Literature summary for 2.3.1.304 extracted from

Jia, Y.; Kappock, T.J.; Frick, T.; Sinskey, A.J.; Stubbe, J.
Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in Chromatium vinosum PHB synthase (2000), Biochemistry, 39, 3927-3936.

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Protein Variants

Protein Variants	Comment	Organism
C130A	89% of wild-type activity in the initial phase of reaction, 39% of wild-type activity in tghe second phase of reaction	Allochromatium vinosum
C130S	121% of wild-type activity in the initial phase of reaction, 16% of wild-type activity in tghe second phase of reaction	Allochromatium vinosum
C149S	0.1% of wild-type activity in the initial phase of reaction, 0.09% of wild-type activity in tghe second phase of reaction	Allochromatium vinosum
c149S/H331Q	no activity	Allochromatium vinosum
D302N	0.012% of wild-type activity in the initial phase of reaction, 0.29% of wild-type activity in tghe second phase of reaction	Allochromatium vinosum
H303Q	0.25% of wild-type activity in the initial phase of reaction, 1.6% of wild-type activity in tghe second phase of reaction	Allochromatium vinosum
H331Q	51% of wild-type activity in the initial phase of reaction, 73% of wild-type activity in tghe second phase of reaction	Allochromatium vinosum

Organism

Organism	UniProt	Comment	Textmining
Allochromatium vinosum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-hydroxybutyryl-CoA + [(R)-3-hydroxybutanoate]n	-	Allochromatium vinosum	[(R)-3-hydroxybutyrate](n+1) + CoA	-	?

Synonyms

Synonyms	Comment	Organism
PHB synthase	-	Allochromatium vinosum

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Release 2023.1 (January 2023)