Reference on EC 3.4.21.98 - hepacivirin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, J.L.; Morgenstern, K.A.; Lin, C.; Fox, T.; Dwyer, M.D.; Landro, J.A.; Chambers, S.P.; Markland, W.; Lepre, C.A.; OMalley, E.T.; Harbeson, S.L.; Rice, C.M.; Murcko, M.A.; Caron, P.R.; Thomson, J.A.
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide [published erratum appears in Cell 1997 Apr 4;89(1):159
Cell
87
343-355
1996
Hepacivirus C
Love, R.A.; Parge, H.E.; Wickersham, J.A.; Hostomsky, Z.; Habuka, N.; Moomaw, E.W.; Adachi, T.; Hostomska, Z.
The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
Cell
87
331-342
1996
Hepacivirus C
Sardana, V.V.; Blue, J.T.; Zugay-Murphy, J.; Sardana, M.K.; Kuo, L.C.
An uniquely purified HCV NS3 protease and NS4A(21-34) peptide form a highly active serine protease complex in peptide hydrolysis
Protein Expr. Purif.
16
440-447
1999
Hepacivirus C
Cicero, D.O.; Barbato, G.; Koch, U.; Ingallinella, P.; Bianchi, E.; Nardi, M.C.; Steinkuhler, C.; Cortese, R.; Matassa, V.; de Francesco, R.; Pessi, A.; Bazzo, R.
Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies
J. Mol. Biol.
289
385-396
1999
Hepacivirus C
Bianchi, E.; Orru, S.; Dal Piaz F.; Ingenito, R.; Casbarra, A.; Biasiol, G.; Koch, U.; Pucci, P.; Pessi, A.
Conformational changes in human hepatitis C virus NS3 protease upon binding of product-based inhibitors
Biochemistry
38
13844-13852
1999
Hepacivirus C
Llinas-Brunet, M.; Bailey, M.; Fazal, G.; Goulet, S.; Halmos, T.; Laplante, S.; Maurice, R.; Poirier, M.; Poupart, M.A.; Thibeault, D.; Wernic, D.; Lamarre, D.
Peptide-based inhibitors of the hepatitis C virus serine protease
Bioorg. Med. Chem. Lett.
8
1713-1718
1998
Hepacivirus C
Dimasi, N.; Pasquo, A.; Martin, F.; di Marco, S.; Steinkuhler, C.; Cortese, R.; Sollazzo, M.
Engineering, characterization and phage display of hepatitis C virus NS3 protease and NS4A cofactor peptide as a single-chain protein
Protein Eng.
11
1257-1265
1998
Hepacivirus C
Taremi, S.S.; Beyer, B.; Maher, M.; Yao, N.; Prosise, W.; Weber, P.C.; Malcolm, B.A.
Construction, expression, and characterization of a novel fully activated recombinant single-chain hepatitis C virus protease
Protein Sci.
7
2143-2149
1998
Hepacivirus C
Steinkuhler, C.; Biasiol, G.; Brunetti, M.; Urbani, A.; Koch, U.; Cortese, R.; Pessi, A.; de Francesco, R.
Product inhibition of the hepatitis C virus NS3 protease
Biochemistry
37
8899-8905
1998
Hepacivirus C
Gnther, R.; Schmidt, W.E.
[Clarifying the crystal structure of hepatitis C virus NS3/NS4A protease complex--basics for the development of specific HCV protease inhibitors?
Z. Gastroenterol.
35
1119-1121
1997
Hepacivirus C
Markland, W.; Petrillo, R.A.; Fitzgibbon, M.; Fox, T.; McCarrick, R.; McQuaid, T.; Fulghum, J.R.; Chen, W.; Fleming, M.A.; Thomson, J.A.; Chambers, S.P.
Purification and characterization of the NS3 serine protease domain of hepatitis C virus expressed in Saccharomyces cerevisiae
J. Gen. Virol.
78
39-43
1997
Hepacivirus C
Wilkinson, T.C.I.; Bunyard, P.R.; Quirk, K; Wilkinson, C.S.
Characterisation of an HCV NS3/NS4A proteinase fusion protein expressed in E.coli using synthetic peptide substrates
Biochem. Soc. Trans.
25
S624
1997
Hepacivirus C
Landro, J.A.; Raybuck, S.A.; Luong, Y.P.C.; OMalley, E.T.; Harbeson, S.L.; Morgenstern, K.A.; Rao, G.; Livingston, D.J.
Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping
Biochemistry
36
9340-9348
1997
Hepacivirus C
Steinkuhler, C.; Urbani, A.; Tomei, L.; Biasiol., G.; Sardana, M.; Bianchi, E.; Pessi, A.; de Francesco, R.
Activity of purified hepatitis C virus protease NS3 on peptide substrates
J. Virol.
70
6694-6700
1996
Hepacivirus C
Steinkhler, C.; Tomei, L.; de Francesco, R.
In vitro activity of hepatitis C virus protease NS3 purified from recombinant Baculovirus-infected Sf9 cells
J. Biol. Chem.
271
6367-6373
1996
Hepacivirus C
Mori, A.; Yamada, K.; Kimura, J.; Koide, J.; Yuasa, S.; Yamada, E.; Miyamura, T.
Enzymatic characterization of purified NS3 serine proteinase of hepatitis C virus expressed in Escherichia coli
FEBS Lett.
378
37-42
1996
Hepacivirus C
DSouza, E.D.A.; Grace, K.; Sangar, D.V.; Rowlands, D.J.; Clarke, B.E.
In vitro cleavage of hepatitis C virus polyprotein substrates by purified recombinant NS3 protease
J. Gen. Virol.
76
1729-1736
1995
Hepacivirus C
Liu, Y.; Stoll, V.S.; Richardson, P.L.; Saldivar, A.; Klaus, J.L.; Molla, A.; Kohlbrenner, W.; Kati, W.M.
Hepatitis C NS3 protease inhibition by peptidyl-alpha-ketoamide inhibitors: kinetic mechanism and structure
Arch. Biochem. Biophys.
421
207-216
2004
Hepacivirus C
Butkiewicz, N.J.; Yao, N.; Wright-Minogue, J.; Zhang, R.; Ramanathan, L.; Lau, J.Y.; Hong, Z.; Dasmahapatra, B.
Hepatitis C NS3 protease: restoration of NS4A cofactor activity by N-biotinylation of mutated NS4A using synthetic peptides
Biochem. Biophys. Res. Commun.
267
278-282
2000
Hepacivirus C
Hwang, J.; Fauzi, H.; Fukuda, K.; Sekiya, S.; Kakiuchi, N.; Shimotohno, K.; Taira, K.; Kusakabe, I.; Nishikawa, S.
The RNA aptamer-binding site of hepatitis C virus NS3 protease
Biochem. Biophys. Res. Commun.
279
557-562
2000
Hepacivirus C
Kasai, N.; Tsumoto, K.; Niwa, S.; Misawa, S.; Ueno, T.; Hayashi, H.; Kumagai, I.
Inhibition of the Hepatitis C Virus NS3 Protease Activity by Fv Fragment of Antibody 8D4
Biochem. Biophys. Res. Commun.
281
416-424
2001
Hepacivirus C
Ingallinella, P.; Bianchi, E.; Ingenito, R.; Koch, U.; Steinkhler, C.; Altamura, S.; Pessi, A.
Optimization of the P'-region of peptide inhibitors of hepatitis C virus NS3/4A protease
Biochemistry
39
12898-12906
2000
Hepacivirus C
Narjes, F.; Brunetti, M.; Colarusso, S.; Gerlach, B.; Koch, U.; Biasiol, G.; Fattori, D.; de Francesco, R.; Matassa, V.G.; Steinkuhler, C.
alpha-Ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease
Biochemistry
39
1849-1861
2000
Hepacivirus C
Koch, U.; Biasiol, G.; Brunetti, M.; Fattori, D.; Pallaoro, M.; Steinkhler, C.
Role of charged residues in the catalytic mechanism of hepatitis C virus NS3 protease: electrostatic precollision guidance and transition-state stabilization
Biochemistry
40
631-640
2001
Hepacivirus C
Ingallinella, P.; Fattori, D.; Altamura, S.; Steinkuhler, C.; Koch, U.; Cicero, D.; Bazzo, R.; Cortese, R.; Bianchi, E.; Pessi, A.
Prime site binding inhibitors of a serine protease: NS3/4A of hepatitis C virus
Biochemistry
41
5483-5492
2002
Hepacivirus C
Liu, Y.; Saldivar, A.; Bess, J.; Solomon, L.; Chen, C.M.; Tripathi, R.; Barrett, L.; Richardson, P.L.; Molla, A.; Kohlbrenner, W.; Kati, W.
Investigating the origin of the slow-binding inhibition of HCV NS3 serine protease by a novel substrate based inhibitor
Biochemistry
42
8862-8869
2003
Hepacivirus C
Priestley, E.S.; De Lucca, I.; Ghavimi, B.; Erickson-Viitanen, S.; Decicco, C.P.
P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease
Bioorg. Med. Chem. Lett.
12
3199-3202
2002
Hepacivirus C
Archer, S.J.; Camac, D.M.; Wu, Z.J.; Farrow, N.A.; Domaille, P.J.; Wasserman, Z.R.; Bukhtiyarova, M.; Rizzo, C.; Jagannathan, S.; Mersinger, L.J.; Kettner, C.A.
Hepatitis C virus NS3 protease requires its NS4A cofactor peptide for optimal binding of a boronic acid inhibitor as shown by NMR
Chem. Biol.
9
79-92
2002
Hepacivirus C
Mak, P.; Palant, O.; Labonte, P.; Plotch, S.
Reconstitution of hepatitis C virus protease activities in yeast
FEBS Lett.
503
13-18
2001
Hepacivirus C
Di Marco, S.; Rizzi, M.; Volpari, C.; Walsh, M.A.; Narjes, F.; Colarusso, S.; De Francesco, R.; Matassa, V.G.; Sollazzo, M.
Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes
J. Biol. Chem.
275
7152-7157
2000
Hepacivirus C
Richer, M.J.; Juliano, L.; Hashimoto, C.; Jean, F.
Serpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition: induced fit as a mechanism for narrow specificity
J. Biol. Chem.
279
10222-10227
2004
Hepacivirus C
Colarusso, S.; Koch, U.; Gerlach, B.; Steinkuhler, C.; De Francesco, R.; Altamura, S.; Matassa, V.G.; Narjes, F.
Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling
J. Med. Chem.
46
345-348
2003
Hepacivirus C
Wyss, D.F.; Arasappan, A.; Senior, M.M.; Wang, Y.S.; Beyer, B.M.; Njoroge, F.G.; McCoy, M.A.
Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening
J. Med. Chem.
47
2486-2498
2004
Hepacivirus C (P26663), Hepacivirus C
Rancourt, J.; Cameron, D.R.; Gorys, V.; Lamarre, D.; Poirier, M.; Thibeault, D.; Llinas-Brunet, M.
Peptide-based inhibitors of the hepatitis C virus NS3 protease: structure-activity relationship at the C-terminal position
J. Med. Chem.
47
2511-2522
2004
Hepacivirus C (P26663)
McCoy, M.A.; Senior, M.M.; Gesell, J.J.; Ramanathan, L.; Wyss, D.F.
Solution structure and dynamics of the single-chain hepatitis C virus NS3 protease NS4A cofactor complex
J. Mol. Biol.
305
1099-1110
2001
Hepacivirus C
Poupart, M.A.; Cameron, D.R.; Chabot, C.; Ghiro, E.; Goudreau, N.; Goulet, S.; Poirier, M.; Tsantrizos, Y.S.
Solid-phase synthesis of peptidomimetic inhibitors for the hepatitis C virus NS3 protease
J. Org. Chem.
66
4743-4751
2001
Hepacivirus C
Slater, M.J.; Amphlett, E.M.; Andrews, D.M.; Bamborough, P.; Carey, S.J.; Johnson, M.R.; Jones, P.S.; Mills, G.; Parry, N.R.; Somers, D.O.N.; Stewart, A.J.; Skarzynski, T.
Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease
Org. Lett.
5
4627-4630
2003
Hepacivirus C
Poliakov, A.; Hubatsch, I.; Shuman, C.F.; Stenberg, G.; Danielson, U.H.
Expression and purification of recombinant full-length NS3 protease-helicase from a new variant of hepatitis C virus
Protein Expr. Purif.
25
363-371
2002
Hepacivirus C
Casbarra, A.; Piaz, F.D.; Ingallinella, P.; Orru, S.; Pucci, P.; Pessi, A.; Bianchi, E.
The effect of prime-site occupancy on the hepatitis C virus NS3 protease structure
Protein Sci.
11
2102-2112
2002
Hepacivirus C
Beyer, B.M.; Zhang, R.; Hong, Z.; Madison, V.; Malcolm, B.A.
Effect of naturally occurring active site mutations on hepatitis C virus NS3 protease specificity
Proteins Struct. Funct. Genet.
43
82-88
2001
Hepacivirus C
Pacini, L.; Bartholomew, L.; Vitelli, A.; Migliaccio, G.
Reporter substrates for assessing the activity of the hepatitis C virus NS3-4A serine protease in living cells
Anal. Biochem.
331
46-59
2004
Hepacivirus C
Shiryaev, S.A.; Ratnikov, B.I.; Chekanov, A.V.; Sikora, S.; Rozanov, D.V.; Godzik, A.; Wang, J.; Smith, J.W.; Huang, Z.; Lindberg, I.; Samuel, M.A.; Diamond, M.S.; Strongin, A.Y.
Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase
Biochem. J.
393
503-511
2006
West Nile virus
Hamill, P.; Jean, F.
Enzymatic characterization of membrane-associated hepatitis C virus NS3-4A heterocomplex serine protease activity expressed in human cells
Biochemistry
44
6586-6596
2005
Hepacivirus C
Tong, X.; Guo, Z.; Wright-Minogue, J.; Xia, E.; Prongay, A.; Madison, V.; Qiu, P.; Venkatraman, S.; Velazquez, F.; Njoroge, F.G.; Malcolm, B.A.
Impact of naturally occurring variants of HCV protease on the binding of different classes of protease inhibitors
Biochemistry
45
1353-1361
2006
Hepacivirus C (P27958)
Poliakov, A.; Johansson, A.; Akerblom, E.; Oscarsson, K.; Samuelsson, B.; Hallberg, A.; Danielson, U.H.
Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors
Biochim. Biophys. Acta
1672
51-59
2004
Hepacivirus C
Johansson, A.; Poliakov, A.; Akerblom, E.; Wiklund, K.; Lindeberg, G.; Winiwater, S.; Danielson, U.H.; Samuelsson, B.; Hallberg, A.
Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-length NS3 (protease-helicase/NTPase): a comparative study of different C-terminals
Bioorg. Med. Chem.
11
2551-2568
2003
Hepacivirus C
Venkatraman, S.; Njoroge, F.G.; Wu, W.; Girijavallabhan, V.; Prongay, A.J.; Butkiewicz, N.; Pichardo, J.
Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid
Bioorg. Med. Chem. Lett.
16
1628-1632
2006
Hepacivirus C
Nall, T.A.; Chappell, K.J.; Stoermer, M.J.; Fang, N.X.; Tyndall, J.D.; Young, P.R.; Fairlie, D.P.
Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease
J. Biol. Chem.
279
48535-48542
2004
West Nile virus
Chappell, K.J.; Nall, T.A.; Stoermer, M.J.; Fang, N.X.; Tyndall, J.D.; Fairlie, D.P.; Young, P.R.
Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions
J. Biol. Chem.
280
2896-2903
2005
West Nile virus
Lin, C.; Gates, C.A.; Rao, B.G.; Brennan, D.L.; Fulghum, J.R.; Luong, Y.P.; Frantz, J.D.; Lin, K.; Ma, S.; Wei, Y.Y.; Perni, R.B.; Kwong, A.D.
In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061
J. Biol. Chem.
280
36784-36791
2005
Hepacivirus C (P26663), Hepacivirus C
Chambers, T.J.; Droll, D.A.; Tang, Y.; Liang, Y.; Ganesh, V.K.; Murthy, K.H.; Nickells, M.
Yellow fever virus NS2B-NS3 protease: characterization of charged-to-alanine mutant and revertant viruses and analysis of polyprotein-cleavage activities
J. Gen. Virol.
86
1403-1413
2005
Yellow fever virus
Bailey, M.D.; Halmos, T.; Goudreau, N.; Lescop, E.; Llinas-Brunet, M.
Novel azapeptide inhibitors of hepatitis C virus serine protease
J. Med. Chem.
47
3788-3799
2004
Hepacivirus C
Llinas-Brunet, M.; Bailey, M.D.; Ghiro, E.; Gorys, V.; Halmos, T.; Poirier, M.; Rancourt, J.; Goudreau, N.
A systematic approach to the optimization of substrate-based inhibitors of the hepatitis C virus NS3 protease: discovery of potent and specific tripeptide inhibitors
J. Med. Chem.
47
6584-6594
2004
Hepacivirus C
Chen, K.X.; Njoroge, F.G.; Pichardo, J.; Prongay, A.; Butkiewicz, N.; Yao, N.; Madison, V.; Girijavallabhan, V.
Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease
J. Med. Chem.
49
567-574
2006
Hepacivirus C
Chen, K.X.; Njoroge, F.G.; Arasappan, A.; Venkatraman, S.; Vibulbhan, B.; Yang, W.; Parekh, T.N.; Pichardo, J.; Prongay, A.; Cheng, K.C.; Butkiewicz, N.; Yao, N.; Madison, V.; Girijavallabhan, V.
Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles
J. Med. Chem.
49
995-1005
2006
Hepacivirus C
Goudreau, N.; Brochu, C.; Cameron, D.R.; Duceppe, J.S.; Faucher, A.M.; Ferland, J.M.; Grand-Maitre, C.; Poirier, M.; Simoneau, B.; Tsantrizos, Y.S.
Potent inhibitors of the hepatitis C virus NS3 protease: design and synthesis of macrocyclic substrate-based beta-strand mimics
J. Org. Chem.
69
6185-6201
2004
Hepacivirus C
Li, X.D.; Sun, L.; Seth, R.B.; Pineda, G.; Chen, Z.J.
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
Proc. Natl. Acad. Sci. USA
102
17717-17722
2005
Hepacivirus C
Loehr, K.; Knox, J.E.; Phong, W.Y.; Ma, N.L.; Yin, Z.; Sampath, A.; Patel, S.J.; Wang, W.L.; Chan, W.L.; Rao, K.R.; Wang, G.; Vasudevan, S.G.; Keller, T.H.; Lim, S.P.
Yellow fever virus NS3 protease: peptide-inhibition studies
J. Gen. Virol.
88
2223-2227
2007
Yellow fever virus
Soderholm, J.; Sallberg, M.
A complete mutational fitness map of the hepatitis C virus nonstructural 3 protease: Relation to recognition by cytotoxic T lymphocytes
J. Infect. Dis.
194
1724-1728
2006
Hepacivirus C
Tedbury, P.R.; Harris, M.
Characterisation of the role of zinc in the hepatitis C virus NS2/3 auto-cleavage and NS3 protease activities
J. Mol. Biol.
366
1652-1660
2007
Hepacivirus C (O92972)
Zuo, G.; Li, Z.; Chen, L.; Xu, X.
Activity of compounds from Chinese herbal medicine Rhodiola kirilowii (Regel) Maxim against HCV NS3 serine protease
Antiviral Res.
76
86-92
2007
Hepacivirus C
Li, X.; Zhang, W.; Qiao, X.; Xu, X.
Prediction of binding for a kind of non-peptic HCV NS3 serine protease inhibitors from plants by molecular docking and MM-PBSA method
Bioorg. Med. Chem.
15
220-226
2007
Hepacivirus C
Chen, K.X.; Vibulbhan, B.; Yang, W.; Cheng, K.C.; Liu, R.; Pichardo, J.; Butkiewicz, N.; Njoroge, F.G.
Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue
Bioorg. Med. Chem.
16
1874-1883
2008
Hepacivirus C
Mastrangelo, E.; Milani, M.; Bollati, M.; Selisko, B.; Peyrane, F.; Pandini, V.; Sorrentino, G.; Canard, B.; Konarev, P.V.; Svergun, D.I.; de Lamballerie, X.; Coutard, B.; Khromykh, A.A.; Bolognesi, M.
Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein
J. Mol. Biol.
372
444-455
2007
Kunjin virus
De Francesco, R.; Carfi, A.
Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus
Adv. Drug Deliv. Rev.
59
1242-1262
2007
Hepacivirus C
Konstantinidis, A.K.; Richardson, P.L.; Kurtz, K.A.; Tripathi, R.; Chen, C.M.; Huang, P.; Randolph, J.; Towne, D.; Donnelly, J.; Warrior, U.; Middleton, T.; Kati, W.M.
Longer wavelength fluorescence resonance energy transfer depsipeptide substrates for hepatitis C virus NS3 protease
Anal. Biochem.
368
156-167
2007
Hepacivirus C
Zhou, Y.; Bartels, D.J.; Hanzelka, B.L.; Mueh, U.; Wei, Y.; Chu, H.M.; Tigges, A.M.; Brennan, D.L.; Rao, B.G.; Swenson, L.; Kwong, A.D.; Lin, C.
Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease
Antimicrob. Agents Chemother.
52
110-120
2008
Hepacivirus C, Hepacivirus C H
Johansson, P.O.; Baeck, M.; Kvarnstroem, I.; Jansson, K.; Vrang, L.; Hamelink, E.; Hallberg, A.; Rosenquist, A.; Samuelsson, B.
Potent inhibitors of the hepatitis C virus NS3 protease: use of a novel P2 cyclopentane-derived template
Bioorg. Med. Chem.
14
5136-5151
2006
Hepacivirus C
Baeck, M.; Johansson, P.O.; Wangsell, F.; Thorstensson, F.; Kvarnstroem, I.; Ayesa, S.; Waehling, H.; Pelcman, M.; Jansson, K.; Lindstroem, S.; Wallberg, H.; Classon, B.; Rydergard, C.; Vrang, L.; Hamelink, E.; Hallberg, A.; Rosenquist, S.; Samuelsson, B.
Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: use of cyclopentane and cyclopentene P2-motifs
Bioorg. Med. Chem.
15
7184-7202
2007
Hepacivirus C
Thorstensson, F.; Wangsell, F.; Kvarnstroem, I.; Vrang, L.; Hamelink, E.; Jansson, K.; Hallberg, A.; Rosenquist, S.; Samuelsson, B.
Synthesis of novel potent hepatitis C virus NS3 protease inhibitors: discovery of 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a N-acyl-L-hydroxyproline bioisostere
Bioorg. Med. Chem.
15
827-838
2007
Hepacivirus C
Arasappan, A.; Njoroge, F.G.; Chen, K.X.; Venkatraman, S.; Parekh, T.N.; Gu, H.; Pichardo, J.; Butkiewicz, N.; Prongay, A.; Madison, V.; Girijavallabhan, V.
P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease
Bioorg. Med. Chem. Lett.
16
3960-3965
2006
Hepacivirus C
Venkatraman, S.; Njoroge, F.G.
Macrocyclic inhibitors of HCV NS3-4A protease: design and structure activity relationship
Curr. Top. Med. Chem.
7
1290-1301
2007
Hepacivirus C
Chappell, K.J.; Stoermer, M.J.; Fairlie, D.P.; Young, P.R.
Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies
J. Biol. Chem.
281
38448-38458
2006
West Nile virus
Johnson, C.L.; Owen, D.M.; Gale, M.
Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense
J. Biol. Chem.
282
10792-10803
2007
Hepacivirus C
Zhou, Y.; Mueh, U.; Hanzelka, B.L.; Bartels, D.J.; Wei, Y.; Rao, B.G.; Brennan, D.L.; Tigges, A.M.; Swenson, L.; Kwong, A.D.; Lin, C.
Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha
J. Biol. Chem.
282
22619-22628
2007
Hepacivirus C
Poliakov, A.; Sandstroem, A.; Akerblom, E.; Danielson, U.H.
Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3
J. Enzyme Inhib. Med. Chem.
22
191-199
2007
Hepacivirus C
Breiman, A.; Vitour, D.; Vilasco, M.; Ottone, C.; Molina, S.; Pichard, L.; Fournier, C.; Delgrange, D.; Charneau, P.; Duverlie, G.; Wychowski, C.; Maurel, P.; Meurs, E.F.
A hepatitis C virus (HCV) NS3/4A protease-dependent strategy for the identification and purification of HCV-infected cells
J. Gen. Virol.
87
3587-3598
2006
Hepacivirus C
Knox, J.E.; Ma, N.L.; Yin, Z.; Patel, S.J.; Wang, W.L.; Chan, W.L.; Ranga Rao, K.R.; Wang, G.; Ngew, X.; Patel, V.; Beer, D.; Lim, S.P.; Vasudevan, S.G.; Keller, T.H.
Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors
J. Med. Chem.
49
6585-6590
2006
West Nile virus
Rosales-Leon, L.; Ortega-Lule, G.; Ruiz-Ordaz, B.
Analysis of the domain interactions between the protease and helicase of NS3 in dengue and hepatitis C virus
J. Mol. Graph. Model.
25
585-594
2007
Dengue virus, Hepacivirus C
Cheng, G.; Zhong, J.; Chisari, F.V.
Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms
Proc. Natl. Acad. Sci. USA
103
8499-8504
2006
Hepacivirus C
Oliva, C.; Rodriguez, A.; Gonzalez, M.; Yang, W.
A quantum mechanics/molecular mechanics study of the reaction mechanism of the hepatitis C virus NS3 protease with the NS5A/5B substrate
Proteins
66
444-455
2007
Hepacivirus C
Cubero, M.; Esteban, J.I.; Otero, T.; Sauleda, S.; Bes, M.; Esteban, R.; Guardia, J.; Quer, J.
Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient
Virology
370
237-245
2008
Hepacivirus C (A6N6Q4), Hepacivirus C (A6N6T5), Hepacivirus C
Franco, S.; Clotet, B.; Martinez, M.A.
A wide range of NS3/4A protease catalytic efficiencies in HCV-infected individuals
Virus Res.
131
260-270
2008
Hepacivirus C, Hepacivirus C (A8DX91), Hepacivirus C (A8DXI7), Hepacivirus C (A8DXT5), Hepacivirus C (B0L492), Hepacivirus C (B0L493), Hepacivirus C (B0L494), Hepacivirus C (B0L495), Hepacivirus C (B0L496), Hepacivirus C (B0L497), Hepacivirus C (Q8JRC7)
Lin, T.I.; Lenz, O.; Fanning, G.; Verbinnen, T.; Delouvroy, F.; Scholliers, A.; Vermeiren, K.; Rosenquist, A.; Edlund, M.; Samuelsson, B.; Vrang, L.; de Kock, H.; Wigerinck, P.; Raboisson, P.; Simmen, K.
In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor
Antimicrob. Agents Chemother.
53
1377-1385
2009
Hepacivirus C, hepatitis C virus genotype 1a
Helbig, K.J.; Yip, E.; McCartney, E.M.; Eyre, N.S.; Beard, M.R.
A screening method for identifying disruptions in interferon signaling reveals HCV NS3/4a disrupts Stat-1 phosphorylation
Antiviral Res.
77
169-176
2008
Hepacivirus C
Dansako, H.; Ikeda, M.; Ariumi, Y.; Wakita, T.; Kato, N.
Double-stranded RNA-induced interferon-beta and inflammatory cytokine production modulated by hepatitis C virus serine proteases derived from patients with hepatic diseases
Arch. Virol.
154
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2009
Hepacivirus C
Bogen, S.; Arasappan, A.; Pan, W.; Ruan, S.; Padilla, A.; Saksena, A.K.; Girijavallabhan, V.; Njoroge, F.G.
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034
Bioorg. Med. Chem. Lett.
18
4219-4223
2008
Hepacivirus C
Raboisson, P.; Lin, T.I.; Kock, H.; Vendeville, S.; Vreken, W.V.; McGowan, D.; Tahri, A.; Hu, L.; Lenz, O.; Delouvroy, F.; Surleraux, D.; Wigerinck, P.; Nilsson, M.; Rosenquist, S.; Samuelsson, B.; Simmen, K.
Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors
Bioorg. Med. Chem. Lett.
18
5095-5100
2008
Hepacivirus C
Avolio, S.; Robertson, K.; Hernando, J.I.; DiMuzio, J.; Summa, V.
Inhibitors of hepatitis C virus NS3/4A: alpha-ketoamide based macrocyclic inhibitors
Bioorg. Med. Chem. Lett.
19
2295-2298
2009
Hepacivirus C
Rebsamen, M.; Meylan, E.; Curran, J.; Tschopp, J.
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases
Cell Death Differ.
15
1804-1811
2008
Hepacivirus C
Mederacke, I.; Wedemeyer, H.; Manns, M.P.
Boceprevir, an NS3 serine protease inhibitor of hepatitis C virus, for the treatment of HCV infection
Curr. Opin. Investig. Drugs
10
181-189
2009
Hepacivirus C
El Hefnawi, M.M.; El Behaidy, W.H.; Youssif, A.A.; Ghalwash, A.Z.; El Housseiny, L.A.; Zada, S.
Natural genetic engineering of hepatitis C virus NS5A for immune system counterattack
Ann. N. Y. Acad. Sci.
1178
173-185
2009
Hepacivirus C
Lenz, O.; Verbinnen, T.; Lin, T.I.; Vijgen, L.; Cummings, M.D.; Lindberg, J.; Berke, J.M.; Dehertogh, P.; Fransen, E.; Scholliers, A.; Vermeiren, K.; Ivens, T.; Raboisson, P.; Edlund, M.; Storm, S.; Vrang, L.; de Kock, H.; Fanning, G.C.; Simmen, K.A.
In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435
Antimicrob. Agents Chemother.
54
1878-1887
2010
Hepacivirus C
Liverton, N.J.; Carroll, S.S.; Dimuzio, J.; Fandozzi, C.; Graham, D.J.; Hazuda, D.; Holloway, M.K.; Ludmerer, S.W.; McCauley, J.A.; McIntyre, C.J.; Olsen, D.B.; Rudd, M.T.; Stahlhut, M.; Vacca, J.P.
MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease
Antimicrob. Agents Chemother.
54
305-311
2010
Hepacivirus C
Salloum, S.; Kluge, S.F.; Kim, A.Y.; Roggendorf, M.; Timm, J.
The resistance mutation R155K in the NS3/4A protease of hepatitis C virus also lead the virus to escape from HLA-A*68-restricted CD8 T cells
Antiviral Res.
87
272-275
2010
Hepacivirus C
Wang, L.; Fu, Q.; Dong, Y.; Zhou, Y.; Jia, S.; Du, J.; Zhao, F.; Wang, Y.; Wang, X.; Peng, J.; Yang, S.; Zhan, L.
Bioluminescence imaging of Hepatitis C virus NS3/4A serine protease activity in cells and living animals
Antiviral Res.
87
50-56
2010
Hepacivirus C
Peres-da-Silva, A.; de Almeida, A.J.; Lampe, E.
Mutations in hepatitis C virus NS3 protease domain associated with resistance to specific protease inhibitors in antiviral therapy naive patients
Arch. Virol.
155
807-811
2010
Hepacivirus C
Massariol, M.J.; Zhao, S.; Marquis, M.; Thibeault, D.; White, P.W.
Protease and helicase activities of hepatitis C virus genotype 4, 5, and 6 NS3-NS4A proteins
Biochem. Biophys. Res. Commun.
391
692-697
2010
Hepacivirus C
Thibeault, D.; Massariol, M.J.; Zhao, S.; Welchner, E.; Goudreau, N.; Gingras, R.; Llinas-Brunet, M.; White, P.W.
Use of the fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A
Biochemistry
48
744-753
2009
Hepacivirus C, Hepacivirus C J
McCauley, J.A.; McIntyre, C.J.; Rudd, M.T.; Nguyen, K.T.; Romano, J.J.; Butcher, J.W.; Gilbert, K.F.; Bush, K.J.; Holloway, M.K.; Swestock, J.; Wan, B.L.; Carroll, S.S.; DiMuzio, J.M.; Graham, D.J.; Ludmerer, S.W.; Mao, S.S.; Stahlhut, M.W.; Fandozzi, C.M.; Trainor, N.; Olsen, D.B.; Vacca, J.P.; Liverton, N.J.
Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor
J. Med. Chem.
53
2443-2463
2010
Hepacivirus C
Lemm, J.A.; OBoyle, D.; Liu, M.; Nower, P.T.; Colonno, R.; Deshpande, M.S.; Snyder, L.B.; Martin, S.W.; St Laurent, D.R.; Serrano-Wu, M.H.; Romine, J.L.; Meanwell, N.A.; Gao, M.
Identification of hepatitis C virus NS5A inhibitors
J. Virol.
84
482-491
2010
Hepacivirus C
Martin, M.M.; Condotta, S.A.; Fenn, J.; Olmstead, A.D.; Jean, F.
In-cell selectivity profiling of membrane-anchored and replicase-associated hepatitis C virus NS3-4A protease reveals a common, stringent substrate recognition profile
Biol. Chem.
392
927-935
2011
Hepacivirus C
Nilsson, M.; Belfrage, A.K.; Lindstroem, S.; Waehling, H.; Lindquist, C.; Ayesa, S.; Kahnberg, P.; Pelcman, M.; Benkestock, K.; Agback, T.; Vrang, L.; Terelius, Y.; Wikstroem, K.; Hamelink, E.; Rydergard, C.; Edlund, M.; Eneroth, A.; Raboisson, P.; Lin, T.I.; de Kock, H.; Wigerinck, P.; Simmen, K.; , S.
Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituents
Bioorg. Med. Chem. Lett.
20
4004-4011
2010
Hepacivirus C
Clarke, M.O.; Chen, X.; Cho, A.; Delaney, W.E.; Doerffler, E.; Fardis, M.; Ji, M.; Mertzman, M.; Pakdaman, R.; Pyun, H.J.; Rowe, T.; Yang, C.Y.; Sheng, X.C.; Kim, C.U.
Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease
Bioorg. Med. Chem. Lett.
21
3568-3572
2011
Hepacivirus C
Bogen, S.L.; Arasappan, A.; Velazquez, F.; Blackman, M.; Huelgas, R.; Pan, W.; Siegel, E.; Nair, L.G.; Venkatraman, S.; Guo, Z.; Doll, R.; Shih, N.Y.; Njoroge, F.G.
Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species
Bioorg. Med. Chem.
18
1854-1865
2010
Hepacivirus C
Abian, O.; Vega, S.; Neira, J.L.; Velazquez-Campoy, A.
Conformational stability of hepatitis C virus NS3 protease
Biophys. J.
99
3811-3820
2010
Hepacivirus C
Liu, Y.H.; Ramanathan, L.; Malcolm, B.; Njoroge, G.; Chan, T.Y.; Pramanik, B.N.
Screening and rank ordering of reversible mechanism-based inhibitors of hepatitis C virus NS3 protease using electrospray ionization mass spectrometry
J. Mass Spectrom.
46
764-771
2011
Hepacivirus C
Geitmann, M.; Dahl, G.; Danielson, U.H.
Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors
J. Mol. Recognit.
24
60-70
2011
Hepacivirus C
Aparicio, E.; Franco, S.; Parera, M.; Andres, C.; Tural, C.; Clotet, B.; Martinez, M.A.
Complexity and catalytic efficiency of hepatitis C virus (HCV) NS3 and NS4A protease quasispecies influence responsiveness to treatment with pegylated interferon plus ribavirin in HCV/HIV-coinfected patients
J. Virol.
85
5961-5969
2011
Hepacivirus C
Romano, K.P.; Laine, J.M.; Deveau, L.M.; Cao, H.; Massi, F.; Schiffer, C.A.
Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease
J. Virol.
85
6106-6116
2011
Hepacivirus C
Jiang, M.; Mani, N.; Lin, C.; Ardzinski, A.; Nelson, M.; Reagan, D.; Bartels, D.; Zhou, Y.; Nicolas, O.; Rao, B.G.; Mueh, U.; Hanzelka, B.; Tigges, A.; Rijnbrand, R.; Kieffer, T.L.
In vitro phenotypic characterization of hepatitis C virus NS3 protease variants observed in clinical studies of telaprevir
Antimicrob. Agents Chemother.
57
6236-6245
2013
Hepacivirus C
Bondada, L.; Rondla, R.; Pradere, U.; Liu, P.; Li, C.; Bobeck, D.; McBrayer, T.; Tharnish, P.; Courcambeck, J.; Halfon, P.; Whitaker, T.; Amblard, F.; Coats, S.J.; Schinazi, R.F.
Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors
Bioorg. Med. Chem. Lett.
23
6325-6330
2013
Hepacivirus C
Parsy, C.; Alexandre, F.R.; Brandt, G.; Caillet, C.; Cappelle, S.; Chaves, D.; Convard, T.; Derock, M.; Gloux, D.; Griffon, Y.; Lallos, L.; Leroy, F.; Liuzzi, M.; Loi, A.G.; Moulat, L.; Musiu, C.; Rahali, H.; Roques, V.; Seifer, M.; Standring, D.; Surleraux, D.
Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease
Bioorg. Med. Chem. Lett.
24
4444-4449
2014
Hepacivirus C (Q0ZNA6), Hepacivirus C
Kirschberg, T.A.; Squires, N.H.; Yang, H.; Corsa, A.C.; Tian, Y.; Tirunagari, N.; Sheng, X.C.; Kim, C.U.
Novel, sulfonamide linked inhibitors of the hepatitis C virus NS3 protease
Bioorg. Med. Chem. Lett.
24
969-972
2014
Hepacivirus C
Ding, Q.; Huang, B.; Lu, J.; Liu, Y.J.; Zhong, J.
Hepatitis C virus NS3/4A protease blocks IL-28 production
Eur. J. Immunol.
42
2374-2382
2012
Hepacivirus C
Morikawa, K.; Gouttenoire, J.; Hernandez, C.; Dao Thi, V.L.; Tran, H.T.; Lange, C.M.; Dill, M.T.; Heim, M.H.; Donze, O.; Penin, F.; Quadroni, M.; Moradpour, D.
Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease
Hepatology
59
423-433
2014
Hepacivirus C
Rimmert, B.; Sabet, S.; Ackad, E.; Yousef, M.S.
A 3D structural model and dynamics of hepatitis C virus NS3/4A protease (genotype 4a, strain ED43) suggest conformational instability of the catalytic triad: implications in catalysis and drug resistivity
J. Biomol. Struct. Dyn.
32
950-958
2014
Hepacivirus C, Hepacivirus C ED43
Meeprasert, A.; Hannongbua, S.; Rungrotmongkol, T.
Key binding and susceptibility of NS3/4A serine protease inhibitors against hepatitis C virus
J. Chem. Inf. Model.
54
1208-1217
2014
Hepacivirus C
Brenndoerfer, E.D.; Brass, A.; Karthe, J.; Ahlen, G.; Bode, J.G.; Saellberg, M.
Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy
J. Immunol.
192
1671-1680
2014
Hepacivirus C
LaPlante, S.R.; Nar, H.; Lemke, C.T.; Jakalian, A.; Aubry, N.; Kawai, S.H.
Ligand bioactive conformation plays a critical role in the design of drugs that target the hepatitis C virus NS3 protease
J. Med. Chem.
57
1777-1789
2014
Hepacivirus C (Q0ZNA6)
Lan, H.Y.; Zhao, Y.; Yang, J.; Sun, M.N.; Lei, Y.F.; Yao, M.; Huang, X.J.; Zhang, J.M.; Xu, Z.K.; Lue, X.; Yin, W.
Establishment of a novel triple-transgenic mouse: conditionally and liver-specifically expressing hepatitis C virus NS3/4A protease
Mol. Biol. Rep.
41
7349-7359
2014
Hepacivirus C
Parera, M.; Martrus, G.; Franco, S.; Clotet, B.; Martinez, M.A.
Canine hepacivirus NS3 serine protease can cleave the human adaptor proteins MAVS and TRIF
PLoS ONE
7
e42481
2012
canine hepacivirus
Abian, O.; Vega, S.; Sancho, J.; Velazquez-Campoy, A.
Allosteric inhibitors of the NS3 protease from the hepatitis C virus
PLoS ONE
8
e69773
2013
Hepacivirus C
Khanizadeh, S.; Ravanshad, M.; Hosseini, S.; Davoodian, P.; Zadeh, A.; Sabahi, F.; Sarvari, J.; Khanlari, Z.; Hasani-Azad, M.
The possible role of NS3 protease activity of hepatitis C virus on fibrogenesis and miR-122 expression in hepatic stellate cells
Acta Virol.
60
242-248
2016
Hepacivirus C
Jensen, S.B.; Serre, S.B.; Humes, D.G.; Ramirez, S.; Li, Y.P.; Bukh, J.; Gottwein, J.M.
Substitutions at NS3 residue 155, 156, or 168 of hepatitis C virus genotypes 2 to 6 induce complex patterns of protease inhibitor resistance
Antimicrob. Agents Chemother.
59
7426-7436
2015
hepatitis C virus genotype 1a, Hepatitis C virus subtype 3a, Hepatitis C virus genotype 4a (O39929), Hepatitis C virus genotype 5a (O91936), Hepatitis C virus genotype 2a (Q99IB8)
Naeem, A.; Waheed, Y.
Sequence analysis of hepatitis C virus nonstructural protein 3-4A serine protease and prediction of conserved B and T cell epitopes
Biomed. Rep.
7
563-566
2017
Hepacivirus C
Shi, F.; Zhang, Y.; Xu, W.
Discovery of a series of novel compounds with moderate anti-hepatitis C virus NS3 protease activity in vitro
Bioorg. Med. Chem.
23
5539-5545
2015
Hepatitis C virus genotype 1b (P26662)
Belfrage, A.K.; Abdurakhmanov, E.; Kerblom, E.; Brandt, P.; Oshalim, A.; Gising, J.; Skogh, A.; Neyts, J.; Danielson, U.H.; Sandstroem, A.
Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease
Bioorg. Med. Chem.
24
2603-2620
2016
Hepacivirus C
Wang, A.X.; Chen, J.; Zhao, Q.; Sun, L.Q.; Friborg, J.; Yu, F.; Hernandez, D.; Good, A.C.; Klei, H.E.; Rajamani, R.; Mosure, K.; Knipe, J.O.; Li, D.; Zhu, J.; Levesque, P.C.; McPhee, F.; Meanwell, N.A.; Scola, P.M.
Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus
Bioorg. Med. Chem. Lett.
27
590-596
2017
hepatitis C virus genotype 1a (P27958), Hepatitis C virus genotype 1b (P26663)
Taylor, J.; Zipfel, S.; Ramey, K.; Vivian, R.; Schrier, A.; Karki, K.; Katana, A.; Kato, D.; Kobayashi, T.; Martinez, R.; Sangi, M.; Siegel, D.; Tran, C.; Yang, Z.; Zablocki, J.; Yang, C.; Wang, Y.; Wang, K.; Chan, K.; Barauskas, O.; Cheng, G.; Jin, D.
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857) A component of Vosevi
Bioorg. Med. Chem. Lett.
29
2428,2436
2019
Hepacivirus C
Oezen, A.; Prachanronarong, K.; Matthew, A.N.; Soumana, D.I.; Schiffer, C.A.
Resistance outside the substrate envelope hepatitis C NS3/4A protease inhibitors
Crit. Rev. Biochem. Mol. Biol.
54
11-26
2019
Hepatitis C virus genotype 1b (P26662)
El-Sayed, S.M.; Ali, M.A.M.; El-Gendy, B.E.M.; Dandash, S.S.; Issac, Y.; Saad, R.; Azab, M.M.; Mohamed, M.R.
Identification of novel small molecule inhibitors against the NS3/4A protease of hepatitis C virus genotype 4a
Curr. Pharm. Des.
24
4484-4491
2018
Hepatitis C virus genotype 4a (O39929)
Wei, Y.; Yang, J.; Kishore Sakharkar, M.; Wang, X.; Liu, Q.; Du, J.; Zhang, J.J.
Evaluating the inhibitory effect of eight compounds from Daphne papyracea against the NS3/4A protease of hepatitis C virus
Nat. Prod. Res.
0
1-4
2018
Hepacivirus C
Yang, C.M.; Yoon, J.C.; Park, J.H.; Lee, J.M.
Hepatitis C virus impairs natural killer cell activity via viral serine protease NS3
PLoS ONE
12
e0175793
2017
Hepatitis C virus genotype 2a (Q99IB8)
Dietz, J.; Lutz, T.; Knecht, G.; Gute, P.; Berkowski, C.; Lange, C.M.; Khaykin, P.; Stephan, C.; Brodt, H.R.; Herrmann, E.; Zeuzem, S.; Sarrazin, C.
Evolution and function of the HCV NS3 protease in patients with acute hepatitis C and HIV coinfection
Virology
485
213-222
2015
Hepacivirus C
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