Reference on EC 2.3.1.304 - poly[(R)-3-hydroxyalkanoate] polymerase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kolibachuk, D.; Miller, A.; Dennis, D.
Cloning, molecular analysis, and expression of the polyhydroxyalkanoic acid synthase (phaC) gene from Chromobacterium violaceum
Appl. Environ. Microbiol.
65
3561-3565
1999
Chromobacterium violaceum (Q9ZHI2), Chromobacterium violaceum
Hai, T.; Lange, D.; Rabus, R.; Steinbuchel, A.
Polyhydroxyalkanoate (PHA) accumulation in sulfate-reducing bacteria and identification of a class III PHA synthase (PhaEC) in Desulfococcus multivorans
Appl. Environ. Microbiol.
70
4440-4448
2004
Desulfococcus multivorans
Zheng, Z.; Li, M.; Xue, X.J.; Tian, H.L.; Li, Z.; Chen, G.Q.
Mutation on N-terminus of polyhydroxybutyrate synthase of Ralstonia eutropha enhanced PHB accumulation
Appl. Microbiol. Biotechnol.
72
896-905
2006
Cupriavidus necator
Yuan, W.; Jia, Y.; Tian, J.; Snell, K.D.; Muh, U.; Sinskey, A.J.; Lambalot, R.H.; Walsh, C.T.; Stubbe, J.
Class I and III polyhydroxyalkanoate synthases from Ralstonia eutropha and Allochromatium vinosum: characterization and substrate specificity studies
Arch. Biochem. Biophys.
394
87-98
2001
Cupriavidus necator, Allochromatium vinosum
Hezayen, F.F.; Steinbuchel, A.; Rehm, B.H.
Biochemical and enzymological properties of the polyhydroxybutyrate synthase from the extremely halophilic archaeon strain 56
Arch. Biochem. Biophys.
403
284-291
2002
Halopiger aswanensis, Halopiger aswanensis DSM 13151
Dai, D.; Reusch, R.N.
Poly-3-hydroxybutyrate synthase from the periplasm of Escherichia coli
Biochem. Biophys. Res. Commun.
374
485-489
2008
Escherichia coli
Mh, U.; Sinskey, A.J.; Kirby, D.P.; Lane, W.S.; Stubbe, J.
PHA synthase from chromatium vinosum: cysteine 149 is involved in covalent catalysis
Biochemistry
38
826-837
1999
Allochromatium vinosum
Jia, Y.; Kappock, T.J.; Frick, T.; Sinskey, A.J.; Stubbe, J.
Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in Chromatium vinosum PHB synthase
Biochemistry
39
3927-3936
2000
Allochromatium vinosum
Jia, Y.; Yuan, W.; Wodzinska, J.; Park, C.; Sinskey, A.J.; Stubbe, J.
Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism
Biochemistry
40
1011-1019
2001
Cupriavidus necator
Tian, J.; Sinskey, A.J.; Stubbe, J.
Detection of intermediates from the polymerization reaction catalyzed by a D302A mutant of class III polyhydroxyalkanoate (PHA) synthase
Biochemistry
44
1495-1503
2005
Allochromatium vinosum
Tian, J.; Sinskey, A.J.; Stubbe, J.
Class III polyhydroxybutyrate synthase: involvement in chain termination and reinitiation
Biochemistry
44
8369-8377
2005
Allochromatium vinosum
Rehm, B.H.; Antonio, R.V.; Spiekermann, P.; Amara, A.A.; Steinbuchel, A.
Molecular characterization of the poly(3-hydroxybutyrate) (PHB) synthase from Ralstonia eutropha: in vitro evolution, site-specific mutagenesis and development of a PHB synthase protein model
Biochim. Biophys. Acta
1594
178-190
2002
Cupriavidus necator
Song, J.J.; Zhang, S.; Lenz, R.W.; Goodwin, S.
In vitro polymerization and copolymerization of 3-hydroxypropionyl-CoA with the PHB synthase from Ralstonia eutropha
Biomacromolecules
1
433-439
2000
Cupriavidus necator
Zhang, S.; Kolvek, S.; Lenz, R.W.; Goodwin, S.
Mechanism of the polymerization reaction initiated and catalyzed by the polyhydroxybutyrate synthase of Ralstonia eutropha
Biomacromolecules
4
504-509
2003
Cupriavidus necator
Zhang, S.; Kolvek, S.; Goodwin, S.; Lenz, R.W.
Poly(hydroxyalkanoic acid) biosynthesis in Ectothiorhodospira shaposhnikovii: characterization and reactivity of a type III PHA synthase
Biomacromolecules
5
40-48
2004
Ectothiorhodospira shaposhnikovii (Q9F5P8 and Q9F5P9), Ectothiorhodospira shaposhnikovii (Q9F5P9), Ectothiorhodospira shaposhnikovii
Matsumoto, K.; Nagao, R.; Murata, T.; Arai, Y.; Kichise, T.; Nakashita, H.; Taguchi, S.; Shimada, H.; Doi, Y.
Enhancement of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) production in the transgenic Arabidopsis thaliana by the in vitro evolved highly active mutants of polyhydroxyalkanoate (PHA) synthase from Aeromonas caviae
Biomacromolecules
6
2126-2130
2005
Aeromonas caviae
Matsumoto, K.; Takase, K.; Aoki, E.; Doi, Y.; Taguchi, S.
Synergistic effects of Glu130Asp substitution in the type II polyhydroxyalkanoate (PHA) synthase: enhancement of PHA production and alteration of polymer molecular weight
Biomacromolecules
6
99-104
2005
Pseudomonas sp.
Normi, Y.M.; Hiraishi, T.; Taguchi, S.; Sudesh, K.; Najimudin, N.; Doi, Y.
Site-directed saturation mutagenesis at residue F420 and recombination with another beneficial mutation of Ralstonia eutropha polyhydroxyalkanoate synthase
Biotechnol. Lett.
27
705-712
2005
Cupriavidus necator
Liebergesell, M.; Sonomoto, K.; Madkour, M.; Mayer, F.; Steinbuchel, A.
Purification and characterization of the poly(hydroxyalkanoic acid) synthase from Chromatium vinosum and localization of the enzyme at the surface of poly(hydroxyalkanoic acid) granules
Eur. J. Biochem.
226
71-80
1994
Allochromatium vinosum
Kichise, T.; Fukui, T.; Yoshida, Y.; Doi, Y.
Biosynthesis of polyhydroxyalkanoates (PHA) by recombinant Ralstonia eutropha and effects of PHA synthase activity on in vivo PHA biosynthesis
Int. J. Biol. Macromol.
25
69-77
1999
Aeromonas caviae
Wodzinska, J.; Snell, K.D.; Rhomberg, A.; Sinskey, A.J.; Biemann, K.; Stubbe, J.
Polyhydroxybutyrate synthase: Evidence for covalent catalysis
J. Am. Chem. Soc.
118
6319-6320
1996
Cupriavidus necator
-
Lu, Q.; Han, J.; Zhou, L.; Zhou, J.; Xiang, H.
Genetic and biochemical characterization of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthase in Haloferax mediterranei
J. Bacteriol.
190
4173-4180
2008
Haloferax mediterranei (I3R9Z3 and I3R9Z4), Haloferax mediterranei
Takase, K.; Taguchi, S.; Doi, Y.
Enhanced synthesis of poly(3-hydroxybutyrate) in recombinant Escherichia coli by means of error-prone PCR mutagenesis, saturation mutagenesis, and in vitro recombination of the type II polyhydroxyalkanoate synthase gene
J. Biochem.
133
139-145
2003
Pseudomonas sp.
Sharma, L.; Panda, B.; Singh, A.K.; Mallick, N.
Studies on poly-beta-hydroxybutyrate synthase activity of Nostoc muscorum
J. Gen. Appl. Microbiol.
52
209-214
2006
Desmonostoc muscorum
Normi, Y.M.; Hiraishi, T.; Taguchi, S.; Abe, H.; Sudesh, K.; Najimudin, N.; Doi, Y.
Characterization and properties of G4X mutants of Ralstonia eutropha PHA synthase for poly(3-hydroxybutyrate) biosynthesis in Escherichia coli
Macromol. Biosci.
5
197-206
2005
Cupriavidus necator
Hai, T.; Hein, S.; Steinbuchel, A.
Multiple evidence for widespread and general occurrence of type-III PHA synthases in cyanobacteria and molecular characterization of the PHA synthases from two thermophilic cyanobacteria: Chlorogloeopsis fritschii PCC 6912 and Synechococcus sp. strain MA19
Microbiology
147
3047-3060
2001
Anabaena cylindrica, Gloeocapsa sp., Synechococcus sp., Synechococcus sp. (Q8RT55), Crocosphaera subtropica ATCC 51142, Crocosphaera subtropica ATCC 51142 (B7KDE2), no activity in Stanieria cyanosphaera, no activity in Cyanothece sp., no activity in Gloeothece membranacea, Chlorogloeopsis fritschii (Q8RTL8), no activity in Cyanothece sp. PCC 8955, no activity in Gloeothece membranacea PCC 6501, no activity in Stanieria cyanosphaera PCC 7437, Anabaena cylindrica SAG 1403-2
Qi, Q.; Rehm, B.H.
Polyhydroxybutyrate biosynthesis in Caulobacter crescentus: molecular characterization of the polyhydroxybutyrate synthase
Microbiology
147
3353-3358
2001
Caulobacter vibrioides (Q9F4K5), Caulobacter vibrioides
Sim, S.J.; Snell, K.D.; Hogan, S.A.; Stubbe, J.; Rha, C.; Sinskey, A.J.
PHA synthase activity controls the molecular weight and polydispersity of polyhydroxybutyrate in vivo
Nat. Biotechnol.
15
63-67
1997
Cupriavidus necator
Matsumoto, K.; Yamada, M.; Leong, C.; Jo, S.; Kuzuyama, T.; Taguchi, S.
A new pathway for poly(3-hydroxybutyrate) production in Escherichia coli and Corynebacterium glutamicum by functional expression of a new acetoacetyl-coenzyme A synthase
Biosci. Biotechnol. Biochem.
75
364-366
2011
Cupriavidus necator
Han, J.; Hou, J.; Liu, H.; Cai, S.; Feng, B.; Zhou, J.; Xiang, H.
Wide distribution among halophilic archaea of a novel polyhydroxyalkanoate synthase subtype with homology to bacterial type III synthases
Appl. Environ. Microbiol.
76
7811-7819
2010
Halobacteriaceae
Yang, T.H.; Jung, Y.K.; Kang, H.O.; Kim, T.W.; Park, S.J.; Lee, S.Y.
Tailor-made type II Pseudomonas PHA synthases and their use for the biosynthesis of polylactic acid and its copolymer in recombinant Escherichia coli
Appl. Microbiol. Biotechnol.
90
603-614
2011
Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas chlororaphis (C0LD26), Pseudomonas chlororaphis, Pseudomonas resinovorans (Q9X5X7), Pseudomonas resinovorans, Pseudomonas sp. (Q9Z3Y1), Pseudomonas sp., Pseudomonas chlororaphis KCTC 12349 (C0LD26), Pseudomonas putida KT 2240, Pseudomonas resinovorans KCTC 12498 (Q9X5X7)
Cho, M.; Brigham, C.J.; Sinskey, A.J.; Stubbe, J.
Purification of polyhydroxybutyrate synthase from its native organism, Ralstonia eutropha: implications for the initiation and elongation of polymer formation in vivo
Biochemistry
51
2276-2288
2012
Cupriavidus necator, Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
Tomizawa, S.; Hyakutake, M.; Saito, Y.; Agus, J.; Mizuno, K.; Abe, H.; Tsuge, T.
Molecular weight change of polyhydroxyalkanoate (PHA) caused by the PhaC subunit of PHA synthase from Bacillus cereus YB-4 in recombinant Escherichia coli
Biomacromolecules
12
2660-2666
2011
Bacillus cereus (D2Z0B8), Bacillus cereus, Priestia megaterium (D2Z0B9), Priestia megaterium, Bacillus cereus YB-4 (D2Z0B8), Bacillus cereus YB-4, Priestia megaterium NBRC15308 (D2Z0B9)
Shozui, F.; Sun, J.; Song, Y.; Yamada, M.; Sakai, K.; Matsumoto, K.; Takase, K.; Taguchi, S.
A new beneficial mutation in Pseudomonas sp. 61-3 polyhydroxyalkanoate (PHA) synthase for enhanced cellular content of 3-hydroxybutyrate-based PHA explored using its enzyme homolog as a mutation template
Biosci. Biotechnol. Biochem.
74
1710-1712
2010
Pseudomonas sp.
Tan, Y.; Neo, P.C.; Najimudin, N.; Sudesh, K.; Muhammad, T.S.; Othman, A.S.; Samian, R.
Cloning and characterization of poly(3-hydroxybutyrate) biosynthesis genes from Pseudomonas sp. USM 4-55
J. Basic Microbiol.
50
179-189
2010
Pseudomonas sp. (C0KTZ0), Pseudomonas sp., Pseudomonas sp. USM4-55 (C0KTZ0)
Sato, S.; Minato, M.; Kikkawa, Y.; Abe, H.; Tsuge, T.
In vitro synthesis of polyhydroxyalkanoate catalyzed by class II and III PHA synthases: A useful technique for surface coatings of a hydrophobic support with PHA
J. Chem. Technol. Biotechnol.
85
779-782
2010
Allochromatium vinosum, Pseudomonas putida
-
Kek, Y.; Chang, C.; Amirul, A.; Sudesh, K.
Heterologous expression of Cupriavidus sp. USMAA2-4 PHA synthase gene in PHB-4 mutant for the production of poly(3-hydroxybutyrate) and its copolymers
World J. Microbiol. Biotechnol.
26
1595-1603
2010
Cupriavidus sp., Cupriavidus sp. USMAA2-4
Zhang, W.; Shrestha, R.; Buckley, R.M.; Jewell, J.; Bossmann, S.H.; Stubbe, J.; Li, P.
Mechanistic insight with HBCH2CoA as a probe to polyhydroxybutyrate (PHB) synthases
ACS Chem. Biol.
9
1773-1779
2014
Cupriavidus necator, Allochromatium vinosum
Thomson, N.; Saika, A.; Ushimaru, K.; Sangiambut, S.; Tsuge, T.; Summers, D.; Sivaniah, E.
Efficient production of active polyhydroxyalkanoate synthase in Escherichia coli by coexpression of molecular chaperones
Appl. Environ. Microbiol.
79
1948-1955
2013
Cupriavidus necator (P23608), Cupriavidus necator, Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 (P23608)
Hyakutake, M.; Tomizawa, S.; Mizuno, K.; Abe, H.; Tsuge, T.
Alcoholytic cleavage of polyhydroxyalkanoate chains by class IV synthases induced by endogenous and exogenous ethanol
Appl. Environ. Microbiol.
80
1421-1429
2014
Bacillus cereus (D2Z0B8 and D2Z0B6), Bacillus cereus, Bacillus cereus YB-4 (D2Z0B8 and D2Z0B6)
Ochi, A.; Matsumoto, K.; Ooba, T.; Sakai, K.; Tsuge, T.; Taguchi, S.
Engineering of class i lactate-polymerizing polyhydroxyalkanoate synthases from Ralstonia eutropha that synthesize lactate-based polyester with a block nature
Appl. Microbiol. Biotechnol.
97
3441-3447
2013
Cupriavidus necator (P23608), Cupriavidus necator, Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 (P23608)
Buckley, R.M.; Stubbe, J.
Chemistry with an artificial primer of polyhydroxybutyrate synthase suggests a mechanism for chain termination
Biochemistry
54
2117-2125
2015
Caulobacter vibrioides
Edkie, G.; Prasad, D.
Bacillus PHA synthase III C gene showed regulatory functions: An in-silico analysis
Biotechnology
13
143-151
2014
Bacillus subtilis (I4EBJ0)
-
Foong, C.; Lau, N.; Deguchi, S.; Toyofuku, T.; Taylor, T.; Sudesh, K.; Matsui, M.
Whole genome amplification approach reveals novel polyhydroxyalkanoate synthases (PhaCs) from Japan Trench and Nankai Trough seawater
BMC Microbiol.
14
318
2014
Marinobacter sp. (U7P2T8), Marinobacter sp. C1S70 (U7P2T8)
Klask, C.; Raberg, M.; Heinrich, D.; Steinbchel, A.
Heterologous expression of various PHA synthase genes in Rhodospirillum rubrum
Chem. Biochem. Eng. Q.
29
75-85
2015
Rhodospirillum rubrum
-
Chen, Y.J.; Tsai, P.C.; Hsu, C.H.; Lee, C.Y.
Critical residues of class II PHA synthase for expanding the substrate specificity and enhancing the biosynthesis of polyhydroxyalkanoate
Enzyme Microb. Technol.
56
60-66
2014
Pseudomonas putida, Pseudomonas putida GPo1 / ATCC29347
Gowda, V.; Shivakumar, S.
Poly(3)hydroxybutyrate (PHB) production in Bacillus thuringiensis IAM 12077 under varied nutrient limiting conditions and molecular detection of class IV PHA synthase gene by PCR
Int. J. Pharm. Bio Sci.
4
B794-B802
2013
Bacillus thuringiensis, Bacillus thuringiensis IAM 12077
-
Tai, Y.T.; Foong, C.P.; Najimudin, N.; Sudesh, K.
Discovery of a new polyhydroxyalkanoate synthase from limestone soil through metagenomic approach
J. Biosci. Bioeng.
121
355-364
2015
uncultured bacterium (A0A0F6WBG5), uncultured bacterium, uncultured bacterium SC8 (A0A0F6WBG5)
Park, S.J.; Kang, K.H.; Lee, H.; Park, A.R.; Yang, J.E.; Oh, Y.H.; Song, B.K.; Jegal, J.; Lee, S.H.; Lee, S.Y.
Propionyl-CoA dependent biosynthesis of 2-hydroxybutyrate containing polyhydroxyalkanoates in metabolically engineered Escherichia coli
J. Biotechnol.
165
93-98
2013
Pseudomonas sp., Pseudomonas sp. MBEL 619
Muniasamy, G.; Perez-Guevara, F.
Use of SNAREs for the immobilization of poly-3-hydroxyalkanoate polymerase type II of Pseudomonas putida CA-3 in secretory vesicles of Saccharomyces cerevisiae ATCC 9763
J. Biotechnol.
172
77-79
2014
Pseudomonas putida, Pseudomonas putida CA-3
Muangsuwan, W.; Ruangsuj, P.; Chaichanachaicharn, P.; Yasawong, M.
A novel nucleic lateral flow assay for screening of PHA-producing haloarchaea
J. Microbiol. Methods
116
8-14
2015
Haloquadratum walsbyi (G0LKV7), Haloquadratum walsbyi DSM 16854 (G0LKV7)
Hyakutake, M.; Tomizawa, S.; Sugahara, I.; Murata, E.; Mizuno, K.; Abe, H.; Tsuge, T.
Carboxy-terminal modification of polyhydroxyalkanoate (PHA) via alcoholysis reaction catalyzed by class IV PHA synthase
Polym. Degrad. Stab.
117
90-96
2015
Bacillus cereus (D2Z0B8 and D2Z0B6), Bacillus cereus YB-4 (D2Z0B8 and D2Z0B6)
-
Chek, M.F.; Hiroe, A.; Hakoshima, T.; Sudesh, K.; Taguchi, S.
PHA synthase (PhaC) interpreting the functions of bioplastic-producing enzyme from a structural perspective
Appl. Microbiol. Biotechnol.
103
1131-1141
2019
Aeromonas caviae, Chromobacterium sp. USM2 (E1APK1), Cupriavidus necator (P23608), Cupriavidus necator, Pseudomonas sp. 61-3 (Q9Z3Y1), Cupriavidus necator Stanier 337 (P23608), Cupriavidus necator 17699 (P23608), Cupriavidus necator DSM 428 (P23608)
Jia, K.; Cao, R.; Hua, D.H.; Li, P.
Study of class I and class III polyhydroxyalkanoate (PHA) synthases with substrates containing a modified side chain
Biomacromolecules
17
1477-1485
2016
Allochromatium vinosum, Caulobacter vibrioides (A0A290N3S7), Caulobacter vibrioides, Chromobacterium sp. USM2 (E1APK1)
Fluechter, S.; Follonier, S.; Schiel-Bengelsdorf, B.; Bengelsdorf, F.R.; Zinn, M.
Anaerobic production of poly(3-hydroxybutyrate) and its precursor 3?hydroxybutyrate from synthesis gas by autotrophic clostridia
Biomacromolecules
20
3271-3282
2019
Clostridium acetireducens (A0A1E8EW93 AND A0A1E8EW64), Clostridium acetireducens DSM 10703 (A0A1E8EW93 AND A0A1E8EW64)
Venkateswar Reddy, M.; Mawatari, Y.; Onodera, R.; Nakamura, Y.; Yajima, Y.; Chang, Y.
Polyhydroxyalkanoates (PHA) production from synthetic waste using Pseudomonas pseudoflava PHA synthase enzyme activity analysis from P. pseudoflava and P. palleronii
Biores. Technol.
234
99-105
2017
Hydrogenophaga palleronii, Hydrogenophaga pseudoflava, Hydrogenophaga pseudoflava (A0A4P6X2C3), Hydrogenophaga pseudoflava NBRC-102513, Hydrogenophaga pseudoflava NBRC-102513 (A0A4P6X2C3)
Miyahara, Y.; Hiroe, A.; Tsuge, T.; Taguchi, S.
Microbial secretion platform for 3-hydroxybutyrate oligomer and its end-capped forms using chain transfer reaction-mediated polyhydroxyalkanoate synthases
Biotechnol. J.
14
e1900201
2019
Bacillus cereus (D2Z0B8), Aeromonas caviae (O32471), Delftia acidovorans (O87110), Cupriavidus necator (P23608), Allochromatium vinosum (P45370), Bacillus sp. INT005 (Q8GI81), Priestia megaterium (Q9ZF92), Cupriavidus necator Stanier 337 (P23608), Cupriavidus necator DSM 428 (P23608), Cupriavidus necator ATCC 17699 (P23608)
Nguyen, T.H.; Ishizuna, F.; Sato, Y.; Arai, H.; Ishii, M.
Physiological characterization of poly-beta-hydroxybutyrate accumulation in the moderately thermophilic hydrogen-oxidizing bacterium Hydrogenophilus thermoluteolus TH-1
J. Biosci. Bioeng.
127
686-689
2019
Hydrogenophilus thermoluteolus (A0A2Z6DVS4), Hydrogenophilus thermoluteolus (A0A2Z6DWT1), Hydrogenophilus thermoluteolus, Hydrogenophilus thermoluteolus DSM 6765 (A0A2Z6DVS4), Hydrogenophilus thermoluteolus DSM 6765 (A0A2Z6DWT1), Hydrogenophilus thermoluteolus TH-1 (A0A2Z6DVS4), Hydrogenophilus thermoluteolus TH-1 (A0A2Z6DWT1)
Sudo, M.; Hori, C.; Ooi, T.; Mizuno, S.; Tsuge, T.; Matsumoto, K.
Synergy of valine and threonine supplementation on poly(2-hydroxybutyrate-block-3-hydroxybutyrate) synthesis in engineered Escherichia coli expressing chimeric polyhydroxyalkanoate synthase
J. Biosci. Bioeng.
129
302-306
2020
Aeromonas caviae (O32471), Aeromonas caviae, Cupriavidus necator (P23608), Cupriavidus necator, Cupriavidus necator Stanier 337 (P23608), Cupriavidus necator DSM 428 (P23608), Cupriavidus necator ATCC 17699 (P23608)
Tan, I.K.P.; Foong, C.P.; Tan, H.T.; Lim, H.; Zain, N.A.; Tan, Y.C.; Hoh, C.C.; Sudesh, K.
Polyhydroxyalkanoate (PHA) synthase genes and PHA-associated gene clusters in Pseudomonas spp. and Janthinobacterium spp. isolated from Antarctica
J. Biotechnol.
313
18-28
2020
Janthinobacterium sp. UMAB-56, Janthinobacterium sp. UMAB-60, Pseudomonas sp. UMAB-08, Pseudomonas sp. UMAB-40, Janthinobacterium sp. UMAB-58
Foong, C.; Lakshmanan, M.; Abe, H.; Taylor, T.; Foong, S.; Sudesh, K.
A novel and wide substrate specific polyhydroxyalkanoate (PHA) synthase from unculturable bacteria found in mangrove soil
J. Polym. Res.
25
23
2018
uncultured bacterium
-
Woo, S.; Lee, S.; Rhee, Y.
Substrate chain-length specificities of polyhydroxyalkanoate synthases PhaC1 and PhaC2 from Pseudomonas aeruginosa P-5
Korean J. Microbiol.
52
455-462
2016
Pseudomonas aeruginosa (H6VX88), Pseudomonas aeruginosa (H6VX89), Pseudomonas aeruginosa P-5 (H6VX88), Pseudomonas aeruginosa P-5 (H6VX89)
-
Du, J.; Rehm, B.
Purification of target proteins from intracellular inclusions mediated by intein cleavable polyhydroxyalkanoate synthase fusions
Microb. Cell Fact.
16
184
2017
Cupriavidus necator (P23608), Cupriavidus necator Stanier 337 (P23608), Cupriavidus necator DSM 428 (P23608), Cupriavidus necator ATCC 17699 (P23608)
Mezzolla, V.; D'Urso, O.; Poltronieri, P.
Role of PhaC type I and type II enzymes during PHA biosynthesis
Polymers (Basel)
10
910
2018
Pseudomonas aeruginosa (Q51513), Pseudomonas mendocina (Q2PMY5), Pseudomonas oleovorans (P26494), Pseudomonas putida (A0A1Y5KN65), Pseudomonas stutzeri (Q848R9)
Lau, N.S.; Sudesh, K.
Revelation of the ability of Burkholderia sp. USM (JCM 15050) PHA synthase to polymerize 4-hydroxybutyrate monomer
AMB Express
2
41
2012
Burkholderia sp. USM (JCM 15050)
Amara, A.A.; Steinbuechel, A.; Rehm, B.H.
In vivo evolution of the Aeromonas punctata polyhydroxyalkanoate (PHA) synthase isolation and characterization of modified PHA synthases with enhanced activity
Appl. Microbiol. Biotechnol.
59
477-482
2002
Aeromonas caviae
Shen, X.W.; Shi, Z.Y.; Song, G.; Li, Z.J.; Chen, G.Q.
Engineering of polyhydroxyalkanoate (PHA) synthase PhaC2Ps of Pseudomonas stutzeri via site-specific mutation for efficient production of PHA copolymers
Appl. Microbiol. Biotechnol.
91
655-665
2011
Pseudomonas stutzeri, Pseudomonas stutzeri 1317
Tajima, K.; Han, X.; Satoh, Y.; Ishii, A.; Araki, Y.; Munekata, M.; Taguchi, S.
In vitro synthesis of polyhydroxyalkanoate (PHA) incorporating lactate (LA) with a block sequence by using a newly engineered thermostable PHA synthase from Pseudomonas sp. SG4502 with acquired LA-polymerizing activity
Appl. Microbiol. Biotechnol.
94
365-376
2012
Pseudomonas sp. SG4502
Qin, L.; Gao, X.; Liu, Q.; Wu, Q.; Chen, G.
Biosynthesis of polyhydroxyalkanoate copolyesters by Aeromonas hydrophila mutant expressing a low-substrate-specificity PHA synthase PhaC2Ps
Biochem. Eng. J.
37
144-150
2007
Pseudomonas stutzeri, Pseudomonas stutzeri 1317
-
Matsumoto, K.; Nagao, R.; Murata, T.; Arai, Y.; Kichise, T.; Nakashita, H.; Taguchi, S.; Shimada, H.; Doi, Y.
Enhancement of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) production in the transgenic Arabidopsis thaliana by the in vitro evolved highly active mutants of polyhydroxyalkanoate (PHA) synthase from Aeromonas caviae
Biomacromolecules
6
2126-2130
2005
Aeromonas caviae
Matsumoto, K.; Aoki, E.; Takase, K.; Doi, Y.; Taguchi, S.
In vivo and in vitro characterization of Ser477X mutations in polyhydroxyalkanoate (PHA) synthase 1 from Pseudomonas sp. 61-3 effects of beneficial mutations on enzymatic activity, substrate specificity, and molecular weight of PHA
Biomacromolecules
7
2436-2442
2006
Pseudomonas sp. 61-3
Liu, C.H.; Chen, H.Y.; Chen, Y.L.; Sheu, D.S.
The polyhydroxyalkanoate (PHA) synthase 1 of Pseudomonas sp. H9 synthesized a 3-hydroxybutyrate-dominant hybrid of short- and medium-chain-length PHA
Enzyme Microb. Technol.
143
109719
2021
Pseudomonas sp. H9 (A0A4R5K593)
Qi, Q.; Rehm, B.H.; Steinbuechel, A.
Synthesis of poly(3-hydroxyalkanoates) in Escherichia coli expressing the PHA synthase gene phaC2 from Pseudomonas aeruginosa comparison of PhaC1 and PhaC2
FEMS Microbiol. Lett.
157
155-162
1997
Pseudomonas aeruginosa
Tan, H.T.; Chek, M.F.; Lakshmanan, M.; Foong, C.P.; Hakoshima, T.; Sudesh, K.
Evaluation of BP-M-CPF4 polyhydroxyalkanoate (PHA) synthase on the production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from plant oil using Cupriavidus necator transformants
Int. J. Biol. Macromol.
159
250-257
2020
Chromobacterium sp. USM2
Lim, H.; Chuah, J.A.; Chek, M.F.; Tan, H.T.; Hakoshima, T.; Sudesh, K.
Identification of regions affecting enzyme activity, substrate binding, dimer stabilization and polyhydroxyalkanoate (PHA) granule morphology in the PHA synthase of Aquitalea sp. USM4
Int. J. Biol. Macromol.
186
414-423
2021
Aquitalea sp. USM4
Sudesh, K.; Taguchi, K.; Doi, Y.
Effect of increased PHA synthase activity on polyhydroxyalkanoates biosynthesis in Synechocystis sp. PCC6803
Int. J. Biol. Macromol.
30
97-104
2002
Synechocystis sp. PCC 6803
Chee, J.Y.; Lau, N.S.; Samian, M.R.; Tsuge, T.; Sudesh, K.
Expression of Aeromonas caviae polyhydroxyalkanoate synthase gene in Burkholderia sp. USM (JCM15050) enables the biosynthesis of SCL-MCL PHA from palm oil products
J. Appl. Microbiol.
112
45-54
2012
Aeromonas caviae
Hiroe, A.; Ushimaru, K.; Tsuge, T.
Characterization of polyhydroxyalkanoate (PHA) synthase derived from Delftia acidovorans DS-17 and the influence of PHA production in Escherichia coli
J. Biosci. Bioeng.
115
633-638
2013
Cupriavidus necator, Delftia acidovorans, Delftia acidovorans DS-17
Hu, F.; You, S.
Inactivation of type I polyhydroxyalkanoate synthase in Aeromonas hydrophila resulted in discovery of another potential PHA synthase
J. Ind. Microbiol. Biotechnol.
34
255-260
2007
Aeromonas hydrophila, Aeromonas hydrophila CGMCC 0911
Pantazaki, A.A.; Tambaka, M.G.; Langlois, V.; Guerin, P.; Kyriakidis, D.A.
Polyhydroxyalkanoate (PHA) biosynthesis in Thermus thermophilus purification and biochemical properties of PHA synthase
Mol. Cell. Biochem.
254
173-183
2003
Thermus thermophilus
Mok, P.S.; Chuah, J.A.; Najimudin, N.; Liew, P.W.; Jong, B.C.; Sudesh, K.
In vivo characterization and application of the PHA synthase from Azotobacter vinelandii for the biosynthesis of polyhydroxyalkanoate containing 4-hydroxybutyrate
Polymers (Basel)
13
1576
2021
Azotobacter vinelandii, Azotobacter vinelandii ATCC 12837
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