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Literature summary for 3.4.21.98 extracted from

  • Zuo, G.; Li, Z.; Chen, L.; Xu, X.
    Activity of compounds from Chinese herbal medicine Rhodiola kirilowii (Regel) Maxim against HCV NS3 serine protease (2007), Antiviral Res., 76, 86-92.
    View publication on PubMed
Search for more literature for 3.4.21.98

Application

Application Comment Organism
drug development nonpeptide inhibitors of hepatitis C virus NS3-SP from Chinese medicinal herb Rhodiola kirilowii (Regel) may serve as potential candiate anti-hepatitis C virus agents Hepacivirus C

Cloned(Commentary)

Cloned (Comment) Organism
recombinant plasmid pMANS34NSH containing MBP-NS3-SP expressed in Escherichia coli JM109 cells. PCI-neo-NS3/4A-SEAP chimeric plasmid expressed in Cos-7 cells Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
(-)-epicatechin-3-O-gallate
-
 Hepacivirus C
(-)-epigallocatechin-3-O-gallate
-
 Hepacivirus C
3,3'-digalloylprocyanidin B2
-
 Hepacivirus C
3,3'-digalloylproprodelphinidin B2 rhodisin Hepacivirus C
additional information methylated 3,3'-digalloylproprodelphinidin B2, hexanoylated (-)-epigallocatechin-3-O-gallate, (-)-epigallocatechin, (-)-epicatechin, gallic acid, luetolin, tyrosol and salidroside show no activity up to 100 micromol Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Synonyms

Synonyms Comment Organism
NS3 serine protease
-
 Hepacivirus C
NS3-SP
-
 Hepacivirus C

Cofactor

Cofactor Comment Organism Structure
additional information NS-4A cofactor Hepacivirus C

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00077
-
-
 Hepacivirus C 3,3'-digalloylproprodelphinidin B2
0.00091
-
-
 Hepacivirus C 3,3'-digalloylprocyanidin B2
0.00851
-
-
 Hepacivirus C (-)-epigallocatechin-3-O-gallate
0.01855
-
-
 Hepacivirus C (-)-epicatechin-3-O-gallate
0.02596
-
 acetylation of the inhibitor Hepacivirus C 3,3'-digalloylproprodelphinidin B2
0.04455
-
 acetylation of the inhibitor Hepacivirus C (-)-epigallocatechin-3-O-gallate
0.05647
-
 methylation of the inhibitor Hepacivirus C (-)-epigallocatechin-3-O-gallate
0.07006
-
 methylation of the inhibitor Hepacivirus C (-)-epicatechin-3-O-gallate