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Information on EC 2.8.2.4 - estrone sulfotransferase and Organism(s) Homo sapiens

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     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.2 Sulfotransferases
                2.8.2.4 estrone sulfotransferase
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Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
oestrogen sulphotransferase, estrogen sulphotransferase, oestrogen sulfotransferase, sulfotransferase 1e1, rest-6, estrogen-st, e2-inactivating estrogen sulfotransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase
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3'-phosphoadenylyl sulfate:oestrone sulfotransferase
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cytosolic sulfotransferase
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E2-inactivating estrogen sulfotransferase
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ESFT
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estrogen sulfotransferase
estrogen sulphotransferase
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estrogen-ST
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estrone sulfotransferase
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oestrogen sulphotransferase
steroid sulfotransferase
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sulfotransferase
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sulfotransferase 1E1
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SULT1A1
SULT1A12
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SULT1A13
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SULT1E1
additional information
-
SULT1E1 belongs tot he superfamily of cytosolic SULTs
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
sulfate group transfer
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-06-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
17beta-estradiol + 3'-phosphoadenylyl sulfate
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram
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-
-
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?
3'-phopshoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + resveratrol 3-O-sulfate + resveratrol 4'-O-sulfate + resveratrol 3,4'-O-disulfate
show the reaction diagram
-
i.e. 3,5,4'-trihydroxystilbene, a phytoestrogen with mixed estrogen agonist/antagonist properties developed as a chemopreventive agent, interaction of resveratrol with 17beta-estradiol, overview
three different sulfate products, product identification by NMR, overview
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?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
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-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
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-
-
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?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 2-methyl-17beta-estradiol
adenosine 3',5'-bisphosphate + 2-methyl-17beta-estradiol 3-sulfate
show the reaction diagram
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-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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-
-
-
?
3'-phosphoadenylyl sulfate + 3-cyano-7-hydroxycoumarin
adenosine 3',5'-bisphosphate + 3-cyano-7-hydroxycoumaryl sulfate
show the reaction diagram
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-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + apigenin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + chrysin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
-
-
-
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?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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-
-
-
?
3'-phosphoadenylyl sulfate + epicatechin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen 3-sulfate
show the reaction diagram
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-
-
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?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + ethinyl estradiol
adenosine 3',5'-bisphosphate + ethinyl estradiol 3-sulfate
show the reaction diagram
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a synthetic oral contraceptive, low activity
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?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
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?
3'-phosphoadenylyl sulfate + quercetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
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?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
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?
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 17alpha-ethinylestradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
isoform SULT1A3
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?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
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-
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?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuranyl sulfate
show the reaction diagram
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r
3'-phosphoadenylylsulfate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine sulfate
show the reaction diagram
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r
3'-phosphoadenylylsulfate + 2-OH-4,2',4'-trichlorodiphenyl ether
adenosine 3',5'-bisphosphate + 2-OH-4,2',4'-trichlorodiphenyl ethyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 2-OH-4,5,3',2',3',4'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 2-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 2-OH-6,7,8-trichlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-6,7,8-trichlorinated dibenzofuranyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzofuranyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrabromo-4,4'isopropylidendiphenol
adenosine 3',5'-bisphosphate + 3,5,3',5'-tetrabromo-4,4'isopropylidendiphenyl sulfate
show the reaction diagram
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r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrachloro-4,4'isopropylidendiphenol
adenosine 3',5'-bisphosphate + 3,5,3',5'- tetrachloro-4,4'isopropylidendiphenyl sulfate
show the reaction diagram
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r
3'-phosphoadenylylsulfate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuranyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuranyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8- etrachlorinated dibenzofuranyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 3-OH-4,5,3',2',3',4'- tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 3-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
show the reaction diagram
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-
-
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r
3'-phosphoadenylylsulfate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
adenosine 3',5'-bisphosphate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl
adenosine 3',5'-bisphosphate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl sulfate
show the reaction diagram
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-
-
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r
3'-phosphoadenylylsulfate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuranyl sulfate
show the reaction diagram
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-
-
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r
3'-phosphoadenylylsulfate + 4-OH-2',4',6'-tribromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-2',4',6'-tribromodiphenyl ethyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 4-OH-3',2',4',6'-tetrabromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-3',2',4',6'-tetrabromodiphenyl ethyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 4-OH-3',5,2',4',6'-pentabromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-3',5,2',4',6'- pentabromodiphenyl ethyl sulfate
show the reaction diagram
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-
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r
3'-phosphoadenylylsulfate + 4-OH-3,3',4'-trichlorated biphenyl
adenosine 3',5'-bisphosphate + 4-OH-3,3',4'-trichlorated biphenyl sulfate
show the reaction diagram
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-
-
-
r
3'-phosphoadenylylsulfate + butylated hydroxyanisole
adenosine 3',5'-bisphosphate + butylated hydroxyanisole sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + catechin hydrate
adenosine 3',5'-bisphosphate + catechin hydrate sulfate
show the reaction diagram
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-
r
3'-phosphoadenylylsulfate + daidzein
adenosine 3',5'-bisphosphate + daidzein sulfate
show the reaction diagram
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r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + epicatechin
adenosine 3',5'-bisphosphate + epicatechin sulfate
show the reaction diagram
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-
r
3'-phosphoadenylylsulfate + epigallocatechin gallate
adenosine 3',5'-bisphosphate + epigallocatechin gallate sulfate
show the reaction diagram
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r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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-
-
-
?
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
show the reaction diagram
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-
-
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?
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
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-
-
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?
3'-phosphoadenylylsulfate + genistein
adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + kaempferol
adenosine 3',5'-bisphosphate + kaempferol sulfate
show the reaction diagram
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-
r
3'-phosphoadenylylsulfate + myricetin
adenosine 3',5'-bisphosphate + myricetin sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + n-propyl gallate
adenosine 3',5'-bisphosphate + n-propyl gallate sulfate
show the reaction diagram
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-
r
3'-phosphoadenylylsulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + quercetin
adenosine 3',5'-bisphosphate + quercetin sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + resveratrol
adenosine 3',5'-bisphosphate + resveratrol sulfate
show the reaction diagram
-
-
-
r
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 2-methyl-17beta-estradiol
adenosine 3',5'-bisphosphate + 2-methyl-17beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
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-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NaCl
-
activates
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-6beta-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one
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-
(+)-hispanone
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-
(-)-6,9:15,16-diepoxy-9alpha-hydroxy-8,9-seco-13(16),14-labdadiene-7-one
-
-
16alpha-hydroxyestrone
-
maximum inhibition at 100 nM
17beta-estradiol
2,4,6-tribromophenol
-
-
2,4,6-Trichlorophenol
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-
2,4,6-triiodophenol
-
-
2,6-Dichloro-4-nitrophenol
2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin
-
-
2-hydroxy-3,4,2',3',4'-pentachlorobiphenyl
-
-
2-hydroxy-3,4,3',4'-tetrachlorobiphenyl
-
-
2-hydroxy-4,5,3',4'-tetrachlorobiphenyl
-
-
2-hydroxy-7,8-dichlorodibenzo-p-dioxin
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-
2-hydroxy-7,8-dichlorodibenzofuran
-
-
2-OH-3,2'-dibromobiphenyl
-
-
3',4',7-trihydroxyisoflavone
-
-
3'-phosphoadenylylsulfate
-
-
3,3',5,5'-tetrachlorobisphenol A
-
-
3,3'-(hydroxy)2-4,4'-dichlorobiphenyl
-
-
-
3,5-dibromo-4-hydroxy-benzoic acid (6-chloro-4-oxo-4H-chromen-3-ylmethylene)-hydrazide
-
DBHM
3,5-dibromo-4-hydroxybenzoic acid (6,8-dichloro-4-oxo-4H-chromen-3-ylmethylene) hydrazide
-
DBHD
3-hydroxy-2,'4',5',2',3',4',5'-heptachlorobiphenyl
-
-
-
3-hydroxy-2,4,5,3',4'-pentachlorobiphenyl
-
-
-
3-hydroxy-2,4,7,8,9-pentachlorodibenzofuran
-
-
3-hydroxy-2,4,7,8-tetrachlorodibenzofuran
-
-
-
3-hydroxy-4,5,2',3',4'-pentachlorobiphenyl
-
-
-
3-hydroxy-4,5,3',4',5'-pentachlorobiphenyl
-
-
-
3-hydroxy-4,5,3',4'-tetrachlorobiphenyl
-
-
-
3-OH-2,2'-dibromobiphenyl
-
-
3-OH-4,4'-dibromobiphenyl
-
-
3alpha-tibolone
-
activates SULT1E1 in MCF-7 cells by 50% and 37% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 63%
3beta-tibolone
-
activates SULT1E1 in MCF-7 cells by 101% and 74% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 54%
4,4'-(hydroxy)2-3,5,'3',5'-tetrachlorobiphenyl
-
-
4,4'-isopropyl idenediphenol-3,3',5,5'-tetrachlorobisphenol
-
-
4,4'-isopropylidenediphenol
-
-
4-ene tibolone
-
inhibits at high concentrations of 0.05 mM by 59%
4-hydroxy-2',3',4',5'-tetrachlorobiphenyl
-
-
4-hydroxy-2',4',6'-trichlorobiphenyl
-
-
4-hydroxy-2,2',3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',3',4',6'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',3',5',6'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',4',6'-tetrachlorobiphenyl
-
-
4-hydroxy-2,3,4,5,6-pentabromodiphenylether
-
-
4-hydroxy-2,3,5,2',3',4',5'-heptachlorobiphenyl
-
-
4-hydroxy-2,3,5,2',3',4'-hexachlorobiphenyl
-
-
4-hydroxy-2,3,5,2',4',5'-hexachlorobiphenyl
-
-
4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
-
-
4-hydroxy-2,3,5,6,2',4',5'-heptachlorobiphenyl
-
-
4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',3',4',6'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',3',5',6'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',4',6'-tetrachlorobiphenyl
-
-
4-hydroxy-3,3',4'-trichlorobiphenyl
-
-
4-hydroxy-3,5,2',3',4',5'-hexachlorobiphenyl
-
-
4-hydroxy-3,5,2',3',4'-pentachlorobiphenyl
-
-
4-hydroxy-3,5,3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-3,5,3',4'-tetrachlorobiphenyl
-
-
4-hydroxy-3,5,3',5'-tetrachlorobiphenyl
-
-
4-hydroxybenzoate esters
-
i.e.parabens, structure-activity relationship, overview
4-hydroxybenzoic acid
-
-
4-OH-2,2'-dibromobiphenyl
-
-
4-OH-3,4'-dibromobiphenyl
-
-
4-OH-4'-monobromobiphenyl
-
-
5,7-dichlorokynurenic acid
-
-
6-OH-2,2'-dibromobiphenyl
-
-
Acetylsalicylate
-
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
adenosine 5'-(beta,gamma-imido) triphosphate
-
i.e. AMP-PNP, a non-hydrolysable ATP analogue
buthionine sulfoxamine
-
a GSH depletor, decreases SULT1E1 activity, but fails to affect the enzyme amount in Hep-G2 cells
butylparaben
-
50% inhibition at 0.021 mM, complete inhibition at 1 mM; strong inhibition, which is threefold higher in vivo than in vitro
Chloroform
-
excess chloroform inactivates
daidzein
-
-
daidzein 4,7-bissulfate
-
IC50: 0.01 mM
diclofenac
-
-
equol
-
potent mixed type inhibitor
ethylparaben
-
; 50% inhibition at 0.080 mM
formononetin
-
-
gavestinel
-
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
genistein
-
potent mixed type inhibitor
GSSG
-
oxidized glutathione, inactivation and kinetics, adenosine 3'-phosphate 5'-phosphosulfate protects
hydroxylated polychlorated biphenyls
-
-
-
Ibuprofen
-
-
ICI 182,720
-
produces a marked decrease (over 50%) of EST activity with respect to untreated control cell cultures at 24 h
indomethacin
-
-
Kynurenic acid
-
-
L689,560
-
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
L701,324
-
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
leosibiric acid A
-
most potent inhibition
leosibiric acid B
-
-
meclofenamate
-
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
Meclofenamic acid
-
-
medrogestone
-
biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview
Mefenamic acid
-
-
methylparaben
-
; 50% inhibition at 0.330 mM
naproxen
-
-
nimesulide
-
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
OrgOD14
-
active substance in Livial (r), above 0.05 mM decreases significantly biosynthesis of estrone by 50-60%, no effect in MDA-MB-231 cells
Pentachlorophenol
-
-
piroxicam
-
-
Promegestone
-
activates SULT1E1 by 26% at low concentrations of 500 nM, inhibits at 0.05 mM by 41%, leads to increased and decreased expression levels, respetively; biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview
propylparaben
-
; 50% inhibition at 0.030 mM
pyridoxal 5'-phosphate
-
a competitive inhibitor for sulfotransferases
quercetin
resveratrol
salicylate
-
-
salicylic acid
-
-
sulindac
-
-
tamoxifen
-
weak inhibition
tibolone
-
activates SULT1E1 in MCF-7 cells by 63% and 44% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 64%
trans-resveratrol
-
0.1 mM resveratrol significantly decreases the SULT1E1-mediated beta-estradiol sulfation
triclosan
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17-hydroxy-19-nor-7-methyl-17-pregn-5(10)-en-20-yn-3-one
3alpha-hydroxy-tibolone
-
biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, in MCF-7 and T4-7D cells, overview
3alpha-tibolone
-
activates SULT1E1 in MCF-7 cells by 50% and 37% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 63%
3beta-hydroxy-tibolone
-
biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, in MCF-7 and T4-7D cells, overview
3beta-hydroxytibolone
-
102% stimulation of activity at 0.0005 mM
3beta-tibolone
-
activates SULT1E1 in MCF-7 cells by 101% and 74% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 54%
4-ene-tibolone
-
-
celecoxib
-
-
medrogestone
Melatonin
-
the level of EST mRNA steady-state of cells treated with melatonin is three times higher than that in control cells
N-acetylcysteine
-
a GSH inducer, increases SULT1E1 activity, but fails to affect the enzyme amount in Hep-G2 cells
NaCl
-
activity of liver EST transiently expressed in COS-1 cells increases 86% in presence of 150 mM
nomegestrol acetate
progesterone
-
specific induction by 0.01 mM, 7fold increase in sulfation of beta-estradiol, Ishikawa endometrial adenocarcinoma cells
Promegestone
quercetin
-
-
resveratrol
-
-
tibolone
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000005 - 0.0082
17beta-estradiol
0.000005
3'-phosphoadenylyl sulfate
-
pH and temperature not specified in the publication
0.000059 - 0.01318
3'-phosphoadenylylsulfate
0.00018
3alpha-tibolone
-
pH 6.5, 37°C, recombinant SULT1E1
0.00048
3beta-tibolone
-
pH 6.5, 37°C, recombinant SULT1E1
0.15
4-nitrophenol
-
pH 6.1, 25°C
0.000038
adenosine 3',5'-bisphosphate
-
pH 6.3, 37°C
0.0053
apigenin
-
pH 6.5, 37°C, recombinant SULT1E1; pH 6.5, 37°C, SULT1E1
0.00033
beta-estradiol
-
isoform SULT1E1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
0.0045
chrysin
-
pH 6.5, 37°C, recombinant SULT1E1; pH 6.5, 37°C, SULT1E1
0.00005 - 0.0607
dehydroepiandrosterone
0.2407 - 79.35
dopamine
0.962
epicatechin
-
pH 6.5, 37°C, recombinant SULT1E1; pH 6.5, 37°C, SULT1E1
0.000004 - 0.0000105
estradiol
0.0001 - 0.0166
estrone
0.000007
ethinyl estradiol
-
pH 7.4, SULT1E1
0.0766 - 0.9372
p-nitrophenol
0.00032 - 0.002
quercetin
0.00058 - 0.0069
resveratrol
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00267 - 0.0217
17beta-estradiol
0.52
4-nitrophenol
-
pH 6.1, 25°C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00011 - 0.694
3-cyano-7-hydroxycoumarin
0.0009 - 0.151
4-nitrophenol
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000013 - 0.00008
17beta-estradiol
0.00006
2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin
-
pH 7.2, 37°C
0.000002
2-hydroxy-7,8-dichlorodibenzo-p-dioxin
-
pH 7.2, 37°C
0.00027
2-hydroxy-7,8-dichlorodibenzofuran
-
pH 7.2, 37°C
0.002
3',4',7-trihydroxyisoflavone
-
-
0.000155
3'-phosphoadenylylsulfate
-
pH 6.3, 37°C
0.000035
3,3',5,5'-tetrachlorobisphenol A
-
pH 7.2, 37°C
0.00000615
3-hydroxy-2,4,7,8,9-pentachlorodibenzofuran
-
pH 7.2, 37°C
0.014
4,4'-isopropylidenediphenol
-
pH 7.2, 37°C
0.00015
4-hydroxy-2,3,4,5,6-pentabromodiphenylether
-
pH 7.2, 37°C
0.002
daidzein
-
-
0.0004
equol
-
-
0.006
formononetin
-
-
0.0005
genistein
-
-
0.00058
quercetin
-
pH 7.4, 37°C
0.00036 - 0.0023
resveratrol
additional information
additional information
-
inactivation kinetics with oxidized glutathione
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0313
(+)-6beta-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one
Homo sapiens
-
at pH 6.0 and 37°C
0.0198
(+)-hispanone
Homo sapiens
-
at pH 6.0 and 37°C
0.0405
(-)-6,9:15,16-diepoxy-9alpha-hydroxy-8,9-seco-13(16),14-labdadiene-7-one
Homo sapiens
-
at pH 6.0 and 37°C
1.5
Acetylsalicylate
Homo sapiens
-
pH 6.5, 37°C, versus beta-estradiol
0.012 - 0.062
butylparaben
0.01
daidzein 4,7-bissulfate
Homo sapiens
-
IC50: 0.01 mM
0.14
Ibuprofen
Homo sapiens
-
pH 6.5, 37°C, versus beta-estradiol
0.0079
leosibiric acid A
Homo sapiens
-
at pH 6.0 and 37°C
0.0232
leosibiric acid B
Homo sapiens
-
at pH 6.0 and 37°C
0.0065
meclofenamate
Homo sapiens
-
pH 6.5, 37°C, versus beta-estradiol
0.0054
Meclofenamic acid
Homo sapiens
-
at pH 6.0 and 37°C
0.19
naproxen
Homo sapiens
-
pH 6.5, 37°C, versus beta-estradiol
0.23
nimesulide
Homo sapiens
-
pH 6.5, 37°C, versus beta-estradiol
0.27 - 9.4
piroxicam
0.91
salicylic acid
Homo sapiens
-
pH 6.5, 37°C, versus beta-estradiol
0.038
sulindac
Homo sapiens
-
pH 6.5, 37°C, versus beta-estradiol
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00000000005
-
NHEK cell enzyme, cytosol, substrate beta-estradiol
0.0000000001
-
skin enzyme, cytosol, substrate estrone
0.0000000008
-
skin enzyme, cytosol, substrate dehydroepiandrosterone
0.0000000011
-
skin enzyme, cytosol, substrate beta-estradiol
0.0000000049
-
recombinant SULT1E1
0.0000000185
-
liver enzyme, cytosol, substrate beta-estradiol
0.000158
-
catechin hydrate as substrate
0.000171
-
daidzein as substrate
0.000193
-
genistein as substrate
0.000343
-
epigallocatechin gallate as substrate
0.000351
-
epicatechin as substrate
0.000393
-
butylated hydroxyanisole as substrate
0.000452
-
kaempferol as substrate
0.000505
-
17alpha-ethynylestradiol as substrate
0.000526
-
estrone as substrate
0.000594
-
myricetin as substrate
0.000597
-
n-propyl gallate as substrate
0.00061
-
quercetin as substrate
0.012
-
purified recombinant SULT1E1 with substrate estrone
0.0455
-
purified recombinant SULT1E1 with substrate 17beta-estradiol
additional information
-
activity in healthy and hyperplasic endometrium with or without polycystic ovary syndrome, overview
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.2
-
assay at
7
-
assay at
7.5
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.8
-
placental enzyme, isoelectrofocusing
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
Ishikawa endometrial adenocarcinoma
Manually annotated by BRENDA team
-
fetal, isoform SULT1E1
Manually annotated by BRENDA team
-
female aortic smooth muscle cell line CRL-1999 cell
Manually annotated by BRENDA team
-
benign, and primary and secondary malignant bone tumors, from patients undergoing routine surgery for skeletal tumors
Manually annotated by BRENDA team
-
stromal cells
Manually annotated by BRENDA team
-
high activity in choroid plexus, isoform SULT1E1
Manually annotated by BRENDA team
-
specific expression of SULT1E1
Manually annotated by BRENDA team
-
recombinant SULT1E1 expressed in insect Sf9 cells
Manually annotated by BRENDA team
-
from from 14 patients operated for symptomatic cholelithiais
Manually annotated by BRENDA team
-
an osteosarcoma cell line, increased expression compared to healthy cells
Manually annotated by BRENDA team
-
epidermal
Manually annotated by BRENDA team
-
fetal, isoform SULT1E1
Manually annotated by BRENDA team
-
fetal and adult, isoform SULT1E1
Manually annotated by BRENDA team
-
estrogen sulfotransferase is significantly more active in the normal breast cell than in the cancer cell
Manually annotated by BRENDA team
-
an osteosarcoma cell line, high SULT1E1 expression level
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
intratumoral stromal cell
Manually annotated by BRENDA team
-
hormone-dependent breast cancer cell line
Manually annotated by BRENDA team
-
a Ewing’s sarcoma cell line, expression level of SULT1E1 is slightly reduced comapred to heathy cells
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
-
estrogen sulfotransferase SULT1E1 regulates inflammatory response and lipid metabolism of human endothelial cells via proliferator-activated receptor gamma
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
ST1E1_HUMAN
294
0
35126
Swiss-Prot
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
34200
-
calculated from cDNA
35000
35120
-
calculated from amino acid sequence
35123
-
2 * 35123, cDNA calculation
36000
-
SDS-PAGE
62000
-
gel filtration
68000
-
SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
additional information
-
detailed structural analysis and comparison of SULT family enzymes, comparison of substrate binding structures, overview, chemical library preparation and ligand binding screens
CRYSTALLIZATION/commentary
ORGANISM
UNIPROT
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D65N/K85E/E86K/F138Y
-
the mutant exhibits increased thermostability (heat inactivation at 43.4°C) compared to the wild type enzyme (42°C)
E12G/N29D/D65N/C83R/N87D/M98V/F138Y/G182S/L195M/H224K
-
the mutant exhibits increased thermostability (heat inactivation at 43.1°C) compared to the wild type enzyme (42°C)
E12G/N29D/F138Y/G182S/L251V
-
the mutant exhibits increased thermostability (heat inactivation at 51.8°C) compared to the wild type enzyme (42°C)
E12G/N29D/V73A/N87D/F138Y/G182S/L195M/E211G/E285G
-
the mutant exhibits increased thermostability (heat inactivation at 52.1°C) compared to the wild type enzyme (42°C)
F138Y/G182S/H224K/E285G
-
the mutant exhibits increased thermostability (heat inactivation at 54.6°C) compared to the wild type enzyme (42°C)
F138Y/G182S/L195M/E211G
-
the mutant exhibits increased thermostability (heat inactivation at 55.8°C) compared to the wild type enzyme (42°C)
H107A
-
site-directed mutagenesis, humSULT1E1, presence of a histidine residue at position 107 is essential for the production of a functional protein, substitution of this amino acid to alanine results in complete loss of activity towards all substrates tested
H224Q
-
naturally ocuring mutation in SULT1E1, genotyping in Jewish women of the Ashkenazi ethnic origin
K85A
-
site-directed mutagenesis, humSULT1E1
K85E/A135T/F138Y/G182S/L251V
-
the mutant exhibits increased thermostability (heat inactivation at 46.3°C) compared to the wild type enzyme (42°C)
N29D/L195M/H224K/L251V
-
the mutant exhibits increased thermostability (heat inactivation at 48.3°C) compared to the wild type enzyme (42°C)
V145E
-
site-directed mutagenesis, humSULT1E1
V73A/N87D/G182S/H224K/L251V/E285G
-
the mutant exhibits increased thermostability (heat inactivation at 52.8°C) compared to the wild type enzyme (42°C)
additional information
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
half-life 2 h, glycerol prevents detectable deterioration of activity over 3 h
30 - 45
-
thermal inactivation at 45°C
42
-
the wild type enzyme is inactivated at 42°C
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C, liver cytosol, 50 mM Tris-HCl, pH 7.8, 0.25 M sucrose, 0.5 mM EDTA, 0.1 mM DTT, and 0.02 mM BHT, no loss of activity during storage
-
-70°C, stable for several days
-
PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
Ni-NTA agarose column chromatography
-
Ni-NTA resin column chromatography, and gel filtration
-
recombinant enzyme
-
recombinant SULT1E1
-
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
EST cDNA cloned and expressed in COS-1 cells
-
EST cDNA subcloned into pKK233-2 and expressed in Escherichia coli XL1-Blue
-
EST cloned and expressed in Escherichia coli K1
-
EST expression analysis in healthy and endometriosis uterine endometrium showing no significant differences
-
EST expression analysis in presence and absence of melatonin
-
EST expression and regulation in invasive breast cancer and ductal carcinoma in situ, overview; expression analysis of the enzyme in healthy and preinvasive and invasive tumor breast tissue
-
expressed in Escherichia coli BL21(DE3) cells
-
expression analysis of EST by real-time RT-PCR in prostate cancer cell lines, overview
-
expression analysis of SULT1E1 in gallbladder tissue
-
expression of GFP-tagged SULT1E1 in HEK-293 cell cytoplasm, subcellular localization study, RT-PCR expression analysis, overview; expression of GFP-tagged SULT1E1 in HEK-293 cells, localization in the cytoplasm
-
expression of SULT1E1 in prostate cancer CAHPV-10 cells leading to changes in the transcriptional expression of selected signal transduction-related genes, real-time RT-PCR expression analysis, overview
-
functional overexpression of SULT1E1 in Escherichia coli strain XL-1 blue cytosol
-
hEST cloned and expressed in Salmonella typhimurium
-
human placental cDNA library constructed in lambda gt11, expression vector encoding estrogen sulfotransferase transfected in human adrenal adenocarcinoma SW-13 cells
-
stable expression of SULT1E1 in MCF-7 cells, expression of His-tagged SULT1E1 using a baculoviral-Spodoptera frugiperda Sf9 cell system
-
SULT1E1 cloned and expressed in Escherichia coli BL21 (DE3)
-
SULT1E1 expression analysis
-
SULT1E1 expression in a prokaryotic expression system
-
SULT1E1, DNA and mino acid sequence determination and analysis, genotyping
-
SULT1E1, quantitative expression analysis in benign and in primary and secondary malignant bone tumors
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme activity is significantly higher in the endometrial carcinoma than in normal endometrial tissues
-
inhibition of cystic fibrosis transmembrane receptor expression in MMNK-1 cells results in the induction SULT1E1 message and activity in Hep-G2 cells
-
insulin-like growth factor-1 increases SULT1E1 mRNA and SULT1E1 protein levels
-
reduced SULT1E1 expression is observed in the eutopic endometrium relative to the superficial lesions as well as during the follicular phase of the menstrual cycle
-
SULT expression in breast cancer cells can be stimulated by promegestone, SULT1E1 expression can be controlled by progesterone during the menstrual cycle and during early pregnancy
-
the enzyme expression is downregulated in ovarian cancer; there are significantly higher mRNA levels in ectopic endometrium of deep infiltrating endometriosis, when compared to the normal endometrium. The enzyme expression is upregulated in endometrial cancer
-
the enzyme expression is low in preadipocytes but increases upon differentiation
-
the increase in SULT1E1 activity results in the alteration of estradiol-regulated protein expression in cystic fibrosis liver, SULT1E1 expression in HepG2 cells is inducible by sterol mediated liver-X-receptor activation although not by progestins that induce SULT1E1 in the endometrium
-
WY14643 decreases SULT1E1 mRNA and SULT1E1 protein levels
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
pharmacology
-
reactivation of endogenous SULT1E1 gene expression may represent a novel therapeutic strategy to inhibit estrogen-dependent growth of breast cancer cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Forbes-Bamforth, K.J.; Coughtrie, M.W.H.
Identification of a new adult human liver sulfotransferase with specificity for endogenous and xenobiotic estrogens
Biochem. Biophys. Res. Commun.
198
707-711
1994
Homo sapiens
Manually annotated by BRENDA team
Chetrite, G.; Pasqualini, J.R.
Steroid sulphotransferase and 17beta-hydroxysteroid dehydrogenase activities in Ishikawa human endometrial adenocarcinoma cells
J. Steroid Biochem. Mol. Biol.
61
27-34
1997
Homo sapiens
Manually annotated by BRENDA team
Nakamura, Y.; Miki, Y.; Suzuki, T.; Nakata, T.; Darnel, A.D.; Moriya, T.; Tazawa, C.; Saito, H.; Ishibashi, T.; Takahashi, S.; Yamada, S.; Sasano, H.
Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta
Am. J. Pathol.
163
1329-1339
2003
Homo sapiens
Manually annotated by BRENDA team
Tseng, L.; Lee, L.Y.; Mazella, J.
Estrogen sulfotransferase in human placenta
J. Steroid Biochem.
22
611-615
1985
Homo sapiens
Manually annotated by BRENDA team
Hondoh, T.; Suzuki, T.; Hirato, K.; Saitoh, H.; Kadofuku, T.; Sato, T.; Yanahara, T.
Purification and properties of estrogen sulfotransferase of human fetal liver
Biomed. Res.
14
129-136
1993
Homo sapiens
-
Manually annotated by BRENDA team
Aksoy, I.A.; Wood, T.C.; Weinshilboum, R.
Human liver estrogen sulfotransferase: identification by cDNA cloning and expression
Biochem. Biophys. Res. Commun.
200
1621-1629
1994
Homo sapiens
Manually annotated by BRENDA team
Bernier, F.; Lopez, S.I.; Labrie, F.; van Luu, T.
Cloning and expression of cDNA encoding human placental estrogen sulfotransferase
Mol. Cell. Endocrinol.
99
R11-R15
1994
Homo sapiens
Manually annotated by BRENDA team
Falany, J.L.; Falany, C.N.
Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone
Endocrinology
137
1395-1401
1996
Homo sapiens
Manually annotated by BRENDA team
Her, C.; Szumlanski, C.; Aksoy, I.A.; Weinshilboum, R.M.
Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase: immunochemical characterization of individual variation
Drug Metab. Dispos.
24
1328-1335
1996
Homo sapiens
Manually annotated by BRENDA team
Kakuta, Y.; Petrotchenko, E.V.; Pedersen, L.C.; Negishi, M.
The sulfuryl transfer mechanism. Crystal structure of a vanadate complex of estrogen sulfotransferase and mutational analysis
J. Biol. Chem.
273
27325-27330
1998
Homo sapiens
Manually annotated by BRENDA team
Zhang, H.; Varlamova, O.; Vargas, F.M.; Falany, C.N.; Leyh, T.S.; Varmalova, O.
Sulfuryl transfer: the catalytic mechanism of human estrogen sulfotransferase
J. Biol. Chem.
273
10888-10892
1998
Homo sapiens
Manually annotated by BRENDA team
Chetrite, G.S.; Kloosterboer, H.J.; Philippe, J.C.; Pasqualini, J.R.
Effect of Org OD14 (LIVIAL) and its metabolites on human estrogen sulphotransferase activity in the hormone-dependent MCF-7 and T-47D, and the hormone-independent MDA-MB-231, breast cancer cell lines
Anticancer Res.
19
269-275
1999
Homo sapiens
Manually annotated by BRENDA team
Pasqualini, J.R.; Chetrite, G.S.
Estrone sulfatase versus estrone sulfotransferase in human breast cancer: potential clinical applications
J. Steroid Biochem. Mol. Biol.
69
287-292
1999
Homo sapiens
Manually annotated by BRENDA team
Qian, Y.; Song, W.C.
Correlation between PAP-dependent steroid binding activity and substrate specificity of mouse and human estrogen sulfotransferases
J. Steroid Biochem. Mol. Biol.
71
123-131
1999
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Hempel, N.; Barnett, A.C.; Bolton-Grob, R.M.; Liyou, N.E.; McManus, M.E.
Site-directed mutagenesis of the substrate-binding cleft of human estrogen sulfotransferase
Biochem. Biophys. Res. Commun.
276
224-230
2000
Homo sapiens
Manually annotated by BRENDA team
Kester, M.H.; Bulduk, S.; Tibboel, D.; Meinl, W.; Glatt, H.; Falany, C.N.; Coughtrie, M.W.; Bergman, A.; Safe, S.H.; Kuiper, G.G.; Schuur, A.G.; Brouwer, A.; Visser, T.J.
Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs
Endocrinology
141
1897-1900
2000
Homo sapiens
Manually annotated by BRENDA team
Otake, Y.; Nolan, A.L.; Walle, U.K.; Walle, T.
Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells
J. Steroid Biochem. Mol. Biol.
73
265-270
2000
Homo sapiens
Manually annotated by BRENDA team
Pai, T.G.; Suiko, M.; Sakakibara, Y.; Liu, M.C.
Sulfation of Flavonoids and Other Phenolic Dietary Compounds by the Human Cytosolic Sulfotransferases
Biochem. Biophys. Res. Commun.
285
1175-1179
2001
Homo sapiens (P49888)
Manually annotated by BRENDA team
Song, W.C.
Biochemistry and reproductive endocrinology of estrogen sulfotransferase
Ann. N. Y. Acad. Sci.
948
43-50
2001
Bos taurus, Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kester, M.H.; Bulduk, S.; van Toor, H.; Tibboel, D.; Meinl, W.; Glatt, H.; Falany, C.N.; Coughtrie, M.W.; Schuur, A.G.; Brouwer, A.; Visser, T.J.
Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters
J. Clin. Endocrinol. Metab.
87
1142-1150
2002
Homo sapiens
Manually annotated by BRENDA team
Pedersen, L.C.; Petrotchenko, E.; Shevtsov, S.; Negishi, M.
Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction
J. Biol. Chem.
277
17928-17932
2002
Homo sapiens (P49888)
Manually annotated by BRENDA team
van Lipzig, M.M.; Commandeur, J.N.; de Kanter, F.J.; Damsten, M.C.; Vermeulen, N.P.; Maat, E.; Groot, E.J.; Brouwer, A.; Kester, M.H.; Visser, T.J.; Meerman, J.H.
Bioactivation of dibrominated biphenyls by cytochrome P450 activity to metabolites with estrogenic activity and estrogen sulfotransferase inhibition capacity
Chem. Res. Toxicol.
18
1691-1700
2005
Homo sapiens
Manually annotated by BRENDA team
Harris, R.M.; Wood, D.M.; Bottomley, L.; Blagg, S.; Owen, K.; Hughes, P.J.; Waring, R.H.; Kirk, C.J.
Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatment
J. Clin. Endocrinol. Metab.
89
1779-1787
2004
Homo sapiens
Manually annotated by BRENDA team
Stanley, E.L.; Hume, R.; Coughtrie, M.W.H.
Expression profiling of human fetal cytosolic sulfotransferases involved in steroid and thyroid hormone metabolism and in detoxification
Mol. Cell. Endocrinol.
240
32-42
2005
Homo sapiens
Manually annotated by BRENDA team
Pasqualini, J.R.; Chetrite, G.S.
Correlation of estrogen sulfotransferase activity and proliferation in normal and carcinomatous human breast. A hypothesis
Anticancer Res.
27
3219-3225
2007
Homo sapiens
Manually annotated by BRENDA team
King, R.S.; Ghosh, A.A.; Wu, J.
Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents
Curr. Drug Metab.
7
745-753
2006
Homo sapiens (P49888)
Manually annotated by BRENDA team
Kapoor, R.; Nimmagadda, D.; Sheng, J.J.
Cellular localization studies on human estrogen sulfotransferase SULT1E1 in human embryonic kidney 293 cells
Drug Metab. Dispos.
35
17-20
2007
Homo sapiens, Homo sapiens (P49888)
Manually annotated by BRENDA team
Ung, D.; Nagar, S.
Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1
Drug Metab. Dispos.
35
740-746
2007
Homo sapiens, Homo sapiens (P49888)
Manually annotated by BRENDA team
Furimsky, A.M.; Green, C.E.; Hunt Sharp, L.E.; Catz, P.; Adjei, A.A.; Parman, T.; Kapetanovic, I.M.; Weinshilboum, R.M.; Iyer, L.V.
Effect of resveratrol on 17{beta}-estradiol sulfation by human hepatic and jejunal S9 and recombinant SULT1E1
Drug Metab. Dispos.
36
129-136
2008
Homo sapiens
Manually annotated by BRENDA team
Hoff, R.H.; Czyryca, P.G.; Sun, M.; Leyh, T.S.; Hengge, A.C.
Transition state of the sulfuryl transfer reaction of estrogen sulfotransferase
J. Biol. Chem.
281
30645-30649
2006
Homo sapiens
Manually annotated by BRENDA team
Hudelist, G.; Wuelfing, P.; Kersting, C.; Burger, H.; Mattsson, B.; Czerwenka, K.; Kubista, E.; Gschwantler-Kaulich, D.; Fink-Retter, A.; Singer, C.F.
Expression of aromatase and estrogen sulfotransferase in preinvasive and invasive breast cancer
J. Cancer Res. Clin. Oncol.
134
67-73
2008
Homo sapiens
Manually annotated by BRENDA team
Li, L.; Falany, C.N.
Elevated hepatic SULT1E1 activity in mouse models of cystic fibrosis alters the regulation of estrogen responsive proteins
J. Cyst. Fibros.
6
23-30
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Allali-Hassani, A.; Pan, P.W.; Dombrovski, L.; Najmanovich, R.; Tempel, W.; Dong, A.; Loppnau, P.; Martin, F.; Thonton, J.; Edwards, A.M.; Bochkarev, A.; Plotnikov, A.N.; Vedadi, M.; Arrowsmith, C.H.
Structural and chemical profiling of the human cytosolic sulfotransferases
PLoS Biol.
5
1063-1078
2007
Homo sapiens (P49888)
-
Manually annotated by BRENDA team
Nakamura, Y.; Suzuki, T.; Fukuda, T.; Ito, A.; Endo, M.; Moriya, T.; Arai, Y.; Sasano, H.
Steroid sulfatase and estrogen sulfotransferase in human prostate cancer
Prostate
66
1005-1012
2006
Homo sapiens
Manually annotated by BRENDA team
Wang, M.; Ebmeier, C.C.; Olin, J.R.; Anderson, R.J.
Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs)
Steroids
71
343-351
2006
Homo sapiens (P49888)
Manually annotated by BRENDA team
Prusakiewicz, J.J.; Harville, H.M.; Zhang, Y.; Ackermann, C.; Voorman, R.L.
Parabens inhibit human skin estrogen sulfotransferase activity: possible link to paraben estrogenic effects
Toxicology
232
248-256
2007
Homo sapiens
Manually annotated by BRENDA team
Maiti, S.; Zhang, J.; Chen, G.
Redox regulation of human estrogen sulfotransferase (hSULT1E1)
Biochem. Pharmacol.
73
1474-1481
2007
Homo sapiens
Manually annotated by BRENDA team
Hui, Y.; Yasuda, S.; Liu, M.Y.; Wu, Y.Y.; Liu, M.C.
On the sulfation and methylation of catecholestrogens in human mammary epithelial cells and breast cancer cells
Biol. Pharm. Bull.
31
769-773
2008
Homo sapiens
Manually annotated by BRENDA team
Svoboda, M.; Sellner, F.; Ekmekcioglu, C.; Klimpfinger, M.; Jaeger, W.; Thalhammer, T.
Expression of estrogen-metabolizing enzymes and estrogen receptors in cholelithiasis gallbladder
Biomed. Pharmacother.
62
690-696
2008
Homo sapiens
Manually annotated by BRENDA team
Hirata, H.; Hinoda, Y.; Okayama, N.; Suehiro, Y.; Kawamoto, K.; Kikuno, N.; Rabban, J.T.; Chen, L.M.; Dahiya, R.
CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility
Cancer
112
1964-1973
2008
Homo sapiens
Manually annotated by BRENDA team
Gong, H.; Jarzynka, M.J.; Cole, T.J.; Lee, J.H.; Wada, T.; Zhang, B.; Gao, J.; Song, W.C.; DeFranco, D.B.; Cheng, S.Y.; Xie, W.
Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase
Cancer Res.
68
7386-7393
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Sato, R.; Suzuki, T.; Katayose, Y.; Miura, K.; Shiiba, K.; Tateno, H.; Miki, Y.; Akahira, J.; Kamogawa, Y.; Nagasaki, S.; Yamamoto, K.; Ii, T.; Egawa, S.; Evans, D.B.; Unno, M.; Sasano, H.
Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors
Cancer Res.
69
914-922
2009
Homo sapiens
Manually annotated by BRENDA team
Kapoor, R.; Sheng, J.J.
Transfection of human prostate cancer CA-HPV-10 cells with cytosolic sulfotransferase SULT1E1 affects estrogen signaling and gene transcription
Drug Metab. Dispos.
36
316-321
2008
Homo sapiens
Manually annotated by BRENDA team
Cohen, S.; Laitman, Y.; Kaufman, B.; Milgrom, R.; Nir, U.; Friedman, E.
SULT1E1 and ID2 genes as candidates for inherited predisposition to breast and ovarian cancer in Jewish women
Fam. Cancer
8
135-144
2008
Homo sapiens
Manually annotated by BRENDA team
Gonzalez, A.; Cos, S.; Martinez-Campa, C.; Alonso-Gonzalez, C.; Sanchez-Mateos, S.; Mediavilla, M.D.; Sanchez-Barcelo, E.J.
Selective estrogen enzyme modulator actions of melatonin in human breast cancer cells
J. Pineal Res.
45
86-92
2008
Homo sapiens
Manually annotated by BRENDA team
Bacallao, K.; Leon, L.; Gabler, F.; Soto, E.; Romero, C.; Valladares, L.; Vega, M.
In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia
J. Steroid Biochem. Mol. Biol.
110
163-169
2008
Homo sapiens
Manually annotated by BRENDA team
Svoboda, M.; Thalhammer, T.; Aust, S.; Arrich, F.; Assadian, O.; Toma, C.D.
Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors
J. Surg. Oncol.
95
572-581
2007
Homo sapiens
Manually annotated by BRENDA team
Hudelist, G.; Czerwenka, K.; Keckstein, J.; Haas, C.; Fink-Retter, A.; Gschwantler-Kaulich, D.; Kubista, E.; Singer, C.F.
Expression of aromatase and estrogen sulfotransferase in eutopic and ectopic endometrium: evidence for unbalanced estradiol production in endometriosis
Reprod. Sci.
14
798-805
2007
Homo sapiens
Manually annotated by BRENDA team
Campisi, I.; Granata, O.M.; Cocciadiferro, L.; Calabro, M.; Polito, L.M.; Carruba, G.
16alpha-hydroxyestrone inhibits estrogen sulfotransferase activity in human liver cancer cells
Ann. N. Y. Acad. Sci.
1155
237-241
2009
Homo sapiens
Manually annotated by BRENDA team
Sasano, H.; Nagasaki, S.; Miki, Y.; Suzuki, T.
New developments in intracrinology of human breast cancer: estrogen sulfatase and sulfotransferase
Ann. N. Y. Acad. Sci.
1155
76-79
2009
Homo sapiens
Manually annotated by BRENDA team
Pasqualini, J.R.
Estrogen sulfotransferases in breast and endometrial cancers
Ann. N. Y. Acad. Sci.
1155
88-98
2009
Homo sapiens
Manually annotated by BRENDA team
Senggunprai, L.; Yoshinari, K.; Yamazoe, Y.
Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases
Biochem. J.
422
455-462
2009
Homo sapiens (P49888)
Manually annotated by BRENDA team
He, D.; Wilborn, T.W.; Falany, J.L.; Li, L.; Falany, C.N.
Repression of CFTR activity in human MMNK-1 cholangiocytes induces sulfotransferase 1E1 expression in co-cultured HepG2 hepatocytes
Biochim. Biophys. Acta
1783
2391-2397
2008
Homo sapiens
Manually annotated by BRENDA team
Falany, C.N.; He, D.; Li, L.; Falany, J.L.; Wilborn, T.W.; Kocarek, T.A.; Runge-Morris, M.
Regulation of hepatic sulfotransferase (SULT) 1E1 expression and effects on estrogenic activity in cystic fibrosis (CF)
J. Steroid Biochem. Mol. Biol.
114
113-119
2009
Homo sapiens
Manually annotated by BRENDA team
Ung, D.; Nagar, S.
Trans-resveratrol-mediated inhibition of beta-oestradiol conjugation in MCF-7 cells stably expressing human sulfotransferases SULT1A1 or SULT1E1, and human liver microsomes
Xenobiotica
39
72-79
2009
Homo sapiens
Manually annotated by BRENDA team
Suzuki, T.; Miki, Y.; Nakamura, Y.; Ito, K.; Sasano, H.
Steroid sulfatase and estrogen sulfotransferase in human carcinomas
Mol. Cell. Endocrinol.
340
148-153
2011
Homo sapiens
Manually annotated by BRENDA team
Sun, M.; Leyh, T.S.
The human estrogen sulfotransferase: a half-site reactive enzyme
Biochemistry
49
4779-4785
2010
Homo sapiens
Manually annotated by BRENDA team
Amar, D.; Berger, I.; Amara, N.; Tafa, G.; Meijler, M.M.; Aharoni, A.
The transition of human estrogen sulfotransferase from generalist to specialist using directed enzyme evolution
J. Mol. Biol.
416
21-32
2012
Homo sapiens (P49888)
Manually annotated by BRENDA team
Xu, Y.; Yang, X.; Wang, Z.; Li, M.; Ning, Y.; Chen, S.; Yin, L.; Li, X.
Estrogen sulfotransferase (SULT1E1) regulates inflammatory response and lipid metabolism of human endothelial cells via PPARgamma
Mol. Cell. Endocrinol.
369
140-149
2013
Homo sapiens, Homo sapiens (P49888)
Manually annotated by BRENDA team
Iida, S.; Kakinuma, H.; Miki, Y.; Abe, K.; Sakurai, M.; Suzuki, S.; Niikawa, H.; Akahira, J.; Suzuki, T.; Sasano, H.
Steroid sulphatase and oestrogen sulphotransferase in human non-small-cell lung carcinoma
Br. J. Cancer
108
1415-1424
2013
Homo sapiens
Manually annotated by BRENDA team
Rizner, T.L.
The important roles of steroid sulfatase and sulfotransferases in gynecological diseases
Front. Pharmacol.
7
30
2016
Homo sapiens (P49888)
Manually annotated by BRENDA team
Narukawa, Y.; Niimura, A.; Noguchi, H.; Tamura, H.; Kiuchi, F.
New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L.
J. Nat. Med.
68
125-131
2014
Homo sapiens (P49888)
Manually annotated by BRENDA team
Piccinato, C.A.; Neme, R.M.; Torres, N.; Sanches, L.R.; Derogis, P.B.; Brudniewski, H.F.; Rosa e Silva, J.C.; Ferriani, R.A.
Effects of steroid hormone on estrogen sulfotransferase and on steroid sulfatase expression in endometriosis tissue and stromal cells
J. Steroid Biochem. Mol. Biol.
158
117-126
2016
Homo sapiens (P49888)
Manually annotated by BRENDA team
Ihunnah, C.A.; Wada, T.; Philips, B.J.; Ravuri, S.K.; Gibbs, R.B.; Kirisci, L.; Rubin, J.P.; Marra, K.G.; Xie, W.
Estrogen sulfotransferase/SULT1E1 promotes human adipogenesis
Mol. Cell. Biol.
34
1682-1694
2014
Homo sapiens (P49888)
Manually annotated by BRENDA team
Li, Y.; Xu, Y.; Li, X.; Qin, Y.; Hu, R.
Effects of PPAR-alpha agonist and IGF-1 on estrogen sulfotransferase in human vascular endothelial and smooth muscle cells
Mol. Med. Rep.
8
133-139
2013
Homo sapiens (P49888)
Manually annotated by BRENDA team
Wang, X.; Chen, X.; Feng, X.; Chang, F.; Chen, M.; Xia, Y.; Chen, L.
Triclosan causes spontaneous abortion accompanied by decline of estrogen sulfotransferase activity in humans and mice
Sci. Rep.
5
18252
2015
Homo sapiens (P49888), Mus musculus
Manually annotated by BRENDA team
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