Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NS4A | enhances the activity of NS3 protease in all cleavages via the formation of an NS3/NS4A | Hepacivirus C |
Application | Comment | Organism |
---|---|---|
pharmacology | the viral protease may be a target for antiviral drugs | Hepacivirus C |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ac-DDIVPC-OH | 0.04 mM, 50% inhibition | Hepacivirus C | |
Ac-DVIVPC-OH | 0.0075 mM, 50% inhibition | Hepacivirus C | |
DDIVPC-OH | 0.071 mM, 50% inhibition | Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
non-structural protein NS5B of hepatitis C virus + H2O | - |
Hepacivirus C | ? + DDIVPC-OH | N-terminal hexapeptide | ? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0075 | - |
Ac-DVIVPC-OH | - |
Hepacivirus C | |
0.04 | - |
Ac-DDIVPC-OH | - |
Hepacivirus C | |
0.071 | - |
DDIVPC-OH | - |
Hepacivirus C |