euglena gracilis
1984
Lucchini, G.; Piazza, I.; Biachetti, R.
Plant Sci. Lett.
36
177-179
Activation of methionine synthetase by a reduced triphosphopyridine nucleotide-dependent flavoprotein system
1974
Fujii, K.; Huennekens, F.M.
J. Biol. Chem.
249
6745-6753
5-methyl-5,6,7,8-tetrahydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with methionine synthetase from bovine brain
1975
Coward, J.K.; Chello, P.L.; Cashmore, A.R.; Parameswaran, K.N.; DeAngelis, L.M.; Bertiono, J.R.
Biochemistry
14
1548-1552
Heterologous high level expression, purification, and enzymological properties of recombinant rat cobalamin-dependent methionine synthase
1999
Yamada, K.; Yamada, S.; Tobimatsu, T.; Torava, T.
J. Biol. Chem.
274
35571-35576
L-Selenohomocysteine: One-step synthesis from L-selenomethionine and kinetic analysis as substrate for methionine synthases
2000
Zhou, Z.S.; Smith, A.E.; Matthews, R.G.
Bioorg. Med. Chem. Lett.
10
2471-2475
Betaine-homocysteine S-methyltransferase (human)
1987
Skiba, W.E.; Wells, M.S.; Mangum, J.H.; Awad, W.M.
Methods Enzymol.
143
384-388
Methionine metabolism in mammals: kinetic study of betaine-homocysteine methyltransferase
1972
Finkelstein, J.D.; Harris, B.J.; Kyle, W.E.
Arch. Biochem. Biophys.
153
320-324
Human hepatic methionine biosynthesis. Purification and characterization of betaine:homocysteine S-methyltransferase
1982
Skiba, W.E.; Taylor, M.P.; Wells, M.S.; Mangum, J.H.; Awad, W.M.
J. Biol. Chem.
257
14944-14948
Betaine:homocysteine methyltransferase from rat liver: purification and inhibition by a boronic acid substrate analog
1992
Lee, K.H.; Cava, M.; Amiri, P.; Ottoboni, T.; Lindquist, R.N.
Arch. Biochem. Biophys.
292
77-86
Inactivation of betaine-homocysteine methyltransferase by adenosylmethionine and adenosylethionine
1984
Finkelstein, J.D.; Martin, J.J.
Biochem. Biophys. Res. Commun.
118
14-19
Evidence for direct methyl transfer in betaine: homocysteine S-methyl-transferase
1983
Awad, W.M.; Whitney, P.L.; Skiba, W.E.; Mangum, J.H.; Wells, M.S.
J. Biol. Chem.
258
12790-12792
Human betaine-homocysteine methyltransferase is a zinc metalloenzyme
1998
Millian, N.S.; Garrow, T.A.
Arch. Biochem. Biophys.
356
93-98
Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase
1996
Garrow, T.A.
J. Biol. Chem.
271
22831-22838
Betaine-homocysteine methyltransferase is a developmentally regulated enzyme crystallin in rhesus monkey lens
1998
Rao, P.V.; Garrow, T.A.; John, F.; Garland, D.; Millian, N.S.; Zigler, J.S., Jr.
J. Biol. Chem.
273
30669-30674
Degradation of glycinebetaine by betaine-homocysteine methyltransferase in Aphanothece halophytica: effect of salt downshock and starvation
2000
Incharoensakdi, A.; Waditee, R.
Curr. Microbiol.
41
227-231
Purification and kinetic properties of betaine-homocysteine methyltransferase from Aphanothece halophytica
2001
Waditee, R.; Incharoensakdi, A.
Curr. Microbiol.
43
107-111
-
Sulphur metabolism. F. Enzymes involved in the synthesis of methionine
1990
Madison, J.T.
Methods Plant Biochem.
3
361-369
Purification and properties of 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase
1970
Whitefield, C.D.; Steers, E.J.; Weissbach, H.
J. Biol. Chem.
245
390-401
-
Methionine synthesis (Yeast)
1971
Burton, E.; Sakami, W.
Methods Enzymol.
17B
388-392
Vitamin-B12-independent methionine synthase from a higher plant (Catharanthus roseus). Molecular characterization, regulation, heterologous expression, and enzyme properties
1995
Eichel, J.; Gonzalez, J.C.; Hotze, M.; Matthews, R.G.; Schroeder, J.
Eur. J. Biochem.
230
1053-1058
The formation of methionine from the monoglutamate form of methyltetrahydrofolate by higher plants
1969
Burton, E.G.; Sakami, W.
Biochem. Biophys. Res. Commun.
36
228-234
Plant methionine synthase: new insights into properties and expression
2000
Eckermann, C.; Eichel, J.; Schroder, J.
Biol. Chem.
381
695-703
Methionine biosynthesis in Escherichia coli: induction and repression of methylmethionine(or adenosylmethionine):homocysteine methyltransferase
1967
Balish, E.; Shapiro, S.K.
Arch. Biochem. Biophys.
119
62-68
Adenosylmethionine-homocysteine transmethylase
1958
Shapiro, S.K.
Biochim. Biophys. Acta
29
405-409
Assay of S-methylmethionine and S-adenosylmethionine homocysteine transmethylases
1959
Shapiro, S.K.; Yphantis, D.A.
Biochim. Biophys. Acta
36
241-244
-
S-Adenosylmethionine:L-homocysteine S-methyltransferase (Saccharomyces cerevisiae)
1971
Shapiro, S.K.
Methods Enzymol.
17B
400-405
The activity of adenosyl-D-methionine and adenosyl-2-methylmethionine in transmethylations
1976
Nakamura, K.D.; Schlenk, F.
Arch. Biochem. Biophys.
177
170-175
Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis
2000
Ranocha, P.; Bourgis, F.; Ziemak, M.J.; Rhodes, D.; Gage, D.A.; Hanson, A.D.
J. Biol. Chem.
275
15962-15968
Reverse methionine biosynthesis from S-adenosylmethionine in eukaryotic cells
2000
Thomas, D.; Becker, A.; Surdin-Kerjan, Y.
J. Biol. Chem.
275
40718-40724
New enzymatic colorimetric assay for total homocysteine
2001
Matsuyama, N.; Yamaguchi, M.; Toyosato, M.; Takayama, M.; Mizuno, K.
Clin. Chem.
47
2155-2157
Purification and characterization of Streptomyces griseus catechol O-methyltransferase
2000
Dhar, K.; Rosazza, J.P.N.
Appl. Environ. Microbiol.
66
4877-4882
The S-methylmethionine cycle in Lemna paucicostata
1990
Mudd, S.H.; Datko, A.H.
Plant Physiol.
93
623-630
Preparation and properties of trimethylsulfonium-tetrahydrofolate methyltransferase
1967
Wagner, C.; Lusty, S.M.; Kung, H.; Rogers, N.L.
J. Biol. Chem.
242
1287-1293
Thetin-homocysteine transmethylase: some further characteristics of the enzyme from rat liver
1958
Maw, G.A.
Biochem. J.
70
168-173
Thetin-homocysteine transmethylase: a preliminary manometric study of the enzyme from rat liver
1956
Maw, G.A.
Biochem. J.
63
116-124
Metabolism of thiopyrimidines and thiopurines
1963
Remy, C.N.
J. Biol. Chem.
238
1078-1084
Purification and characterization of L-serine transacetylase and O-acetyl-L-serine sulfhydrylase from kidney bean seedlings (Phaseolus vulgaris)
1971
Smith, I.K.; Thompson, J.F.
Biochim. Biophys. Acta
227
288-295
Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine b-synthase and serine acetyltransferase from Trypanosoma
2001
Nozaki, T.; Shigeta, Y.; Saito-Nakano, Y.; Imada, M.; Kruger, W.D.
J. Biol. Chem.
276
6516-6523
Regulation of aspartate family amino acid biosynthesis in Brevibacterium flavum. VII. Properities of homoserine O-transacetylase
1973
Miyajima, R.; Shiio, I.
J. Biochem.
73
1061-1068
Partial purification and some properties of homoserine O-acetyltransferase of a methionine auxotroph of Saccharomyces cerevisiae
1987
Yamagata, S.
J. Bacteriol.
169
3458-3463
Cystathionine gamma-lyase of Streptomyces phaeochromogenes. The occurrence of cystathionine gamma-lyase in filamentous bacteria and its purification and characterization
1984
Nagasawa, T.; Kanzaki, H.; Yamada, H.
J. Biol. Chem.
259
10393-10403
Kinetic properties and characteristics of mouse liver mitochondrial asparagine aminotransferase
1986
Maul, D.M.; Schuster, S.M.
Arch. Biochem. Biophys.
251
585-593
Evidence for the identity of O-acetylserine sulfhydrylase with O-acetylhomoserine sulfhydrylase in yeast
1974
Yamagata, S.; Takeshima, K.; Naiki, N.
J. Biochem.
75
1221-1229
O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast. Further purification and characterization as a pyridoxal enzyme
1976
Yamagata, S.; Takeshima, K.
J. Biochem.
80
777-785
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1
2003
Mino, K.; Ishikawa, K.
J. Bacteriol.
185
2277-2284
Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine
1967
Flavin, M.; Slaughter, C.
Biochim. Biophys. Acta
132
400-405
Cystathionine gamma-synthase from Salmonella. Beta elimination and replacement reactions and inhibition by O-succinylserine
1969
Guggenheim, S.; Flavin, M.
J. Biol. Chem.
244
3722-3727
Cystathionine gamma-synthase. A pyridoxal phosphate enzyme catalyzing rapid exchanges of beta and alpha hydrogen atoms in amino acids
1969
Guggenheim, S.; Flavin, M.
J. Biol. Chem.
244
6217-6227
-
Cystathionine gamma-synthase (Salmonella)
1971
Kaplan, M.; Guggenheim, S.
Methods Enzymol.
17B
425-433
Cystathionine -synthase. Studies of hydrogen exchange reactions
1972
Posner, B.I.; Flavin, M.
J. Biol. Chem.
247
6402-6411
Purification and characterization of cystathionine gamma-synthase type II from Bacillus sphaericus
1987
Kanzaki, H.; Kobayashi, M.; Nagasawa, T.; Yamada, H.
Eur. J. Biochem.
163
105-112
Purification and properties of cystathionine gamma-synthase from wheat (Triticum aestivum L.)
1994
Kreft, B.D.; Townsend, A.; Pohlenz, H.D.; Laber, B.
Plant Physiol.
104
1215-1220
Methionine biosynthesis in higher plants. I. Purification and characterization of cystathionine gamma-synthase from spinach chloroplasts
1995
Ravanel, S.; Droux, M.; Douce, R.
Arch. Biochem. Biophys.
316
572-584
O-Acetylhomoserine sulfhydrylase from Neurospora. Purification and consideration of its function in homocysteine and methionine synthesis
1971
Kerr, D.S.
J. Biol. Chem.
246
95-102
O-Alkylhomoserine synthesis catalyzed by O-acetylhomoserine sulfhydrylase in microorganisms
1977
Murooka,Y.; Kakihara, K.; Miwa, T.; Seto, K.; Harada, T.
J. Bacteriol.
130
62-73
Methionine biosynthesis in Brevibacterium flavum: Properties and essential role of O-acetylhomoserine sulfhydrylase
1982
Ozaki, H.; Shiio, I.
J. Biochem.
91
1163-1171
O-Acetylhomoserine sulfhydrylase of the fission yeast Schizosaccharomyces pombe: Partial purification, characterization, and its probable role in homocysteine biosynthesis
1984
Yamagata, S.
J. Biochem.
96
1511-1523
-
Synthesis of selenocystine and selenohomocystine with O-acetylhomoserine sulfhydrylase
1985
Chocat, P.; Esaki, N.; Tanaka, H.; Soda, K.
Agric. Biol. Chem.
49
1143-1150
-
Purification and properties of O-acetyl-L-homoserine O-sulfhydrylase from Aspergillus nidulans
1990
Yamagata, S.; Paszewski, A.; Lewandowska, I.
J. Gen. Appl. Microbiol.
36
137-141
In vivo analysis of various substrates utilized by cystathionine gamma-synthase and O-acetylhomoserine sulfhydrylase in methionine biosynthesis
2003
Hacham, Y.; Gophna, U.; Amir, R.
Mol. Biol. Evol.
20
1513-1520
gamma, delta-Dioxovalerate aminotransferase activity in Rhodopseudomonas spheroides
1963
Neuberger, A.; Turner, J.M.
Biochim. Biophys. Acta
67
342-345
The transamination of L-cystathionine, L-cystine and related compounds by a bovine kidney transaminase
1986
Ricci, G.; Nardini, M.; Federici, G.; Cavallini, D.
Eur. J. Biochem.
157
57-63
Homoserine kinase from Escherichia coli K12
1976
Burr, B.; Walker, J.; Truffa-Bachi, P.; Cohen, G.N.
Eur. J. Biochem.
62
519-526
Crystallization and preliminary x-ray diffraction analysis of the active core of human recombinant cystathionine beta-synthase: an enzyme involved in vascular disease
2001
Janosik, M.; Meier, M.; Kery, V.; Oliveriusova, J.; Burkhard, P.; Kraus, J.P.
Acta Crystallogr. Sect. D
D57
289-291
The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase
1999
Griffith, O.W.; Mulcahy, R.T.
Adv. Enzymol. Relat. Areas Mol. Biol.
73
209-267
Molecular and functional analyses of the metC gene of Lactococcus lactis, encoding cystathionine beta-lyase
2000
Fernandez, M.; van Doesburg, W.; Rutten, G.A.; Marugg, J.D.; Alting, A.C.; van Kranenburg, R.; Kuipers, O.P.
Appl. Environ. Microbiol.
66
42-48
Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes
2001
Vadon-Le Goff, S.; Delaforge, M.; Boucher, J.L.; Janosik, M.; Kraus, J.P.; Mansuy, D.
Biochem. Biophys. Res. Commun.
283
487-492
Assignment of enzymatic functions to specific regions of the PLP-dependent heme protein cystathionine beta-synthase
1999
Taoka, S.; Widjaja, L.; Banerjee, R.
Biochemistry
38
13155-13161
Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites
1999
Taoka, S.; West, M.; Banerjee, R.
Biochemistry
38
2738-2744
Characterization of the heme in human cystathionine beta-synthase by X-ray absorption and electron paramagnetic resonance spectroscopies
2000
Ojha, S.; Hwang, J.; Kabil, O.; Penner-Hahn, J.E.; Banerjee, R.
Biochemistry
39
10542-10547
Domain architecture of the heme-independent yeast cystathionine beta-synthase provides insights into mechanisms of catalysis and regulation
2000
Jhee, K.H.; McPhie, P.; Miles, E.W.
Biochemistry
39
10548-10556
Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region
2001
Janosik, M.; Kery, V.; Gaustadnes, M.; Maclean, K.N.; Kraus, J.P.
Biochemistry
40
10625-10633
The reaction of yeast cystathionine beta-synthase is rate-limited by the conversion of aminoacrylate to cystathionine
2001
Jhee, K.H.; Niks, D.; McPhie, P.; Dunn, M.F.; Miles, E.W.
Biochemistry
40
10873-10880
Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme
2002
Taoka, S.; Lepore, B.W.; Kabil, O.; Ojha, S.; Ringe, D.; Banerjee, R.
Biochemistry
41
10454-10461
Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase
2002
Evande, R.; Blom, H.; Boers, G.H.; Banerjee, R.
Biochemistry
41
11832-11837
Yeast cystathionine beta-synthase reacts with L-allothreonine, a non-natural substrate, and L-homocysteine to form a new amino acid, 3-methyl-L-cystathionine
2002
Jhee, K.H.; Niks, D.; McPhie, P.; Dunn, M.F.; Miles, E.W.
Biochemistry
41
1828-1835
Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase
2002
Ojha, S.; Wu, J.; LoBrutto, R.; Banerjee, R.
Biochemistry
41
4649-4654
Kinetics of the yeast cystathionine beta-synthase forward and reverse reactions: continuous assays and the equilibrium constant for the reaction
2003
Aitken, S.M.; Kirsch, J.F.
Biochemistry
42
571-578
Role of active-site residues Thr81, Ser82, Thr85, Gln157, and Tyr158 in yeast cystathionine beta-synthase catalysis and reaction specificity
2004
Aitken, S.M.; Kirsch, J.F.
Biochemistry
43
1963-1971
Structural insights into mutations of cystathionine beta-synthase
2003
Meier, M.; Oliveriusova, J.; Kraus, J.P.; Burkhard, P.
Biochim. Biophys. Acta
1647
206-213
Reaction mechanism and regulation of cystathionine beta-synthase
2003
Banerjee, R.; Evande, R.; Kabil, O.; Ojha, S.; Taoka, S.
Biochim. Biophys. Acta
1647
30-35
Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein
2001
Meier, M.; Janosik, M.; Kery, V.; Kraus, J.P.; Burkhard, P.
EMBO J.
20
3910-3916
Biochemical characterization of cystine lyase from broccoli (Brassica oleracea var. italica)
1999
Ramirez, E.C.; Whitaker, J.R.
J. Agric. Food Chem.
47
2218-2225
Functional properties of the active core of human cystathionine beta-synthase crystals
2001
Bruno, S.; Schiaretti, F.; Burkhard, P.; Kraus, J.P.; Janosik, M.; Mozzarelli, A.
J. Biol. Chem.
276
16-19
Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme
2001
Kabil, O.; Toaka, S.; LoBrutto, R.; Shoemaker, R.; Banerjee, R.
J. Biol. Chem.
276
19350-19355
Stopped-flow kinetic analysis of the reaction catalyzed by the full-length yeast cystathionine beta-synthase
2002
Taoka, S.; Banerjee, R.
J. Biol. Chem.
277
22421-22425
A novel enhancing mechanism for hydrogen sulfide-producing activity of cystathionine beta-synthase
2002
Eto, K.; Kimura, H.
J. Biol. Chem.
277
42680-42685
Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation
2002
Oliveriusova, J.; Kery, V.; Maclean, K.N.; Kraus, J.P.
J. Biol. Chem.
277
48386-48394
Tumor necrosis factor-a-induced targeted proteolysis of cystathionine beta-xynthase modulates redox homeostasis
2003
Zou, C.G.; Banerjee, R.
J. Biol. Chem.
278
16802-16808
Cystathionine {beta}-synthase: structure, function, regulation and location of homocystinuria-causing mutations
2004
Miles, E.W.; Kraus, J.P.
J. Biol. Chem.
279
29871-29874
Modulation of cyanoalanine synthase and O-acetylserine (thiol) lyases A and B activity by beta-substituted alanyl and anion inhibitors
2002
Warrilow, A.G.; Hawkesford, M.J.
J. Exp. Bot.
53
439-445
Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme
2001
Taoka, S.; Banerjee, R.
J. Inorg. Biochem.
87
245-251
Mercuric chloride-induced spin or ligation state changes in ferric or ferrous human cystathionine beta-synthase inhibit enzyme activity
2001
Taoka, S.; Green, E.L.; Loehr, T.M.; Banerjee, R.
J. Inorg. Biochem.
87
253-259
Yeast cytoplasmic and mitochondrial methionyl-tRNA synthetases: two structural frameworks for identical functions
2001
Senger, B.; Despons, L.; Walter, P.; Jakubowski, H.; Fasiolo, F.
J. Mol. Biol.
311
205-216
On the mechanism of the inhibition of Na(+), K(+)-ATPase activity caused by homocysteine
2002
Streck, E.L.; Zugno, A.I.; Tagliari, B.; Sarkis, J.J.; Wajner, M.; Wannmacher, C.M.; Wyse, A.T.
Int. J. Dev. Neurosci.
20
77-81
Active-site-mutagenesis study of rat liver betaine-homocysteine S-methyltransferase
2003
Gonzalez, B.; Campillo, N.; Garrido, F.; Gasset, M.; Sanz-Aparicio, J.; Pajares, M.A.
Biochem. J.
370
945-952
Transcriptional regulation of methionine synthase by homocysteine and choline in Aspergillus nidulans
2003
Kacprzak, M.M.; Lewandowska, I.; Matthews, R.G.; Paszewski, A.
Biochem. J.
376
517-524
Betaine homocysteine methyltransferase: gene cloning and expression analysis in rat liver cirrhosis
2003
Forestier, M.; Banninger, R.; Reichen, J.; Solioz, M.
Biochim. Biophys. Acta
1638
29-34
Homocysteine increases methionine synthase mRNA level in Caco-2 cells
2004
Ortiou, S.; Alberto, J.M.; Gueant, J.L.; Merten, M.
Cell. Physiol. Biochem.
14
407-414
Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase
2003
Collinsova, M.; Castro, C.; Garrow, T.A.; Yiotakis, A.; Dive, V.; Jiracek, J.
Chem. Biol.
10
113-122
In vitro modification of betaine-homocysteine S-methyltransferase by tissue-type transglutaminase
2004
Ichikawa, A.; Ohashi, Y.; Terada, S.; Natsuka, S.; Ikura, K.
Int. J. Biochem. Cell Biol.
36
1981-1992
Heterologous expression, purification, and characterization of recombinant rat cysteine dioxygenase
2005
Chai, S.C.; Jerkins, A.A.; Banik, J.J.; Shalev, I.; Pinkham, J.L.; Uden, P.C.; Maroney, M.J.
J. Biol. Chem.
280
9865-9869
Characterization of the salt-inducible methionine synthase from barley leaves
2004
Narita, Y.; Taguchi, H.; Nakamura, T.; Ueda, A.; Shi, W.; Takabe, T.
Plant Sci.
167
1009-1016
High production of methyl mercaptan by L-methionine-alpha-deamino-gamma-mercaptomethane lyase from Treponema denticola
2005
Fukamachi, H.; Nakano, Y.; Okano, S.; Shibata, Y.; Abiko, Y.; Yamashita, Y.
Biochem. Biophys. Res. Commun.
331
127-131
Purification, characterization and gene cloning of thermostable o-acetyl-L-homoserine sulfhydrylase forming gamma-cyano-alpha-aminobutyric acid
2003
Omura, H.; Ikemoto, M.; Kobayashi, M.; Shimizu, S.; Yoshida, T.; Nagasawa, T.
J. BIOSCI. BIOENG.
96
53-58
A continuous spectrophotometric assay for human cystathionine beta-synthase
2005
Shen, W.; McGath, M.K.; Evande, R.; Berkowitz, D.B.
Anal. Biochem.
342
103-110
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine
2004
Chen, X.; Jhee, K.H.; Kruger, W.D.
J. Biol. Chem.
279
52082-52086
Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: a basis for the design of specific inhibitors
2006
Frey, D.; Braun, O.; Briand, C.; Vašák, M.; Grütter, M.G.
Structure
14
901-911
Preparation, crystallization and preliminary X-ray analysis of the methionine synthase (MetE) from Streptococcus mutans
2006
Fu, T.M.; Zhang, X.Y.; Li, L.F.; Liang, Y.H.; Su, X.D.
Acta Crystallogr. Sect. F
62
984-985
Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver
2006
Ratnam, S.; Wijekoon, E.P.; Hall, B.; Garrow, T.A.; Brosnan, M.E.; Brosnan, J.T.
Am. J. Physiol. Endocrinol. Metab.
290
E933-E939
Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats
2006
Nieman, K.M.; Hartz, C.S.; Szegedi, S.S.; Garrow, T.A.; Sparks, J.D.; Schalinske, K.L.
Am. J. Physiol. Endocrinol. Metab.
291
E1235-E1242
Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells
2007
Schaefer, C.; Hoffmann, L.; Heldt, K.; Lornejad-Schaefer, M.R.; Brauers, G.; Gehrmann, T.; Garrow, T.A.; Haeussinger, D.; Mayatepek, E.; Schwahn, B.C.; Schliess, F.
Am. J. Physiol. Gastrointest. Liver Physiol.
292
G1089-G1098
Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae
2005
Suliman, H.S.; Sawyer, G.M.; Appling, D.R.; Robertus, J.D.
Arch. Biochem. Biophys.
441
56-63
Synergistic, random sequential binding of substrates in cobalamin-independent methionine synthase
2006
Taurog, R.E.; Jakubowski, H.; Matthews, R.G.
Biochemistry
45
5083-5091
Activation of methyltetrahydrofolate by cobalamin-independent methionine synthase
2006
Taurog, R.E.; Matthews, R.G.
Biochemistry
45
5092-5102
The prognostic significance of genetic polymorphisms (methylenetetrahydrofolate reductase C677T, methionine synthase A2756G, thymidilate synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma
2006
Sarbia, M.; Stahl, M.; von Weyhern, C.; Weirich, G.; Puehringer-Oppermann, F.
Br. J. Cancer
94
203-207
Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?
2006
Pajares, M.A.; Perez-Sala, D.
Cell. Mol. Life Sci.
63
2792-2803
Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles
2007
Banks, E.C.; Doughty, S.W.; Toms, S.M.; Wheelhouse, R.T.; Nicolaou, A.
FEBS J.
274
287-299
Crystal structure and solution characterization of the activation domain of human methionine synthase
2007
Wolthers, K.R.; Toogood, H.S.; Jowitt, T.A.; Marshall, K.R.; Leys, D.; Scrutton, N.S.
FEBS J.
274
738-750
An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor
2007
Ye, S.; Wu, X.; Wei, L.; Tang, D.; Sun, P.; Bartlam, M.; Rao, Z.
J. Biol. Chem.
282
3391-3402
Comparative localization of cystathionine beta-synthase and cystathionine gamma-lyase in retina: differences between amphibians and mammals
2007
Pong, W.W.; Stouracova, R.; Frank, N.; Kraus, J.P.; Eldred, W.D.
J. Comp. Neurol.
505
158-165
S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase
2006
Jiracek, J.; Collinsova, M.; Rosenberg, I.; Budesinsky, M.; Protivinska, E.; Netusilova, H.; Garrow, T.A.
J. Med. Chem.
49
3982-3989
Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication
2005
Pejchal, R.; Ludwig, M.L.
PLoS Biol.
3
e31
Homocysteine remethylation in young broilers fed varying levels of methionine, choline, and betaine
2006
Pillai, P.B.; Fanatico, A.C.; Beers, K.W.; Blair, M.E.; Emmert, J.L.
Poult. Sci.
85
90-95
Human methionine synthase reductase is a molecular chaperone for human methionine synthase
2006
Yamada, K.; Gravel, R.A.; Toraya, T.; Matthews, R.G.
Proc. Natl. Acad. Sci. USA
103
9476-9481
Purification and characterization of the wild type and truncated human cystathionine beta-synthase enzymes expressed in E. coli
2007
Frank, N.; Kent, J.O.; Meier, M.; Kraus, J.P.
Arch. Biochem. Biophys.
470
64-72
Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding
2006
Frank, N.; Kery, V.; Maclean, K.N.; Kraus, J.P.
Biochemistry
45
11021-11029
A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer
2007
Sen, S.; Banerjee, R.
Biochemistry
46
4110-4116
S-Adenosylhomocysteine hydrolase from the thermophilic archaeon Sulfolobus solfataricus: purification, physico-chemical and immunological properties.
1993
Porcelli, M.; Cacciapuoti, G.; Fusco, S.; Iacomino, G.; Gambacorta, A.; De Rosa, M.; Zappia, V.
Biochim. Biophys. Acta
1164
179-188
Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response
2006
Chen, X.; Wang, L.; Fazlieva, R.; Kruger, W.D.
Hum. Mutat.
27
474-482
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2
2007
Colgan, S.M.; Tang, D.; Werstuck, G.H.; Austin, R.C.
Int. J. Biochem. Cell Biol.
39
1843-1851
Dynamics of carbon monoxide binding to cystathionine beta-synthase
2006
Puranik, M.; Weeks, C.L.; Lahaye, D.; Kabil, O.; Taoka, S.; Nielsen, S.B.; Groves, J.T.; Banerjee, R.; Spiro, T.G.
J. Biol. Chem.
281
13433-13438
Structural insights into pathogenic mutations in heme-dependent cystathionine-beta-synthase
2006
Yamanishi, M.; Kabil, O.; Sen, S.; Banerjee, R.
J. Inorg. Biochem.
100
1988-1995
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway
2007
Goyer, A.; Collakova, E.; Shachar-Hill, Y.; Hanson, A.D.
Plant Cell Physiol.
48
232-242
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity
2006
Prudova, A.; Bauman, Z.; Braun, A.; Vitvitsky, V.; Lu, S.C.; Banerjee, R.
Proc. Natl. Acad. Sci. USA
103
6489-6494
Cystathionine beta synthase participates in murine oocyte maturation mediated by homocysteine
2007
Liang, R.; Yu, W.D.; Du, J.B.; Yang, L.J.; Yang, J.J.; Xu, J.; Shang, M.; Guo, J.Z.
Reprod. Toxicol.
24
89-96
Inhibition of sulfur compounds and antioxidants on MMP-2 and -9 at the activity level found during neonatal hypoxia-reoxygenation
2006
Emara, M.; Cheung, P.Y.
Eur. J. Pharmacol.
544
168-173
Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro
2008
Tang, C.; Zhang, Z.; Xu, B.; Li, M.; Liu, J.; Cui, J.
Anticancer Drugs
19
697-704
Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc
2008
Castro, C.; Millian, N.S.; Garrow, T.A.
Arch. Biochem. Biophys.
472
26-33
Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases
2008
Rodriguez, C.; Martinez-Gonzalez, J.; Raposo, B.; Alcudia, J.F.; Guadall, A.; Badimon, L.
Cardiovasc. Res.
79
7-13
Influence of the cystathionine beta-synthase 844ins68 and methylenetetrahydrofolate reductase 677C>T polymorphisms on folate and homocysteine concentrations
2008
Summers, C.M.; Hammons, A.L.; Mitchell, L.E.; Woodside, J.V.; Yarnell, J.W.; Young, I.S.; Evans, A.; Whitehead, A.S.
Eur. J. Hum. Genet.
16
1010-1013
Lysyl oxidase and endothelial dysfunction: mechanisms of lysyl oxidase down-regulation by pro-inflammatory cytokines
2008
Alcudia, J.F.; Martinez-Gonzalez, J.; Guadall, A.; Gonzalez-Diez, M.; Badimon, L.; Rodriguez, C.
Front. Biosci.
13
2721-2727
Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer
2008
Leclerc, D.; Rozen, R.
J. Biol. Chem.
283
3151-3160
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase
2008
Szegedi, S.S.; Castro, C.C.; Koutmos, M.; Garrow, T.A.
J. Biol. Chem.
283
8939-8945
Homocysteine effects on cellular glutathione peroxidase (GPx-1) activity under in vitro conditions
2007
Durmaz, A.; Dikmen, N.
J. Enzyme Inhib. Med. Chem.
22
733-738
Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization
2008
Li, F.; Feng, Q.; Lee, C.; Wang, S.; Pelleymounter, L.L.; Moon, I.; Eckloff, B.W.; Wieben, E.D.; Schaid, D.J.; Yee, V.; Weinshilboum, R.M.
Mol. Genet. Metab.
94
326-335
Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit
2008
Mizuno, Y.; Isotani, E.; Ohno, K.; Nagai, A.; Imamura, M.; Azuma, H.
Vascul. Pharmacol.
48
21-31
Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase
2008
Zhu, W.; Lin, A.; Banerjee, R.
Biochemistry
47
6226-6232
S-Methylmethionine metabolism in Escherichia coli
1999
Thanbichler, M.; Neuhierl, B.; Böck A.
J. Bacteriol.
181
662-665
A family of S-methylmethionine-dependent thiol/selenol methyltransferases. Role in selenium tolerance and evolutionary relation
1999
Neuhierl, B.; Thanbichler, M.; Lottspeich, F.; Böck, A.
J. Biol. Chem.
274
5407-5414
-
Diastereospecific, enzymically catalysed transmethylation from S-methyl-L-Lmethionine to L-homocysteine, a naturally occurring process
1989
Grue-Sorensen, G.; Kelstrup, E.; Kjaer, A.; Madsen, J.O.
J. Chem. Soc. Perkin Trans. I
1984
1091-1097
The S-methylmethionine cycle in angiosperms: ubiquity, antiquity and activity
2001
Ranocha, P.; McNeil, S.D.; Ziemak, M.J.; Li, C.; Tarczynski, M.C.; Hanson, A.D.
Plant J.
25
575-584
Characterization of selenocysteine methyltransferases from Astragalus species with contrasting selenium accumulation capacity
2009
Sors, T.G.; Martin, C.P.; Salt, D.E.
Plant J.
59
110-122
Inhibition of cystathionine-beta-synthase activity during renal ischemia-reperfusion: role of pH and nitric oxide
2008
Prathapasinghe, G.A.; Siow, Y.L.; Xu, Z.; O, K.
Am. J. Physiol. Renal Physiol.
295
F912-F922
Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase
2008
Carballal, S.; Madzelan, P.; Zinola, C.F.; Grana, M.; Radi, R.; Banerjee, R.; Alvarez, B.
Biochemistry
47
3194-3201
Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations
2008
Ozaki, S.; Inada, A.; Sada, K.
Biosci. Biotechnol. Biochem.
72
2318-2323
Characterization, expression and localization of S-adenosylhomocysteine hydrolase from amphioxus Branchiostoma belcheri tsingtaunese
2008
Wang, Y.; Zhao, B.; Zhang, S.; Qu, X.
Biosci. Rep.
28
135-144
-
Modulation of cystathionine beta-synthase activity by altering heme environment
2008
Ozaki, S.; Doi, M.; Migita, C.T.
Chem. Lett.
37
208-209
Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease
2009
Wadham, C.; Mangoni, A.A.
Expert. Opin. Drug Metab. Toxicol.
5
303-319
Origin and evolution of the c.844_845ins68/c.833T>C mutations within the cystathionine beta-synthase gene in great apes
2008
Romano, M.; Bacalini, M.G.; Verschoor, E.J.; Crovella, S.; Baralle, F.E.
FEBS Lett.
582
423-426
Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion
2009
Shintani, T.; Iwabuchi, T.; Soga, T.; Kato, Y.; Yamamoto, T.; Takano, N.; Hishiki, T.; Ueno, Y.; Ikeda, S.; Sakuragawa, T.; Ishikawa, K.; Goda, N.; Kitagawa, Y.; Kajimura, M.; Matsumoto, K.; Suematsu, M.
Hepatology
49
141-150
Cystathionine beta-synthase p.S466L mutation causes hyperhomocysteinemia in mice
2008
Gupta, S.; Wang, L.; Hua, X.; Krijt, J.; Kozich, V.; Kruger, W.D.
Hum. Mutat.
29
1048-1054
Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone
2008
Majtan, T.; Singh, L.R.; Wang, L.; Kruger, W.D.; Kraus, J.P.
J. Biol. Chem.
283
34588-34595
Homocysteine reduces endothelial progenitor cells in stroke patients through apoptosis
2009
Alam, M.M.; Mohammad, A.A.; Shuaib, U.; Wang, C.; Ghani, U.; Schwindt, B.; Todd, K.G.; Shuaib, A.
J. Cereb. Blood Flow Metab.
29
157-165
SAM levels, gene expression of SAM synthetase, methionine synthase and ACC oxidase, and ethylene emission from N. suaveolens flowers
2009
Roeder, S.; Dreschler, K.; Wirtz, M.; Cristescu, S.M.; van Harren, F.J.; Hell, R.; Piechulla, B.
Plant Mol. Biol.
70
535-546
Kinetic characterization of recombinant human cystathionine beta-synthase purified from E. coli
2009
Belew, M.S.; Quazi, F.I.; Willmore, W.G.; Aitken, S.M.
Protein Expr. Purif.
64
139-145
Microbial L-methioninase: production, molecular characterization, and therapeutic applications
2010
El-Sayed, A.S.
Appl. Microbiol. Biotechnol.
86
445-467
Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization
2008
Mercer, C.; Kaliappan, A.; Dennis, P.
Autophagy
4
185-194
Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats
2009
Kharbanda, K.K.; Vigneswara, V.; McVicker, B.L.; Newlaczyl, A.U.; Bailey, K.; Tuma, D.; Ray, D.E.; Carter, W.G.
Biochem. Biophys. Res. Commun.
381
523-527
Kinetic analysis of site-directed mutants of methionine synthase from Candida albicans
2009
Prasannan, P.; Suliman, H.S.; Robertus, J.D.
Biochem. Biophys. Res. Commun.
382
730-734
Investigation of residues Lys112, Glu136, His138, Gly247, Tyr248, and Asp249 in the active site of yeast cystathionine beta-synthase
2009
Lodha, P.H.; Shadnia, H.; Woodhouse, C.M.; Wright, J.S.; Aitken, S.M.
Biochem. Cell Biol.
87
531-540
Characterization of the S289A,D mutants of yeast cystathionine beta-synthase
2009
Quazi, F.; Aitken, S.M.
Biochim. Biophys. Acta
1794
892-897
Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex
2009
Wolthers, K.R.; Scrutton, N.S.
FEBS J.
276
1942-1951
An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity
2010
Liu, H.H.; Lu, P.; Guo, Y.; Farrell, E.; Zhang, X.; Zheng, M.; Bosano, B.; Zhang, Z.; Allard, J.; Liao, G.; Fu, S.; Chen, J.; Dolim, K.; Kuroda, A.; Usuka, J.; Cheng, J.; Tao, W.; Welch, K.; Liu, Y.; Pease, J.; de Keczer, S.A.; Masjedizadeh, M.; Hu, J.S.; Weller, P.; Garrow, T.; Peltz, G.
Genome Res.
20
28-35
Spectroscopic study of the cobalamin-dependent methionine synthase in the activation conformation: effects of the Y1139 residue and S-adenosylmethionine on the B12 cofactor
2008
Liptak, M.D.; Datta, S.; Matthews, R.G.; Brunold, T.C.
J. Am. Chem. Soc.
130
16374-16381
Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coli
2009
Hondorp, E.R.; Matthews, R.G.
J. Bacteriol.
191
3407-3410
Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes
2010
Majtan, T.; Liu, L.; Carpenter, J.F.; Kraus, J.P.
J. Biol. Chem.
285
15866-15873
Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation
2009
Singh, S.; Madzelan, P.; Stasser, J.; Weeks, C.L.; Becker, D.; Spiro, T.G.; Penner-Hahn, J.; Banerjee, R.
J. Inorg. Biochem.
103
689-697
Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase
2009
Vanek, V.; Budesinsky, M.; Kabeleova, P.; Sanda, M.; Kozisek, M.; Hanclova, I.; Mladkova, J.; Brynda, J.; Rosenberg, I.; Koutmos, M.; Garrow, T.A.; Jiracek, J.
J. Med. Chem.
52
3652-3665
Hepatic cystathionine beta-synthase activity does not increase in response to methionine supplementation in rats fed a low casein diet: association with plasma homocysteine concentrations
2009
Ohuchi, S.; Morita, T.; Mori, M.; Sugiyama, K.
J. Nutr. Sci. Vitaminol.
55
178-185
Metal active site elasticity linked to activation of homocysteine in methionine synthases
2008
Koutmos, M.; Pejchal, R.; Bomer, T.M.; Matthews, R.G.; Smith, J.L.; Ludwig, M.L.
Proc. Natl. Acad. Sci. USA
105
3286-3291
A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor
2008
Datta, S.; Koutmos, M.; Pattridge, K.A.; Ludwig, M.L.; Matthews, R.G.
Proc. Natl. Acad. Sci. USA
105
4115-4120
Insights into the reactivation of cobalamin-dependent methionine synthase
2009
Koutmos, M.; Datta, S.; Pattridge, K.A.; Smith, J.L.; Matthews, R.G.
Proc. Natl. Acad. Sci. USA
106
18527-18532
H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
2009
Chiku, T.; Padovani, D.; Zhu, W.; Singh, S.; Vitvitsky, V.; Banerjee, R.
J. Biol. Chem.
284
11601-11612
Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway
2009
Tyagi, N.; Gillespie, W.; Vacek, J.C.; Sen, U.; Tyagi, S.C.; Lominadze, D.
J. Cell. Physiol.
220
257-266
Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur
2010
Stipanuk, M.H.; Ueki, I.
J. Inherit. Metab. Dis.
34
17-32
Hydrogen sulfide mitigates matrix metalloproteinase-9 activity and neurovascular permeability in hyperhomocysteinemic mice
2010
Tyagi, N.; Givvimani, S.; Qipshidze, N.; Kundu, S.; Kapoor, S.; Vacek, J.C.; Tyagi, S.C.
Neurochem. Int.
56
301-307
-
New function and application of the cysteine synthase from archaea
2010
Ishikawa, K.; Mino, K.; Nakamura, T.
Biochem. Eng. J.
48
315-322
Cross-talk between the catalytic core and the regulatory domain in cystathionine beta-synthase: study by differential covalent labeling and computational modeling
2010
Hnizda, A.; Spiwok, V.; Jurga, V.; Kozich, V.; Kodicek, M.; Kraus, J.P.
Biochemistry
49
10526-10534
Pre-steady-state kinetic analysis of enzyme-monitored turnover during cystathionine beta-synthase-catalyzed H2S generation
2011
Singh, S.; Ballou, D.; Banerjee, R.
Biochemistry
50
419-425
Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice
2011
Jensen, K.K.; Geoghagen, N.S.; Jin, L.; Holt, T.G.; Luo, Q.; Malkowitz, L.; Ni, W.; Quan, S.; Waters, M.G.; Zhang, A.; Zhou, H.H.; Cheng, K.; Luo, M.J.
Eur. J. Pharmacol.
650
86-93
Cystathionine beta-synthase mutations: effect of mutation topology on folding and activity
2010
Kozich, V.; Sokolova, J.; Klatovska, V.; Krijt, J.; Janosik, M.; Jelinek, K.; Kraus, J.P.
Hum. Mutat.
31
809-819
Restoring assembly and activity of cystathionine beta-synthase mutants by ligands and chemical chaperones
2011
Kopecka, J.; Krijt, J.; Rakova, K.; Kozich, V.
J. Inherit. Metab. Dis.
34
39-48
Determination of cystathionine beta-synthase activity in human plasma by LC-MS/MS: potential use in diagnosis of CBS deficiency
2011
Krijt, J.; Kopecka, J.; Hnizda, A.; Moat, S.; Kluijtmans, L.A.; Mayne, P.; Kozich, V.
J. Inherit. Metab. Dis.
34
49-55
Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine beta-synthase
2010
Koutmos, M.; Kabil, O.; Smith, J.L.; Banerjee, R.
Proc. Natl. Acad. Sci. USA
107
20958-20963
Dimethylarginine dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes
2012
Cillero-Pastor, B.; Mateos, J.; Fernandez-Lopez, C.; Oreiro, N.; Ruiz-Romero, C.; Blanco, F.J.
Arthritis Rheum.
64
204-212
Quantification of homocysteine-related metabolites and the role of betaine-homocysteine S-methyltransferase in HepG2 cells
2013
Korinek, M.; Sistek, V.; Mladkova, J.; Mikes, P.; Jiracek, J.; Selicharova, I.
Biomed. Chromatogr.
27
111-121
Homocysteine methyltransferases Mht1 and Sam4 prevent the accumulation of age-damaged (R,S)-AdoMet in the yeast Saccharomyces cerevisiae
2010
Vinci, C.R.; Clarke, S.G.
J. Biol. Chem.
285
20526-20531
Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development
2012
Lee, M.B.; Kooistra, M.; Zhang, B.; Slow, S.; Fortier, A.L.; Garrow, T.A.; Lever, M.; Trasler, J.M.; Baltz, J.M.
J. Biol. Chem.
287
33094-33103
Corticoadrenal activity in rat regulates betaine-homocysteine S-methyltransferase expression with opposite effects in liver and kidney
2012
Fridman, O.; Morales, A.V.; Bortoni, L.E.; Turk-Noceto, P.C.; Prieto, E.A.
J. Biosci.
37
115-123
Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2
2012
Mladkova, J.; Vanek, V.; Budesinsky, M.; Elbert, T.; Demianova, Z.; Garrow, T.A.; Jiracek, J.
J. Med. Chem.
55
6822-6831
. Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway
2013
Uda, N.; Matoba, Y.; Kumagai, T.; Oda, K.; Noda, M.; Sugiyama, M
Antimicrob. Agents Chemother.
57
2603-2612
Characterization of homocysteine gamma-lyase from submerged and solid cultures of Aspergillus fumigatus ASH (JX006238)
2013
El-Sayed, A.S.; Khalaf, S.A.; Aziz, H.A.
J. Microbiol. Biotechnol.
23
499-510
Non-thermal effects of microwaves on proteins: thermophilic enzymes as model system
1997
Porcelli, M.; Cacciapuoti, G.; Fusco, S.; Massa, R.; d'Ambrosio, G.; Bertoldo, C.; De Rosa, M.; Zappia, V.
FEBS Lett.
402
102-106
Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase
2013
Yadav, P.K.; Yamada, K.; Chiku, T.; Koutmos, M.; Banerjee, R.
J. Biol. Chem.
288
20002-20013
The thiamine biosynthetic enzyme ThiC catalyzes multiple turnovers and is inhibited by S-adenosylmethionine (AdoMet) metabolites
2013
Palmer, L.D.; Downs, D.M.
J. Biol. Chem.
288
30693-30699
Cystathionine beta synthase modulates senescence of human endothelial cells
2012
Albertini, E.; Koziel, R.; Duerr, A.; Neuhaus, M.; Jansen-Duerr, P.
Aging
4
664-673
Homocysteine metabolism in peripheral blood mononuclear cells: evidence for cystathionine beta-synthase activity in resting state
2012
Katko, M.; Zavaczki, E.; Jeney, V.; Paragh, G.; Balla, J.; Varga, Z.
Amino Acids
43
317-326
Assays for methionine beta-lyase and S-adenosyl-L-homocysteine hydrolase based on enzymatic formation of CdS quantum dots in situ
2012
Saa, L.; Mato, J.M.; Pavlov, V.
Anal. Chem.
84
8961-8965
Characterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteins
2013
Casique, L.; Kabil, O.; Banerjee, R.; Martinez, J.C.; De Lucca, M.
Gene
531
117-124
Cystathionine beta-synthase mutants exhibit changes in protein unfolding: conformational analysis of misfolded variants in crude cell extracts
2012
Hnizda, A.; Jurga, V.; Rakova, K.; Kozich, V.
J. Inherit. Metab. Dis.
35
469-477
Reduced response of cystathionine beta-synthase (CBS) to S-adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in homocystinuria patients
2014
Mendes, M.I.; Colaco, H.G.; Smith, D.E.; Ramos, R.J.; Pop, A.; van Dooren, S.J.; Tavares de Almeida, I.; Kluijtmans, L.A.; Janssen, M.C.; Rivera, I.; Salomons, G.S.; Leandro, P.; Blom, H.J.
J. Inherit. Metab. Dis.
37
245-254
Hippocampal cystathionine beta synthase in young and aged mice
2014
Bruintjes, J.J.; Henning, R.H.; Douwenga, W.; van der Zee, E.A.
Neurosci. Lett.
563
135-139
Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance
2013
Bhattacharyya, S.; Saha, S.; Giri, K.; Lanza, I.R.; Nair, K.S.; Jennings, N.B.; Rodriguez-Aguayo, C.; Lopez-Berestein, G.; Basal, E.; Weaver, A.L.; Visscher, D.W.; Cliby, W.; Sood, A.K.; Bhattacharya, R.; Mukherjee, P.
PLoS ONE
8
e79167
Recombinant S-adenosylhomocysteine hydrolase from Thermotoga maritima: cloning, overexpression, characterization, and thermal purification studies
2013
Lozada-Ramirez, J.D.; Sanchez-Ferrer, A.; Garcia-Carmona, F.
Appl. Biochem. Biotechnol.
170
639-653
Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation
2014
Wang, Y.; Kavran, J.M.; Chen, Z.; Karukurichi, K.R.; Leahy, D.J.; Cole, P.A.
J. Biol. Chem.
289
31361-31372
Plant-driven repurposing of the ancient S-adenosylmethionine repair enzyme homocysteine S-ethyltransferase
2014
Bradbury, L.M.; Ziemak, M.J.; El Badawi-Sidhu, M.; Fiehn, O.; Hanson, A.D.
Biochem. J.
463
279-286
Identification and characterization of arsenite methyltransferase from an archaeon, Methanosarcina acetivorans C2A
2014
Wang, P.P.; Sun, G.X.; Zhu, Y.G.
Environ. Sci. Technol.
48
12706-12713
The cobalamin-independent methionine synthase enzyme captured in a substrate-induced closed conformation
2015
Ubhi, D.K.; Robertus, J.D.
J. Mol. Biol.
427
901-909
Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase
2014
Mladkova, J.; Hladilkova, J.; Diamond, C.E.; Tryon, K.; Yamada, K.; Garrow, T.A.; Jungwirth, P.; Koutmos, M.; Jiracek, J.
Proteins
82
2552-2564
Organization of the human mitochondrial hydrogen sulfide oxidation pathway
2014
Libiad, M.; Yadav, P.; Vitvitsky, V.; Martinov, M.; Banerjee, R.
J. Biol. Chem.
289
30901-30910
Structure-based insights into the role of the Cys-Tyr crosslink and inhibitor recognition by mammalian cysteine dioxygenase
2016
Driggers, C.M.; Kean, K.M.; Hirschberger, L.L.; Cooley, R.B.; Stipanuk, M.H.; Karplus, P.A.
J. Mol. Biol.
428
3999-4012
Organization of the human mitochondrial hydrogen sulfide oxidation pathway
2014
Libiad, M.; Yadav, P.; Vitvitsky, V.; Martinov, M.; Banerjee, R.
J. Biol. Chem.
289
30901-30910
Biogenesis of hydrogen sulfide and thioethers by cystathionine beta-synthase
2018
Majtan, T.; Krijt, J.; Sokolova, J.; Krizkova, M.; Ralat, M.A.; Kent, J.; Gregory, J.F.; Kozich, V.; Kraus, J.P.
Antioxid. Redox Signal.
28
311-323
Recombinant S-adenosylhomocysteine hydrolase from thermotoga maritima Cloning, overexpression, characterization, and thermal purification studies
2013
Lozada-Ramirez, J.; Sanchez-Ferrer, A.; Garcia-Carmona, F.
Appl. Biochem. Biotechnol.
170
639-653
Structural characterization and functional analysis of cystathionine beta-synthase an enzyme involved in the reverse transsulfuration pathway of Bacillus anthracis
2017
Devi, S.; Abdul Rehman, S.A.; Tarique, K.F.; Gourinath, S.
FEBS J.
284
3862-3880
Serine racemase a key player in apoptosis and necrosis
2014
Canu, N.; Ciotti, M.T.; Pollegioni, L.
Front. Synaptic Neurosci.
6
9
Insights into the regulatory domain of cystathionine beta-synthase characterization of six variant proteins
2014
Mendes, M.I.; Santos, A.S.; Smith, D.E.; Lino, P.R.; Colaco, H.G.; de Almeida, I.T.; Vicente, J.B.; Salomons, G.S.; Rivera, I.; Blom, H.J.; Leandro, P.
Hum. Mutat.
35
1195-1202
Molecular cloning and characterization of L-methionine gamma-lyase from Streptomyces avermitilis
2015
Kudou, D.; Yasuda, E.; Hirai, Y.; Tamura, T.; Inagaki, K.
J. Biosci. Bioeng.
120
380-383
Crystallographic and mutational analyses of cystathionine beta-synthase in the H2S-synthetic gene cluster in Lactobacillus plantarum
2017
Matoba, Y.; Yoshida, T.; Izuhara-Kihara, H.; Noda, M.; Sugiyama, M.
Protein Sci.
26
763-783
S-inosyl-L-homocysteine hydrolase, a novel enzyme involved in S-adenosyl-L-methionine recycling
2015
Miller, D.; Xu, H.; White, R.H.
J. Bacteriol.
197
2284-2291
Betaine homocysteine S-methyltransferase emerges as a new player of the nuclear methionine cycle
2017
Perez-Miguelsanz, J.; Vallecillo, N.; Garrido, F.; Reytor, E.; Perez-Sala, D.; Pajares, M.A.
Biochim. Biophys. Acta
1864
1165-1182
-
Characterization of a selenium-resistance-enhancing homocysteine s-methyltransferase from Aegilops tauschii
2018
Wu, L.; Shang, Y.; Liu, T.; Chen, W.; Liu, B.; Zhang, L.; Liu, D.; Zhang, B.; Zhang, H.
Cereal Res. Commun.
46
263-274
-
Crystal structure of S-adenosyl-L-homocysteine hydrolase from Cytophaga hutchinsonii, a case of combination of crystallographic and non-crystallographic symmetry
2018
Czyrko, J.; Jaskolski, M.; Brzezinski, K.
Croat. Chem. Acta
91
153-162
Identification and functional characterization of a novel selenocysteine methyltransferase from Brassica juncea L.
2019
Chen, M.; Zeng, L.; Luo, X.; Mehboob, M.Z.; Ao, T.; Lang, M.
J. Exp. Bot.
70
6401-6416
A coupled photometric assay for characterization of S-adenosyl-L-homocysteine hydrolases in the physiological hydrolytic direction
2017
Kailing, L.L.; Bertinetti, D.; Herberg, F.W.; Pavlidis, I.V.
New Biotechnol.
39
11-17
Identification and biochemical characterization of the serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase in Marchantia polymorpha
2018
Akashi, H.; Okamura, E.; Nishihama, R.; Kohchi, T.; Hirai, M.Y.
Front. Plant Sci.
9
956
Novel regulatory mechanism of serine biosynthesis associated with 3-phosphoglycerate dehydrogenase in Arabidopsis thaliana
2017
Okamura, E.; Hirai, M.Y.
Sci. Rep.
7
3533