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Literature summary for 3.4.21.98 extracted from

  • Jiang, M.; Mani, N.; Lin, C.; Ardzinski, A.; Nelson, M.; Reagan, D.; Bartels, D.; Zhou, Y.; Nicolas, O.; Rao, B.G.; Mueh, U.; Hanzelka, B.; Tigges, A.; Rijnbrand, R.; Kieffer, T.L.
    In vitro phenotypic characterization of hepatitis C virus NS3 protease variants observed in clinical studies of telaprevir (2013), Antimicrob. Agents Chemother., 57, 6236-6245.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.98

Protein Variants

Protein Variants Comment Organism
A156F rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
A156N rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
A156S frequently observed mutant with lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
A156T frequently observed mutant with higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
A156V rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
I132V rarely observed mutant, does not confer resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
R155G rarely observed mutant, confers lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
R155I rarely observed mutant, confers lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
R155K frequently observed mutant with lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
R155M rarely observed mutant, confers lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
R155S rarely observed mutant, confers lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
R155T frequently observed mutant with lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
R155T/D168N rarely observed mutant, confers lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
T54A frequently observed mutant with lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
T54A/A156S rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
T54S frequently observed mutant with lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
T54S/A156S rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
T54S/A156T rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
T54S/R155K rarely observed mutant, confers lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V361L rarely observed mutant, does not confer resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36A frequently observed mutant with lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36A/A156T rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36A/R155K rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36A/R155T rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36A/T54A rarely observed mutant, confers lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36C rarely observed mutant, confers lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36G rarely observed mutant, confers lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36I rarely observed mutant, does not confer resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36L/R155K rarely observed mutant, confers lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36M frequently observed mutant with lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36M/A156T rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36M/R155K frequently observed mutant with higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36M/R155T rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C
V36M/T54S/R155K rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
telaprevir
-
 Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Synonyms

Synonyms Comment Organism
NS3-4A protease
-
 Hepacivirus C