Literature summary for 3.4.21.98 extracted from

Soderholm, J.; Sallberg, M.
A complete mutational fitness map of the hepatitis C virus nonstructural 3 protease: Relation to recognition by cytotoxic T lymphocytes (2006), J. Infect. Dis., 194, 1724-1728.

Search for more literature for 3.4.21.98

Application

Application	Comment	Organism
drug development	design of epitope-based vaccines, where epitopes preferably should be those in which the virus is unable to mutate due to viral fitness	Hepacivirus C

Protein Variants

Protein Variants	Comment	Organism
additional information	sequentially mutated 180 protease-domain residues to Ala or Gly in a functional full-length NS3/4A gene. Most (87%) protease residues can be replaced and protease activity is retained, suggesting that the protease has an unexpectedly high plasticity	Hepacivirus C

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	human leukocyte antigen A2restricted epitope in which substitutions at 5 of 9 residues destroy the protease	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
nonstructural 3 protease	-	Hepacivirus C
NS3 protease	-	Hepacivirus C
NS3/4A protease	-	Hepacivirus C

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Release 2023.1 (January 2023)